Nanotechnology-Based ROS-Triggered Therapeutic Strategies in Multiple Cancer

Mohanty, Sonali; Paul, Subhankar

doi:10.1007/978-981-16-5422-0_119

Sonali Mohanty² &
Subhankar Paul²

44 Accesses
1 Citations

Abstract

Reactive oxygen species (ROS) has been found to be a key player in the development of several hallmarks of cancer. One of the distinguishing characteristics of cancer is an elevated level of ROS, which when enhanced further makes it an effective cytotoxic agent in the treatment of malignant cancer. Due to the numerous side effects associated with conventional chemotherapy alone, major part of the research has been focused on the integration of nanomaterials with ROS-mediated therapy for finding a new paradigm of tumor treatment, such as oxidation therapy, photodynamic therapy (PDT), and sonodynamic therapy (SDT). The presence of pro-oxidative functional groups on the surface of the nanomaterials and the redox-cycling that takes place on the reactive surface of transition metal-based nanomaterial and the interaction between cell and particle are some of the key factors responsible for nanoparticle-induced ROS generation. The advancement of cancer biology research has resulted in the introduction and development of cancer nanomedicines, which provide a basis for using nanotechnology to improve therapeutic approaches. This chapter discusses the role of nanomaterial as ROS-generating agents or its carrier in different tumor targeted therapies. It also throws a brief insight on different commercially available ROS-generating anticancer drugs with improved pharmacokinetic profile through use of nanocarriers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Abbreviations

BPQDs:: Ultra-small black phosphorus quantum dots
DHA:: Docosahexaenoic acid
LDH:: Lactate dehydrogenase
LDL:: Low density lipoproteins
LPO:: Lipid peroxidation
MAP:: Mitogen activated protein
NPs:: Nanoparticles
PEG:: Polyethylene glycol
PGLA:: Poly lactic-co-Glycolic Acid
PMMA:: Polymethyl methacrylate
PS:: Photosensitizer
TPPS:: Meso-tetrakis (4-sulfonatophenyl) porphyrin
ZnPc:: Zinc phthalocyanine

