Biomedical Applications of Chitin

S, Hema; U Chandran, Greeshma; P R, Jyothi; Sambhudevan, Sreedha

doi:10.1007/978-981-16-6603-2_25-1

Hema S⁵,
Greeshma U Chandran⁵,
Jyothi P R⁶ &
…
Sreedha Sambhudevan⁵

128 Accesses
3 Altmetric

Abstract

Chitin is a biopolymer widely distributed in nature, and it is the second most abundant polysaccharide after cellulose. Due to its biological activities and usefulness in industry, chitosan and its oligosaccharides have recently attracted a lot of interest. Chitosan is a nontoxic biopolymer made by deacetylating chitin. Chitin, chitosan, and its derivatives are often employed in food science, tissue engineering, and wound healing. Easy techniques for making chitin and chitosan nanofibers have recently been established, and research on the biological uses of chitin and chitosan nanofibers is continuing. This chapter aims to analyze the recent advances in biomedical applications of chitin and its derivatives.

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References

M.M. Abo Elsoud, E.M. el Kady, Current trends in fungal biosynthesis of chitin and chitosan. Bull. Nat. Res. Centre 43(1), 59 (2019). https://doi.org/10.1186/s42269-019-0105-y
Article Google Scholar
N. Acosta, C. Jiménez, V. Borau, A. Heras, Extraction and characterization of chitin from crustaceans. Biomass Bioenergy 5(2), 145–153 (1993). https://doi.org/10.1016/0961-9534(93)90096-M
Article CAS Google Scholar
F. Ahmed, F.M. Soliman, M.A. Adly, H.A.M. Soliman, M. El-Matbouli, M. Saleh, Recent progress in biomedical applications of chitosan and its nanocomposites in aquaculture: a review. Res. Vet. Sci. 126, 68–82 (2019). https://doi.org/10.1016/j.rvsc.2019.08.005
Article CAS Google Scholar
A. Alishahi, M. Aïder, Applications of chitosan in the seafood industry and aquaculture: a review. Food Bioprocess Technol. 5(3), 817–830 (2012). https://doi.org/10.1007/s11947-011-0664-x
Article CAS Google Scholar
I. Aranaz, N. Acosta, C. Civera, B. Elorza, J. Mingo, C. Castro, M. Gandía, A. Heras Caballero, Cosmetics and cosmeceutical applications of chitin, chitosan and their derivatives. Polymers 10(2), 213 (2018). https://doi.org/10.3390/polym10020213
Article CAS Google Scholar
K. Azuma, S. Ifuku, T. Osaki, Y. Okamoto, S. Minami, Preparation and biomedical applications of chitin and chitosan nanofibers. J. Biomed. Nanotechnol. 10(10), 2891–2920 (2014). https://doi.org/10.1166/jbn.2014.1882
Article CAS Google Scholar
G. Behl, J. Iqbal, N.J. O’Reilly, P. McLoughlin, L. Fitzhenry, Synthesis and characterization of poly(2-hydroxyethylmethacrylate) contact lenses containing chitosan nanoparticles as an ocular delivery system for dexamethasone sodium phosphate. Pharm. Res. 33(7), 1638–1648 (2016). https://doi.org/10.1007/s11095-016-1903-7
Article CAS Google Scholar
S. Bi, F. Li, D. Qin, M. Wang, S. Yuan, X. Cheng, X. Chen, Construction of chitin functional materials based on a “green” alkali/urea solvent and their applications in biomedicine: recent advance. Appl. Mater. Today 23, 101030 (2021). https://doi.org/10.1016/j.apmt.2021.101030
Article Google Scholar
H.S. Blair, J. Guthrie, T.-K. Law, P. Turkington, Chitosan and modified chitosan membranes I. Preparation and characterisation. J. Appl. Polym. Sci. 33(2), 641–656 (1987). https://doi.org/10.1002/app.1987.070330226
Article CAS Google Scholar
Z. Cai, X. Mo, K. Zhang, L. Fan, A. Yin, C. He, H. Wang, Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. Int. J. Mol. Sci. 11(9), 3529–3539 (2010). https://doi.org/10.3390/ijms11093529
