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Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis

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Abstract

This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.

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Acknowledgements

This study was financially supported by a grant from FAPESP (Fundo de Amparo à Pesquisa do Estado de São Paulo).

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Authors and Affiliations

  1. Unit of Rheumatology–Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences (FCM/UNICAMP), Barão Geraldo, Campinas-SP, CEP: 13081-970, Mail box 611, Brazil

    Rubens Bonfiglioli, Roseneide A. Conde, Percival D. Sampaio-Barros & Manoel B. Bertolo

  2. Laboratory of Molecular Immunology, State University of São Paulo at Ribeirão Preto, Ribeirão Preto, Brazil

    Paulo Louzada-Junior & Eduardo A. Donadi

Authors
  1. Rubens Bonfiglioli
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  2. Roseneide A. Conde
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  3. Percival D. Sampaio-Barros
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  4. Paulo Louzada-Junior
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  5. Eduardo A. Donadi
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  6. Manoel B. Bertolo
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Correspondence to Rubens Bonfiglioli.

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Bonfiglioli, R., Conde, R.A., Sampaio-Barros, P.D. et al. Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis. Clin Rheumatol 27, 709–712 (2008). https://doi.org/10.1007/s10067-007-0770-3

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  • DOI: https://doi.org/10.1007/s10067-007-0770-3

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