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Nanobiomaterial-Based Biosensors for the Diagnosis of Infectious Diseases

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Handbook of Nanobioelectrochemistry

Abstract

Infectious diseases are among the primary causes of millions of deaths every year. Early detection of these diseases is a crucial step in controlling outbreaks. Therefore, the development of reliable, rapid, inexpensive, convenient, and point-of-care devices for diagnosing infectious diseases is at the forefront of research. In recent decades, the utilization of nanostructures in biosensing platforms has led to significant advancements in disease diagnosis. This is due to the diverse range of available nanostructures and the ability to customize their physicochemical properties. This chapter provides an overview of the application of nanobiomaterials in constructing biosensors for monitoring infectious diseases. Additionally, it explains strategies to create high-performance biosensors by harnessing the benefits of gold, silver, magnetic, and carbon-based nanobiomaterials.

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References

  • Afsahi S, Lerner MB, Goldstein JM, Lee J, Tang X, Bagarozzi DA Jr, Pan D, Locascio L, Walker A, Barron F, Goldsmith BR (2018) Novel graphene-based biosensor for early detection of Zika virus infection. Biosens Bioelectron 100:85–88

    Article  CAS  PubMed  Google Scholar 

  • Ahangar LE, Mehrgardi MA (2017) Amplified detection of hepatitis B virus using an electrochemical DNA biosensor on a nanoporous gold platform. Bioelectrochemistry 117:83–88

    Article  CAS  PubMed  Google Scholar 

  • Amiri M, Bezaatpour A, Jafari H, Boukherroub R, Szunerits S (2018) Electrochemical methodologies for the detection of pathogens. ACS Sens 3(6):1069–1086

    Article  CAS  PubMed  Google Scholar 

  • Baranwal A, Srivastava A, Kumar P, Bajpai VK, Maurya PK, Chandra P (2018) Prospects of nanostructure materials and their composites as antimicrobial agents. Front Microbiol 9:422

    Article  PubMed  PubMed Central  Google Scholar 

  • Beyene HD, Werkneh AA, Bezabh HK, Ambaye TG (2017) Synthesis paradigm and applications of silver nanoparticles (AgNPs), a review. Sustain Mater Technol 13:18–23

    CAS  Google Scholar 

  • Bhatnagar I, Mahato K, Ealla KKR, Asthana A, Chandra P (2018) Chitosan stabilized gold nanoparticle mediated self-assembled gliP nanobiosensor for diagnosis of invasive aspergillosis. Int J Biol Macromol 110:449–456

    Article  CAS  PubMed  Google Scholar 

  • Böttcher B, Wynne S, Crowther R (1997) Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386(6620):88–91

    Article  PubMed  Google Scholar 

  • Campuzano S, Yanez-Sedeno P, Pingarron JM (2017) Molecular biosensors for electrochemical detection of infectious pathogens in liquid biopsies: current trends and challenges. Sensors (Basel) 17(11):2533

    Article  PubMed  Google Scholar 

  • Carinelli S, Xufre Ballesteros C, Marti M, Alegret S, Pividori MI (2015) Electrochemical magneto-actuated biosensor for CD4 count in AIDS diagnosis and monitoring. Biosens Bioelectron 74:974–980

    Article  CAS  PubMed  Google Scholar 

  • Cesewski E, Johnson BN (2020) Electrochemical biosensors for pathogen detection. Biosens Bioelectron 159:112214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen L, Lv S, Liu M, Chen C, Sheng J, Luo X (2018) Low-fouling magnetic nanoparticles and evaluation of their potential application as disease markers assay in whole serum. ACS Appl Nano Mater 1(6):2489–2495

    Article  CAS  Google Scholar 

  • Cui HF, Xu TB, Sun YL, Zhou AW, Cui YH, Liu W, Luong JH (2015) Hairpin DNA as a biobarcode modified on gold nanoparticles for electrochemical DNA detection. Anal Chem 87(2):1358–1365