References

Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan MA, Sethi G (2019a) Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements. Biomol Ther 9(11):735. https://doi.org/10.3390/biom9110735
Article CAS Google Scholar
Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan MA, Sethi G (2019b) Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements. Biomol Ther 9(11). https://doi.org/10.3390/biom9110735
Ahamed M, Ali D, Alhadlaq HA, Akhtar MJ (2013) Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2). Chemosphere 93(10):2514–2522. https://doi.org/10.1016/j.chemosphere.2013.09.047
Article CAS Google Scholar
Ahmed O (2016) Relationships between oxidative stress, cancer development and therapeutic interventions. Cancer Med Anti Cancer Drugs 1:1–2. https://doi.org/10.4172/2576-1447.1000e104
Article Google Scholar
Ali I, Alsehli M, Scotti L, Tullius Scotti M, Tsai S-T, Yu R-S, Hsieh MF, Chen J-C (2020) Progress in polymeric Nano-medicines for Theranostic cancer treatment. Polymers 12(3):598
Article CAS Google Scholar
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492
Article Google Scholar
Canavese G, Ancona A, Racca L, Canta M, Dumontel B, Barbaresco F, Limongi T, Cauda V (2018) Nanoparticle-assisted ultrasound: a special focus on sonodynamic therapy against cancer. Chem Eng J 340:155–172. https://doi.org/10.1016/j.cej.2018.01.060
Article CAS Google Scholar
Chu X, Mao L, Johnson O, Li K, Phan J, Yin Q, Li L, Zhang J, Chen W, Zhang Y (2019) Exploration of TiO2 nanoparticle mediated microdynamic therapy on cancer treatment. Nanomedicine: nanotechnology, Biol Med 18:272–281. https://doi.org/https://doi.org/10.1016/j.nano.2019.02.016
Ciccarese F, Raimondi V, Sharova E, Silic-Benussi M, Ciminale V (2020) Nanoparticles as tools to target redox homeostasis in cancer cells. Antioxidants (Basel) 9(3):211. https://doi.org/10.3390/antiox9030211
Article CAS Google Scholar
Conklin KA (2004) Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther 3(4):294–300. https://doi.org/10.1177/1534735404270335
Article CAS Google Scholar
Cordani M, Somoza A (2019) Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment. Cell Mol Life Sci 76. https://doi.org/10.1007/s00018-018-2973-y
Dadwal A, Baldi A, Kumar Narang R (2018) Nanoparticles as carriers for drug delivery in cancer. Artif Cells Nanomed Biotechnol 46(sup2):295–305. https://doi.org/10.1080/21691401.2018.1457039
Article CAS Google Scholar
Di Meo S, Reed TT, Venditti P, Victor VM (2016) Role of ROS and RNS sources in physiological and pathological conditions. Oxidative Med Cell Longev 2016:1245049. https://doi.org/10.1155/2016/1245049
Article CAS Google Scholar
Dixit S, Novak T, Miller K, Zhu Y, Kenney ME, Broome AM (2015) Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale 7(5):1782–1790. https://doi.org/10.1039/c4nr04853a
Article CAS Google Scholar
Dixon Scott J, Lemberg Kathryn M, Lamprecht Michael R, Skouta R, Zaitsev Eleina M, Gleason Caroline E, Patel Darpan N, Bauer Andras J, Cantley Alexandra M, Yang Wan S, Morrison B, Stockwell Brent R (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072. https://doi.org/10.1016/j.cell.2012.03.042
Article CAS Google Scholar
Doane TL, Burda C (2012) The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy. Chem Soc Rev 41(7):2885–2911. https://doi.org/10.1039/C2CS15260F
Article CAS Google Scholar
Dos Santos CA, Seckler MM, Ingle AP, Gupta I, Galdiero S, Galdiero M, Gade A, Rai M (2014) Silver nanoparticles: Therapeutical uses, toxicity, and safety issues. J Pharm Sci 103(7):1931–1944. https://doi.org/10.1002/jps.24001
Article CAS Google Scholar
Egusquiaguirre SP, Igartua M, Hernández RM, Pedraz JL (2012) Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research. Clin Transl Oncol 14(2):83–93. https://doi.org/10.1007/s12094-012-0766-6
