Abstract
Marine organisms contain valuable chemical compounds as secondary metabolites such as bioactive peptides that survive in harsh marine environments produced by organisms. They have been considered by scientists for use in medicine and pharmaceutical researches due to their unique and unknown biological properties. Studies on a variety of marine-derived peptides have shown that these compounds as antimicrobial, antiviral, antioxidant, antihypertensive, and anticancer agents can be useful in the treatment of various diseases. While many marine peptides are in various phases of clinical trials, two marine peptide-derived drugs have been approved by the Food and Drug Administration (FDA), too. This chapter highlights the recent two decades of researches on the biological properties of peptides derived from a variety of living organisms, including microbes, plants, and marine animals, in vivo, vitro, and clinical trials and their potential for disease treatment.
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References
Abuine R, Rathnayake AU, Byun H-G (2019) Biological activity of peptides purified from fish skin hydrolysates. Fish Aquat Sci 22(1):10. https://doi.org/10.1186/s41240-019-0125-4
Admassu H, Gasmalla MAA, Yang R, Zhao W (2018) Bioactive peptides derived from seaweed protein and their health benefits: antihypertensive, antioxidant, and antidiabetic properties. J Food Sci 83(1):6–16. https://doi.org/10.1111/1750-3841.14011
Agrawal S, Adholeya A, Deshmukh SK (2016) The pharmacological potential of non-ribosomal peptides from marine sponge and tunicates. Front Pharmacol 7:333. https://doi.org/10.3389/fphar.2016.00333
Agrawal S, Acharya D, Adholeya A, Barrow CJ, Deshmukh SK (2017) Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential. Front Pharmacol 8:828. https://doi.org/10.3389/fphar.2017.00828
Almeida C, El Maddah F, Kehraus S, Schnakenburg G, König GM (2016) Endolides A and B, vasopressin and serotonin-receptor interacting N-methylated peptides from the sponge-derived fungus Stachylidium sp. Org Lett 18(3):528–531. https://doi.org/10.1021/acs.orglett.5b03553
Alonso-Álvarez S, Pardal E, Sánchez-Nieto D, Navarro M, Caballero MD, Mateos MV, Martín A (2017) Plitidepsin: design, development, and potential place in therapy. Drug Des Devel Ther 11:253–264. https://doi.org/10.2147/DDDT.S94165
Álvarez-Viñas M, Flórez-Fernández N, Torres MD, Domínguez H (2019) Successful approaches for a red seaweed biorefinery. Mar Drugs 17(11). https://doi.org/10.3390/md17110620
Anand M, Alagar M, Ranjitha J, Selvaraj V (2019) Total synthesis and anticancer activity of a cyclic heptapeptide from marine sponge using water soluble peptide coupling agent EDC. Arab J Chem 12(8):2782–2787. https://doi.org/10.1016/j.arabjc.2014.05.037
Andreev YA, Osmakov DI, Koshelev SG, Maleeva EE, Logashina YA, Palikov VA, Palikova YA, Dyachenko IA, Kozlov SA (2018) Analgesic activity of acid-sensing ion channel 3 (ASIС3) inhibitors: sea anemones peptides Ugr9-1 and APETx2 versus low molecular weight compounds. Mar Drugs 16(12):500. https://doi.org/10.3390/md16120500
Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. J Chromatogr B 803(1):41–53. https://doi.org/10.1016/j.jchromb.2003.11.005
Arizza V, Schillaci D (2016) Chapter 12 - Echinoderm antimicrobial peptides: the ancient arms of the deuterostome innate immune system (L. Ballarin & M. B. T.-L. in I. Cammarata (eds.); pp. 159–176). Academic Press. https://doi.org/10.1016/B978-0-12-803252-7.00012-6
Arumugam V, Venkatesan M, Murugesan S, Ayyasamy R, Ramachandran S, Sundaresan U, Pugazhendhi A (2019) Metabolite profiling, molecular docking and in vitro anticancer potential of marine ascidian Didemnum sp. Process Biochem. https://doi.org/10.1016/j.procbio.2019.09.021
