Skip to main content
SpringerLink
Log in

Immunomodulatory Properties of Nutraceuticals and Functional Foods

  • Chapter
  • First Online:
Nutraceuticals and Functional Foods in Immunomodulators

  • 317 Accesses

Abstract

The immune system is a complex assembly of coordinated cells to maintain human health. Nowadays, there is a growing interest in maintaining the immune system in proper conditions to counteract noncommunicable chronic diseases, harmful entities (toxic xenobiotics, allergens, and microbial pathogens), cancer, and emerging infectious and autoimmune diseases that currently affect health systems worldwide. Adequate human nutrition is essential for the maintenance and modulation of the immune system. This is due to the different functional ingredients that can be found in food matrices such as fruits, vegetables, dairy products, meat, cereals, and oils. Among these, polyphenolic antioxidants, vitamins, probiotics, prebiotics, and peptides can be highlighted. All the above dietary functional ingredients act as immunomodulators since they have a direct or indirect immunostimulatory response by interacting with immune cells and triggering stimulating responses for antibodies and anti-inflammatory cytokine and chemokine secretions but also for suppressing pro-inflammatory cytokines. Therefore, these immunomodulator compounds have been considered as adjuvants in the prevention and treatment of some infectious diseases and some others related to autoimmunity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abbas AK, Lichtman AH, Pober JS (2011) Innate immunity. In: Cellular and molecular immunology, 7th edn. Elsevier, Philadelphia

    Google Scholar 

  • Acurcio LB, Bastos RW, de Cicco Sandes SH, de Carvalho Guimarães AC, Alves CG, dos Reis DC, Wuyts S, Nunes ÁC, Cassali GD, Lebeer S, de Souza MR, Nicoli JR (2017) Protective effects of milk fermented by Lactobacillus plantarum B7 from Brazilian artisanal cheese on a Salmonella enterica serovar Typhimurium infection in BALB/c mice. Journal of Functional Foods 33:436–445

    Article  CAS  Google Scholar 

  • Adorini L, Penna G (2008) Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4(8):404–412

    Article  CAS  Google Scholar 

  • Aguilar-Toalá JE, Santiago-López L, Peres CM, Peres C, Garcia HS, Vallejo-Cordoba B et al (2017) Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains. J Dairy Sci 100(1):65–75

    Article  Google Scholar 

  • Ahola AJ, Lassenius MI, Forsblom C, Harjutsalo V, Lehto M, Groop PH (2017) Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity. Sci Rep 7(1):1–9

    Article  Google Scholar 

  • Albenzio M, Santillo A, Caroprese M, Della Malva A, Marino R (2017) Bioactive peptides in animal food products. Foods 6(5):35

    Article  Google Scholar 

  • Alwarawrah Y, Kiernan K, MacIver NJ (2018) Changes in nutritional status impact immune cell metabolism and function. Front Immunol 9:1055

    Article  Google Scholar 

  • Amigo L, Martínez-Maqueda D, Hernández-Ledesma B (2020) In Silico and in vitro analysis of multifunctionality of animal food-derived peptides. Foods 9(8):991

    Article  CAS  Google Scholar 

  • Ang A, Pullar JM, Currie MJ, Vissers MC (2018) Vitamin C and immune cell function in inflammation and cancer. Biochem Soc Trans 46(5):1147–1159

    Article  CAS  Google Scholar 

  • Ashraf GM, Tarasov VV, Makhmutovа A, Chubarev VN, Avila-Rodriguez M, Bachurin SO, Aliev G (2019) The possibility of an infectious etiology of Alzheimer disease. Mol Neurobiol 56(6):4479–4491

    Article  CAS  Google Scholar 

  • Aslam MF, Majeed S, Aslam S, Irfan JA (2017) Vitamins: key role players in boosting up immune response–a mini review. Vitamins and Minerals 6:153

    Google Scholar 

  • Azad M, Kalam A, Sarker M, Wan D (2018) Immunomodulatory effects of probiotics on cytokine profiles. Biomed Res Int:10

    Google Scholar 

  • Babbar N, Dejonghe W, Gatti M, Sforza S, Elst K (2016) Pectic oligosaccharides from agricultural by-products: production, characterization and health benefits. Crit Rev Biotechnol 36(4):594–606

    Article  CAS  Google Scholar 

  • Barbé F, Le Feunteun S, Rémond D, Ménard O, Jardin J, Henry G et al (2014) Tracking the in vivo release of bioactive peptides in the gut during digestion: mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs. Food Res Int 63:147–156

    Article  Google Scholar 

  • Bechaux J, Gatellier P, Le Page JF, Drillet Y, Sante-Lhoutellier V (2019) A comprehensive review of bioactive peptides obtained from animal byproducts and their applications. Food Funct 10(10):6244–6266

    Article  CAS  Google Scholar 

  • Bendix M, Greisen S, Dige A, Hvas CL, Bak N, Jørgensen SP, Dahlerup JF, Deleuran B, Agnholt J (2017) Vitamin D increases programmed death receptor-1 expression in Crohn’s disease. Oncotarget 8(15):24177

    Article  Google Scholar 

  • Bermudez-Brito M, Rösch C, Schols HA, Faas MM, de Vos P (2015) Resistant starches differentially stimulate toll-like receptors and attenuate proinflammatory cytokines in dendritic cells by modulation of intestinal epithelial cells. Mol Nutr Food Res 59(9):1814–1826

    Article  CAS  Google Scholar 

  • Bivona JJ III, Patel S, Vajdy M (2017) Induction of cellular and molecular immunomodulatory pathways by vitamin E and vitamin C. Expert Opin Biol Ther 17(12):1539–1551

    Article  CAS  Google Scholar 

  • Boehm T (2011) Design principles of adaptive immune systems. Nat Rev Immunol 11(5):307–317

    Article  CAS  Google Scholar 

  • Boldogh I, Kruzel ML (2008) Colostrinin™: an oxidative stress modulator for prevention and treatment of age-related disorders. J Alzheimers Dis 13(3):303–321

    Article  CAS  Google Scholar 

  • Boothapandi M, Ramanibai R (2019) Immunomodulatory effect of natural flavonoid chrysin (5, 7-dihydroxyflavone) on LPS stimulated RAW 264.7 macrophages via inhibition of NF-κB activation. Process Biochem 84:186–195

    Article  CAS  Google Scholar 

  • Boretti A, Banik BK (2020) Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. Pharma Nutrition 12:100190

    Article  Google Scholar 

  • Butel MJ (2014) Probiotics, gut microbiota and health. Med Mal Infect 44(1):1–8

    Article  Google Scholar 

  • Cai J, Li X, Du H, Jiang C, Xu S, Cao Y (2020) Immunomodulatory significance of natural peptides in mammalians: promising agents for medical application. Immunobiology 225(3):151936

    Article  CAS  Google Scholar 

  • Cai Y, Li YF, Tang LP, Tsoi B, Chen M, Chen H, Chen X-M, Tan R-R, Kurihara H, He RR (2015) A new mechanism of vitamin C effects on a/FM/1/47 (H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int 2015:675149

    Article  Google Scholar 

  • Cao Q, Gao X, Lin Y, Yue C, Wang Y, Quan F, Quan F, Zhang Z, Liu X, Lu Y, Zhan Y, Yang H, Li X, Di Qin LB, Hao K, Yang H (2019) Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes. Theranostics 9(25):7490