Article CAS Google Scholar
El-Hussein A, Hamblin MR (2017) ROS generation and DNA damage with photo-inactivation mediated by silver nanoparticles in lung cancer cell line. IET Nanobiotechnol 11(2):173–178. https://doi.org/10.1049/iet-nbt.2015.0083
Article Google Scholar
Elshama S, Abdallah M, Abdel-Karim R (2018) Zinc oxide nanoparticles: therapeutic benefits and toxicological hazards. Open Nanomed J 5:16–22. https://doi.org/10.2174/1875933501805010016
Article Google Scholar
Fubini B, Hubbard A (2003) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 34(12):1507–1516. https://doi.org/10.1016/s0891-5849(03)00149-7
Article CAS Google Scholar
Fukui H, Iwahashi H, Nishio K, Hagihara Y, Yoshida Y, Horie M (2017) Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses. Toxicol Ind Health 33(9):687–695. https://doi.org/10.1177/0748233717707361
Article CAS Google Scholar
Gagliardi A, Giuliano E, Venkateswararao E, Fresta M, Bulotta S, Awasthi V, Cosco D (2021) Biodegradable polymeric nanoparticles for drug delivery to solid Tumors. Front Pharmacol 12(17). https://doi.org/10.3389/fphar.2021.601626
Gaur S, Chen L, Yen T, Wang Y, Zhou B, Davis M, Yen Y (2012) Preclinical study of the cyclodextrin-polymer conjugate of camptothecin CRLX101 for the treatment of gastric cancer. Nanomed Nanotechnol Biol Med 8(5):721–730. https://doi.org/10.1016/j.nano.2011.09.007
Article CAS Google Scholar
Ghorbani M, Soheili S, Moradhaseli S, Shokouhian A (2013) Histopathological effects of ZnO nanoparticles on liver and heart tissues in Wistar rats. Adv Biores 4:83–88
Google Scholar
Hinger D, Navarro F, Käch A, Thomann J-S, Mittler F, Couffin A-C, Maake C (2016) Photoinduced effects of m-tetrahydroxyphenylchlorin loaded lipid nanoemulsions on multicellular tumor spheroids. J Nanobiotechnol 14(1):68. https://doi.org/10.1186/s12951-016-0221-x
Article CAS Google Scholar
Hou J, Wang L, Wang C, Zhang S, Liu H, Li S, Wang X (2019) Toxicity and mechanisms of action of titanium dioxide nanoparticles in living organisms. J Environ Sci (China) 75:40–53. https://doi.org/10.1016/j.jes.2018.06.010
Article CAS Google Scholar
Huang J, Liu F, Han X, Zhang L, Hu Z, Jiang Q, Wang Z, Ran H, Wang D, Li P (2018) Nanosonosensitizers for highly efficient sonodynamic cancer theranostics. Theranostics, 8(22):6178–6194. https://doi.org/10.7150/thno.29569
Jarosz A, Skoda M, Dudek I, Szukiewicz D (2016) Oxidative stress and mitochondrial activation as the Main mechanisms underlying graphene toxicity against human cancer cells. Oxidative Med Cell Longev 2016:5851035. https://doi.org/10.1155/2016/5851035
Article CAS Google Scholar
Karlsson HL, Gustafsson J, Cronholm P, Möller L (2009) Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size. Toxicol Lett 188(2):112–118. https://doi.org/10.1016/j.toxlet.2009.03.014
Article CAS Google Scholar
Kim JK, Seo SJ, Kim KH, Kim TJ, Chung MH, Kim KR, Yang TK (2010) Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect. Nanotechnology 21(42):425102. https://doi.org/10.1088/0957-4484/21/42/425102
Article CAS Google Scholar
Knaapen AM, Borm PJ, Albrecht C, Schins RP (2004) Inhaled particles and lung cancer. Part A: mechanisms. Int J Cancer 109(6):799–809. https://doi.org/10.1002/ijc.11708
Article CAS Google Scholar
Kwon S, Ko H, You DG, Kataoka K, Park JH (2019) Nanomedicines for reactive oxygen species mediated approach: an emerging paradigm for cancer treatment. Acc Chem Res 52(7):1771–1782. https://doi.org/10.1021/acs.accounts.9b00136
Article CAS Google Scholar
Lamch Ł, Bazylińska U, Kulbacka J, Pietkiewicz J, Bieżuńska-Kusiak K, Wilk KA (2014) Polymeric micelles for enhanced Photofrin II® delivery, cytotoxicity and pro-apoptotic activity in human breast and ovarian cancer cells. Photodiagn Photodyn Ther 11(4):570–585. https://doi.org/10.1016/j.pdpdt.2014.10.005
