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Vancomycin and Methicillin Resistance in Staphylococcus aureus: What Is the Next?

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Handbook on Antimicrobial Resistance

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Abstract

Initially four decades ago, Staphylococcus aureus caused infections in clinical and civic situations. This microbe has instigated a significant amount of burden. A subset of antimicrobial-resistant S. aureus, viz., methicillin-resistant S. aureus (MRSA) and vancomycin-intermediate/vancomycin-resistant S. aureus (VISA/VRSA), are prioritized as high-risk pathogens by the WHO for controlling the antimicrobial resistance (AMR). Due to its various virulence weapons and the ongoing evolution of AMR, this pathogen has occupied key significance in the last four decades. These resistant pathogens, which were confined to hospital-acquired infections, are now being found in a growing number of civic surroundings and also in food-producing faunas. The global epidemiology of MRSA and VRSA has been extensively illustrated. This chapter dealt on the evolution of AMR in the pathogen S. aureus, as well as the identification of resistance mechanism identified. As a result, the need for novel antimicrobials to treat these AMR bacteria is highlighted along with the future prediction on the development of resistance.

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Authors and Affiliations

  1. Microbiology Fermentation and Biotechnology Division of ICAR-Central Institute of Fisheries Technology (ICAR-CIFT), Cochin, Kerala, India

    Ms Anna Sherin Pulithara Sebastian & Murugadas Vaiyapuri

  2. Visakhapatnam Research Centre of ICAR-Central Institute of Fisheries Technology, Visakhapatnam, Andhra Pradesh, India

    Madhusudana Rao Badireddy

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  1. Ms Anna Sherin Pulithara Sebastian
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  2. Murugadas Vaiyapuri
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  3. Madhusudana Rao Badireddy
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Correspondence to Murugadas Vaiyapuri .

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Editors and Affiliations

  1. ICAR-Central Institute of Fisheries Tech, Kerala, India

    Mukteswar Prasad Mothadaka

  2. ICAR-Central Institute of Fisheries Tech, Kerala, India

    Murugadas Vaiyapuri

  3. Visakhapatnam Research Centre, ICAR-Central Institute of Fisheries Tech, Visakhapatnam, Andhra Pradesh, India

    Madhusudana Rao Badireddy

  4. ICAR-Central Institute of Fisheries Tech, Kerala, India

    Chandragiri Nagarajrao Ravishankar

  5. World Health Organization Regional Offic, New Delhi, India

    Rajesh Bhatia

  6. Indian Council of Agricultural Research, New Delhi, India

    Joykrushna Jena

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Pulithara Sebastian, A.S., Vaiyapuri, M., Badireddy, M.R. (2023). Vancomycin and Methicillin Resistance in Staphylococcus aureus: What Is the Next?. In: Mothadaka, M.P., Vaiyapuri, M., Rao Badireddy, M., Nagarajrao Ravishankar, C., Bhatia, R., Jena, J. (eds) Handbook on Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-16-9723-4_17-1

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