    Article  CAS  PubMed  Google Scholar 

  • Dadfar SM, Roemhild K, Drude NI, von Stillfried S, Knuchel R, Kiessling F, Lammers T (2019) Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications. Adv Drug Deliv Rev 138:302–325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dakshayini BS, Reddy KR, Mishra A, Shetti NP, Malode SJ, Basu S, Naveen S, Raghu AV (2019) Role of conducting polymer and metal oxide-based hybrids for applications in ampereometric sensors and biosensors. Microchem J 147:7–24

    Article  CAS  Google Scholar 

  • de la Escosura-Muniz A, Maltez-da Costa M, Sanchez-Espinel C, Diaz-Freitas B, Fernandez-Suarez J, Gonzalez-Fernandez A, Merkoci A (2010) Gold nanoparticle-based electrochemical magnetoimmunosensor for rapid detection of anti-hepatitis B virus antibodies in human serum. Biosens Bioelectron 26(4):1710–1714

    Article  PubMed  Google Scholar 

  • Deng J, Zhao S, Liu Y, Liu C, Sun J (2020) Nanosensors for diagnosis of infectious diseases. ACS Appl Bio Mater 4(5):3863–3879

    Article  PubMed  Google Scholar 

  • Dzudzevic Cancar H, Soylemez S, Akpinar Y, Kesik M, Goker S, Gunbas G, Volkan M, Toppare L (2016) A novel acetylcholinesterase biosensor: core-shell magnetic nanoparticles incorporating a conjugated polymer for the detection of organophosphorus pesticides. ACS Appl Mater Interfaces 8(12):8058–8067

    Article  CAS  PubMed  Google Scholar 

  • Fan J, Yuan L, Liu Q, Tong C, Wang W, Xiao F, Liu B, Liu X (2019) An ultrasensitive and simple assay for the hepatitis C virus using a reduced graphene oxide-assisted hybridization chain reaction. Analyst 144(13):3972–3979

    Article  CAS  PubMed  Google Scholar 

  • Farzin L, Shamsipur M, Samandari L, Sheibani S (2020) HIV biosensors for early diagnosis of infection: the intertwine of nanotechnology with sensing strategies. Talanta 206:120201

    Article  CAS  PubMed  Google Scholar 

  • Freitas M, Sá Couto M, Barroso MF, Pereira C, de-los-Santos-Álvarez N, Miranda-Ordieres AJ, Lobo-Castañón MJ, Delerue-Matos C (2016) Highly monodisperse Fe3O4@Au superparamagnetic nanoparticles as reproducible platform for genosensing genetically modified organisms. ACS Sens 1(8):1044–1053

    Article  CAS  Google Scholar 

  • Furst AL, Francis MB (2019) Impedance-based detection of bacteria. Chem Rev 119(1):700–726

    Article  CAS  PubMed  Google Scholar 

  • Gill AAS, Singh S, Thapliyal N, Karpoormath R (2019) Nanomaterial-based optical and electrochemical techniques for detection of methicillin-resistant Staphylococcus aureus: a review. Mikrochim Acta 186(2):114

    Article  PubMed  Google Scholar 

  • Golchin K, Golchin J, Ghaderi S, Alidadiani N, Eslamkhah S, Eslamkhah M, Davaran S, Akbarzadeh A (2018) Gold nanoparticles applications: from artificial enzyme till drug delivery. Artif Cells Nanomed Biotechnol 46(2):250–254

    Article  CAS  PubMed  Google Scholar 

  • Gong Q, Wang Y, Yang H (2017) A sensitive impedimetric DNA biosensor for the determination of the HIV gene based on graphene-Nafion composite film. Biosens Bioelectron 89(Pt 1):565–569

    Article  CAS  PubMed  Google Scholar 

  • Gong Q, Han H, Yang H, Zhang Z, Sun X, Liang Y, Liu Z, Zhang W, Qiao J (2019) Sensitive electrochemical DNA sensor for the detection of HIV based on a polyaniline/graphene nanocomposite J. Materiomics, 5:313–319

    Google Scholar 

  • Gu W, Deng X, Gu X, Jia X, Lou B, Zhang X, Li J, Wang E (2015) Stabilized, superparamagnetic functionalized graphene/Fe3O4@Au nanocomposites for a magnetically-controlled solid-state electrochemiluminescence biosensing application. Anal Chem 87(3):1876–1881

    Article  CAS  PubMed  Google Scholar 

  • Guo S, Wang E (2007) Synthesis and electrochemical applications of gold nanoparticles. Anal Chim Acta 598(2):181–192

    Article  CAS  PubMed  Google Scholar 

  • Gupta S, Murthy CN, Prabha CR (2018) Recent advances in carbon nanotube based electrochemical biosensors. Int J Biol Macromol 108:687–703

    Article  CAS  PubMed  Google Scholar 

  • Haghniaz R, Rabbani A, Vajhadin F, Khan T, Kousar R, Khan AR, Montazerian H, Iqbal J, Libanori A, Kim H-J (2021) Anti-bacterial and wound healing-promoting effects of zinc ferrite nanoparticles. J Nanobiotechnol 19(1):1–15

    Article  Google Scholar 

  • Haghshenas M, Mazloum-Ardakani M, Alizadeh Z, Vajhadin F, Naeimi H (2020) A sensing platform using Ag/Pt core-shell nanostructures supported on multiwalled carbon nanotubes to detect hydroxyurea. Electroanalysis 32(10):2137–2145

    Article  CAS  Google Scholar 

  • Hassanpour S, Baradaran B, de la Guardia M, Baghbanzadeh A, Mosafer J, Hejazi M, Mokhtarzadeh A, Hasanzadeh M (2018) Diagnosis of hepatitis via nanomaterial-based electrochemical, optical or piezoelectrical biosensors: a review on recent advancements. Mikrochim Acta 185(12):568

    Article  PubMed  Google Scholar 

  • Huang J, Xie Z, Xie Z, Luo S, Xie L, Huang L, Fan Q, Zhang Y, Wang S, Zeng T (2016) Silver nanoparticles coated graphene electrochemical sensor for the ultrasensitive analysis of avian influenza virus H7. Anal Chim Acta 913:121–127

    Article  CAS  PubMed  Google Scholar 

  • Iijima S (1991) Helical microtubules of graphitic carbon. Nature 354(6348):56–58

    Article  CAS  Google Scholar 

  • Jin S, Poudyal S, Marinero EE, Kuhn RJ, Stanciu L (2016) Impedimetric Dengue Biosensor based on Functionalized Graphene Oxide Wrapped Silica Particle, Electrochim. Acta 194:422–430

    Google Scholar 

  • Jin X, Zhang H, Li YT, Xiao MM, Zhang ZL, Pang DW, Wong G, Zhang ZY, Zhang GJ (2019) A field effect transistor modified with reduced graphene oxide for immunodetection of Ebola virus. Mikrochim Acta 186(4):223

    Article  PubMed  Google Scholar 

  • Kashish BS, Jyoti A, Mahato K, Chandra P, Prakash R (2017) Highly sensitive in vitro biosensor for enterotoxigenic escherichia coli detection based on ssDNA Anchored on PtNPs-chitosan nanocomposite. Electroanalysis 29(11):2665–2671

    Article  CAS  Google Scholar 

  • Kergoat L, Piro B, Berggren M, Horowitz G, Pham MC (2012) Advances in organic transistor-based biosensors: from organic electrochemical transistors to electrolyte-gated organic field-effect transistors. Anal Bioanal Chem 402(5):1813–1826

    Article  CAS  PubMed  Google Scholar 

  • Kumar S, Ahlawat W, Kumar R, Dilbaghi N (2015) Graphene, carbon nanotubes, zinc oxide and gold as elite nanomaterials for fabrication of biosensors for healthcare. Biosens Bioelectron 70:498–503

    Article  CAS  PubMed  Google Scholar 

  • Lee KX, Shameli K, Yew YP, Teow SY, Jahangirian H, Rafiee-Moghaddam R, Webster TJ (2020) Recent developments in the facile bio-synthesis of gold nanoparticles (AuNPs) and their biomedical applications. Int J Nanomedicine 15:275–300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li J, Xu Q, Wei X, Hao Z (2013) Electrogenerated chemiluminescence immunosensor for Bacillus thuringiensis Cry1Ac based on Fe3O4@Au nanoparticles. J Agric Food Chem 61(7):1435–1440

    Article  CAS  PubMed  Google Scholar 

  • Li X, Scida K, Crooks RM (2015a) Detection of hepatitis B virus DNA with a paper electrochemical sensor. Anal Chem 87(17):9009–9015

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Deng J, Fang L, Yu K, Huang H, Jiang L, Liang W, Zheng J (2015b) A novel electrochemical DNA biosensor based on HRP-mimicking hemin/G-quadruplex wrapped GOx nanocomposites as tag for detection of Escherichia coli O157:H7. Biosens Bioelectron 63:1–6

    Article  PubMed  Google Scholar 

  • Lin Y, Ren J, Qu X (2014) Nano-gold as artificial enzymes: hidden talents. Adv Mater 26(25):4200–4217

    Article  CAS  PubMed  Google Scholar 

  • Liu G, Lin Y (2007) Nanomaterial labels in electrochemical immunosensors and immunoassays. Talanta 74(3):308–317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu F, Kim YH, Cheon DS, Seo TS (2013) Micropatterned reduced graphene oxide based field-effect transistor for real-time virus detection. Sensors Actuators B Chem 186:252–257

    Article  CAS  Google Scholar 

  • Li X, Liu T, Zhang Y, Ni X, Nur Hossain M, Chen X, Huang H, Kraat H (2021) A novel electrochemical immunosensor for hepatitis B surface antigen based on Fe3O4 nanoflowers and heterogeneous chain reaction signal amplification strategy, Talanta 221:121459

    Google Scholar 

  • Maduraiveeran G, Sasidharan M, Ganesan V (2018) Electrochemical sensor and biosensor platforms based on advanced nanomaterials for biological and biomedical applications. Biosens Bioelectron 103:113–129

    Article  CAS  PubMed  Google Scholar 

  • Mahapatra S, Chandra P (2020) Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis. Biosens Bioelectron 165:112361

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahar B, Laslau C, Yip R, Sun Y (2007) Development of carbon nanotube-based sensors—a review. IEEE Sensors J 7(2):266–284

    Article  CAS  Google Scholar 

  • Mahshid SS, Flynn SE, Mahshid S (2020) The potential application of electrochemical biosensors in the COVID-19 pandemic: a perspective on the rapid diagnostics of SARS-CoV-2. Biosens Bioelectron 176:112905

    Article  PubMed  PubMed Central  Google Scholar 

  • Markwalter CF, Kantor AG, Moore CP, Richardson KA, Wright DW (2019) Inorganic complexes and metal-based nanomaterials for infectious disease diagnostics. Chem Rev 119(2):1456–1518

    Article  CAS  PubMed  Google Scholar 

  • Meng X, Fan K, Yan X (2019) Nanozymes: an emerging field bridging nanotechnology and enzymology. Sci China Life Sci 62(11):1543–1546

    Article  PubMed  Google Scholar 

  • Moço ACR, Guedes PH, Flauzino JMR, da Silva HS, Vieira JG, Castro ACH, Gomes ÉVR, Tolentino FM, Soares MMCN, Madurro JM, Brito-Madurro AG (2019) Electrochemical detection of Zika virus in biological samples: a step for diagnosis point-of-care. Electroanalysis 31(8):1580–1587