Article CAS Google Scholar
Li S, Mason CE, Melnick A (2016) Genetic and epigenetic heterogeneity in acute myeloid leukemia. Curr Opin Genet Dev 36:100–106. https://doi.org/10.1016/j.gde.2016.03.011
Article CAS Google Scholar
Liang C, Zhang X, Yang M, Dong X (2019) Recent Progress in Ferroptosis inducers for cancer therapy. Adv Mater 31(51):1904197. https://doi.org/10.1002/adma.201904197
Article CAS Google Scholar
Liberti MV, Locasale JW (2016) The Warburg effect: how does it benefit cancer cells? Trends Biochem Sci 41(3):211–218. https://doi.org/10.1016/j.tibs.2015.12.001
Article CAS Google Scholar
Lucky SS, Soo KC, Zhang Y (2015) Nanoparticles in photodynamic therapy. Chem Rev 115(4):1990–2042. https://doi.org/10.1021/cr5004198
Article CAS Google Scholar
Ma A, Chen H, Cui Y, Luo Z, Liang R, Wu Z, Chen Z, Yin T, Ni J, Zheng M, Cai L (2019) Metalloporphyrin complex-based Nanosonosensitizers for deep-tissue tumor Theranostics by noninvasive Sonodynamic therapy. Small 15(5):1804028. https://doi.org/10.1002/smll.201804028
Article CAS Google Scholar
Mahanta S, Paul S (2015a) Bovine α-lactalbumin functionalized graphene oxide nano-sheet exhibits enhanced biocompatibility: a rational strategy for graphene-based targeted cancer therapy. Colloids Surf B Biointerfaces 134:178–187. https://doi.org/10.1016/j.colsurfb.2015.06.061
Article CAS Google Scholar
Mahanta S, Paul S (2015b) Stable self-assembly of bovine α-Lactalbumin exhibits target-specific Antiproliferative activity in multiple cancer cells. ACS Appl Mater Interfaces 7(51):28177–28187. https://doi.org/10.1021/acsami.5b06076
Article CAS Google Scholar
Mahanta S, Paul S, Srivastava A, Pastor A, Kundu B, Chaudhuri TK (2015) Stable self-assembled nanostructured hen egg white lysozyme exhibits strong anti-proliferative activity against breast cancer cells. Colloids Surf B Biointerfaces 130:237–245. https://doi.org/10.1016/j.colsurfb.2015.04.017
Article CAS Google Scholar
Malhotra N, Chen J-R, Sarasamma S, Audira G, Siregar P, Liang S-T, Lai Y-H, Lin G-M, Ger T-R, Hsiao C-D (2019) Ecotoxicity assessment of Fe3O4 magnetic nanoparticle exposure in adult zebrafish at an environmental pertinent concentration by Behavioral and biochemical testing. Nano 9(6):873
CAS Google Scholar
Malhotra N, Lee J-S, Liman RAD, Ruallo JMS, Villaflores OB, Ger T-R, Hsiao C-D (2020) Potential toxicity of iron oxide magnetic nanoparticles: a review. Molecules 25(14):3159
Article CAS Google Scholar
McHale AP, Callan JF, Nomikou N, Fowley C, Callan B (2016) Sonodynamic therapy: concept, mechanism and application to cancer treatment. Adv Exp Med Biol 880:429–450. https://doi.org/10.1007/978-3-319-22536-4_22
Article CAS Google Scholar
Mittal S, Pandey A (2014) Cerium oxide nanoparticles induced toxicity in human lung cells: role of ROS mediated DNA damage and apoptosis. Biomed Res Int 2014. https://doi.org/10.1155/2014/891934
Moghimi SM, Hunter AC, Murray JC (2005) Nanomedicine: current status and future prospects. FASEB J 19(3):311–330. https://doi.org/10.1096/fj.04-2747rev
Article CAS Google Scholar
Nel A, Xia T, Mädler L, Li N (2006) Toxic potential of materials at the nanolevel. Science (New York, NY) 311(5761):622–627. https://doi.org/10.1126/science.1114397
Article CAS Google Scholar
Nishiyama N, Morimoto Y, Jang WD, Kataoka K (2009) Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy. Adv Drug Deliv Rev 61(4):327–338. https://doi.org/10.1016/j.addr.2009.01.004
Article CAS Google Scholar
Nogueira DR, Rolim CM, Farooqi AA (2014) Nanoparticle induced oxidative stress in cancer cells: adding new pieces to an incomplete jigsaw puzzle. Asian Pac J Cancer Prev 15(12):4739–4743. https://doi.org/10.7314/apjcp.2014.15.12.4739
