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Penicillium: A Treasure Trove for Antimycobacterial and Antioxidant Metabolites

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Fungi Bioactive Metabolites

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Abstract

Penicillium, belonging to the phylum Ascomycota, is one of the most studied genera for its therapeutic properties. Based on ascocarps, it can be divided into two groups: Eupenicillium and Talaromyces. Bioactive secondary metabolites with antimicrobial, anticancer, antimycobacterial, antioxidant, anti-inflammatory, insecticidal, and biocontrol properties have been isolated from various species of this genus. The agricultural, biotechnological, and pharmaceutical applications of these metabolites are currently being investigated. This chapter highlights the potential of antimycobacterial, and antioxidant compounds isolated from Penicillium spp., including alkaloids, chromones, penicillanic acids, polyketides, steroids, terpenoids, and their derivatives. Biotechnological interventions, such as cocultivation, epigenetics, and genetic engineering, applied to enhance bioactivities, are elaborated. Furthermore, biologically synthesized metallic nanoparticles to augment the production of such metabolites in the genus would also be discussed.

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References

  • Agrawal S, Deshmukh SK, Reddy MS, Prasad R, Goel M (2020) Endolichenic fungi: a hidden source of bioactive metabolites. S Afr J Bot 134:163–186

    Article  CAS  Google Scholar 

  • Ali Shah Z, Khan K, Iqbal Z, Masood T, Hemeg HA, Rauf A (2022) Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches. Ann Med 54(1):2102–2114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amarendra V, Varsha NT, Santhosh RS (2015) Plackett-Burman statistical optimization of media components for anti-mycobacterial metabolite production by marine Penicillium chrysogenum DSOA. J Pharm Sci Res 7(7):409–415

    CAS  Google Scholar 

  • Andrioli WJ, Simão TLBV, Ferreira DP, Araújo MH, Calixto SD, Bastos JK, Seldin L, Lasunskaia E, Muzitano MF (2022) Antimycobacterial and anti-inflammatory activities of metabolites from endophytic and soil fungi. Phytomed Plus 2(3):100312

    Article  Google Scholar 

  • Arora DS, Chandra P (2011) In vitro antioxidant potential of some soil fungi: screening of functional compounds and their purification from Penicillium citrinum. Appl Biochem Biotechnol 165(2):639–651

    Article  CAS  PubMed  Google Scholar 

  • Arora DS, Chandra P, Jeet Kaur G (2012) Optimization and assay of antioxidant potential of two Penicillium spp. by different procedures. Curr Biotechnol 1(1):2–10

    Article  CAS  Google Scholar 

  • Bai Y, Yi P, Zhang S, Hu J, Pan H (2021) Novel antioxidants and α-glycosidase and protein tyrosine phosphatase 1b inhibitors from an endophytic fungus Penicillium brefeldianum F4a. J Fungi 7(11):913

    Article  CAS  Google Scholar 

  • Baines D, Seal R (2016) Natural food additives, ingredients and flavourings. Woodhead Publishing, Oxford

    Google Scholar 

  • Bhattacharya S (2014) Reactive oxygen species and cellular defense system. In: Yadav UCS, Rani V (eds) Free radicals in human health and disease. Springer, New York, pp 17–29

    Google Scholar 

  • Bode HB, Bethe B, Höfs R, Zeeck A (2002) Big effects from small changes: possible ways to explore nature’s chemical diversity. Chembiochem 3(7):619

    Article  CAS  PubMed  Google Scholar 

  • Canturk Z, Kocabiyik E, Ozturk N, İlhan S (2017) Evaluation of antioxidant and antiproliferative metabolites of Penicillium flavigenum isolated from hypersaline environment: Tuz (salt) Lake by Xcelligence technology. Microbiology 86(3):346–354

    Article  CAS  Google Scholar 

  • CDC (2019) Vaccines. https://www.cdc.gov/tb/topic/basics/vaccines.htm

  • Chen C-H, Shaw C-Y, Chen C-C, Tsai Y-C (2002) 2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5. J Nat Prod 65(5):740–741

    Article  CAS  PubMed  Google Scholar 

  • Chidananda C, Sattur AP (2007) Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans. J Agric Food Chem 55(8):2879–2883

    Article  CAS  PubMed  Google Scholar 

  • Danagoudar A, Pratap GK, Shantaram M, Ghosh K, Kanade SR, Joshi CG (2020) Characterization, cytotoxic and antioxidant potential of silver nanoparticles biosynthesised using endophytic fungus (Penicillium citrinum CGJ-C1). Mater Today Commun 25:101385