Asha KK, Remya Kumari KR, Ashok Kumar K, Chatterjee NS, Anandan R, Mathew S (2016) Sequence determination of an antioxidant peptide obtained by enzymatic hydrolysis of oyster Crassostrea madrasensis (Preston). Int J Pept Res Ther 22(3):421–433. https://doi.org/10.1007/s10989-016-9521-0
Barbosa F, Pinto E, Kijjoa A, Pinto M, Sousa E (2020) Targeting antimicrobial drug resistance with marine natural products. Int J Antimicrob Agents 56(1):106005. https://doi.org/10.1016/j.ijantimicag.2020.106005
Bashir KMI, Sohn JH, Kim J-S, Choi J-S (2020) Identification and characterization of novel antioxidant peptides from mackerel (Scomber japonicus) muscle protein hydrolysates. Food Chem 323:126809. https://doi.org/10.1016/j.foodchem.2020.126809
Benkendorff K (2010) Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs. Biol Rev Camb Philos Soc 85(4):757–775. https://doi.org/10.1111/j.1469-185X.2010.00124.x
Boot CM, Tenney K, Valeriote FA, Crews P (2006) Highly N-methylated linear peptides produced by an atypical sponge-derived Acremonium sp. J Nat Prod 69(1):83–92. https://doi.org/10.1021/np0503653
Boot CM, Amagata T, Tenney K, Compton JE, Pietraszkiewicz H, Valeriote FA, Crews P (2007) Four classes of structurally unusual peptides from two marine-derived fungi: structures and bioactivities. Tetrahedron 63(39):9903–9914. https://doi.org/10.1016/j.tet.2007.06.034
Boto A, Pérez de la Lastra JM, González CC (2018) The road from host-defense peptides to a new generation of antimicrobial drugs. Molecules (Basel, Switzerland) 23(2):311. https://doi.org/10.3390/molecules23020311
Buijs Y, Bech PK, Vazquez-Albacete D, Bentzon-Tilia M, Sonnenschein EC, Gram L, Zhang S-D (2019) Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies. Nat Prod Rep 36(9):1333–1350. https://doi.org/10.1039/C9NP00020H
Buonocore F, Picchietti S, Porcelli F, Della Pelle G, Olivieri C, Poerio E, Bugli F, Menchinelli G, Sanguinetti M, Bresciani A, Gennari N, Taddei AR, Fausto AM, Scapigliati G (2019) Fish-derived antimicrobial peptides: activity of a chionodracine mutant against bacterial models and human bacterial pathogens. Dev Comparat Immunol 96:9–17. https://doi.org/10.1016/j.dci.2019.02.012
Cardoso S, Carvalho L G, Silva P, Rodrigues M, Pereira O, Pereira L (2014) Bioproducts from seaweeds: a review with special focus on the Iberian Peninsula. Curr Org Chem 18. https://doi.org/10.2174/138527281807140515154116
Cardoso MH, Ribeiro SM, Nolasco DO, de la Fuente-Núñez C, Felício MR, Gonçalves S, Matos CO, Liao LM, Santos NC, Hancock REW, Franco OL, Migliolo L (2016) A polyalanine peptide derived from polar fish with anti-infectious activities. Sci Rep 6(1):21385. https://doi.org/10.1038/srep21385
Chen Z, Song Y, Chen Y, Huang H, Zhang W, Ju J (2012) Cyclic heptapeptides, cordyheptapeptides C–E, from the marine-derived fungus acremonium persicinum SCSIO 115 and their cytotoxic activities. J Nat Prod 75(6):1215–1219. https://doi.org/10.1021/np300152d
Chen B, Fan D-Q, Zhu K-X, Shan Z-G, Chen F-Y, Hou L, Cai L, Wang K-J (2015) Mechanism study on a new antimicrobial peptide Sphistin derived from the N-terminus of crab histone H2A identified in haemolymphs of Scylla paramamosain. Fish Shellfish Immunol 47(2):833–846. https://doi.org/10.1016/j.fsi.2015.10.010
Chen E, Chen Q, Chen S, Xu B, Ju J, Wang H (2017) Mathermycin, a lantibiotic from the marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Appl Environ Microbiol 83(15):e00926–e00917. https://doi.org/10.1128/AEM.00926-17
Chen L, Hu J-S, Xu J-L, Shao C-L, Wang G-Y (2018) Biological and chemical diversity of ascidian-associated microorganisms. Mar Drugs 16(10):362. https://doi.org/10.3390/md16100362
