Abstract
In the present time, our understanding of disease pathogenesis has changed significantly due to the advent of newer technology and recent scientific breakthroughs. The network models consisting of the genomic regions are being prepared by combining the developed molecular phenotyping profiling with deep clinical phenotyping, which can influence the levels of transcripts, proteins, and metabolites and can be exploited in various ways in diagnosing diseases and personalized drug development. Digital biomarkers (BM) can support in disease diagnosis in multiple ways, including patient identification to treatment recommendation. The use of “omics” technology and large sample sizes has resulted in vast data sets, providing a wealth of knowledge about different illnesses and their links to intrinsic biology. The analysis of such extensive data requires sophisticated computational and statistical methods. New data can be converted into usable knowledge to allow for faster diagnosis and treatment choices using these advanced technologies, such as artificial intelligence, machine learning algorithms, computational biology, and digital BMs. As a result, it is expected that such advancements would aid in the fight against infectious disorders, epidemics, and pandemics. Hence, in this article, we would explore the importance of various AI tools that can be utilized for drug discovery and precision medicine.
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References
Ahmed SF, Quadeer AA, McKay MR (2020) Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies. Viruses 12:254
Allam Z, Jones DS (2020) On the coronavirus (COVID-19) outbreak and the Smart City network: universal data sharing standards coupled with artificial intelligence (AI) to benefit urban health monitoring and management. Healthcare 8:46
Aravanis AM, Lee M, Klausner RD (2017) Next-generation sequencing of circulating tumor DNA for early cancer detection. Cell 168:571–574
Asadzadeh A, Pakkhoo S, Saeidabad MM, Khezri H, Ferdousi R (2020) Information technology in emergency management of COVID-19 outbreak. Inform Med Unlocked 21:100475
Bherwani H, Anjum S, Kumar S, Gautam S, Gupta A, Kumbhare H et al (2020) Understanding COVID-19 transmission through Bayesian probabilistic modeling and GIS-based Voronoi approach: a policy perspective. Environ Dev Sustain 23:5846–5864
Bogoch II, Brady OJ, Kraemer MUG, German M, Creatore MI, Kulkarni MA et al (2016) Anticipating the international spread of Zika virus from Brazil. Lancet 387:335–336
Cai CZ, Han LY, Chen X, Cao ZW, Chen YZ (2005) Prediction of functional class of the SARS coronavirus proteins by a statistical learning method. J Proteome Res 4:1855–1862
Chow S-C (2017) Biosimilar clinical development
Christaki E (2015) New technologies in predicting, preventing and controlling emerging infectious diseases. Virulence 6:558–565
Chu HY, Englund JA, Starita LM, Famulare M, Brandstetter E, Nickerson DA et al (2020) Early detection of Covid-19 through a citywide pandemic surveillance platform. N Engl J Med 383:185–187
Cleemput S, Dumon W, Fonseca V, Karim WA, Giovanetti M, Alcantara LC et al (2020) Genome detective coronavirus typing tool for rapid identification and characterization of novel coronavirus genomes. Bioinformatics 36:3552–3555
De Groot AS, Einck L, Moise L, Chambers M, Ballantyne J, Malone RW et al (2013) Making vaccines “on demand”: a potential solution for emerging pathogens and biodefense? Hum Vaccin Immunother 9:1877–1884
Elfiky AA (2020) Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci 248:117477
Eureka (2019a). The future of drug discovery: AI impacting upon hit ID strategies. https://eureka.criver.com/the-future-of-drug-discovery-ai-impacting-upon-hit-id-strategies/
Eureka (2019b). Image-based cell profiling. https://eureka.criver.com/image-based-cell-profiling/
Fleming N (2018) How artificial intelligence is changing drug discovery. Nature 557:S55–S57
Francis F, Ishengoma DS, Mmbando BP, Rutta ASM, Malecela MN, Mayala B et al (2017) Deployment and use of mobile phone technology for real-time reporting of fever cases and malaria treatment failure in areas of declining malaria transmission in Muheza district North-Eastern Tanzania. Malar J 16:308
Ghoshal B, Tucker A (2020) Estimating uncertainty and interpretability in deep learning for coronavirus (COVID-19) detection. arXiv
Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP et al (2017) Long-term outcomes of imatinib treatment for chronic myeloid Leukemia. N Engl J Med 376:917–927
Hu Z, Ge Q, Li S, Jin L, Xiong M (2020) Artificial intelligence forecasting of covid-19 in China. arXiv
Kantarjian H, O’Brien S, Jabbour E, Garcia-Manero G, Quintas-Cardama A, Shan J et al (2012) Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood 119:1981–1987
Kim J, Zhang J, Cha Y, Kolitz S, Funt J, Chong RE et al (2020) Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19). J Transl Med 18:257
Lan J, Lu S, Deng Y, Wen B, Chen H, Wang W et al (2016) Bioinformatics-based Design of Peptide Vaccine Candidates Targeting Spike Protein of MERS-CoV and immunity analysis in mice. Bing Du Xue Bao 32:77–81
Mak KK, Pichika MR (2019) Artificial intelligence in drug development: present status and future prospects. Drug Discov Today 24:773–780
