Abstract
A new approach for producing polymer nanoparticles made of bovine serum albumin-poly(methyl methacrylate) conjugate by precipitating in supercritical CO2 is reported. The nanoparticles were loaded with the anti-tumor drug camptothecin. With albumin serving as a nutrient to cells, the drug-encapsulated nanoparticle shows an enhanced ability to kill cancer cells compared to that of the free drug in solution both in vitro and in vivo.
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Hua, M., Hua, X. Polymer Nanoparticles Prepared by Supercritical Carbon Dioxide for in Vivo Anti-cancer Drug Delivery. Nano-Micro Lett. 6, 20–23 (2014). https://doi.org/10.1007/BF03353764
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DOI: https://doi.org/10.1007/BF03353764