Article Google Scholar
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2:8. https://doi.org/10.1186/1743-8977-2-8
Article CAS Google Scholar
Oerlemans C, Bult W, Bos M, Storm G, Nijsen JFW, Hennink WE (2010) Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res 27(12):2569–2589. https://doi.org/10.1007/s11095-010-0233-4
Article CAS Google Scholar
Ong C, Lim JZZ, Ng CT, Li JJ, Yung LYL, Bay BH (2013) Silver nanoparticles in cancer: therapeutic efficacy and toxicity. Curr Med Chem 20(6):772–781. https://doi.org/10.2174/092986713805076685
Article CAS Google Scholar
Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin H-S (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16(1):71. https://doi.org/10.1186/s12951-018-0392-8
Article CAS Google Scholar
Pi J, Jin H, Liu R, Song B, Wu Q, Liu L, Jiang J, Yang F, Cai H, Cai J (2012) Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells. Appl Microbiol Biotechnol 97. https://doi.org/10.1007/s00253-012-4359-7
Pillai G (2014) Nanomedicines for cancer therapy: an update of FDA approved and those under various stages of development. SOJ Pharm Pharm Sci 1. https://doi.org/10.15226/2374-6866/1/2/00109
Qiuhong Z, Wang N, Ma M, Luo Y, Chen H (2019) Transferrin receptor-mediated sequential intercellular nanoparticles relay for tumor deep penetration and Sonodynamic therapy. Adv Ther 2. https://doi.org/10.1002/adtp.201800152
Roca-Agujetas V, de Dios C, Lestón L, Marí M, Morales A, Colell A (2019) Recent insights into the mitochondrial role in autophagy and its regulation by oxidative stress. Oxidative Med Cell Longev 2019:3809308. https://doi.org/10.1155/2019/3809308
Article CAS Google Scholar
Senapati S, Mahanta AK, Kumar S, Maiti P (2018) Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduct Target Ther 3(1):7. https://doi.org/10.1038/s41392-017-0004-3
Article CAS Google Scholar
Shakeel M, Jabeen F, Shabbir S, Asghar MS, Khan MS, Chaudhry AS (2016) Toxicity of Nano-titanium dioxide (TiO2-NP) through various routes of exposure: a review. Biol Trace Elem Res 172(1):1–36. https://doi.org/10.1007/s12011-015-0550-x
Article CAS Google Scholar
Sharma HS, Sharma A (2012) Neurotoxicity of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 11(1):65–80. https://doi.org/10.2174/187152712799960817
Article CAS Google Scholar
Shen Z, Liu T, Li Y, Lau J, Yang Z, Fan W, Zhou Z, Shi C, Ke C, Bregadze VI, Mandal SK, Liu Y, Li Z, Xue T, Zhu G, Munasinghe J, Niu G, Wu A, Chen X (2018) Fenton-reaction-Acceleratable magnetic nanoparticles for Ferroptosis therapy of Orthotopic brain Tumors. ACS Nano 12(11):11355–11365. https://doi.org/10.1021/acsnano.8b06201
Article CAS Google Scholar
Smith KR, Klei LR, Barchowsky A (2001) Arsenite stimulates plasma membrane NADPH oxidase in vascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 280(3):L442–L449. https://doi.org/10.1152/ajplung.2001.280.3.L442
Article CAS Google Scholar
Srivastava RK, Rahman Q, Kashyap MP, Singh AK, Jain G, Jahan S, Lohani M, Lantow M, Pant AB (2013) Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549. Hum Exp Toxicol 32(2):153–166. https://doi.org/10.1177/0960327112462725
Article CAS Google Scholar
Tada D, Baptista M (2015) Photosensitizing nanoparticles and the modulation of reactive oxygen species generation. Front Chem 3. https://doi.org/10.3389/fchem.2015.00033
Thannickal VJ, Fanburg BL (2000) Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279(6):L1005–L1028. https://doi.org/10.1152/ajplung.2000.279.6.L1005
Article CAS Google Scholar
Wang J, Yi J (2009) Cancer cell killing via ROS: to increase or decrease, that is a question. Cancer Biol Ther 7:1875–1884. https://doi.org/10.4161/cbt.7.12.7067
