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Stem Cell Differentiation Mediated by Biomaterials/Surfaces

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Polymeric Biomaterials for Tissue Regeneration

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Abstract

Directing the differentiation of stem cells into a specific stromal lineage such as adipocyte, chondrocyte, fibroblast, myocyte, and osteoblast cell is a key and important step for medical uses. However, the uncontrolled and inefficient proliferative and differentiation behaviors of stem cells are still the significant challenges. Since the stem cell fate is strongly determined by the characteristics of the microenvironment in vitro, the biomaterials/surfaces constructs in two-dimensional or three-dimensional (3D) artificial structures could offer the several biological, mechanical, and chemical cues to modulate the cellular proliferation, and most importantly lineage particular differentiation. Besides these regulation cues, adding growth components existing in the ECM also holds the potential for guiding the stem cell fate in vitro. Therefore, this chapter aims to provide an update on the influencing cues that are being explored to govern stem cell fate, with a focus on the differentiation of bone marrow-derived mesenchymal stem cells (MSCs). The factors discussed here include topography, porosity and pore size, stiffness, hierarchy structure, chemical properties, and genetic factors.

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  1. School of Material Science and Engineering, East China University of Science and Technology, Shanghai, P.R. China

    Hongyan He & Changsheng Liu

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  1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China

    Changyou Gao

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He, H., Liu, C. (2023). Stem Cell Differentiation Mediated by Biomaterials/Surfaces. In: Gao, C. (eds) Polymeric Biomaterials for Tissue Regeneration. Springer, Singapore. https://doi.org/10.1007/978-981-99-6948-7_8

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