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Micro-Nano Structured Materials for DNA/RNA Amplification-Based Electrochemical Tests

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Handbook of Nanobioelectrochemistry

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Abstract

Nucleic acid amplification is now a standardized analytical technique, allowing precise and rapid determination of the presence of a determined DNA/RNA sequence. Moreover, some sophisticated equipment allows the exquisite quantification of the number of copies originally presented in a sample; many different protocols, enzymes, labels, and equipment have been developed over time, allowing high throughput and automatization. In the same way, modern nanotechnology has been developed over several decades, and now almost any laboratory can synthesize and characterize nanoparticles of different materials and tune size and shape. We believe there is then an opportunity to merge both already mature technological areas and find new and exciting applications to improve the analytical performance, lower the per-analysis cost, and make the whole process (from reagents elaboration to disposal) more environmentally friendly. Here we explore some of the possibilities for nanoscience and nucleic acid amplification to come together to obtain better analytical systems.

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Authors and Affiliations

  1. Laboratory of Biosensors and Bioanalysis (LABB), Biological Chemistry Department and IQUIBICEN-CONICET, Science School, University of Buenos Aires, Buenos Aires, Argentina

    Federico Figueredo, Mónica Mosquera-Ortega & Eduardo Cortón

  2. Basic Science Department, National Technology University - FRGP, General Pacheco, Buenos Aires, Argentina

    Mónica Mosquera-Ortega

Authors
  1. Federico Figueredo
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  2. Mónica Mosquera-Ortega
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  3. Eduardo Cortón
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Correspondence to Eduardo Cortón .

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Editors and Affiliations

  1. Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

    Uday Pratap Azad

  2. School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, India

    Pranjal Chandra

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Figueredo, F., Mosquera-Ortega, M., Cortón, E. (2023). Micro-Nano Structured Materials for DNA/RNA Amplification-Based Electrochemical Tests. In: Azad, U.P., Chandra, P. (eds) Handbook of Nanobioelectrochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-19-9437-1_19

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