Article Google Scholar
Waris G, Ahsan H (2006) Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 5:14–14. https://doi.org/10.1186/1477-3163-5-14
Article CAS Google Scholar
Wu J, Lin Y, Li H, Jin Q, Ji J (2017) Zwitterionic stealth peptide-capped 5-aminolevulinic acid prodrug nanoparticles for targeted photodynamic therapy. J Colloid Interface Sci 485:251–259. https://doi.org/10.1016/j.jcis.2016.09.012
Article CAS Google Scholar
Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794–1807. https://doi.org/10.1021/nl061025k
Article CAS Google Scholar
Xu Y, Qin Z, Ma J, Cao W, Zhang P (2020) Recent progress in nanotechnology based ferroptotic therapies for clinical applications. Eur J Pharmacol 880:173198. https://doi.org/10.1016/j.ejphar.2020.173198
Article CAS Google Scholar
Yao X, Yang P, Jin Z, Jiang Q, Guo R, Xie R, He Q, Yang W (2019) Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis. Biomaterials 197:268–283. https://doi.org/10.1016/j.biomaterials.2019.01.026
Article CAS Google Scholar
Yi G, Hong S, Son J, Yoo J, Park C, Choi Y, Koo H (2018) Recent advances in nanoparticle carriers for photodynamic therapy. Quant Imaging Med Surg 8:433–443. https://doi.org/10.21037/qims.2018.05.04
Article Google Scholar
Yin W, Li J, Ke W, Zha Z, Ge Z (2017) Integrated nanoparticles to synergistically elevate tumor oxidative stress and suppress Antioxidative capability for amplified oxidation therapy. ACS Appl Mater Interfaces 9. https://doi.org/10.1021/acsami.7b08347
Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques-Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali AM (2017) The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nanotechnol 8(1):6. https://doi.org/10.1186/s12645-017-0032-2
Article CAS Google Scholar
Zhang Y, Chen W, Wang S, Liu Y, Pope C (2008) Phototoxicity of zinc oxide nanoparticle Conjugatesin human ovarian cancer NIH: OVCAR-3 cells. J Biomed Nanotechnol 4:432–438. https://doi.org/10.1166/jbn.2008.006
Article Google Scholar
Zhou L-Q, Li P, Cui X-W, Dietrich CF (2020) Ultrasound nanotheranostics in fighting cancer: advances and prospects. Cancer Lett 470:204–219. https://doi.org/10.1016/j.canlet.2019.11.034
Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

Structural Biology and Nanomedicine Laboratory, Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha, India
Sonali Mohanty & Subhankar Paul

Authors

Sonali Mohanty
View author publications
You can also search for this author in PubMed Google Scholar
Subhankar Paul
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Subhankar Paul .

Editor information

Editors and Affiliations

Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
Sajal Chakraborti

Section Editor information

Department of Chemistry and Biochemistry, University of Texas, El Paso, Texas, USA
Mahesh Narayan
School of Biotechnology, KIIT Deemed to be University, Institute of Eminence, Bhubaneswar, India
Gopal C. Kundu
Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela-, Odisha, India
Subhankar Paul
Institute of Bioinformatics and Biotechnology, SavitribaiPhule Pune University, Pune, Maharastra, India
Tuli Dey
Department of Animal Biotechnology, Lala lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
Minakshi Prasad

Rights and permissions

Reprints and permissions

Copyright information

About this entry

Cite this entry

Mohanty, S., Paul, S. (2022). Nanotechnology-Based ROS-Triggered Therapeutic Strategies in Multiple Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_119

Download citation

DOI: https://doi.org/10.1007/978-981-16-5422-0_119
Published: 29 September 2022
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-5421-3
Online ISBN: 978-981-16-5422-0
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics