Skip to main content
SpringerLink
Log in

Chronic Toxicological Effects of Carbamazepine on Daphnia magna Straus: Effects on Reproduction Traits, Body Length, and Intrinsic Growth

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

In recent years, pharmaceuticals and personal care products (PPCPs) that remain in the environment have become increasingly important. Carbamazepine (CBZ) is a widely used antiepileptic drug that has a potential impact on the environment due to its Physico-chemical properties, which are rarely eliminated in conventional water treatment. Daphnia magna Straus (DMS) is a fundamental link of aquatic ecosystem chain. The influence of CBZ toxicity on DMS can effectively reflect the effects of CBZ toxicity on the aquatic environment. In this study, DMS was used as a subject to assess the chronic effects of CBZ exposure. It was found that after 21 days of CBZ exposure, the breeding frequency, the total number of eggs laid, body length, and intrinsic growth rate of DMS decreased with increasing CBZ concentrations. Maximum reductions of 69% in fecundity and 60% in fertility were observed at 0.5 mg/L CBZ, while a maximum reduction of 60% in body length was observed at 0.001 mg/L CBZ concentration. The integrated biomarker response version 2 (IBRv2) analysis suggests that with the increase in CBZ concentration, the overall negative effect of CBZ on DMS was enhanced.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Brandhof EJVD, Montforts M (2010) Fish embryo toxicity of carbamazepine, diclofenac and metoprolol. Ecotoxicol Environ Saf 73(8):1866

    Google Scholar 

  • Chen H, Gu X, Zeng Q, Mao Z, Liang X, Martyniuk CJ (2019) Carbamazepine disrupts molting hormone signaling and inhibits molting and growth of Eriocheir sinensis at environmentally relevant concentrations. Aquat Toxicol 208:138–145

    Article  CAS  Google Scholar 

  • Dietrich S, Ploessl F, Bracher F, Laforsch C (2010) Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in daphnia magna—a multigenerational study. Chemosphere 79(1):60–66

    Article  CAS  Google Scholar 

  • Duarte IA, Reis-Santos P, Fran AS, Cabral H, Fonseca VF (2017) Biomarker responses to environmental contamination in estuaries: a comparative multi-taxa approach. Aquat Toxicol 183:31–34

    Article  CAS  Google Scholar 

  • Ekpeghere KI, Sim WJ, Lee HJ, Oh JE (2018) Occurrence and distribution of carbamazepine, nicotine, estrogenic compounds, and their transformation products in wastewater from various treatment plants and the aquatic environment. Sci Total Environ 640–641:1015–1023

    Article  CAS  Google Scholar 

  • Fraz S, Lee AH, Wilson JY (2018) Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). Aquat Toxicol 198:1–9

    Article  CAS  Google Scholar 

  • Fu J, Lee WN, Coleman C, Nowack K, Carter J, Huang CH (2019) Removal of pharmaceuticals and personal care products by two-stage biofiltration for drinking water treatment. Sci Total Environ 664:240–248

    Article  CAS  Google Scholar 

  • Ladewig V, Jungmann D, Kohler HR, Schirling M, Triebskorn R, Nagel R (2006) Population structure and dynamics of Gammarus fossarum (Amphipoda) upstream and downstream from effluents of sewage treatment plants. Arch Environ Contam Toxicol 50:370–383

    Article  CAS  Google Scholar 

  • Leblanc GA, Mclachlan JB (2010) Molt-independent growth inhibition of Daphnia magna by a vertebrate antiandrogen. Environ Toxicol Chem 18:1450–1455

    Article  Google Scholar 

  • Li ZH, Zlabek V, Velisek J, Grabic R, Machova J, Kolarova J et al (2011) Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic. Ecotox Environ Saf 74:319–327

    Article  CAS  Google Scholar 

  • Lürling M, Sargant E, Roessink I (2010) Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine. Environ Toxicol 21:172–180

    Article  CAS  Google Scholar 

  • Marques CR, Nelson A, Fernando G (2004) Life-history traits of standard and autochthonous cladocerans: II. Acute and chronic effects of acetylsalicylic acid metabolites. Environ Toxicol 19:527–540