Manica M, Cadow J (2019) Novel AI tools to accelerate cancer research. 11. https://www.ibm.com/blogs/research/2019/07/ai-tools-for-cancer-research/
Matthews H, Hanison J, Nirmalan N (2016) “Omics”-informed drug and biomarker discovery: opportunities, challenges and future perspectives. Proteomes
McCall B (2020) COVID-19 and artificial intelligence: protecting healthcare workers and curbing the spread. Lancet Digit Heal 2:e166–e167
Medicine P (2019) Harnessing the modified proteome for increased diagnostic power, pp 33–39
Michelozzi P, de Donato F, Scortichini M, de Sario M, Noccioli F, Rossi P et al (2020) Mortality impacts of the coronavirus disease (COVID-19) outbreak by sex and age: rapid mortality surveillance system, Italy, 1 February to 18 April 2020. Eur Secur 25:2000620
Moutinho-Ribeiro P, Macedo G, Melo SA (2019) Pancreatic cancer diagnosis and management: has the time come to prick the bubble? Front Endocrinol 9:779
Oskooei A, Born J, Manica M, Subramanian V, Sáez-Rodríguez J, Martínez MR (2018) PaccMann: prediction of anticancer compound sensitivity with multi-modal attention-based neural networks. arXiv
Quezada H, Guzmán-Ortiz AL, Díaz-Sánchez H, Valle-Rios R, Aguirre-Hernández J (2017) Omics-based biomarkers: current status and potential use in the clinic. Boletin Medico del Hospital Infantil de Mexico 74:219–226
Ricoca Peixoto V, Nunes C, Abrantes A (2020) Epidemic surveillance of Covid-19: considering uncertainty and under-ascertainment. Port J Public Health 38:23–29
Rovetta A, Bhagavathula AS (2020) COVID-19-related web search behaviors and infodemic attitudes in Italy: infodemiological study. MIR Public Health Surveill 6:e19374
Roy L, Guilhot J, Krahnke T, Guerci-Bresler A, Druker BJ, Larson RA et al (2006) Survival advantage from imatinib compared with the combination interferon-α plus cytarabine in chronic-phase chronic myelogenous leukemia: historical comparison between two phase 3 trials. Blood 108:1478–1484
Sandhu R, Gill HK, Sood SK (2016) Smart monitoring and controlling of pandemic influenza a (H1N1) using social network analysis and cloud computing. J Comput Sci 12:11–22
Seyhan A, Carini C (2014) Biomarkers for drug development: the time is now. In: Carini C, Menon S, Chang M (eds) Clinical and statistical considerations in personalized medicine. Chapman & Hall, CRC Press, pp 16–41
Seyhan AA, Carini C (2019) Are innovation and new technologies in precision medicine paving a new era in patients centric care? J Transl Med 17:114
Shan F, Gao Y, Wang J, Shi W, Shi N, Han M, et al (2020) Lung infection quantification of COVID-19 in CT images with deep learning. arXiv
Song Y, Jiang J, Wang X, Yang D, Bai C (2020) Prospect and application of internet of things technology for prevention of SARIs. Clin eHealth 3:1–4
Srinivasa Rao ASR, Vazquez JA (2020) Identification of COVID-19 can be quicker through artificial intelligence framework using a mobile phone-based survey when cities and towns are under quarantine. Infect Control Hosp Epidemiol 41:826–830
Steensberg A, Simons TD (2015) Beyond biomarkers in drug discovery and development. Drug Discov Today 20(3):289–291
Tahir Ul Qamar M, Alqahtani SM, Alamri MA, Chen LL (2020) Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants. J Pharm Anal 10:313–319
The Medical Futurist (2020) https://medicalfuturist.com/how-digital-health-technology-can-help-manage-the-coronavirus-outbreak/
Vaishya R, Javaid M, Khan IH, Haleem A (2020) Artificial intelligence (AI) applications for COVID-19 pandemic. Diabetes Metab Syndr Clin Res Rev 14:337–339
Wang J (2020) Fast identification of possible drug treatment of coronavirus disease-19 (COVID-19) through computational drug repurposing study. J Chem Inf Model 60:3277–3286
Xie X, Gong Y, Wan S, Li X (2005) Computer aided detection of SARS based on radiographs data mining. In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J (2020) Chest CT for typical coronavirus disease 2019 (COVID-19) pneumonia: relationship to negative RT-PCR testing. Radiology 296:E41–E45
Xu C, Luo X, Yu C, Cao SJ (2020) The 2019-nCoV epidemic control strategies and future challenges of building healthy smart cities. Indoor Built Environ 29:639–644
Yu L, Wu S, Hao X, Dong X, Mao L, Pelechano V et al (2020) Rapid detection of COVID-19 coronavirus using a reverse transcriptional loop-mediated isothermal amplification (RT-LAMP) diagnostic platform. Clin Chem 66:975–977. https://doi.org/10.1093/clinchem/hvaa102
Yue M, Clapham HE, Cook AR (2020) Estimating the size of a COVID-19 epidemic from surveillance systems. Epidemiology 31:567–569
Zhang J, Xie Y, Pang G, Liao Z, Verjans J, Li W et al (2020) Viral pneumonia screening on chest X-rays using confidence-aware anomaly detection. IEEE Trans Med Imaging 40:879–890
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Sobti, R.C., Kumari, M., Singhla, M., Bhandari, R. (2022). Emerging Technologies: Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design, and Targeting. In: Sobti, R., Dhalla, N.S. (eds) Biomedical Translational Research. Springer, Singapore. https://doi.org/10.1007/978-981-16-9232-1_1
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