    Article  CAS  Google Scholar 

  • Demain AL, Elander RP (1999) The beta-lactam antibiotics: past, present, and future. Antonie Leeuwenhoek 75(1–2):5–19

    Article  CAS  PubMed  Google Scholar 

  • Deshmukh SK, Agrawal S, Prakash V, Gupta MK, Reddy MS (2020) Anti-infectives from mangrove endophytic fungi. S Afr J Bot 134:237–263

    Article  CAS  Google Scholar 

  • Ebada SS, Ebrahim W (2019) A new antioxidant decalin polyketide from freshwater-sediment-derived fungus Penicillium spp. Strain S1a1. ChemistrySelect 4(33):9814–9816

    Article  CAS  Google Scholar 

  • El-Hawary S, Sayed A, Mohammed R, Hassan H, Zaki M, Rateb M, Mohammed T, Amin E, Abdelmohsen U (2018) Epigenetic modifiers induce bioactive phenolic metabolites in the marine-derived fungus Penicillium brevicompactum. Mar Drugs 16(8):253

    Article  PubMed  PubMed Central  Google Scholar 

  • Faustino M, Veiga M, Sousa P, Costa E, Silva S, Pintado M (2019) Agro-food byproducts as a new source of natural food additives. Molecules 24(6):1056

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferreira MC, de Carvalho CR, Zani CL, Rosa LH (2019) Antimycobacterial and antiplasmodial compounds produced by endophytic fungi: an overview. In: Advances in endophytic fungal research. Springer, Cham, pp 17–33

    Chapter  Google Scholar 

  • Fleming A (1980) On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. Influenzae. Clin Infect Dis 2(1):129–139

    Article  CAS  Google Scholar 

  • Govindappa M, Farheen H, Chandrappa CP, Channabasava, Rai RV, Raghavendra VB (2016) Mycosynthesis of silver nanoparticles using extract of endophytic fungi, Penicillium species of Glycosmis mauritiana, and its antioxidant, antimicrobial, anti-inflammatory and tyrokinase inhibitory activity. Adv Nat Sci Nanosci Nanotechnol 7(3):035014

    Article  Google Scholar 

  • Gupta P, Rai N, Verma A, Saikia D, Singh SP, Kumar R, Singh SK, Kumar D, Gautam V (2022) Green-based approach to synthesize silver nanoparticles using the fungal endophyte Penicillium oxalicum and their antimicrobial, antioxidant, and in vitro anticancer potential. ACS Omega 7(50):46653–46673

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hashem AH, Khalil AMA, Reyad AM, Salem SS (2021) Biomedical applications of mycosynthesized selenium nanoparticles using Penicillium expansum ATTC 36200. Biol Trace Elem Res 199:3998–4008

    Article  CAS  PubMed  Google Scholar 

  • Hayashi K, Suzuki K, Kawaguchi M, Nakajima T, Suzuki T, Numata M, Nakamura T (1995) Isolation of an antioxidant from Penicillium roquefortii IFO 5956. Biosci Biotechnol Biochem 59(2):319–320

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa Y, Morimoto K, Iseki S (1991) Atrovenetin as a potent antioxidant compound from Penicillium species. J Am Oil Chem Soc 68(9):666–668

    Article  CAS  Google Scholar 

  • Jakovljevic V, Milicevic J, Stojanovic J, Solujic S, Vrvic M (2014) Antioxidant activity of ethanolic extract of Penicillium chrysogenum and Penicillium fumiculosum. Chem Ind 68(1):43–49

    Article  CAS  Google Scholar 

  • Jakovljevic VD, Nikolić JM, Matić SLJ, Stanić SM, Vrvić MM (2018) Mycochemical screening, antioxidant and dna protecting activity of Penicillium cyclopium and Penicillium brevicompactum. Farmacia 66(3):494–501

    Article  CAS  Google Scholar 

  • Jouda JB, Mawabo IK, Notedji A, Mbazoa CD, Nkenfou J, Wandji J, Nkenfou CN (2016) Anti-mycobacterial activity of polyketides from Penicillium spp. endophyte isolated from Garcinia nobilis against mycobacterium smegmatis. Int J Mycobacteriol 5(2):192–196

    Article  PubMed  Google Scholar 

  • Kaur R, Kaur J, Kaur M, Kalotra V, Chadha P, Kaur A, Kaur A (2020) An endophytic Penicillium oxalicum isolated from Citrus Limon possesses antioxidant and genoprotective potential. J Appl Microbiol 128(5):1400–1413

    Article  CAS  PubMed  Google Scholar 

  • Kowanga KD, Munissi JJE, Masalu R, Nyandoro SS, Masimba P, Gatebe E (2018) Antimycobacterial and cytotoxic activities of extracts from fungal isolates of Lake Magadi. Int J Biol Chem Sci 11(5):2430