    Article  Google Scholar 

  • Ng BY, Xiao W, West NP, Wee EJ, Wang Y, Trau M (2015) Rapid, single-cell electrochemical detection of mycobacterium tuberculosis using colloidal gold nanoparticles. Anal Chem 87(20):10613–10618

    Article  CAS  PubMed  Google Scholar 

  • Nourani S, Ghourchian H, Boutorabi SM (2013) Magnetic nanoparticle-based immunosensor for electrochemical detection of hepatitis B surface antigen. Anal Biochem 441(1):1–7

    Article  CAS  PubMed  Google Scholar 

  • Pashchenko O, Shelby T, Banerjee T, Santra S (2018) A comparison of optical, electrochemical, magnetic, and colorimetric point-of-care biosensors for infectious disease diagnosis. ACS Infect Dis 4(8):1162–1178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pei F, Wang P, Ma E, Yang Q, Yu H, Gao C, Li Y, Liu Q, Dong Y (2019) A sandwich-type electrochemical immunosensor based on RhPt NDs/NH2-GS and Au NPs/PPy NS for quantitative detection hepatitis B surface antigen. Bioelectrochemistry 126:92–98

    Article  CAS  PubMed  Google Scholar 

  • Palomar Q, Gondran C, Marks M, Cosnier S, Holzinger M (2018) Impedimetric quantification of anti-dengue antibodies using functional carbon nanotube deposits validated with blood plasma assays, Electrochim. Acta 274:84–90

    Google Scholar 

  • Qasim M, Lim DJ, Park H, Na D (2014) Nanotechnology for diagnosis and treatment of infectious diseases. J Nanosci Nanotechnol 14(10):7374–7387

    Article  CAS  PubMed  Google Scholar 

  • Rabbani A, Haghniaz R, Khan T, Khan R, Khalid A, Naz SS, Ul-Islam M, Vajhadin F, Wahid F (2021) Development of bactericidal spinel ferrite nanoparticles with effective biocompatibility for potential wound healing applications. RSC Adv 11(3):1773–1782

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rivas L, Medina-Sanchez M, de la Escosura-Muniz A, Merkoci A (2014) Improving sensitivity of gold nanoparticle-based lateral flow assays by using wax-printed pillars as delay barriers of microfluidics. Lab Chip 14(22):4406–4414

    Article  CAS  PubMed  Google Scholar 

  • Roberts A, Chauhan N, Islam S, Mahari S, Ghawri B, Gandham RK, Majumdar SS, Ghosh A, Gandhi S (2020) Graphene functionalized field-effect transistors for ultrasensitive detection of Japanese encephalitis and avian influenza virus. Sci Rep 10(1):14546

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanati A, Jalali M, Raeissi K, Karimzadeh F, Kharaziha M, Mahshid SS, Mahshid S (2019) A review on recent advancements in electrochemical biosensing using carbonaceous nanomaterials. Mikrochim Acta 186(12):773

    Article  CAS  PubMed  Google Scholar 

  • Sayhi M, Ouerghi O, Belgacem K, Arbi M, Tepeli Y, Ghram A, Anik U, Osterlund L, Laouini D, Diouani MF (2018) Electrochemical detection of influenza virus H9N2 based on both immunomagnetic extraction and gold catalysis using an immobilization-free screen printed carbon microelectrode. Biosens Bioelectron 107:170–177

    Article  CAS  PubMed  Google Scholar 

  • Schroeder V, Savagatrup S, He M, Lin S, Swager TM (2019) Carbon nanotube chemical sensors. Chem Rev 119(1):599–663

    Article  CAS  PubMed  Google Scholar 

  • Sengani M, Grumezescu AM, Rajeswari VD (2017) Recent trends and methodologies in gold nanoparticle synthesis – a prospective review on drug delivery aspect. OpenNano 2:37–46