Article CAS Google Scholar
T. Chandy, C.P. Sharma, Prostaglandin E1-immobilized poly(vinyl alcohol)-blended chitosan membranes: blood compatibility and permeability properties. J. Appl. Polym. Sci. 44(12), 2145–2156 (1992). https://doi.org/10.1002/app.1992.070441210
Article CAS Google Scholar
F. Croisier, C. Jérôme, Chitosan-based biomaterials for tissue engineering. Eur. Polym. J. 49(4), 780–792 (2013). https://doi.org/10.1016/j.eurpolymj.2012.12.009
Article CAS Google Scholar
N. Dagalakis, J. Flink, P. Stasikelis, J.F. Burke, I.v. Yannas, Design of an artificial skin. Part III. Control of pore structure. J. Biomed. Mater. Res. 14(4), 511–528 (1980). https://doi.org/10.1002/jbm.820140417
Article CAS Google Scholar
Daraghmeh, N. H., Chowdhry, B. Z., Leharne, S. A., Al Omari, M. M., & Badwan, A. A. (2011). Chitin (pp. 35–102). https://doi.org/10.1016/B978-0-12-387667-6.00002-6
Book Google Scholar
S.S. Das, S. Kar, S.K. Singh, P.R.P. Verma, A. Hussain, S. Beg, Chitosan-based systems for oral drug delivery applications, in Chitosan in Drug Delivery, (Elsevier, 2022), pp. 23–53. https://doi.org/10.1016/B978-0-12-819336-5.00009-1
Chapter Google Scholar
J.F. de Souza, K.N. Maia, P.S. de Oliveira Patrício, G.M. Fernandes-Cunha, M.G. da Silva, C.E. de Matos Jensen, G.R. da Silva, Ocular inserts based on chitosan and brimonidine tartrate: development, characterization and biocompatibility. J. Drug Deliv. Sci. Technol. 32, 21–30 (2016). https://doi.org/10.1016/j.jddst.2016.01.008
Article CAS Google Scholar
C. Dwivedi, A. Gupta, A. Chaudhary, C.K. Nandi, Gold nanoparticle chitosan composite hydrogel beads show efficient removal of methyl parathion from waste water. RSC Adv. 4(75), 39830 (2014). https://doi.org/10.1039/C4RA03870C
Article CAS Google Scholar
E.M. El-Diasty, Z.E. Nesreen, A.M. Hoda, AideiaUsing of Chitosan as Antifungal Agentin Kariesh Cheese. New York Sci. J. 5(9), 5–10 (2012)
Google Scholar
H. el Knidri, R. Belaabed, A. Addaou, A. Laajeb, A. Lahsini, Extraction, chemical modification and characterization of chitin and chitosan. Int. J. Biol. Macromol. 120, 1181–1189 (2018). https://doi.org/10.1016/j.ijbiomac.2018.08.139
Article CAS Google Scholar
L.B. Escudero, P.Y. Quintas, R.G. Wuilloud, G.L. Dotto, Recent advances on elemental biosorption. Environ. Chem. Lett. 17(1), 409–427 (2019). https://doi.org/10.1007/s10311-018-0816-6
Article CAS Google Scholar
O. Felt, Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention. Int. J. Pharm. 180(2), 185–193 (1999). https://doi.org/10.1016/S0378-5173(99)00003-4
Article CAS Google Scholar
F. Galiano, K. Briceño, T. Marino, A. Molino, K.V. Christensen, A. Figoli, Advances in biopolymer-based membrane preparation and applications. J. Membr. Sci. 564, 562–586 (2018). https://doi.org/10.1016/j.memsci.2018.07.059
Article CAS Google Scholar
F. Gassara, C. Antzak, C.M. Ajila, S.J. Sarma, S.K. Brar, M. Verma, Chitin and chitosan as natural flocculants for beer clarification. J. Food Eng. 166, 80–85 (2015). https://doi.org/10.1016/j.jfoodeng.2015.05.028
Article CAS Google Scholar
V. Gerdts, G. Mutwiri, J. Richards, S. Hurk, D.L. van Den, A.A. Potter, Carrier molecules for use in veterinary vaccines. Vaccine 31(4), 596–602 (2013). https://doi.org/10.1016/j.vaccine.2012.11.067
Article Google Scholar
I. Hamed, F. Özogul, J.M. Regenstein, Industrial applications of crustacean by-products (chitin, chitosan, and chitooligosaccharides): a review. Trends Food Sci. Technol. 48, 40–50 (2016). https://doi.org/10.1016/j.tifs.2015.11.007
Article CAS Google Scholar