    Article  Google Scholar 

  • Li H-T, Sun Y, Xie F, Wang M, Chen J-Y, Zhou H, Ding Z-T (2022) Xanthene and citrinin derivatives from the endophytic fungus Penicillium spp. T2-11. Tetrahedron Lett 90:153626

    Article  CAS  Google Scholar 

  • Lin Z, Wen J, Zhu T, Fang Y, Gu Q, Zhu W (2008) Chrysogenamide a from an endophytic fungus associated with Cistanche deserticola and its neuroprotective effect on SH-SY5Y cells. J Antibiot 61(2):81–85

    Article  CAS  Google Scholar 

  • Liu D-S, Rong X-G, Kang H-H, Ma L-Y, Hamann MT, Liu W-Z (2018) Raistrickiones a−E from a highly productive strain of Penicillium raistrickii generated through thermo change. Mar Drugs 16(6):213

    Article  PubMed  PubMed Central  Google Scholar 

  • Lu ZY, Lin ZJ, Wang WL, Du L, Zhu TJ, Fang YC, Gu QQ, Zhu WM (2008) Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57. J Nat Prod 71(4):543–546

    Article  CAS  PubMed  Google Scholar 

  • Macleod M (2018) Learning lessons from MVA85A, a failed booster vaccine for BCG. BMJ 360:k66. https://doi.org/10.1136/bmj.k66

    Article  PubMed  Google Scholar 

  • Manjunath HM, Joshi CG, Raju NG (2016) Biofabrication of gold nanoparticles using marine endophytic fungus—Penicillium citrinum. IET Nanobiotechnol 11(1):40–44

    Article  PubMed Central  Google Scholar 

  • Mapari SA, Nielsen KF, Larsen TO, Frisvad JC, Meyer AS, Thrane U (2005) Exploring fungal biodiversity for the production of water-soluble pigments as potential natural food colorants. Curr Opin Biotechnol 16(2):231–238

    Article  CAS  PubMed  Google Scholar 

  • Mishra RC, Goel M, Barrow CJ, Deshmukh SK (2020) Endophytic fungi—an untapped source of potential antioxidants. Curr Bioact Compd 16(7):944–964

    Article  CAS  Google Scholar 

  • Mishra RC, Kalra R, Dwivedi N, Goel M (2021) Exploring endophytes using “Omics”: an approach for sustainable production of bioactive metabolites. In: Prasad R, Nayak SC, Kharwar RN, Dubey NK (eds) Mycoremediation and environmental sustainability, Fungal biology. Springer, Cham, pp 349–376

    Chapter  Google Scholar 

  • Mishra RC, Barrow CJ, Kalra R, Dwivedi N, Deshmukh SK, Goel M (2022a) Phylogenetic diversity and antioxidant activity of selected fungi from ethno-medicinal plants and soil. Mycol Prog 21(2):1–17.

    Article  Google Scholar 

  • Mishra RC, Kalra R, Dilawari R, Goel M, Barrow CJ (2022b) Bio-synthesis of Aspergillus terreus mediated gold nanoparticle: antimicrobial, antioxidant, antifungal and in vitro cytotoxicity studies. Materials 15(11):3877

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakakita Y, Yomosa K, Hirota A, Sakai H (1984) Isolation of a novel phenolic compound from Penicillium janthinellum biourge. Agric Biol Chem 48(1):239–240

    CAS  Google Scholar 

  • Nicoletti R, Trincone A (2016) Bioactive compounds produced by strains of Penicillium and Talaromyces of marine origin. Mar Drugs 14(2):37

    Article  PubMed  PubMed Central  Google Scholar 

  • Nischitha R, Shivanna MB (2021) Metabolite fingerprinting, in vitro antimicrobial and antioxidant activities and in-silico docking in Alloteropsis cimicina and its endophytic fungus Penicillium pinophilum. Mol Biol Rep 48(5):4021–4037

    Article  CAS  PubMed  Google Scholar 

  • Nischitha R, Shivanna MB (2022) Screening of secondary metabolites and antioxidant potential of endophytic fungus Penicillium citrinum and host Digitaria bicornis by spectrophotometric and electrochemical methods. Arch Microbiol 204(4):206

    Article  CAS  PubMed  Google Scholar 

  • Padmapriya C, Murugesan R (2016) Optimization of SSF parameters for natural red pigment production from Penicillium purpurogenum using cassava waste by central composite design. J Appl Nat Sci 8(3):1663–1669

