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Pro-inflammatory effects of silver nanoparticles in the intestine

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Abstract

Nanotechnology is a promising technology of the twenty-first century, being a rapidly evolving field of research and industrial innovation widely applied in our everyday life. Silver nanoparticles (AgNP) are considered the most commercialized nanosystems worldwide, being applied in diverse sectors, from medicine to the food industry. Considering their unique physical, chemical and biological properties, AgNP have gained access into our daily life, with an exponential use in food industry, leading to an increased inevitable human oral exposure. With the growing use of AgNP, several concerns have been raised, in recent years, about their potential hazards to human health, more precisely their pro-inflammatory effects within the gastrointestinal system. Therefore a review of the literature has been undertaken to understand the pro-inflammatory potential of AgNP, after human oral exposure, in the intestine. Despite the paucity of information reported in the literature about this issue, existing studies indicate that AgNP exert a pro-inflammatory action, through generation of oxidative stress, accompanied by mitochondrial dysfunction, interference with transcription factors and production of cytokines. However, further studies are needed to elucidate the mechanistic pathways and molecular targets involved in the intestinal pro-inflammatory effects of AgNP.

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The present work was supported by UID/QUI/50006/2020 with funding from FCT/MCTES through national funds and ‘Programa Operacional Competitividade e Internacionalização (COMPETE) (PTDC/NAN-MAT/29248/2017-POCI‑01‑0145‑FEDER‑029248). Adelaide Sousa thanks FCT (Fundação para a Ciência e Tecnologia) and ESF (European Social Fund) through POCH (Programa Operacional Capital Humano) for her PhD grant reference SFRH/BD/150656/2020. Marisa Freitas acknowledges her contract under the Scientific Employment Stimulus—Individual Call (CEEC Individual) 2020.04126.CEECIND/CP1596/CT0006.

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Authors and Affiliations

  1. LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n.º 228, 4050-313, Porto, Portugal

    Adelaide Sousa, Daniela Ribeiro, Eduarda Fernandes & Marisa Freitas

  2. Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, UK

    Tracey D. Bradshaw

  3. Faculty of Agrarian Sciences and Environment, University of the Azores, 9700-042, Angra do Heroísmo, Açores, Portugal

    Daniela Ribeiro

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  1. Adelaide Sousa
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  2. Tracey D. Bradshaw
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  3. Daniela Ribeiro
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  4. Eduarda Fernandes
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  5. Marisa Freitas
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Correspondence to Eduarda Fernandes or Marisa Freitas.

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Sousa, A., Bradshaw, T.D., Ribeiro, D. et al. Pro-inflammatory effects of silver nanoparticles in the intestine. Arch Toxicol 96, 1551–1571 (2022). https://doi.org/10.1007/s00204-022-03270-w

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  • DOI: https://doi.org/10.1007/s00204-022-03270-w

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