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Anterior–apical Transvaginal Mesh (Calistar-S) for Treatment of Advanced Urogenital Prolapse: Surgical and Functional Outcomes at 1 Year

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Abstract

Introduction and hypothesis

Calistar-S is a single-incision synthetic mesh kit that addresses apical and anterior compartment prolapse. The aims of this study were to evaluate the short-term objective and subjective outcomes at the 1-year follow-up. The secondary objectives were to evaluate quality of life and lower urinary tract symptoms (LUTS) outcomes, as well as surgical complications.

Methods

Records of 108 patients with symptomatic advanced pelvic organ prolapse (stages III and IV) who underwent prolapse surgery using the Calistar-S system from June 2018 to August 2022 were reviewed. The primary outcome was the objective cure of anterior and apical prolapse < stage 1, and the subjective cure was the negative response to questions 2 and 3 of the Pelvic Organ Prolapse Distress Inventory-6. Secondary outcomes measured quality of life, the presence of lower urinary tract symptoms, and complications.

Results

A total of 101 patients were evaluated. The overall objective cure rate is 97% and the subjective cure rate is 92.1%. Good outcomes were seen in all three compartments. Secondary outcomes show significant improvement in all validated questionnaires. Persistence and de novo urinary incontinence were 15.2% and 18.2% post-operatively. There is one case of bladder injury and one case of vaginal mesh exposure.

Conclusions

The Calistar-S System is a safe and efficient method for treating advanced-stage POP. We observed good anatomical results and subjective relief with a minimal complication rate. LUTS have also been positively affected, showing a high success rate. Additional studies are needed to establish the long-term efficacy of this system.

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Author information

Authors and Affiliations

  1. Division of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, 5, Fu-Hsin Street, Kwei-Shan, Linkou, Tao-Yuan City, 333, Taiwan

    Tsia-Shu Lo, Eyal Rom, Wu-Chiao Hsieh & Yi-Hao Lin

  2. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung Medical Center, Keelung, Taiwan

    Tsia-Shu Lo

  3. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei Medical Center, Taipei, Taiwan

    Tsia-Shu Lo

  4. School of Medicine, Chang Gung University, Taoyuan, Taiwan

    Tsia-Shu Lo, Wu-Chiao Hsieh & Yi-Hao Lin

  5. Department of Obstetrics and Gynecology, Women and Children Hospital (Hospital Tunku Azizah), Kuala Lumpur, Malaysia

    Fazlin Harun

  6. Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Tucheng Medical Center, New Taipei City, Taiwan

    Lan-Sin Jhang

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  1. Tsia-Shu Lo
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Contributions

T.-S. Lo: project development, management data analysis, manuscript editing; E. Rom: manuscript writing; F. Harun: manuscript editing; L.-S. Jhang: data analysis; W.-C. Hsieh: data collection; Y.-H. Lin: data analysis.

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Correspondence to Tsia-Shu Lo.

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Lo, TS., Rom, E., Harun, F. et al. Anterior–apical Transvaginal Mesh (Calistar-S) for Treatment of Advanced Urogenital Prolapse: Surgical and Functional Outcomes at 1 Year. Int Urogynecol J (2024). https://doi.org/10.1007/s00192-024-05749-9

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