    CAS  Google Scholar 

  • Pan JH, Chen Y, Huang YH, Tao YW, Wang J, Li Y, Peng Y, Dong T, Lai XM, Lin YC (2011) Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes. Arch Pharm Res 34(7):1177–1181

    Article  CAS  PubMed  Google Scholar 

  • Patridge E, Gareiss P, Kinch MS, Hoyer D (2016) An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discov Today 21(2):204–207

    Article  CAS  PubMed  Google Scholar 

  • Pelo S, Mavumengwana V, Green E (2020) Diversity and antimicrobial activity of culturable fungal endophytes in Solanum mauritianum. Int J Environ Res Public Health 17(2):439

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pisoschi AM, Pop A (2015) The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem 97:55–74

    Article  CAS  PubMed  Google Scholar 

  • Prasher P, Sharma M, Mehta M, Paudel KR, Satija S, Chellappan DK, Dureja H, Gupta G, Tambuwala MM, Negi P, Wich PR, Hansbro NG, Hansbro PM, Dua K (2020) Plants derived therapeutic strategies targeting chronic respiratory diseases: chemical and immunological perspective. Chem Biol Interact 325:109125

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Qi F-H, Jing T-Z, Wang Z-X, Zhan Y-G (2009) Fungal endophytes from Acer ginnala maxim: isolation, identification and their yield of gallic acid. Lett Appl Microbiol 49(1):98–104

    Article  CAS  PubMed  Google Scholar 

  • Radhakrishnan M, Saravanan D, Balagurunathan R, Kumar V (2011) Fungal bioprospecting from sundarban mangrove forest with special reference to antibacterial and antimycobacterial activity. Int J Pharmtech Res 3(2):719–723

    Google Scholar 

  • Sahu MK, Singh D, Ghosh SC, Das A, Jha H (2022) Bioactive potential of secondary metabolites of rhizospheric fungus Penicillium citrinum isolate-ABRF3. J BioSci Biotechnol 11(1):1–14

    CAS  Google Scholar 

  • Samanthi K, Wickramaarachchi S, Wijeratne E, Paranagama P (2015) Two new antioxidant active polyketides from Penicillium citrinum, an endolichenic fungus isolated from Parmotreama species in Sri Lanka. J Natl Sci Found Sri Lanka 43(2):119

    Article  Google Scholar 

  • Samson RA, Pitt JI (2000) Integration of modern taxonomic methods for Penicillium and Aspergillus classification. Harwood Academic Publishers, Amsterdam

    Google Scholar 

  • dos Santos PO, Ferraz CG, Ribeiro PR, Miranda FM, da Silva F, de Souza JT, de Roque MR, Soares ACF (2019) Antioxidant and antibacterial activities of the chlorine pigment sclerotiorin from Penicillium mallochii and its chemotaxonomic significance. Biochem Syst Ecol 86:103915

    Article  Google Scholar 

  • Shahid M, Dar FK, Ismaeel AY, Al-Mahmeed A, Sindi KA, Malik A, Khan HM (2013) Plant natural products as a potential source of antimicrobial agents: an overview and a glimpse on recent developments. In: Sahai A, Malik A, Shahzad A, Shahid M (eds) Recent trends in biotechnology and therapeutic applications of medicinal plants. Springer, New York, pp 93–107

    Chapter  Google Scholar 

  • Sikandar A, Zhang M, Wang Y, Zhu X, Liu X, Fan H, Xuan Y, Chen L, Duan Y (2020) Mycochemical screening and analysis, antioxidant activity, and biochemical composition of fermentation strain Snef 1216 (Penicillium chrysogenum). J Anal Methods Chem 2020:e3073906

    Article  Google Scholar 

  • Singh R, Walia A (2019) Antioxidant and antimicrobial activities of Penicillium spp. lectins. Arch Biol Sci 71(3):517–524

    Article  Google Scholar 

  • Song T-Y, Yen G-C (2002) Antioxidant properties of Antrodia camphorata in submerged culture. J Agric Food Chem 50(11):3322–3327

    Article  CAS  PubMed  Google Scholar 

  • Sun H-H, Mao W-J, Chen Y, Guo S-D, Li H-Y, Qi X-H, Chen Y-L, Xu J (2009) Isolation, chemical characteristics and antioxidant properties of the polysaccharides from marine fungus Penicillium spp. F23-2. Carbohydr Polym 78(1):117–124

    Article  CAS  Google Scholar 

  • Taha ZK, Hawar SN, Sulaiman GM (2019) Extracellular biosynthesis of silver nanoparticles from Penicillium italicum and its antioxidant, antimicrobial and cytotoxicity activities. Biotechnol Lett 41(8–9):899–914