    Article  CAS  Google Scholar 

  • Cavaglieri CR, Nishiyama A, Fernandes LC, Curi R, Miles EA, Calder PC (2003) Differential effects of short-chain fatty acids on proliferation and production of pro-and anti-inflammatory cytokines by cultured lymphocytes. Life Sci 73(13):1683–1690

    Article  CAS  Google Scholar 

  • Chaisuwan W, Jantanasakulwong K, Wangtueai S, Phimolsiripol Y, Chaiyaso T, Techapun C, Phongthai S, You SG, Regenstein J, Seesuriyachan P (2020) Microbial exopolysaccharides for immune enhancement: fermentation, modifications and bioactivities. Food Biosci 35:100564

    Article  CAS  Google Scholar 

  • Chalamaiah M, Yu W, Wu J (2018) Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: a review. Food Chem 245:205–222

    Article  CAS  Google Scholar 

  • Chan BCL, Li LF, Hu SQ, Wat E, Wong ECW, Zhang VX, Lau CBS, Wong CK, Hon KLE, Hui PCL, Leung PC (2015) Gallic acid is the major active component of cortex moutan in inhibiting immune maturation of human monocyte-derived dendritic cells. Molecules 20(9):16388–16403

    Article  CAS  Google Scholar 

  • Chandra RK (1974) Rosette-forming T lymphocytes and cell-mediated immunity in malnutrition. Br Med J 3(5931):608–609

    Article  CAS  Google Scholar 

  • Chandran M, Maung AC, Mithal A, Parameswaran R (2020) Vitamin D in COVID-19: dousing the fire or averting the storm?–a perspective from the Asia-Pacific. Osteoporosis and Sarcopenia 6(3):97–105

    Article  Google Scholar 

  • Chandrashekar PM, Venkatesh YP (2012) Fructans from aged garlic extract produce a delayed immunoadjuvant response to ovalbumin antigen in BALB/c mice. Immunopharmacol Immunotoxicol 34(1):174–180

    Article  Google Scholar 

  • Chandrashekara PM, Venkatesh YP (2016) Immunostimulatory properties of fructans derived from raw garlic (Allium sativum L.). Bioact Carbohydr Diet Fibre 8(2):65–70

    Article  CAS  Google Scholar 

  • Chatterjee C, Gleddie S, Xiao C-W (2018) Soybean bioactive peptides and their functional properties. Nutrients 10:1211

    Article  Google Scholar 

  • Chen K, Chen H, Faas MM, de Haan BJ, Li J, Xiao P, Zhang H, Diana J, de Vos P, Sun J (2017) Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis. Mol Nutr Food Res 61(8):1601006

    Article  Google Scholar 

  • Chen F, He D, Yan B (2020a) Apigenin attenuates allergic responses of ovalbumin-induced allergic rhinitis through modulation of Th1/Th2 responses in experimental mice. Dose-Response 18(1):1559325820904799

    Article  CAS  Google Scholar 

  • Chen L, Hu C, Hood M, Zhang X, Zhang L, Kan J, Du J (2020b) A novel combination of vitamin C, curcumin and Glycyrrhizic acid potentially regulates immune and inflammatory response associated with coronavirus infections: a perspective from system biology analysis. Nutrients 12(4):1193

    Article  CAS  Google Scholar 

  • Chen YC, Wu YJ, Hu CY (2019) Monosaccharide composition influence and immunomodulatory effects of probiotic exopolysaccharides. Int J Biol Macromol 133:575–582

    Article  CAS  Google Scholar 

  • Childs CE, Calder PC, Miles EA (2019) Diet and immune function. Nutrients 11(8):1933

    Article  CAS  Google Scholar 

  • Chinen J, Shearer WT (2010) Secondary immunodeficiencies, including HIV infection. J Allergy Clin Immunol 125(2):S195–S203

    Article  Google Scholar 

  • Clarke ST, Green-Johnson JM, Brooks SP, Ramdath DD, Bercik P, Avila C, Inglis GD, Green J, Yanke LJ, Selinger LB, Kalmokoff M (2016) β2-1 Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults. Br J Nutr 115(10):1748–1759

    Article  CAS  Google Scholar 

  • Combs GF (2012) Vitamin C. In: The vitamins. Academic Press, pp 233–259

    Chapter  Google Scholar 

  • Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β–and retinoic acid–dependent mechanism. J Exp Med 204(8):1757–1764

    Article  CAS  Google Scholar 

  • Corona-Hernandez RI, Álvarez-Parrilla E, Lizardi-Mendoza J, Islas-Rubio AR, de la Rosa LA, Wall-Medrano A (2013) Structural stability and viability of microencapsulated probiotic bacteria: a review. Compr Rev Food Sci Food Saf 12(6):614–628

    Article  CAS  Google Scholar 

  • Cuevas A, Saavedra N, Salazar LA, Abdalla DS (2013) Modulation of immune function by polyphenols: possible contribution of epigenetic factors. Nutrients 5(7):2314–2332

    Article  CAS  Google Scholar 

  • Cunningham-Rundles S, McNeeley DF, Moon A (2005) Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol 115(6):1119–1128

    Article  CAS  Google Scholar 

  • Custódio G, Schwarz P, Crispim D, Moraes RB, Czepielewski M, Leitão CB, Rech TH (2018) Association between vitamin D levels and inflammatory activity in brain death: a prospective study. Transpl Immunol 48:65–69

    Article  Google Scholar 

  • Daoud AK, Tayyar MA, Fouda IM, Harfeil NA (2009) Effects of diabetes mellitus vs. in vitro hyperglycemia on select immune cell functions. J Immunotoxicol 6(1):36–41

    Article  CAS  Google Scholar 

  • de Almada CN, Almada CN, Martinez RC, Sant'Ana AS (2016) Paraprobiotics: evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods. Trends Food Sci Technol 58:96–114

    Article  Google Scholar 

  • De Angelis E, Pilolli R, Bavaro SL, Monaci L (2017) Insight into the gastro-duodenal digestion resistance of soybean proteins and potential implications for residual immunogenicity. Food Funct 8:1599–1610

    Article  Google Scholar 

  • de Moraes Alves MM, Brito LM, Souza AC, Queiroz BCSH, de Carvalho TP, Batista JF, Oliveira JSDSM, de Mendonça IL, de Sousa Lira SR, Chaves MH, Gonçalves JCR (2017) Gallic and ellagic acids: two natural immunomodulator compounds solve infection of macrophages by Leishmania major. Naunyn Schmiedeberg's Arch Pharmacol 390(9):893–903

    Article  Google Scholar 

  • Delphi L, Sepehri H (2016) Apple pectin: a natural source for cancer suppression in 4T1 breast cancer cells in vitro and express p53 in mouse bearing 4T1 cancer tumors, in vivo. Biomed Pharmacother 84:637–644

    Article  CAS  Google Scholar 

  • Dinarello CA, Nold-Petry C, Nold M, Fujita M, Li S, Kim S, Bufler P (2016) Suppression of innate inflammation and immunity by interleukin-37. Eur J Immunol 46(5):1067–1081

    Article  CAS  Google Scholar 

  • Djaldetti M, Bessler H (2017) Probiotic strains modulate cytokine production and the immune interplay between human peripheral blood mononuclear cells and colon cancer cells. FEMS Microbiol Lett 364(3):fmx014

    Article  Google Scholar 

  • Dobrange E, Peshev D, Loedolff B, Van den Ende W (2019) Fructans as immunomodulatory and antiviral agents: the case of Echinacea. Biomol Ther 9(10):615

    CAS  Google Scholar 

  • Dong CX, Zhang WS, Sun QL, Jiang YJ, Fu Z, Zhang Y, Du J, Sun Y-X, Tao N, Yao Z (2018) Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression. Int J Biol Macromol 115:1233–1240

    Article  CAS  Google Scholar 

  • Dutra RC (2017) Kinin receptors: key regulators of autoimmunity. Autoimmun Rev 16(2):192–207

    Article  CAS  Google Scholar 

  • Ebrahimpour-Koujan S, Milajerdi A, Larijani B, Esmaillzadeh A (2020) Effects of probiotics on salivary cytokines and immunoglobulins: a systematic review and meta-analysis on clinical trials. Sci Rep 10(1):1–11

    Article  Google Scholar 

  • Elenius V, Palomares O, Waris M, Turunen R, Puhakka T, Rückert B, Vuorinen T, Allander T, Vahlberg T, Akdis M, Camargo CA Jr, Akdis CA, Jartti T (2017) The relationship of serum vitamins a, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response. PLoS One 12(2):e0172350

    Article  Google Scholar 

  • El-Feki MA, Amin HM, Abdalla AA, Fesal M (2016) Immunomodulatory and anti-oxidant effects of alpha-Lipoic acid and vitamin E on lipopolysaccharide-induced liver injury in rats. Middle East Journal of Applied Sciences 6(03):460–467

    Google Scholar 

  • Elitsur Y, Neace C, Liu X, Dosescu J, Moshier JA (1997) Vitamin a and retinoic acids immunomodulation on human gut lymphocytes. Immunopharmacology 35(3):247–253

    Article  CAS  Google Scholar 

  • Enciso J, Mendoza L, Pelayo R (2015) Normal vs. malignant hematopoiesis: the complexity of acute leukemia through systems biology. Front Genet 6:290

    Article  Google Scholar 

  • Erkelens MN, Mebius RE (2017) Retinoic acid and immune homeostasis: a balancing act. Trends Immunol 38(3):168–180

    Article  CAS  Google Scholar 

  • Escobar-Puentes AA, Rincón S, García-Gurrola A, Zepeda A, Martínez-Bustos F (2019) Preparation and characterization of succinylated nanoparticles from high-amylose starch via the extrusion process followed by ultrasonic energy. Food Bioprocess Technol 12(10):1672–1682

    Article  CAS  Google Scholar 

  • Fernández RG, Leehan JA, Pastrana RF, Muñiz RO (2005) Effect of malnutrition on K+ current in T lymphocytes. Clin Diagn Lab Immunol 12(7):808–813

    Google Scholar 

  • Fernández-Riejos P, Najib S, Santos-Alvarez J, Martín-Romero C, Pérez-Pérez A, González-Yanes C, Sánchez-Margalet V (2010) Role of leptin in the activation of immune cells. Mediat Inflamm 2010:1–10

    Article  Google Scholar 

  • Fernández-Tomé S, Hernández-Ledesma B (2019) Current state of art after twenty years of the discovery of bioactive peptide lunasin. Food Res Int 116:71–78

    Article  Google Scholar 

  • Filardo S, Di Pietro M, Mastromarino P, Sessa R (2020) Therapeutic potential of resveratrol against emerging respiratory viral infections. Pharmacol Ther 214:107613

    Article  CAS  Google Scholar 

  • Fraga CG, Croft KD, Kennedy DO, Tomás-Barberán FA (2019) The effects of polyphenols and other bioactives on human health. Food Funct 10(2):514–528

    Article  CAS  Google Scholar 

  • Frece J, Kos B, Svetec IK, Zgaga Z, Beganovic J, Lebos A, Suskovic J (2009) Synbiotic effect of Lactobacillus helveticus M92 and prebiotics on the intestinal microflora and immune system of mice. J Dairy Res 76(1):98

    Article  CAS  Google Scholar 

  • Galdeano CM, Cazorla SI, Dumit JML, Vélez E, Perdigón G (2019) Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab 74(2):115–124

    Article  Google Scholar 

  • Gandhi GR, Neta MTSL, Sathiyabama RG, Quintans JDSS, de Silva AMDO, de Souza Araújo AA, Narain N, Júnior LJQ, Gurgel RQ (2018) Flavonoids as Th1/Th2 cytokines immunomodulators: a systematic review of studies on animal models. Phytomedicine 44:74–84

    Article  CAS  Google Scholar 

  • Gaspar C, Donders GG, Palmeira-de-Oliveira R, Queiroz JA, Tomaz C, Martinez-de-Oliveira J, Palmeira-de-Oliveira A (2018) Bacteriocin production of the probiotic Lactobacillus acidophilus KS400. AMB Express 8(1):153

    Article  CAS  Google Scholar 

  • Georgiev YN, Paulsen BS, Kiyohara H, Ciz M, Ognyanov MH, Vasicek O, Rise F, Denev PN, Yamada H, Lojek A, Kussovski V, Barsett H, Krastanov AI, Yanakieva IZ, Kratchanova MG (2017) The common lavender (Lavandula angustifolia mill.) pectic polysaccharides modulate phagocytic leukocytes and intestinal Peyer’s patch cells. Carbohydr Polym 174:948–959

    Article  CAS  Google Scholar 

  • Ghanem ENB, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN (2015) The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J Immunol 194(3):1090–1099

    Article  Google Scholar 

  • Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: the international scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491

    Article  Google Scholar 

  • Gibson GR, Probert HM, Van Loo J, Rastall RA, Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17(2):259–275

    Article  CAS  Google Scholar 

  • Gill HS, Rutherfurd KJ (2001) Viability and dose–response studies on the effects of the immunoenhancing lactic acid bacterium Lactobacillus rhamnosus in mice. Br J Nutr 86(2):285–289

    Article  CAS  Google Scholar 

  • Gonzalez SM, Aguilar-Jimenez W, Trujillo-Gil E, Zapata W, Su RC, Ball TB, Rugeles MT (2019) Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. PLoS One 14(9):e0222878

    Article  CAS  Google Scholar 

  • Gonzalez H, Hagerling C, Werb Z (2018) Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev 32(19–20):1267–1284

    Article  CAS  Google Scholar 

  • Gutiérrez Nava ZJ, Jiménez-Aparicio AR, Herrera-Ruiz ML, Jiménez-Ferrer E (2017) Immunomodulatory effect of Agave tequilana evaluated on an autoimmunity like-SLE model induced in Balb/c mice with pristane. Molecules 22(6):848

    Article  Google Scholar 

  • Hardy H, Harris J, Lyon E, Beal J, Foey AD (2013) Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients 5(6):1869–1912

    Article  CAS  Google Scholar 

  • Harirchian MH, Mohammadpour Z, Fatehi F, Firoozeh N, Bitarafan S (2019) A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin a supplementation in autoimmune diseases. Clin Nutr 38(5):2038–2044