S. Hirano, A facile method for the preparation of novel membranes from N -acyl- and N -arylidene-chitosan gels. Agric. Biol. Chem. 42(10), 1939–1940 (1978). https://doi.org/10.1080/00021369.1978.10863280
Article CAS Google Scholar
J. Hou, B.E. Aydemir, A.G. Dumanli, Understanding the structural diversity of chitins as a versatile biomaterial. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 379(2206) (2021). https://doi.org/10.1098/rsta.2020.0331
T.M. Hubert Ribeiro, M.C. dos Santos, Chitin Adsorbents to Wastewater Treatment (2019), pp. 131–140. https://doi.org/10.1007/978-3-030-26810-7_8
Book Google Scholar
B.T. Iber, V.T. Okomoda, S.A. Rozaimah, N.A. Kasan, Eco-friendly approaches to aquaculture wastewater treatment: assessment of natural coagulants vis-a-vis chitosan. Bioresour. Technol. Rep. 15, 100702 (2021). https://doi.org/10.1016/j.biteb.2021.100702
Article CAS Google Scholar
S. Ifuku, Chitin and chitosan nanofibers: preparation and chemical modifications. Molecules 19(11), 18367–18380 (2014). https://doi.org/10.3390/molecules191118367
Article CAS Google Scholar
S. Islam, M.A.R. Bhuiyan, M.N. Islam, Chitin and chitosan: structure, properties and applications in biomedical engineering. J. Polym. Environ. 25(3), 854–866 (2017). https://doi.org/10.1007/s10924-016-0865-5
Article CAS Google Scholar
R. Jayakumar, D. Menon, K. Manzoor, S.V. Nair, H. Tamura, Biomedical applications of chitin and chitosan based nanomaterials – a short review. Carbohydr. Polym. 82(2), 227–232 (2010a). https://doi.org/10.1016/j.carbpol.2010.04.074
Article CAS Google Scholar
R. Jayakumar, M. Prabaharan, S.V. Nair, S. Tokura, H. Tamura, N. Selvamurugan, Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog. Mater. Sci. 55(7), 675–709 (2010b). https://doi.org/10.1016/j.pmatsci.2010.03.001
Article CAS Google Scholar
R. Jayakumar, K.P. Chennazhi, S. Srinivasan, S.v. Nair, T. Furuike, H. Tamura, Chitin scaffolds in tissue engineering. Int. J. Mol. Sci. 12(3), 1876–1887 (2011). https://doi.org/10.3390/ijms12031876
Article CAS Google Scholar
A. Jimtaisong, N. Saewan, Utilization of carboxymethyl chitosan in cosmetics. Int. J. Cosmet. Sci. 36(1), 12–21 (2014). https://doi.org/10.1111/ics.12102
Article CAS Google Scholar
M.B. Kaczmarek, K. Struszczyk-Swita, X. Li, M. Szczęsna-Antczak, M. Daroch, Enzymatic modifications of chitin, chitosan, and chitooligosaccharides. Front. Bioeng. Biotechnol. 7 (2019). https://doi.org/10.3389/fbioe.2019.00243
D. Kamilya, M.I.R. Khan, Chitin and chitosan as promising immunostimulant for aquaculture, in Handbook of Chitin and Chitosan, (Elsevier, 2020), pp. 761–771. https://doi.org/10.1016/B978-0-12-817966-6.00024-8
Chapter Google Scholar
E. Khor, L.Y. Lim, Implantable applications of chitin and chitosan. Biomaterials 24(13), 2339–2349 (2003). https://doi.org/10.1016/S0142-9612(03)00026-7
Article CAS Google Scholar
B. Krajewska, Application of chitin- and chitosan-based materials for enzyme immobilizations: a review. Enzym. Microb. Technol. 35(2–3), 126–139 (2004). https://doi.org/10.1016/j.enzmictec.2003.12.013
Article CAS Google Scholar
K. Kurishima, K. Miyazaki, H. Watanabe, T. Shiozawa, H. Ishikawa, H. Satoh, N. Hizawa, Lung cancer patients with synchronous colon cancer. Molecular Clin. Oncol. (2017). https://doi.org/10.3892/mco.2017.1471
E.J. Lee, B.K. Huh, S.N. Kim, J.Y. Lee, C.G. Park, A.G. Mikos, Y.B. Choy, Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair. Prog. Mater. Sci. 89, 392–410 (2017). https://doi.org/10.1016/j.pmatsci.2017.06.003
