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Molecular control of the female germline stem cell niche size in Drosophila

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Abstract

Adult stem cells have a unique capacity to renew themselves and generate differentiated cells that are needed in the body. These cells are recruited and maintained by the surrounding microenvironment, known as the stem cell niche, during organ development. Thus, the stem cell niche is required for proper tissue homeostasis, and its dysregulation is associated with tumorigenesis and tissue degeneration. The identification of niche components and the mechanisms that regulate niche establishment and maintenance, however, are just beginning to be uncovered. Germline stem cells (GSCs) of the Drosophila ovary provide an excellent model for studying the stem cell niche in vivo because of their well-characterized cell biology and the availability of genetic tools. In this review, we introduce the ovarian GSC niche, and the key signaling pathways for niche precursor segregation, niche specification, and niche extracellular environment establishment and niche maintenance that are involved in regulating niche size during development and adulthood.

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Acknowledgements

We thank Marcus Calkins for English editing.

Funding

The work was supported by the intramural funding from the Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan and the Ministry of Science and Technology, Taiwan (107-2311-B-001-004-MY3).

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  1. Chun-Ming Lai

    Present address: Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, New York, NY, 10065, USA

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  1. Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan

    Hwei-Jan Hsu, Majid Bahader & Chun-Ming Lai

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MB wrote the introduction, CML drew the germarium and larval ovary schemes, and HJH wrote the paper.

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Hsu, HJ., Bahader, M. & Lai, CM. Molecular control of the female germline stem cell niche size in Drosophila. Cell. Mol. Life Sci. 76, 4309–4317 (2019). https://doi.org/10.1007/s00018-019-03223-0

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