    Article  CAS  Google Scholar 

  • Hartog A, Belle FN, Bastiaans J, de Graaff P, Garssen J, Harthoorn LF, Vos AP (2015) A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides. J Nutr Biochem 26(3):227–233

    Article  CAS  Google Scholar 

  • Hastreiter AA, Dos Santos GG, Santos EWC, Makiyama EN, Borelli P, Fock RA (2020) Protein malnutrition impairs bone marrow endothelial cells affecting hematopoiesis. Clin Nutr 39(5):1551–1559

    Article  CAS  Google Scholar 

  • Heinz SA, Henson DA, Nieman DC, Austin MD, Jin F (2010) A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects. Br J Nutr 104(6):849–857

    Article  CAS  Google Scholar 

  • Holásková E, Galuszka P, Mičúchová A, Šebela M, Öz MT, Frébort I (2018) Molecular farming in barley: development of a novel production platform to produce human antimicrobial peptide LL-37. Biotechnol J 13(6):1700628

    Article  Google Scholar 

  • Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA et al (2018) Vitamin D supplementation during pregnancy: effect on the neonatal immune system in a randomized controlled trial. J Allergy Clin Immunol 141(1):269–278

    Article  CAS  Google Scholar 

  • Hu S, Kuwabara R, Beukema M, Ferrari M, de Haan BJ, Walvoort MT et al (2020) Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3. Carbohydr Polym 249:116863

    Article  CAS  Google Scholar 

  • Huang Z, Liu Y, Qi G, Brand D, Zheng SG (2018) Role of vitamin a in the immune system. J Clin Med 7(9):258

    Article  CAS  Google Scholar 

  • Husain A, Kaushik A, Awasthi H, Singh DP, Khan R, Mani D (2017) Immunomodulatory and antioxidant activities of fresh juice extracts of Brahmi and Guduchi. Indian J Tradit Knowl 16(3):498–505

    Google Scholar 

  • Ishikawa H, Kutsukake E, Fukui T, Sato I, Shirai T, Kurihara T, Okada N, Danbara H, Toba M, Kohda N, Maeda Y, Matsumoto T (2010) Oral administration of heat-killed Lactobacillus plantarum strain b240 protected mice against Salmonella enterica Serovar Typhimurium. Biosci Biotechnol Biochem 74(7):1338–1342

    Article  CAS  Google Scholar 

  • Jakhar R, Paul S, Chauhan AK, Kang SC (2014) Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage. Int Immunopharmacol 22(2):356–365

    Article  CAS  Google Scholar 

  • Jiang F, Du C, Jiang W, Wang L, Du SK (2020) The preparation, formation, fermentability, and applications of resistant starch. Int J Biol Macromol 150:1155–1161

    Article  CAS  Google Scholar 

  • Jørgensen MJ, Fisker AB, Sartono E, Andersen A, Erikstrup C, Lisse IM, Yazdanbakhsh M, Aaby P, Benn CS (2013) The effect of at-birth vitamin a supplementation on differential leucocyte counts and in vitro cytokine production: an immunological study nested within a randomised trial in Guinea-Bissau. Br J Nutr 109(3):467–477

    Article  Google Scholar 

  • Kaji R, Kiyoshima-Shibata J, Tsujibe S, Nanno M, Shida K (2018) Probiotic induction of interleukin-10 and interleukin-12 production by macrophages is modulated by co-stimulation with microbial components. J Dairy Sci 101(4):2838–2841

    Article  CAS  Google Scholar 

  • Kawase M, He F, Kubota A, Yoda K, Miyazawa K, Hiramatsu M (2012) Heat-killed Lactobacillus gasseri TMC0356 protects mice against influenza virus infection by stimulating gut and respiratory immune responses. FEMS Immunology & Medical Microbiology 64(2):280–288

    Article  CAS  Google Scholar 

  • Keservani RK, Sharma AK, Kesharwani RK (2016) Nutracetical and functional foods for cardiovascular health, food process engineering: emerging technologies and innovations in food engineering, Edited by Murlidhar Meghwal, Megh R. Goyal, Apple Academic Press, CRC Press, Taylor and Francis Vol 5

    Google Scholar 

  • Keservani RK, Sharma AK, Kesharwani RK (2017) An overview and therapeutic applications of nutraceutical and functional foods. In: Recent advances in drug delivery technology, pp 160–201

    Chapter  Google Scholar 

  • Keservani RK, Sharma AK, Kesharwani RK (2020a) Nutraceuticals and dietary supplements: applications in health improvement and disease management. CRC Press

    Book  Google Scholar 

  • Keservani RK, Sharma AK, Kesharwani RK (2020b) Delivery approaches and Nanosystems, volume 2 (drug targeting aspects of nanotechnology). Apple Academic Press, p 2017

    Google Scholar 

  • Khalil ES, Manap A, Yazid M, Mustafa S, Alhelli AM, Shokryazdan P (2018) Probiotic properties of exopolysaccharide-producing Lactobacillus strains isolated from Tempoyak. Molecules 23(2):398

    Article  Google Scholar 

  • Khan H, Sureda A, Belwal T, Çetinkaya S, Süntar İ, Tejada S, Devkota HP, Ullah H, Aschner M (2019) Polyphenols in the treatment of autoimmune diseases. Autoimmun Rev 18(7):647–657

    Article  CAS  Google Scholar 

  • Kilani-Jaziri S, Mokdad-Bzeouich I, Krifa M, Nasr N, Ghedira K, Chekir-Ghedira L (2017) Immunomodulatory and cellular anti-oxidant activities of caffeic, ferulic, and p-coumaric phenolic acids: a structure–activity relationship study. Drug Chem Toxicol 40(4):416–424

    Article  CAS  Google Scholar 

  • Kim JH, Lee JK (2015) Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt’s lymphoma cells. Arch Pharm Res 38(11):2042–2048

    Article  CAS  Google Scholar 

  • Kim YH, Won YS, Yang X, Kumazoe M, Yamashita S, Hara A, Takagaki A, Goto K, Nanjo F, Tachibana H (2016) Green tea catechin metabolites exert immunoregulatory effects on CD4+ T cell and natural killer cell activities. J Agric Food Chem 64(18):3591–3597

    Article  CAS  Google Scholar 

  • Kolehmainen M, Mykkanen O, Kirjavainen PV, Leppanen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimia R, Pulkkinen L et al (2012) Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Molecular Nutrition and Food Research 56:1501–1510

    Article  CAS  Google Scholar 

  • Kumar VP, Prashanth KH, Venkatesh YP (2015) Structural analyses and immunomodulatory properties of fructo-oligosaccharides from onion (Allium cepa). Carbohydr Polym 117:115–122

    Article  CAS  Google Scholar 

  • Kumar SJ, Rajendra S, Singh ANS (2017) Health prospects of bioactive peptides derived from seed storage proteins. In: State-of-the-art Technologies in food science. Apple Academic Press, Florida, pp 24–35

    Google Scholar 

  • Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H (2012) A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One 7(2):e32094

    Article  CAS  Google Scholar 

  • Lang A, Salomon N, Wu JC, Kopylov U, Lahat A, Har-Noy O, Ching JY, Cheong PK, Avidan B, Gamus D, Kaimakliotis I (2015) Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol 13(8):1444–1449