Article CAS Google Scholar
B. Li, J. Elango, W. Wu, Recent advancement of molecular structure and biomaterial function of chitosan from marine organisms for pharmaceutical and nutraceutical application. Appl. Sci. 10(14), 4719 (2020). https://doi.org/10.3390/app10144719
Article CAS Google Scholar
X. Liu, L. Ma, Z. Mao, C. Gao, Chitosan-Based Biomaterials for Tissue Repair and Regeneration (2011), pp. 81–127. https://doi.org/10.1007/12_2011_118
Book Google Scholar
T.Y. Liu, L. Zhao, Z.L. Wang, Removal of hexavalent chromium from wastewater by Fe0-nanoparticles-chitosan composite beads: characterization, kinetics and thermodynamics. Water Sci. Technol. 66(5), 1044–1051 (2012). https://doi.org/10.2166/wst.2012.278
Article CAS Google Scholar
J. Lizardi-Mendoza, W.M. Argüelles Monal, F.M. Goycoolea Valencia, Chemical characteristics and functional properties of chitosan, in Chitosan in the Preservation of Agricultural Commodities, (Elsevier, 2016), pp. 3–31. https://doi.org/10.1016/B978-0-12-802735-6.00001-X
Chapter Google Scholar
H.F. Lu, K. Narayanan, S.-X. Lim, S. Gao, M.F. Leong, A.C.A. Wan, A 3D microfibrous scaffold for long-term human pluripotent stem cell self-renewal under chemically defined conditions. Biomaterials 33(8), 2419–2430 (2012). https://doi.org/10.1016/j.biomaterials.2011.11.077
Article CAS Google Scholar
J. Ma, Y. Sahai, Chitosan biopolymer for fuel cell applications. Carbohydr. Polym. 92(2), 955–975 (2013). https://doi.org/10.1016/j.carbpol.2012.10.015
Article CAS Google Scholar
M. Malerba, R. Cerana, Recent applications of chitin- and chitosan-based polymers in plants. Polymers 11(5), 839 (2019). https://doi.org/10.3390/polym11050839
Article CAS Google Scholar
V. Manigandan, R. Karthik, S. Ramachandran, S. Rajagopal, Chitosan applications in food industry, in Biopolymers for Food Design, (Elsevier, 2018), pp. 469–491. https://doi.org/10.1016/B978-0-12-811449-0.00015-3
Chapter Google Scholar
M.E. Mathew, J.C. Mohan, K. Manzoor, S.V. Nair, H. Tamura, R. Jayakumar, Folate conjugated carboxymethyl chitosan–manganese doped zinc sulphide nanoparticles for targeted drug delivery and imaging of cancer cells. Carbohydr. Polym. 80(2), 442–448 (2010). https://doi.org/10.1016/j.carbpol.2009.11.047
Article CAS Google Scholar
R.D. Milholland, A leaf spot disease of highbush blueberry caused by Alternaria tenuissima. Phytopathology 63(11), 1395 (1973). https://doi.org/10.1094/Phyto-63-1395
Article Google Scholar
K. Mizuno, K. Yamamura, K. Yano, T. Osada, S. Saeki, N. Takimoto, T. Sakurai, Y. Nimura, Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice. J. Biomed. Mater. Res. 64A(1), 177–181 (2003). https://doi.org/10.1002/jbm.a.10396
Article CAS Google Scholar
M. Moattari, H.M. Kouchesfehani, G. Kaka, S.H. Sadraie, M. Naghdi, Evaluation of nerve growth factor (NGF) treated mesenchymal stem cells for recovery in neurotmesis model of peripheral nerve injury. J. Cranio-Maxillofac. Surg. 46(6), 898–904 (2018). https://doi.org/10.1016/j.jcms.2018.03.015
Article Google Scholar
N. Morin-Crini, E. Lichtfouse, G. Torri, G. Crini, Fundamentals and Applications of Chitosan (2019a), pp. 49–123. https://doi.org/10.1007/978-3-030-16538-3_2
Book Google Scholar
N. Morin-Crini, E. Lichtfouse, G. Torri, G. Crini, Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry. Environ. Chem. Lett. 17(4), 1667–1692 (2019b). https://doi.org/10.1007/s10311-019-00904-x
Article CAS Google Scholar
