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Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

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Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a–n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

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Acknowledgments

We acknowledge the financial support from Innovation Technology Commission to ABCT, The Hong Kong Polytechnic University and the research Grant: 30-13-135 (FRG1/13-14/035) (Dr. C. H. Chui) from Hong Kong Baptist University. Professor R. Gambari is supported by AIRC (IG-13575). Lastly, Miss Po-Yee Chung would like to thank the chief supervision of Dr. Kim-Hung Lam.

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Authors and Affiliations

  1. State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China

    Po-Yee Chung, Chor-Hing Cheng, Johnny Cheuk-On Tang & Kim-Hung Lam

  2. Department of Life Sciences and Biotechnology, Centre of Biotechnology, University of Ferrara, Ferrara, Italy

    Roberto Gambari

  3. Department of Chemistry, Guangzhou University, Guangzhou, China

    Yi-Xin Chen

  4. Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China

    Zhao-Xiang Bian, Albert Sun-Chi Chan & Chung-Hin Chui

  5. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China

    Polly Hang-Mei Leung

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  1. Po-Yee Chung
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  2. Roberto Gambari
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  3. Yi-Xin Chen
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  4. Chor-Hing Cheng
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  5. Zhao-Xiang Bian
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  7. Johnny Cheuk-On Tang
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  8. Polly Hang-Mei Leung
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  9. Chung-Hin Chui
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  10. Kim-Hung Lam
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Corresponding authors

Correspondence to Chung-Hin Chui or Kim-Hung Lam.

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Chung, PY., Gambari, R., Chen, YX. et al. Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities. Med Chem Res 24, 1568–1577 (2015). https://doi.org/10.1007/s00044-014-1217-4

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  • DOI: https://doi.org/10.1007/s00044-014-1217-4

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