    Article  CAS  Google Scholar 

  • Larbi A, Cexus O, Bosco N (2018) Nutrition as a tool to reverse immunosenescence? In: Immunity and Inflammation in Health and Disease. Academic Press, pp 319–337

    Chapter  Google Scholar 

  • Lawrence DM, Seth P, Durham L, Diaz F, Boursiquot R, Ransohoff RM, Major EO (2006) Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells. Glia 53(1):81–91

    Article  Google Scholar 

  • Lee GY, Han SN (2018) The role of vitamin E in immunity. Nutrients 10(11):1614

    Article  Google Scholar 

  • Lépine AF, de Hilster RH, Leemhuis H, Oudhuis L, Buwalda PL, de Vos P (2019) Higher chain length distribution in Debranched Type-3 resistant starches (RS3) increases TLR signaling and supports dendritic cell cytokine production. Mol Nutr Food Res 63(2):1801007

    Article  Google Scholar 

  • Lewis ED, Meydani SN, Wu D (2019) Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life 71(4):487–494

    Article  CAS  Google Scholar 

  • Li W, Kim TI, Kim JH, Chung HS (2019) Immune checkpoint PD-1/PD-L1 CTLA-4/CD80 are blocked by Rhus verniciflua Stokes and its active compounds. Molecules 24(22):4062

    Article  CAS  Google Scholar 

  • Li RR, Pang LL, Du Q, Shi Y, Dai WJ, Yin KS (2010) Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma. Immunopharmacol Immunotoxicol 32(3):364–370

    Article  CAS  Google Scholar 

  • Li P, Yin YL, Li D, Kim SW, Wu G (2007) Amino acids and immune function. Br J Nutr 98(2):237–252

    Article  CAS  Google Scholar 

  • Lim CC, Ferguson LR, Tannock GW (2005) Dietary fibres as “prebiotics”: implications for colorectal cancer. Mol Nutr Food Res 49(6):609–619

    Article  Google Scholar 

  • Lim WH, Kireta S, Leedham E, Russ GR, Coates PT (2007) Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients. Kidney Int 72(9):1138–1148

    Article  CAS  Google Scholar 

  • Linares DM, Gomez C, Renes E, Fresno JM, Tornadijo ME, Ross RP, Stanton C (2017) Lactic acid bacteria and bifidobacteria with potential to design natural biofunctional health-promoting dairy foods. Front Microbiol 8:846

    Article  Google Scholar 

  • Lis M, Szczypka M, Suszko-Pawłowska A, Sokół-Łętowska A, Kucharska A, Obmińska-Mrukowicz B (2020) Hawthorn (crataegus monogyna) phenolic extract modulates lymphocyte subsets and humoral immune response in mice. Planta Med 86(02):160–168

    Article  CAS  Google Scholar 

  • Llewellyn A, Foey A (2017) Probiotic modulation of innate cell pathogen sensing and signaling events. Nutrients 9(10):1156

    Article  Google Scholar 

  • Lucarini M (2017) Bioactive peptides in milk: from encrypted sequences to nutraceutical aspects. Beverages 3(3):41

    Article  Google Scholar 

  • Maestri E, Marmiroli M, Marmiroli N (2016) Bioactive peptides in plant-derived foodstuffs. J Proteome 147:140–155

    Article  CAS  Google Scholar 

  • Mähler A, Steiniger J, Bock M, Klug L, Parreidt N, Lorenz M, Zimmermann BF, Krannich A, Paul F, Boschmann M (2015) Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial. Am J Clin Nutr 101(3):487–495

    Article  Google Scholar 

  • Mancia G, Rea F, Ludergnani M, Apolone G, Corrao G (2020) Renin–angiotensin–aldosterone system blockers and the risk of Covid-19. N Engl J Med 382(25):2431–2440

    Article  CAS  Google Scholar 

  • McAnulty LS, Nieman DC, Dumke CL, Shooter LA, Henson DA, Utter AC, Milne G, McAnulty SR (2011) Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. Appl Physiol Nutr Metab 36(6):976–984

    Article  CAS  Google Scholar 

  • Meijerink M, Rösch C, Taverne N, Venema K, Gruppen H, Schols HA, Wells JM (2018) Structure dependent-immunomodulation by sugar beet arabinans via a SYK tyrosine kinase-dependent signaling pathway. Front Immunol 9:1972

    Article  Google Scholar 

  • Mele C, Caputo M, Bisceglia A, Samà MT, Zavattaro M, Aimaretti G, Pagano L, Prodam F, Marzullo P (2020) Immunomodulatory effects of vitamin D in thyroid diseases. Nutrients 12(5):1444

    Article  CAS  Google Scholar 

  • Meydani SN, Han SN, Wu D (2005) Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immunol Rev 205(1):269–284

    Article  CAS  Google Scholar 

  • Mikkelsen K, Stojanovska L, Prakash M, Apostolopoulos V (2017) The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 96:58–71

    Article  CAS  Google Scholar 

  • Mirshekar MA, Sarkaki A, Farbood Y, Naseri MKG, Badavi M, Mansouri MT, Haghparast A (2018) Neuroprotective effects of gallic acid in a rat model of traumatic brain injury: behavioral, electrophysiological, and molecular studies. Iran J Basic Med Sci 21(10):1056

    Google Scholar 

  • Miyazawa K, He F, Kawase M, Kubota A, Yoda K, Hiramatsu M (2011) Enhancement of immunoregulatory effects of Lactobacillus gasseri TMC0356 by heat treatment and culture medium. Lett Appl Microbiol 53(2):210–216

    Article  CAS  Google Scholar 

  • Mokhtari-Zaer A, Hosseini M, Salmani H, Arab Z, Zareian P (2020) Vitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress. Life Sci 253:117703

    Article  CAS  Google Scholar 

  • Monobe M, Ema K, Tokuda Y, Maeda-Yamamoto M (2010) Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways. Cytotechnology 62(3):201–203

    Article  CAS  Google Scholar 

  • Mora JR, Iwata M, Von Andrian UH (2008) Vitamin effects on the immune system: vitamins a and D take Centre stage. Nat Rev Immunol 8(9):685–698

    Article  CAS  Google Scholar 

  • Moreno-Vilet L, Garcia-Hernandez MH, Delgado-Portales RE, Corral-Fernandez NE, Cortez-Espinosa N, Ruiz-Cabrera MA, Portales-Perez DP (2014) In vitro assessment of agave fructans (Agave salmiana) as prebiotics and immune system activators. Int J Biol Macromol 63:181–187

    Article  CAS  Google Scholar 

  • Moronta J, Smaldini PL, Fossati CA, Añon MC, Docena GH (2016) The anti-inflammatory SSEDIKE peptide from Amaranth seeds modulates IgE-mediated food allergy. J Funct Foods 25:579–587

    Article  CAS  Google Scholar 

  • Muñoz-González I, Espinosa-Martos I, Rodríguez JM, Jiménez-Girón A, Martin-Alvarez PJ, Bartolomé B, Moreno-Arribas MV (2014) Moderate consumption of red wine can modulate human intestinal inflammatory response. J Agric Food Chem 62(43):10567–10575

    Article  Google Scholar 

  • Nagpal R, Behare P, Rana R, Kumar A, Kumar M, Arora S et al (2011) Bioactive peptides derived from milk proteins and their health beneficial potentials: an update. Food Funct 2(1):18–27