S.A. Muhmed, N.A.M. Nor, J. Jaafar, A.F. Ismail, M.H.D. Othman, M.A. Rahman, F. Aziz, N. Yusof, Emerging chitosan and cellulose green materials for ion exchange membrane fuel cell: a review. Energy Ecol. Environ. 5(2), 85–107 (2020). https://doi.org/10.1007/s40974-019-00127-4
Article Google Scholar
S. Nakatsuka, A.L. Andrady, Permeability of vitamin B-12 in chitosan membranes. Effect of crosslinking and blending with poly(vinyl alcohol) on permeability. J. Appl. Polym. Sci. 44(1), 17–28 (1992). https://doi.org/10.1002/app.1992.070440103
Article CAS Google Scholar
A.K. Nayak, S.A. Ahmad, M.S. Hasnain, Chitosan-based nanoparticles in drug delivery, in Chitosan in Drug Delivery, (Elsevier, 2022), pp. 55–82. https://doi.org/10.1016/B978-0-12-819336-5.00014-5
Chapter Google Scholar
P. Nechita, Applications of chitosan in wastewater treatment, in Biological Activities and Application of Marine Polysaccharides, (InTech, 2017). https://doi.org/10.5772/65289
Chapter Google Scholar
R. Parhi, Drug delivery applications of chitin and chitosan: a review. Environ. Chem. Lett. 18(3), 577–594 (2020). https://doi.org/10.1007/s10311-020-00963-5
Article CAS Google Scholar
A. Percot, C. Viton, A. Domard, Optimization of chitin extraction from shrimp shells. Biomacromolecules 4(1), 12–18 (2003). https://doi.org/10.1021/bm025602k
Article CAS Google Scholar
L. Popa, M.V. Ghica, C.E. Dinu-Pîrvu, T. Irimia, Chitosan: a good candidate for sustained release ocular drug delivery systems, in Chitin-Chitosan – Myriad Functionalities in Science and Technology, (InTech, 2018). https://doi.org/10.5772/intechopen.76039
Chapter Google Scholar
H. Pospieszny, S. Chirkov, J. Atabekov, Induction of antiviral resistance in plants by chitosan. Plant Sci. 79(1), 63–68 (1991). https://doi.org/10.1016/0168-9452(91)90070-O
Article CAS Google Scholar
S.A. Qamar, M. Ashiq, M. Jahangeer, A. Riasat, M. Bilal, Chitosan-based hybrid materials as adsorbents for textile dyes–a review. Case Stud. Chem. Environ. Eng. 2, 100021 (2020). https://doi.org/10.1016/j.cscee.2020.100021
Article Google Scholar
Y. Qin, L. Cai, D. Feng, B. Shi, J. Liu, W. Zhang, Y. Shen, Combined use of chitosan and alginate in the treatment of wastewater. J. Appl. Polym. Sci. 104(6), 3581–3587 (2007). https://doi.org/10.1002/app.26006
Article CAS Google Scholar
C.T. Reinhart, N.A. Peppas, Solute diffusion in swollen membranes. Part II. Influence of crosslinking on diffusive properties. J. Membr. Sci. 18, 227–239 (1984). https://doi.org/10.1016/S0376-7388(00)85036-X
Article CAS Google Scholar
M. Rinaudo, Chitin and chitosan: properties and applications. Prog. Polym. Sci. 31(7), 603–632 (2006). https://doi.org/10.1016/j.progpolymsci.2006.06.001
Article CAS Google Scholar
M.V. Rivas, A. Kolender, N.B. D’Accorso, Chemically modified chitosan for biomolecule delivery, in Chitosan in Drug Delivery, (Elsevier, 2022), pp. 501–518. https://doi.org/10.1016/B978-0-12-819336-5.00018-2
Chapter Google Scholar
A. Rouhani Shirvan, M. Shakeri, A. Bashari, Recent advances in application of chitosan and its derivatives in functional finishing of textiles, in The Impact and Prospects of Green Chemistry for Textile Technology, (Elsevier, 2019), pp. 107–133. https://doi.org/10.1016/B978-0-08-102491-1.00005-8
Chapter Google Scholar
J.C. Roy, F. Salaün, S. Giraud, A. Ferri, G. Chen, J. Guan, Solubility of chitin: solvents, solution behaviors and their related mechanisms, in Solubility of Polysaccharides, (InTech, 2017). https://doi.org/10.5772/intechopen.71385
Chapter Google Scholar
