Abstract
Although heart diseases continue to be the leading cause of death worldwide, advances performed in recent decades have facilitated a decrease in the mortality rate related to severe heart diseases. This is due to the recognition that has been acquiring the role of the immune system and its contribution to the progression of heart disease. Recent studies have shown that there is a close relationship between cardiac disturbances and inflammatory mediators produced by immune system cells since there is a close interaction between the innate and adaptive immune response in the pathophysiology of heart diseases. Regarding innate immune response, macrophages are the leading cells, which play a fundamental role in a wide variety of cardiac disorders. These cells produce a variety of cytokines that open up a wide range of therapeutic possibilities in the treatment of heart diseases. However, under certain circumstances, it is known that immune system cells can cause irreparable damage that contributes to heart failure. Therefore, it is essential to study the crosstalk between innate and adaptive response in order to better understand the mechanism of action of the different cardiac disturbances. In this sense, biotechnology emerges as a pioneering tool that allows on the one hand to effectively detect the various cardiovascular and inflammatory diseases, and on the other, to develop innovative therapies that result in effective treatments.
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Junho, C.V.C., de Yurre, A.R., Medei, E., Sorelli Carneiro-Ramos, M. (2023). Cardioimmunology: An Interdisciplinary Approach. In: Ribeiro de Araujo, D., Carneiro-Ramos, M. (eds) Biotechnology Applied to Inflammatory Diseases. Interdisciplinary Biotechnological Advances. Springer, Singapore. https://doi.org/10.1007/978-981-19-8342-9_1
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