    Article  CAS  Google Scholar 

  • Nantz MP, Rowe CA, Muller C, Creasy R, Colee J, Khoo C, Percival SS (2013) Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study. Nutr J 12(1):161

    Article  Google Scholar 

  • Naqash F, Masoodi FA, Rather SA, Wani SM, Gani A (2017) Emerging concepts in the nutraceutical and functional properties of pectin–a review. Carbohydr Polym 168:227–239

    Article  CAS  Google Scholar 

  • Ndiaye F, Vuong T, Duarte J, Aluko RE, Matar C (2012) Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds. Eur J Nutr 51(1):29–37

    Article  CAS  Google Scholar 

  • Nielsen SD, Beverly RL, Qu Y, Dallas DC (2017) Milk bioactive peptide database: a comprehensive database of milk protein-derived bioactive peptides and novel visualization. Food Chem 232:673–682

    Article  CAS  Google Scholar 

  • Nwobodo DC, Ugwu MC (2020) Immunomodulatory potentials of probiotics: a review. Asian Journal of Immunology:1–15

    Google Scholar 

  • Okayasu I, Hana K, Nemoto N, Yoshida T, Saegusa M, Yokota-Nakatsuma A et al (2016) Vitamin a inhibits development of dextran sulfate sodium-induced colitis and colon cancer in a mouse model. Biomed Res Int 2016:4874809

    Article  Google Scholar 

  • Orona-Tamayo D, Valverde ME, Paredes-López O (2019) Bioactive peptides from selected latin american food crops–a nutraceutical and molecular approach. Crit Rev Food Sci Nutr 59(12):1949–1975

    Article  CAS  Google Scholar 

  • Orrù B, Szekeres-Bartho J, Bizzarri M, Spiga AM, Unfer V (2020) Inhibitory effects of vitamin D on inflammation and IL-6 release. A further support for COVID-19 management? Eur Rev Med Pharmacol Sci 24(15):8187–8193

    Google Scholar 

  • O'Sullivan SM, O'Callaghan YC, O'Keeffe MB, FitzGerald RJ, O'Brien NM (2019) Immunomodulatory activity of 5 kDa permeate fractions of casein hydrolysates generated using a range of enzymes in Jurkat T cells and RAW264. 7 macrophages. Int Dairy J 91:9–17

    Article  CAS  Google Scholar 

  • Palm NW, Medzhitov R (2009) Pattern recognition receptors and control of adaptive immunity. Immunol Rev 227(1):221–233

    Article  CAS  Google Scholar 

  • Panghal A, Janghu S, Virkar K, Gat Y, Kumar V, Chhikara N (2018) Potential non-dairy probiotic products–a healthy approach. Food Biosci 21:80–89

    Article  CAS  Google Scholar 

  • Pawelec G (2018) Age and immunity: what is “immunosenescence”? Exp Gerontol 105:4–9

    Article  CAS  Google Scholar 

  • Peng M, Tabashsum Z, Anderson M, Truong A, Houser AK, Padilla J et al (2020) Effectiveness of probiotics, prebiotics, and prebiotic-like components in common functional foods. Compr Rev Food Sci Food Saf 19(4):1908–1933

    Article  CAS  Google Scholar 

  • Popov SV, Ovodov YS (2013) Polypotency of the immunomodulatory effect of pectins. Biochem Mosc 78(7):823–835

    Article  CAS  Google Scholar 

  • Rachid M, Matar C, Duarte J, Perdigon G (2006) Effect of milk fermented with a Lactobacillus helveticus R389 (+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice. FEMS Immunology & Medical Microbiology 47(2):242–253

    Article  CAS  Google Scholar 

  • Rekha RS, Mily A, Sultana T, Haq A, Ahmed S, Kamal SM et al (2018) Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D 3 as host directed therapy. BMC Infect Dis 18(1):303

    Article  Google Scholar 

  • Reyes-Díaz A, Del-Toro-Sánchez CL, Rodríguez-Figueroa JC, Valdéz-Hurtado S, Wong-Corral FJ, Borboa-Flores J, González-Osuna MF, Perez-Perez LM, González-Vega RI (2019) Legume proteins as a promising source of anti-inflammatory peptides. Current Protein and Peptide Science 20(12):1204–1217

    Article  Google Scholar 

  • Reyes-Díaz A, González-Córdova AF, Hernández-Mendoza A, Reyes-Díaz R, Vallejo-Cordoba B (2018) Immunomodulation by hydrolysates and peptides derived from milk proteins. Int J Dairy Technol 71(1):1–9

    Article  Google Scholar 

  • Ripari V (2019) Techno-functional role of exopolysaccharides in cereal-based, yogurt-like beverages. Beverages 5(1):16

    Article  CAS  Google Scholar 

  • Rizzello CG, Tagliazucchi D, Babini E, Rutella GS, Saa DLT, Gianotti A (2016) Bioactive peptides from vegetable food matrices: research trends and novel biotechnologies for synthesis and recovery. J Funct Foods 27:549–569

    Article  CAS  Google Scholar 

  • Rook GA, Steele J, Fraher L, Barker S, Karmali R, O'riordan J, Stanford J (1986) Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57(1):159

    CAS  Google Scholar 

  • Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A (2013) Phenol-explorer 3.0: a major update of the phenol-explorer database to incorporate data on the effects of food processing on polyphenol content. Database 2013:bat070. https://doi.org/10.1093/database/bat070

    Article  Google Scholar 

  • Ruiter B, Patil SU, Shreffler WG (2015) Vitamins a and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells. Clin Exp Allergy 45(7):1214–1225

    Article  CAS  Google Scholar 

  • Rytter MJH, Kolte L, Briend A, Friis H, Christensen VB (2014) The immune system in children with malnutrition–a systematic review. PLoS One 9(8):e105017

    Article  Google Scholar 

  • Santiago-López L, Hernández-Mendoza A, Garcia HS, Mata-Haro V, Vallejo-Cordoba B, González-Córdova AF (2015) The effects of consuming probiotic-fermented milk on the immune system: a review of scientific evidence. Int J Dairy Technol 68(2):153–165

    Article  Google Scholar 

  • Santiago-López L, Hernández-Mendoza A, Mata-Haro V, Vallejo-Cordoba B, González-Córdova AF (2018) Immune response induced by fermented milk with potential probiotic strains isolated from artisanal Cocido cheese. Food Agric Immunol 29(1):911–929

    Article  Google Scholar 

  • Santiago-López L, Hernández-Mendoza A, Vallejo-Cordoba B, Mata-Haro V, González-Córdova AF (2016) Food-derived immunomodulatory peptides. J Sci Food Agric 96(11):3631–3641

    Article  Google Scholar 

  • Schaafsma G, Slavin JL (2015) Significance of inulin fructans in the human diet. Compr Rev Food Sci Food Saf 14(1):37–47

    Article  CAS  Google Scholar 

  • Shadnoush M, Hosseini RS, Mehrabi Y, Delpisheh A, Alipoor E, Faghfoori Z, Mohammadpour N, Moghadam JZ (2013) Probiotic yogurt affects pro-and anti-inflammatory factors in patients with inflammatory bowel disease. Iranian journal of pharmaceutical research: IJPR 12(4):929

