Abstract
This study aimed to investigate the testicular function of Mugil cephalus that inhabit Wadi El-Rayan lakes. Testes of fish inhabiting the upper lake (site 2) and the lower lake (site 3) of Wadi El-Rayan showed significant decreases in gonadosomatic index, high accumulation levels of six metals, and eight organochlorine pesticide residues. Compared to reference fish, high percentages of histological alterations as testicular degeneration, germ cell reduction, testicular inflammation, vacuolization, and loss of tubular arrangement were observed in sites 2 and 3. Moreover, endocrine disruption signs were recorded based on the percentage of ovotestis appearance and the ovotestis severity index values. The maximum defective testicular antioxidant mechanisms were recorded in site 3 as indicated by sharp decreases in catalase, superoxide dismutase, glutathione reduced levels, and high thiobarbituric acid reactive substances. Finally, long-term exposure to Wadi El-Rayan water may impair the reproductive health of fish via testicular oxidative damage and endocrine disruption.
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Data Availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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This study was supported by the Researchers Supporting Project number (RSP-2021/25), King Saud University, Riyadh, Saudi Arabia.
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All authors contributed to the study’s conception and design. Material preparation, data collection, and analysis were performed by [AAA-K], [SA-Q], and [RA-G]. The first draft of the manuscript was written by [AAA-K] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Abdel-Khalek, A.A., Al-Quraishy, S. & Abdel-Gaber, R. Long-Term Exposure to the Water of Wadi El-Rayan Lakes Induced Testicular Damage and Endocrine Disruption in Mugil cephalus. Bull Environ Contam Toxicol 108, 663–671 (2022). https://doi.org/10.1007/s00128-021-03406-1
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DOI: https://doi.org/10.1007/s00128-021-03406-1