S. Sarode, P. Upadhyay, M.A. Khosa, T. Mak, A. Shakir, S. Song, A. Ullah, Overview of wastewater treatment methods with special focus on biopolymer chitin-chitosan. Int. J. Biol. Macromol. 121, 1086–1100 (2019). https://doi.org/10.1016/j.ijbiomac.2018.10.089
Article CAS Google Scholar
R.M.H. Sayed-Elahl, N.M. El-Shinawy, K. Nagy, A trial for improvement of Kareish cheese quality by using chitosan nanoparticles. Egypt. J. Vet. Sci. 50(8), 69–80 (2019). https://doi.org/10.21608/ejvs.2020.19943.1135
Article Google Scholar
N. Shaari, S.K. Kamarudin, Chitosan and alginate types of bio-membrane in fuel cell application: an overview. J. Power Sources 289, 71–80 (2015). https://doi.org/10.1016/j.jpowsour.2015.04.027
Article CAS Google Scholar
J.L. Shamshina, T. Oldham (Konak), R.D. Rogers, Applications of Chitin in Agriculture (2019), pp. 125–146. https://doi.org/10.1007/978-3-030-16581-9_4
Book Google Scholar
J.L. Shamshina, A. Kelly, T. Oldham, R.D. Rogers, Agricultural uses of chitin polymers. Environ. Chem. Lett. 18(1), 53–60 (2020). https://doi.org/10.1007/s10311-019-00934-5
Article CAS Google Scholar
R. Shanmuganathan, T.N.J.I. Edison, F. Lewis Oscar, P. Kumar, S. Shanmugam, A. Pugazhendhi, Chitosan nanopolymers: an overview of drug delivery against cancer. Int. J. Biol. Macromol. 130, 727–736 (2019). https://doi.org/10.1016/j.ijbiomac.2019.02.060
Article CAS Google Scholar
R. Sharp, A review of the applications of chitin and its derivatives in agriculture to modify plant-microbial interactions and improve crop yields. Agronomy 3(4), 757–793 (2013). https://doi.org/10.3390/agronomy3040757
Article CAS Google Scholar
S.K. Shukla, A.K. Mishra, O.A. Arotiba, B.B. Mamba, Chitosan-based nanomaterials: a state-of-the-art review. Int. J. Biol. Macromol. 59, 46–58 (2013). https://doi.org/10.1016/j.ijbiomac.2013.04.043
Article CAS Google Scholar
D.K. Singh, A.R. Ray, Controlled release of glucose through modified chitosan membranes. J. Membr. Sci. 155(1), 107–112 (1999). https://doi.org/10.1016/S0376-7388(98)00311-1
Article CAS Google Scholar
D.K. Singh, A.R. Ray, Biomedical applications of chitin, chitosan, and their derivatives. J. Macromol. Sci. Polym. Rev. 40(1), 69–83 (2000). https://doi.org/10.1081/MC-100100579
Article Google Scholar
E. Soroush, Z. Mohammadpour, M. Kharaziha, H.R. Bakhsheshi-Rad, F. Berto, Polysaccharides-based nanofibrils: from tissue engineering to biosensor applications. Carbohydr. Polym. 291, 119670 (2022). https://doi.org/10.1016/j.carbpol.2022.119670
Article CAS Google Scholar
H. Tamura, T. Furuike, Chitin and chitosan, in Encyclopedia of Polymeric Nanomaterials, (Springer, Berlin/Heidelberg, 2014), pp. 1–4. https://doi.org/10.1007/978-3-642-36199-9_322-1Q
Chapter Google Scholar
F. Tashakori-Sabzevar, S.A. Mohajeri, Development of ocular drug delivery systems using molecularly imprinted soft contact lenses. Drug Dev. Ind. Pharm. 41(5), 703–713 (2015). https://doi.org/10.3109/03639045.2014.948451
Article CAS Google Scholar
H. Ueno, H. Yamada, I. Tanaka, N. Kaba, M. Matsuura, M. Okumura, T. Kadosawa, T. Fujinaga, Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs. Biomaterials 20(15), 1407–1414 (1999). https://doi.org/10.1016/S0142-9612(99)00046-0
Article CAS Google Scholar
C.L. Velásquez, M.R. Pirela, Biochemical aspects of the chitin fungicidal activity in agricultural uses, in Chitosan in the Preservation of Agricultural Commodities, (Elsevier, 2016), pp. 279–298. https://doi.org/10.1016/B978-0-12-802735-6.00010-0
Chapter Google Scholar
K. Vellingiri, T. Ramachandran, M. Senthilkumar, Eco-friendly application of nano chitosan in antimicrobial coatings in the textile industry. Nanosci. Nanotechnol. Lett. 5(5), 519–529 (2013). https://doi.org/10.1166/nnl.2013.1575