    Google Scholar 

  • Shahidi F, Zhong Y (2008) Bioactive peptides. Journal of AOAC international 91(4):914–931

    Article  CAS  Google Scholar 

  • Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, Apostolopoulos V, Stojanovska L (2020) Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19? Maturitas 143:1–9

    Article  Google Scholar 

  • Sheikhhossein F, Amini MR, Shahinfar H, Djafari F, Safabakhsh M, Shab-Bidar S (2020) Effects of chromium supplementation on inflammatory biomarkers: a systematic review and dose-response meta-analysis of randomized controlled trials. European Journal of Integrative Medicine 37:101147

    Article  Google Scholar 

  • Shih CH, Wang WH, Chen CM, Ko WC (2020) Hesperetin-5, 7, 3′-O-Trimethylether dually inhibits phosphodiesterase 3/4 and Methacholine-induced airway Hyperresponsiveness in sensitized and challenged mice. Drug Des Devel Ther 14:519

    Article  CAS  Google Scholar 

  • Shimizu T, Hettiarachchy N (2012) Food-derived bioactive peptides in the market. In: Food proteins and peptides-chemistry, functionality, interactions, and commercialization. CRC Press Boca Raton, FL, pp 375–392

    Chapter  Google Scholar 

  • Shokryazdan P, Jahromi MF, Navidshad B, Liang JB (2017) Effects of prebiotics on immune system and cytokine expression. Med Microbiol Immunol 206(1):1–9

    Article  CAS  Google Scholar 

  • Simon AK, Hollander GA, McMichael A (2015) Evolution of the immune system in humans from infancy to old age. Proc R Soc B 282:20143085

    Article  Google Scholar 

  • Singh MV, Chapleau MW, Harwani SC, Abboud FM (2014) The immune system and hypertension. Immunol Res 59(1–3):243–253

    Article  CAS  Google Scholar 

  • Skrobot A, Demkow U, Wachowska M (2018) Immunomodulatory role of vitamin D: a review. Advances in Experimental Medicine and Biology–Clinical and Experimental Biomedicine 2:13–23

    Article  Google Scholar 

  • Spinas E, Saggini A, Kritas SK, Cerulli G, Caraffa A, Antinolfi P, Pantalone A, Frydas A, Tei M, Speziali A, Saggini R, Pandolfi F, Conti P (2015) Crosstalk between vitamin B and immunity. J Biol Regul Homeost Agents 29(2):283–288

    CAS  Google Scholar 

  • Sun X, Acquah C, Aluko RE, Udenigwe CC (2020) Considering food matrix and gastrointestinal effects in enhancing bioactive peptide absorption and bioavailability. J Funct Foods 64:103680

    Article  CAS  Google Scholar 

  • Sun H, Jenssen H (2012) Milk derived peptides with immune stimulating antiviral properties. Milk Protein. Intech. Rijeka, Croatia, pp 45–82

    Google Scholar 

  • Szczurko O, Shear N, Taddio A, Boon H (2011) Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial. BMC Complement Altern Med 11(1):21

    Article  Google Scholar 

  • Takele Y, Adem E, Getahun M, Tajebe F, Kiflie A, Hailu A, Raynes J, Mengesha B, Ayele TA, Shkedy Z, Lemma M, Diro E, Toulza F, Modolell M, Munder M, Müller I, Kropf P (2016) Malnutrition in healthy individuals results in increased mixed cytokine profiles, altered neutrophil subsets and function. PLoS One 11(8):e0157919

    Article  CAS  Google Scholar 

  • Tanaka M, Kishimoto Y, Sasaki M, Sato A, Kamiya T, Kondo K, Iida K (2018) Terminalia bellirica (Gaertn.) Roxb. Extract and gallic acid attenuate LPS-induced inflammation and oxidative stress via MAPK/NF-κB and Akt/AMPK/Nrf2 pathways. Oxidative Med Cell Longev 2018

    Google Scholar 

  • Tang X, He Z, Dai Y, Xiong YL, Xie M, Chen J (2010) Peptide fractionation and free radical scavenging activity of zein hydrolysate. J Agric Food Chem 58(1):587–593

    Article  CAS  Google Scholar 

  • Trachootham D, Chupeerach C, Tuntipopipat S, Pathomyok L, Boonnak K, Praengam K et al (2017) Drinking fermented milk containing Lactobacillus paracasei 431 (IMULUS™) improves immune response against H1N1 and cross-reactive H3N2 viruses after influenza vaccination: a pilot randomized triple-blinded placebo controlled trial. J Funct Foods 33:1–10

    Article  CAS  Google Scholar 

  • Triantos C, Kalafateli M, Aggeletopoulou I, Diamantopoulou G, Spantidea PI, Michalaki M, Vourli G, Konstantakis C, Assimakopoulos SF, Manolakopoulos S, Gogos C, Kyriazopoulou V, Mouzaki A, Thomopoulos K (2020) Vitamin D-related immunomodulation in patients with liver cirrhosis. Eur J Gastroenterol Hepatol 32(7):867–876

    Article  CAS  Google Scholar 

  • Tuo Y, Song X, Song Y, Liu W, Tang Y, Gao Y, Jiang S, Qian F, Mu G (2018) Screening probiotics from Lactobacillus strains according to their abilities to inhibit pathogen adhesion and induction of pro-inflammatory cytokine IL-8. J Dairy Sci 101(6):4822–4829

    Article  CAS  Google Scholar 

  • Urbanska AM, Paul A, Bhahena J, Prakash S (2010) Suppression of tumorigenesis: modulation of inflammatory cytokines by oral administration of microencapsulated probiotic yogurt formulation. Int J Inflamm 2010

    Google Scholar 

  • Valcheva R, Dieleman LA (2016) Prebiotics: definition and protective mechanisms. Best Pract Res Clin Gastroenterol 30(1):27–37

    Article  CAS  Google Scholar 

  • van Gorkom GN, Lookermans EL, Van Elssen CH, Bos GM (2019) The effect of vitamin C (ascorbic acid) in the treatment of patients with cancer: a systematic review. Nutrients 11(5):977

    Article  Google Scholar 

  • Vogt LM, Meyer D, Pullens G, Faas MM, Venema K, Ramasamy U et al (2014) Toll-like receptor 2 activation by β2→ 1-fructans protects barrier function of T84 human intestinal epithelial cells in a chain length–dependent manner. J Nutr 144(7):1002–1008

    Article  CAS  Google Scholar 

  • Vogt L, Ramasamy U, Meyer D, Pullens G, Venema K, Faas MM et al (2013) Immune modulation by different types of β2→ 1-fructans is toll-like receptor dependent. PLoS One 8(7):e68367

    Article  CAS  Google Scholar 

  • Vugic L, Colson N, Nikbakht E, Gaiz A, Holland OJ, Kundur AR, Singh I (2020) Anthocyanin supplementation inhibits secretion of pro-inflammatory cytokines in overweight and obese individuals. J Funct Foods 64:103596

    Article  CAS  Google Scholar 

  • Wang X, Quinn PJ (1999) Vitamin E and its function in membranes. Prog Lipid Res 38(4):309–336

    Article  CAS  Google Scholar 

  • Wang Q, Wang P, Xiao Z (2018) Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. Int J Mol Med 41(4):1887–1898

