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Anti-herpes simplex type-1 (HSV-1) activity from the roots of Jatropha multifida L

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Abstract

A new long chain, multifidione (1), together with seven known lathyrane-type diterpenes, 15-epi-4Z-jatrogrossidentadion (2), 4Z-jatrogrossidentadion (3), 2-epi-hydroxy isojatrogrossidentadion (4), 2-hydroxyisojatrogrossidentadion (5), 4E-jatrogrossidentadion (6), 15-epi-4E-jatrogrossidentadion (7), and jatrogrossidion (8), was isolated from the roots of Jatropha multifida L. The chemical structure of this new compound was elucidated by spectroscopic techniques. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated all compounds were evaluated for herpes simplex type-1 (HSV-1). Among them, compound 6 showed the highest activity against HSV-1 (IC50 2.05 μg/mL), whereas the IC50 value of the standard drug, acyclovir, was 3.58 μg/mL. These results suggest that compound 6 may has a potential target for anti-HSV-1 drug development.

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Acknowledgements

We acknowledge financial support from University of Phayao (grant no. RD61027). Supports from the Thailand Research Fund (grant no. DBG6180030) and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, School of Science, University of Phayao, Maeka, Muang, Phayao, 56000, Thailand

    Ratchanaporn Chokchaisiri, Jaranwit Srijun, Sarot Cheenpracha & Lucksagoon Ganranoo

  2. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand

    Waraluck Chaichompoo & Apichart Suksamrarn

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  1. Ratchanaporn Chokchaisiri
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  2. Jaranwit Srijun
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  3. Waraluck Chaichompoo
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  4. Sarot Cheenpracha
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  5. Lucksagoon Ganranoo
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  6. Apichart Suksamrarn
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Correspondence to Ratchanaporn Chokchaisiri.

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Chokchaisiri, R., Srijun, J., Chaichompoo, W. et al. Anti-herpes simplex type-1 (HSV-1) activity from the roots of Jatropha multifida L. Med Chem Res 29, 328–333 (2020). https://doi.org/10.1007/s00044-019-02484-5

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  • DOI: https://doi.org/10.1007/s00044-019-02484-5

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