Article Google Scholar
M. Vijayakumar, K. Priya, S. Ilavenil, B. Janani, V. Vedarethinam, T. Ramesh, M.V. Arasu, N.A. Al-Dhabi, Y.-O. Kim, H.-J. Kim, Shrimp shells extracted chitin in silver nanoparticle synthesis: expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. Int. J. Biol. Macromol. 165, 1402–1409 (2020). https://doi.org/10.1016/j.ijbiomac.2020.10.032
Article CAS Google Scholar
A.C.A. Wan, B.C.U. Tai, CHITIN – a promising biomaterial for tissue engineering and stem cell technologies. Biotechnol. Adv. 31(8), 1776–1785 (2013). https://doi.org/10.1016/j.biotechadv.2013.09.007
Article CAS Google Scholar
Y. Wan, B. Peppley, K.A.M. Creber, V.T. Bui, E. Halliop, Preliminary evaluation of an alkaline chitosan-based membrane fuel cell. J. Power Sources 162(1), 105–113 (2006). https://doi.org/10.1016/j.jpowsour.2006.07.027
Article CAS Google Scholar
S.M. Wu, K. Hochedlinger, Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat. Cell Biol. 13(5), 497–505 (2011). https://doi.org/10.1038/ncb0511-497
Article CAS Google Scholar
L. Xiao, Chitosan application in textile processing. Curr. Trends Fashion Technol. Text. Eng. 4(2) (2018). https://doi.org/10.19080/CTFTTE.2018.04.555635
T.-L. Yang, Chitin-based materials in tissue engineering: applications in soft tissue and epithelial organ. Int. J. Mol. Sci. 12(3), 1936–1963 (2011). https://doi.org/10.3390/ijms12031936
Article CAS Google Scholar
I. Younes, M. Rinaudo, Chitin and chitosan preparation from marine sources. Structure, properties and applications. Mar. Drugs 13(3), 1133–1174 (2015). https://doi.org/10.3390/md13031133
Article CAS Google Scholar
B.C.-E. Zhou, C. Kan, C. Sun, J. Du, C. Xu, A review of chitosan textile applications. AATCC J. Res. 6(1_Suppl), 8–14 (2019). https://doi.org/10.14504/ajr.6.S1.2
Article CAS Google Scholar

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Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, Kerala, India
Hema S, Greeshma U Chandran & Sreedha Sambhudevan
Department of Chemistry, M A College, Ernakulam, Kerala, India
Jyothi P R

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Hema S
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Greeshma U Chandran
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Jyothi P R
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Sreedha Sambhudevan
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Correspondence to Sreedha Sambhudevan .

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School of Chemical Science, Mahatma Gandhi University, Kottayam, India
Sabu Thomas
Mahatma Gandhi University, Kottayam, India
Ajitha AR
Department of Chemistry, Newman College, Thodupuzha, India
Cintil Jose Chirayil
Department of Chemistry, Newman College, Idukki, India
Bejoy Thomas

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S, H., U Chandran, G., P R, J., Sambhudevan, S. (2023). Biomedical Applications of Chitin. In: Thomas, S., AR, A., Jose Chirayil, C., Thomas, B. (eds) Handbook of Biopolymers . Springer, Singapore. https://doi.org/10.1007/978-981-16-6603-2_25-1

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DOI: https://doi.org/10.1007/978-981-16-6603-2_25-1
Received: 19 October 2022
Accepted: 20 October 2022
Published: 22 February 2023
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-6603-2
Online ISBN: 978-981-16-6603-2
eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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