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Effects of neutrophil fate on inflammation

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Abstract

Introduction

Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infectious agents by expressing large numbers of membrane receptors. Upon tissue injury or pathogen invasion, neutrophils are the first immune cells to reach the site of injury and participate in the inflammatory response.

Materials and methods

A thorough search on PubMed related to neutrophil death or clearance pathways was performed.

Conclusion

Inflammatory response and tissue damage can be aggravated when neutrophils are not removed rapidly from the site of injury. Recent studies have shown that neutrophils can be cleared through a variety of pathways, including non-inflammatory and inflammatory death, as well as reverse migration. Non-inflammatory death pathways include apoptosis and autophagy. Inflammatory death pathways include necroptosis, pyroptosis and NETosis. This review highlights the basic properties of neutrophils and the impact of their clearance pathways on the inflammatory response.

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Funding

This work was supported by the Natural Science Foundation of Hunan Province (2022JJ40390, 2022JJ30521), Project of Hunan Provincial Health Commission (202217014497) and Doctoral Research Startup Fund Project of the Second Affiliated Hospital of University of South China (2021B03).

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  1. Yuan Xiao and Yang Cheng contributed equally to this work.

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  1. Department of Anesthesiology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China

    Yuan Xiao, Yang Cheng, Wen-Jie Liu, Kun Liu, Yan Wang, Feng Xu, De-Ming Wang & Yi Yang

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Yuan Xiao, Yang Cheng, and Feng Xu drafted the article; Kun Liu and Yan Wang prepared Fig. 1. Wen-Jie Liu, De-Ming Wang, and Yi Yang critically revised the article. All authors reviewed the manuscript.

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Xiao, Y., Cheng, Y., Liu, WJ. et al. Effects of neutrophil fate on inflammation. Inflamm. Res. 72, 2237–2248 (2023). https://doi.org/10.1007/s00011-023-01811-2

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