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The Role of Glia in Huntington’s Disease

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The Biology of Glial Cells: Recent Advances

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Abstract

The accumulation of intracellular protein deposits as inclusion bodies is the common pathological hallmark of most age-related neurodegenerative disorders including Huntington’s diseases (HD). HD is an autosomal dominantly inherited neurodegenerative disorder caused by an aberrant expansion of CAG repeats in the coding region of huntingtin gene. The mutant huntingtin protein form aggregates in neurons and causes neuronal dysfunction and degeneration in multiple ways including transcriptional dysregulation, dysfunction in protein quality control system, etc. Marked inflammatory reaction has been observed in postmortem brain samples of HD patients as well as in various mouse models of HD that could be linked at least in part with the pathogenesis of HD. Here we review the recent studies that have revealed the critical role of glial cells and inflammation in the pathogenesis of HD.

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Authors and Affiliations

  1. Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon, Haryana, India

    Tripti Joshi

  2. School of Bioscience, Indian Institute of Technology, Kharagpur, Kharagpur, West Bengal, India

    Nihar Ranjan Jana

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  1. Tripti Joshi
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Correspondence to Nihar Ranjan Jana .

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Editors and Affiliations

  1. School of Studies in Neuroscience, Jiwaji University, Gwalior, Madhya Pradesh, India

    Ishan Patro

  2. Cellular and Molecular Neurosciences, National Brain Research Centre, Manesar, Haryana, India

    Pankaj Seth

  3. School of Studies in Neuroscience, Jiwaji University, Gwalior, Madhya Pradesh, India

    Nisha Patro

  4. National Brain Research Centre, Manesar, Haryana, India

    Prakash Narain Tandon

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This work was supported by the core grant of NBRC provided by the Department of Biotechnology, Govt. of India, as well as from the ISIRD, SRIC of IIT Kharagpur.

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Joshi, T., Jana, N.R. (2022). The Role of Glia in Huntington’s Disease. In: Patro, I., Seth, P., Patro, N., Tandon, P.N. (eds) The Biology of Glial Cells: Recent Advances. Springer, Singapore. https://doi.org/10.1007/978-981-16-8313-8_24

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