Skip to main content
SpringerLink
Log in

Bayesian Adaptive Design for Immunotherapy and Targeted Therapy

  • Book
  • © 2023

Overview

Authors:
  1. Haitao Pan

    1. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

  2. Ying Yuan

    1. Department of Biostatistics, MD Anderson Cancer Center, The University of Texas, Houston, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • The first book focusing on novel adaptive designs for targeted and immunotherapies
  • Comprehensive coverage of state-of-the-art Bayesian adaptive designs, such as model-assisted designs
  • Including many real-world trial examples

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (9 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Phase I Trials

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Introduction to Phase I Dose-Finding Clinical Trials

      • Haitao Pan, Ying Yuan
      Pages 3-14

    3. Phase I Designs for Late-Onset Toxicity

      • Haitao Pan, Ying Yuan
      Pages 15-43

  3. Phase I/II Trials

    1. Front Matter

      Pages 45-45
      Download chapter PDF

    2. Optimal Biological Dose and Phase I/II Trials

      • Haitao Pan, Ying Yuan
      Pages 47-52

    3. Model-Based Designs for Identification of Optimal Biological Dose

      • Haitao Pan, Ying Yuan
      Pages 53-70

    4. Model-Assisted Designs for Identifying the Optimal Biological Dose

      • Haitao Pan, Ying Yuan
      Pages 71-88

  4. Phase II Trials

    1. Front Matter

      Pages 89-89
      Download chapter PDF

    2. Single Arm Phase II Clinical Trial

      • Haitao Pan, Ying Yuan
      Pages 91-118

    3. Randomized Phase II Designs

      • Haitao Pan, Ying Yuan
      Pages 119-146

  5. Master-Protocol Trials

    1. Front Matter

      Pages 147-147
      Download chapter PDF

    2. Introduction to Basket Trials

      • Haitao Pan, Ying Yuan
      Pages 149-200

    3. Platform Trials

      • Haitao Pan, Ying Yuan
      Pages 201-262
Back to top

Keywords

About this book

This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate practitioners to learn and use the designs in practice.

Authors and Affiliations

  • Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, USA

    Haitao Pan

  • Department of Biostatistics, MD Anderson Cancer Center, The University of Texas, Houston, USA

    Ying Yuan

Bibliographic Information

  • Book Title: Bayesian Adaptive Design for Immunotherapy and Targeted Therapy

  • Authors: Haitao Pan, Ying Yuan

  • DOI: https://doi.org/10.1007/978-981-19-8176-0

  • Publisher: Springer Singapore

  • eBook Packages: Mathematics and Statistics, Mathematics and Statistics (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2023

  • Hardcover ISBN: 978-981-19-8174-6Published: 20 April 2023

  • Softcover ISBN: 978-981-19-8467-9Published: 21 April 2024

  • eBook ISBN: 978-981-19-8176-0Published: 19 April 2023

  • Edition Number: 1

  • Number of Pages: XI, 262

  • Number of Illustrations: 8 b/w illustrations, 50 illustrations in colour

  • Topics: Statistics for Life Sciences, Medicine, Health Sciences

Publish with us

Policies and ethics

Back to top

Search

Navigation