Abstract
Objective
To review the preparation, characteristics and research progress of different PsA animal models.
Methods
Computerized searches were conducted in CNKI, PubMed and other databases to classify and discuss the relevant studies on PsA animal models. The search keywords were “PsA and animal model(s), PsA and animal(s), PsA and mouse, PsA and mice, PsA and rat(s), PsA and rabbit(s), PsA and dog(s)”
Results
The experimental animals currently used to study PsA are mainly rodents, including mice and rats. According to the different methods of preparing the models, the retrieved animal models were classified into spontaneous or genetic mutation, transgenic and induced animal models. These PsA animal models involve multiple pathogenesis, some experimental animals’ lesions appear in a short and comprehensive cycle, some have a high success rate in molding, and some are complex and less reproducibility. This article summarizes the preparation methods, advantages and disadvantages of different models.
Conclusions
The animal models of PsA aim to mimic the clinicopathological alterations of PsA patients through gene mutation, transgenesis or targeted proinflammatory factor and to reveal new pathogenic pathways and therapeutic targets by exploring the pathological features and clinical manifestations of the disease. This work will have very far-reaching implications for the in-depth understanding of PsA and the development of new drugs.
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Data availability
All data included in this study are available upon request by contact with the corresponding author.
Abbreviations
- PsA:
-
Psoriatic arthritis
- PsO:
-
Psoriasis
- AE:
-
Ankylosing enthesitis
- SpA:
-
Spondyloarthritis
- ANKENT:
-
Ankylosing enthesopathy
- RA:
-
Rheumatoid arthritis
- CV:
-
Conventional
- GF:
-
Germ-free
- Hβ2m:
-
Human β2 micro-globulin
- SPF:
-
Specific pathogen-free
- MIP:
-
Mannan-induced PsO and PsA
- mCAIA:
-
Mannan-enhanced collagen antibody-induced arthritis
- MHC:
-
The major histocompatibility complex
- EGF:
-
Epidermal growth factor
- TGF-β:
-
Transforming growth factor β
- SOCS3:
-
Suppressor of cytokine signaling 3
- STAT3:
-
Signal transducer and activator of transcription 3
- CIA:
-
Collagen-induced arthritis
- ROS:
-
Reactive oxygen species
- NOS2:
-
Nitric oxide synthase 2
- FLS:
-
Synovial fibroblasts
- EEV:
-
Enhanced episomal vector
- PBMC:
-
Peripheral blood mononuclear cell
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Acknowledgements
In writing this paper, I have benefited from the presence of my supervisors and my participators. They generously helped me collect materials I needed and made many invaluable suggestions. I hereby extend my grateful thanks to them for their kind help, without which the paper would not have been what it is.
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This work was supported by the Shanxi Province Overseas Students Science and Technology Activities Merit-based Funding Project [Grant number 20210003].
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This article is mainly written by LB. YS wrote part of the manuscript and proofread the manuscript. ZN and CZ helped us collect literature information. GZ and LZ reviewed the manuscript and proposed final revisions. All authors contributed to the article and approved the submitted version.
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Bai, LK., Su, YZ., Ning, ZD. et al. Challenges and opportunities in animal models of psoriatic arthritis. Inflamm. Res. 72, 1291–1301 (2023). https://doi.org/10.1007/s00011-023-01752-w
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DOI: https://doi.org/10.1007/s00011-023-01752-w