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In Vivo, Ex Vivo, and In Vitro Models Systems for Liver Cancer Research

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Cancer claims the lives of millions of people worldwide. Liver cancer represents one such form of cancer that has a high incidence with a poor survival rate when diagnosed late and increased mortality. Hence, pursuing research to understand the disease pathology and progression is indispensable to curtail mortality. In the past century, methods for studying liver cancer have advanced greatly, giving significant insight into the hallmarks of cancer. For many years, several model systems have been carried out to imitate the characteristics of liver cancer cells in humans; for instance, to understand virus-mediated cancer occurrence in living things and to study liver cancer in cultured cells. In this chapter, several in vivo, ex vivo, and in vitro models are elaborately described such as transgenic and knockout mice, the type of cancer cell lines, 3D spheroid cultures, gene-editing techniques, and the idea of cancer stem cells pertaining to liver cancer. In vivo, ex vivo, and in vitro model systems are important for cancer research because they help to understand liver cancer biology and development of therapeutic measures for better liver cancer treatment.

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Authors and Affiliations

  1. Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, KTR Campus, Chennai, India

    S. Solaipriya, N. Mahalakshmi, R. Prajitha & V. Sivaramakrishnan

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  1. S. Solaipriya
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  2. N. Mahalakshmi
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  3. R. Prajitha
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  4. V. Sivaramakrishnan
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Correspondence to V. Sivaramakrishnan .

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Editors and Affiliations

  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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Solaipriya, S., Mahalakshmi, N., Prajitha, R., Sivaramakrishnan, V. (2022). In Vivo, Ex Vivo, and In Vitro Models Systems for Liver Cancer Research. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_19-1

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