    Article  Google Scholar 

  • Sharifi M, Hasan A, Haghighat S, Taghizadeh A, Attar F, Bloukh SH, Edis Z, Xue M, Khan S, Falahati M (2021) Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: challenges and opportunities. Talanta 223(Pt 1):121704

    Article  CAS  PubMed  Google Scholar 

  • Sinawang PD, Rai V, Ionescu RE, Marks RS (2016) Electrochemical lateral flow immunosensor for detection and quantification of dengue NS1 protein. Biosens Bioelectron 77:400–408

    Article  CAS  PubMed  Google Scholar 

  • Steinmetz M, Lima D, Viana AG, Fujiwara ST, Pessoa CA, Etto RM, Wohnrath K (2019) A sensitive label-free impedimetric DNA biosensor based on silsesquioxane-functionalized gold nanoparticles for Zika virus detection. Biosens Bioelectron 141:111351

    Article  CAS  PubMed  Google Scholar 

  • Teengam P, Siangproh W, Tontisirin S, Jiraseree-amornkun A, Chuaypen N, Tangkijvanich P, Henry CS, Ngamrojanavanich N, Chailapakul O (2021) NFC-enabling smartphone-based portable amperometric immunosensor for hepatitis B virus detection. Sens Actuators B Chem 326:128825

    Article  CAS  Google Scholar 

  • Urbanova V, Magro M, Gedanken A, Baratella D, Vianello F, Zboril R (2014) Nanocrystalline iron oxides, composites, and related materials as a platform for electrochemical, magnetic, and chemical biosensors. Chem Mater 26(23):6653–6673

    Article  CAS  Google Scholar 

  • Vajhadin F, Ahadian S, Travas-Sejdic J, Lee J, Mazloum-Ardakani M, Salvador J, Aninwene GE 2nd, Bandaru P, Sun W, Khademhossieni A (2020) Electrochemical cytosensors for detection of breast cancer cells. Biosens Bioelectron 151:111984

    Article  CAS  PubMed  Google Scholar 

  • Wang J (2005a) Carbon-nanotube based electrochemical biosensors: a review. Electroanalysis 17(1):7–14

    Article  CAS  Google Scholar 

  • Wang J (2005b) Nanomaterial-based electrochemical biosensors. Analyst 130(4):421–426

    Article  CAS  PubMed  Google Scholar 

  • Wang Z, Hu T, Liang R, Wei M (2020) Application of zero-dimensional nanomaterials in biosensing. Front Chem 8:320

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei S, Xiao H, Cao L, Chen Z (2020) A label-free immunosensor based on graphene oxide/Fe3O4/Prussian blue nanocomposites for the electrochemical determination of HBsAg. Biosensors (Basel) 10(3):24

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Gao Y, Zhang X, Wang H, Xia T, Bian C, Liang S, Tang X, Wang X (2019) Electrochemical immunosensor for HBe antigen detection based on a signal amplification strategy: the co-catalysis of horseradish peroxidase and nanoporous gold. Sensors Actuators B Chem 284:296–304

    Article  CAS  Google Scholar 

  • Zhou X, Jiang X, Qu M, Aninwene GE, Jucaud V, Moon JJ, Gu Z, Sun W, Khademhosseini A (2020) Engineering antiviral vaccines. ACS Nano 14(10):12370–12389

    Article  CAS  PubMed  Google Scholar 

  • Zhu C, Yang G, Li H, Du D, Lin Y (2015) Electrochemical sensors and biosensors based on nanomaterials and nanostructures. Anal Chem 87(1):230–249

    Article  CAS  PubMed  Google Scholar 

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Vajhadin, F., Mazloum-Ardakani, M. (2023). Nanobiomaterial-Based Biosensors for the Diagnosis of Infectious Diseases. In: Azad, U.P., Chandra, P. (eds) Handbook of Nanobioelectrochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-19-9437-1_12

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