    Article  CAS  PubMed  Google Scholar 

  • Thakor R, Mistry H, Patel H, Jhala D, Parmar N, Bariya H (2022) Biogenic synthesis of silver nanoparticles mediated by the consortium comprising the marine fungal filtrates of Penicillium oxalicum and Fusarium hainanense along with their antimicrobial, antioxidant, larvicidal and anticancer potency. J Appl Microbiol 133(2):857–869

    Article  CAS  PubMed  Google Scholar 

  • Toghueo RMK, Boyom FF (2020) Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications. 3. Biotech 10(3):107

    Google Scholar 

  • Uchida R, Miyazaki H, Yamaguchi Y, Ishijima H, Tomoda H (2016) Pyranonigrin L, a new antioxidant, produced by the hot spring-derived fungus Penicillium adametzii BF-0003. Nat Prod Commun 11(8):1111–1114

    PubMed  Google Scholar 

  • Valentão P, Fernandes E, Carvalho F, Andrade PB, Seabra RM, de Bastos ML (2002) Antioxidant activity of Hypericum androsaemum infusion: scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid. Biol Pharm Bull 25(10):1320–1323

    Article  PubMed  Google Scholar 

  • Visamsetti A, Ramachandran SS, Kandasamy D (2016) Penicillium chrysogenum DSOA associated with marine sponge (Tedania anhelans) exhibit antimycobacterial activity. Microbiol Res 185:55–60

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Wang H, Liu T, Xin Z (2014) A PKS I gene-based screening approach for the discovery of a new polyketide from Penicillium citrinum Salicorn 46. Appl Microbiol Biotechnol 98(11):4875–4885

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Li F, Zhuang H, Chen X, Li L, Qiao W, Zhang J (2015) Effects of plant polyphenols and α-tocopherol on lipid oxidation, residual nitrites, biogenic amines, and N-nitrosamines formation during ripening and storage of dry-cured bacon. LWT Food Sci Technol 60(1):199–206

    Article  CAS  Google Scholar 

  • Wei Q, Bai J, Yan D, Bao X, Li W, Liu B, Zhang D, Qi X, Yu D, Hu Y (2021) Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Acta Pharm Sin B 11(2):572–587

    Article  CAS  PubMed  Google Scholar 

  • WHO (2022) Global tuberculosis report. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022

  • Yang Z, Zhu M, Li D, Zeng R, Han B (2017) N-me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway. Bioorg Med Chem 25(24):6614–6622

    Article  CAS  PubMed  Google Scholar 

  • Yuan Y, Tian J-M, Xiao J, Shao Q, Gao J-M (2013) Bioactive metabolites isolated from Penicillium spp. YY-20, the endophytic fungus from Ginkgo biloba. Nat Prod Res 28(4):278–281

    Article  PubMed  Google Scholar 

  • Yuan W-H, Zhang Y, Zhang P, Ding R-R (2017) Antioxidant sesquiterpenes from Penicillium citreonigrum. Nat Prod Commun 12(12):1239–1244

    Google Scholar 

  • Zakariya NA, Majeed S, Jusof WHW (2022) Investigation of antioxidant and antibacterial activity of iron oxide nanoparticles (IONPS) synthesized from the aqueous extract of Penicillium spp. Sensor Int 3:100164

    Article  Google Scholar 

  • Zheng H, He W, Jiao W, Xia H, Sun L, Wang S, Xiao J, Ou X, Zhao Y, Shen A (2021) Molecular characterization of multidrug-resistant tuberculosis against levofloxacin, moxifloxacin, bedaquiline, linezolid, clofazimine, and delamanid in southwest of China. BMC Infect Dis 21(1):330. https://doi.org/10.1186/s12879-021-06024-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Sustainable Agriculture Program, The Energy and Resources Institute (TERI), Gurugram, Haryana, India

    Mehak Kaur, Hishita Peshwani & Mayurika Goel

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  1. Mehak Kaur
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  2. Hishita Peshwani
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  3. Mayurika Goel
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Correspondence to Mayurika Goel .

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Editors and Affiliations

  1. Research and Development, Greenvention Biotech Pvt. Ltd., Pune, Maharashtra, India

    Sunil Kumar Deshmukh

  2. Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Jacqueline Aparecida Takahashi

  3. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India

    Sanjai Saxena

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Kaur, M., Peshwani, H., Goel, M. (2024). Penicillium: A Treasure Trove for Antimycobacterial and Antioxidant Metabolites. In: Deshmukh, S.K., Takahashi, J.A., Saxena, S. (eds) Fungi Bioactive Metabolites. Springer, Singapore. https://doi.org/10.1007/978-981-99-5696-8_9

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