    CAS  Google Scholar 

  • Wang Y, Xie J, Wang N, Li Y, Sun X, Zhang Y, Zhang H (2013) Lactobacillus casei Zhang modulate cytokine and toll-like receptor expression and beneficially regulate poly I: C-induced immune responses in RAW264. 7 macrophages. Microbiol Immunol 57(1):54–62

    Article  CAS  Google Scholar 

  • Wang Y, Zhou Z, Diao Y, Strappe P, Blanchard C (2017) The potential role of p53 and MAPK pathways in the hepatotoxicity of deep-fried oil and in resistant starch-induced protection. Eur J Lipid Sci Technol 119(8):1600296

    Article  Google Scholar 

  • Weir EK, Thenappan T, Bhargava M, Chen Y (2020) Does vitamin D deficiency increase the severity of COVID-19? Clin Med 20(4):e107

    Article  Google Scholar 

  • Wintergerst ES, Maggini S, Hornig DH (2006) Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab 50(2):85–94

    Article  CAS  Google Scholar 

  • Wu LH, Lin C, Lin HY, Liu YS, Wu CYJ, Tsai CF et al (2016) Naringenin suppresses neuroinflammatory responses through inducing suppressor of cytokine signaling 3 expression. Mol Neurobiol 53(2):1080–1091

    Article  CAS  Google Scholar 

  • Xia S, Li XP, Cheng L, Han MT, Zhang MM, Shao QX et al (2015) Fish oil–rich diet promotes hematopoiesis and alters hematopoietic niche. Endocrinology 156(8):2821–2830

    Article  CAS  Google Scholar 

  • Xiao J, Song J, Hodara V, Ford A, Wang XL, Shi Q, Chen L, VandeBerg JL (2013) Research article protective effects of resveratrol on TNF- -induced endothelial cytotoxicity in baboon femoral arterial endothelial cells. J Diabetes Res 2013:185172

    Article  Google Scholar 

  • Xing L, Liu R, Cao S, Zhang W, Guanghong Z (2019) Meat protein based bioactive peptides and their potential functional activity: a review. Int J Food Sci Technol 54(6):1956–1966

    Article  CAS  Google Scholar 

  • Xu Q, Hong H, Wu J, Yan X (2019) Bioavailability of bioactive peptides derived from food proteins across the intestinal epithelial membrane: a review. Trends Food Sci Technol 86:399–411

    Article  CAS  Google Scholar 

  • Xue H, Ren H, Zhang L, Sun X, Wang W, Zhang S et al (2016) Alpha-tocopherol ameliorates experimental autoimmune encephalomyelitis through the regulation of Th1 cells. Iran J Basic Med Sci 19(5):561

    Google Scholar 

  • Yang H, Sun Y, Cai R, Chen Y, Gu B (2020) The impact of dietary fiber and probiotics in infectious diseases. Microb Pathog 140:103931

    Article  CAS  Google Scholar 

  • Yin DT, Zhao XH (2017) Impact of exogenous strains on in vitro fermentation and anti-colon cancer activities of maize resistant starch and xylo-oligosaccharides. Starch-Stärke 69(11–12):1700064

    Article  Google Scholar 

  • Yoshimura M, Akiyama H, Kondo K, Sakata K, Matsuoka H, Amakura Y, Teshima R, Yoshida T (2013) Immunological effects of oenothein B, an ellagitannin dimer, on dendritic cells. Int J Mol Sci 14(1):46–56

    Article  CAS  Google Scholar 

  • Zeng J, Jiang J, Zhu W, Chu Y (2016) Heat-killed yogurt-containing lactic acid bacteria prevent cytokine-induced barrier disruption in human intestinal Caco-2 cells. Ann Microbiol 66(1):171–178

    Article  CAS  Google Scholar 

  • Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, Butcher EC (2013) Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells. Mucosal Immunol 6(4):847–856

    Article  CAS  Google Scholar 

  • Zhai Z, Wang J, Huang B, Yin S (2019) Low-fat yogurt alleviates the pro-inflammatory cytokine IL-1β-induced intestinal epithelial barrier dysfunction. J Dairy Sci 102(2):976–984

    Article  CAS  Google Scholar 

  • Zhao J, Ma J, Zhang Q, Tian J, Wang Y, Meng X (2020) Cyanidin-3-glucoside attenuates silica-induced pulmonary inflammatory responses by modulating T cell immune responses and STAT1/STAT3 signaling. J Funct Foods 68:103911

    Article  CAS  Google Scholar 

  • Zhao J, Zang J, Lin Y, Wang Y, Li D, Meng X (2019) Polyphenol-rich blue honeysuckle extract alleviates silica-induced lung fibrosis by modulating Th immune response and NRF2/HO-1 MAPK signaling. J Funct Foods 53:176–186

    Article  CAS  Google Scholar 

  • Zheng B, Wang T, Wang H, Chen L, Zhou Z (2020a) Studies on nutritional intervention of rice starch-oleic acid complex (resistant starch type V) in rats fed by high-fat diet. Carbohydr Polym 243:116637

    Article  Google Scholar 

  • Zheng J, Wittouck S, Salvetti E, Franz CM, Harris HM, Mattarelli P et al (2020b) A taxonomic note on the genus Lactobacillus: description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Int J Syst Evol Microbiol 70(4):2782–2858

    Article  CAS  Google Scholar 

  • Zunino SJ, Peerson JM, Freytag TL, Breksa AP, Bonnel EL, Woodhouse LR, Storms DH (2014) Dietary grape powder increases IL-1β and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans. Br J Nutr 112(3):369–380

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors wish to thank the National Council for Science and Technology for the financial support through the postdoctoral scholarship (177611).

Author information

Authors and Affiliations

  1. Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Mexico

    Adriana García-Gurrola & Alberto A. Escobar-Puentes

  2. Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juarez, Anillo Envolvente del Pronaf y Estocolmo s/n, CP, Chihuahua, Mexico

    Abraham Wall-Medrano

  3. Laboratorio de Inmunobiología y Regulación del Transporte Iónico, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Mexico

    Miguel A. Olivas-Aguirre

  4. Departamento de Ciencias de la Salud, Universidad de Sonora (Campus Cajeme), Hermosillo, Mexico

    Francisco J. Olivas-Aguirre

Authors
  1. Adriana García-Gurrola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abraham Wall-Medrano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Miguel A. Olivas-Aguirre
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Francisco J. Olivas-Aguirre
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alberto A. Escobar-Puentes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alberto A. Escobar-Puentes .

Editor information

Editors and Affiliations

  1. Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India

    Rajesh K. Kesharwani

  2. Faculty of B. Pharmacy, CSM Group of Institutions, Prayagraj, Uttar Pradesh, India

    Raj K. Keservani

  3. All India Council for Technical Education, New Delhi, India

    Anil K. Sharma

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

García-Gurrola, A., Wall-Medrano, A., Olivas-Aguirre, M.A., Olivas-Aguirre, F.J., Escobar-Puentes, A.A. (2022). Immunomodulatory Properties of Nutraceuticals and Functional Foods. In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Nutraceuticals and Functional Foods in Immunomodulators. Springer, Singapore. https://doi.org/10.1007/978-981-19-2507-8_2

Download citation

Publish with us

Policies and ethics

Search

Navigation