    Article  CAS  Google Scholar 

  • Nkoom M, Lu G, Liu J, Yang H, Dong H (2019) Bioconcentration of the antiepileptic drug carbamazepine and its physiological and biochemical effects on Daphnia magna. Ecotox Environ Saf 72:11–18

    Article  CAS  Google Scholar 

  • Oda S, Tatarazako N, Watanabe H, Morita M, Iguchi T (2005) Genetic differences in the production of male neonates in Daphnia magna exposed to juvenile hormone analogs. Chemosphere 61:1168–1174

    Article  CAS  Google Scholar 

  • Oropesa AL, Floro AM, Palma P (2016) Assessment of the effects of the carbamazepine on the endogenous endocrine system of Daphnia magna. Environ Sci Pollut Res Int 23(17):17311–17321

    Article  CAS  Google Scholar 

  • Palma P, Palma VL, Fernandes RM, Soares AM, Barbosa IR (2009) Endosulfan sulphate interferes with reproduction, embryonic development and sex differentiation in Daphnia magna. Ecotox Environ Saf 72:344–350

    Article  CAS  Google Scholar 

  • Qiang L, Cheng J, Yi J, Rotchell JM, Zhu X, Zhou J (2016) Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior. Ecotoxicology 25:1426–1437

    Article  CAS  Google Scholar 

  • Rao YF, Liang Q, Yang H, Chu WJ (2014) Degradation of carbamazepine by Fe(II)-activated persulfate process. J Hazard Mater 268:23–32

    Article  CAS  Google Scholar 

  • Sanchez W, Burgeot T, Porcher JM (2013) A novel “Integrated Biomarker Response” calculation based on reference deviation concept. Environ Sci Pollut R 20:2721–2725

    Article  CAS  Google Scholar 

  • Songlin W, Ning Z (2016) Removal of carbamazepine from aqueous solution using sono-activated persulfate process. Ultrason Sonochem 29:156–162

    Article  CAS  Google Scholar 

  • Thomas H (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5–17

    Article  Google Scholar 

  • Trombini C, Hampel M, Blasco J (2019) Assessing the effect of human pharmaceuticals (carbamazepine, diclofenac and ibuprofen) on the marine clam Ruditapes philippinarum: an integrative and multibiomarker approach Aquatic toxicology. Aquat Toxicol 208:146–156

    Article  CAS  Google Scholar 

  • Yan Q, Zhang YX, Jia K, Gan XM, Peng XY, Guo JS (2015) A preliminary study on the occurrence of pharmaceutically active compounds in the river basins and their removal in two conventional drinking water treatment plants in Chongqing, China. Clean Soil Air Water 43:794–803

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The present study was supported by Grants from the National Natural Science Foundation of China [No. 41671320]; the National Science and Technology Major Project of the Ministry of Science and Technology of China [No. 2016YFD0201203]; the Natural Science Foundation of Shandong Province, China [Nos. JQ201711 and ZR2016JL029].

Author information

Author notes

  1. Yu Tian and Xiaoming Xia have contributed equally to this work.

Authors and Affiliations

  1. College of Resources and Environment, Shandong Agricultural University, Taian, 271000, China

    Yu Tian, Jinhua Wang, Lusheng Zhu, Jun Wang & Fengzhao Zhang

  2. College of Plant Protection, Shandong Agricultural University, Taian, 271000, China

    Xiaoming Xia

  3. State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan, 430072, Hubei, China

    Zulfiqar Ahmad

  4. Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA

    Zulfiqar Ahmad

Authors
  1. Yu Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoming Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jinhua Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lusheng Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fengzhao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zulfiqar Ahmad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jinhua Wang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tian, Y., Xia, X., Wang, J. et al. Chronic Toxicological Effects of Carbamazepine on Daphnia magna Straus: Effects on Reproduction Traits, Body Length, and Intrinsic Growth. Bull Environ Contam Toxicol 103, 723–728 (2019). https://doi.org/10.1007/s00128-019-02715-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00128-019-02715-w

Keywords

Search

Navigation