Abstract
Bacteriophage, being the most abundant organism on earth, has provided a virtually unlimited resource to develop various novel and exciting biotechnological and medical strategies. Although phage therapy was conceived nearly a century ago, its real power was only realized with the global emergence of multidrug-resistant bacterial pathogens. With tremendous progress in various technologies like high-throughput next-generation sequencing, genome editing, and synthetic biology, new avenues have opened up to explore phages. In this review, we tried to explore the various phage engineering strategy which has been used to develop mutant phages having multivalent applications. Phage engineering promises to develop mutant phages, which can be used to deliver cargos into cells/tissues that can enhance the immune response and prevent infection. These engineering approaches have the potential to accelerate basic biotechnological research as well as have the ability to develop into new therapeutics in the future.
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Kumar, S., Pattnaik, R., Sahu, P.S., Bhattacharya, B. (2022). Bacteriophage and Virus Engineering. In: Suar, M., Misra, N., Dash, C. (eds) Microbial Engineering for Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-19-3979-2_6
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DOI: https://doi.org/10.1007/978-981-19-3979-2_6
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