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The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis

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Abstract

Background

Recent studies have suggested that irritable bowel syndrome (IBS) could be a risk factor for osteoporosis although the evidence is still limited. The current study aimed to comprehensively examine the risk of osteoporosis among patients with IBS using systematic review and meta-analysis technique.

Methodology

Literature search was independently conducted by two investigators using MEDLINE, EMBASE, and Google Scholar database up to October 2019. Eligible study must evaluate whether patients with IBS have a higher risk of osteoporosis and/or osteoporotic fracture. It could be either cross-sectional study, case-control study, or cohort study. Point estimates and standard errors from each eligible study were combined together using the generic inverse variance method of DerSimonian and Laird.

Results

Of the 320 articles identified from the three databases, four cohort and one cross-sectional study with 526,633 participants met the eligibility criteria and were included into the meta-analysis. All five studies investigated the risk of osteoporosis among patients with IBS, and the pooled analysis found that patients with IBS had a significantly higher risk of osteoporosis than individuals without IBS with the pooled risk ratio of 1.95 (95% CI, 1.04–3.64; I2 100%). Sensitivity analysis including only cohort studies found a lower RR (pooled RR 1.55; 95% CI, 1.39–1.72) with a lower I2 (59%). Three studies investigated the risk of osteoporotic fracture, and the pooled analysis found that patients with IBS also had a higher risk of osteoporotic fracture than individuals without IBS with the pooled risk ratio of 1.58 although statistical significance was not reached (95% CI, 0.95–2.62; I2 99%). Sensitivity analysis including only cohort studies found a lower RR (pooled RR 1.27; 95% CI, 1.20–1.39) with a dramatically lower I2 (0%). Limitations included high heterogeneity and reliance on diagnostic codes.

Conclusion

A significantly increased risk of osteoporosis among IBS patients was observed in this study. Early intervention to prevent the development of osteoporosis, such as weight-bearing exercise, adequate intake of vitamin D and calcium, and early screening for osteoporosis, may be beneficial to these patients although further studies are still required to confirm the efficacy and cost-effectiveness of this approach.

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Acknowledgments

We would like to thank Mr. Matthew Roslund, a medical librarian at Bassett Medical Center in Cooperstown, NY, for his assistance with language editing.

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Authors and Affiliations

  1. Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    W. Wongtrakul

  2. Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    N. Charoenngam

  3. Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, USA

    P. Ungprasert

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  1. W. Wongtrakul
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  2. N. Charoenngam
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  3. P. Ungprasert
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All authors had access to the data. W.W. and N.C. drafted the manuscript. P.U. edited manuscript. All authors approved the manuscript.

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Correspondence to P. Ungprasert.

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Wongtrakul, W., Charoenngam, N. & Ungprasert, P. The association between irritable bowel syndrome and osteoporosis: a systematic review and meta-analysis. Osteoporos Int 31, 1049–1057 (2020). https://doi.org/10.1007/s00198-020-05318-y

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