Chen J, Gong F, Chen M-F, Li C, Hong P, Sun S, Zhou C, Qian Z-J (2019) In vitro vascular-protective effects of a tilapia by-product oligopeptide on angiotensin II-Induced hypertensive endothelial injury in HUVEC by Nrf2/NF-κB pathways. Mar Drugs 17(7):431. https://doi.org/10.3390/md17070431
Chen J, Tan L, Li C, Zhou C, Hong P, Sun S, Qian Z-J (2020) Mechanism analysis of a novel angiotensin-I-converting enzyme inhibitory peptide from isochrysis zhanjiangensis microalgae for suppressing vascular injury in human umbilical vein endothelial cells. J Agric Food Chem 68(15):4411–4423. https://doi.org/10.1021/acs.jafc.0c00925
Cheng KC-C, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su X, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J (2015) Actinoramide A identified as a potent antimalarial from titration-based screening of marine natural product extracts. J Nat Prod 78(10):2411–2422. https://doi.org/10.1021/acs.jnatprod.5b00489
Cheung IWY, Li-Chan ECY (2010) Angiotensin-I-converting enzyme inhibitory activity and bitterness of enzymatically-produced hydrolysates of shrimp (Pandalopsis dispar) processing byproducts investigated by Taguchi design. Food Chem 122(4):1003–1012. https://doi.org/10.1016/j.foodchem.2010.03.057
Cheung RC, Ng TB, Wong JH (2015) Marine peptides: bioactivities and applications. Mar Drugs 13(7). https://doi.org/10.3390/md13074006
Chi C-F, Hu F-Y, Wang B, Li T, Ding G-F (2015) Antioxidant and anticancer peptides from the protein hydrolysate of blood clam (Tegillarca granosa) muscle. J Funct Foods 15:301–313. https://doi.org/10.1016/j.jff.2015.03.045
Choi H, Lee DG (2012) Synergistic effect of antimicrobial peptide arenicin-1 in combination with antibiotics against pathogenic bacteria. Res Microbiol 163(6–7):479–486. https://doi.org/10.1016/j.resmic.2012.06.001
Cusimano MG, Spinello A, Barone G, Schillaci D, Cascioferro S, Magistrato A, Parrino B, Arizza V, Vitale M (2019) A synthetic derivative of antimicrobial peptide holothuroidin 2 from mediterranean sea cucumber (Holothuria tubulosa) in the control of listeria monocytogenes. Mar Drugs 17(3). https://doi.org/10.3390/md17030159
Dahiya R, Singh S, Sharma A, Chennupati SV, Maharaj S (2016) First total synthesis and biological screening of a proline-rich cyclopeptide from a Caribbean marine sponge. Mar Drugs 14(12):228. https://doi.org/10.3390/md14120228
Daletos G, Kalscheuer R, Koliwer-Brandl H, Hartmann R, de Voogd NJ, Wray V, Lin W, Proksch P (2015) Callyaerins from the marine sponge callyspongia aerizusa: cyclic peptides with antitubercular activity. J Nat Prod 78(8):1910–1925. https://doi.org/10.1021/acs.jnatprod.5b00266
de Barros E, Gonçalves RM, Cardoso MH, Santos NC, Franco OL, Cândido ES (2019) Snake venom cathelicidins as natural antimicrobial peptides. Front Pharmacol 10:1415. https://doi.org/10.3389/fphar.2019.01415
De Domenico S, De Rinaldis G, Paulmery M, Piraino S, Leone A (2019) Barrel jellyfish (rhizostoma pulmo) as source of antioxidant peptides. Mar Drugs 17(2):134. https://doi.org/10.3390/md17020134
Deer TR, Pope JE, Hanes MC, McDowell GC (2019) Intrathecal therapy for chronic pain: a review of morphine and ziconotide as firstline options. Pain Med (Malden, Mass.) 20(4):784–798. https://doi.org/10.1093/pm/pny132
Deng Z, Liu Y, Wang J, Wu S, Geng L, Sui Z, Zhang Q (2018) Antihypertensive effects of two novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Gracilariopsis lemaneiformis (rhodophyta) in spontaneously hypertensive rats (SHRs). Mar Drugs 16(9):299. https://doi.org/10.3390/md16090299
Deshmukh AA, Weist JL, Leight JL (2018) Detection of proteolytic activity by covalent tethering of fluorogenic substrates in zymogram gels. BioTechniques 64(5):203–210. https://doi.org/10.2144/btn-2018-0005
Dewapriya P, Khalil ZG, Prasad P, Salim AA, Cruz-Morales P, Marcellin E, Capon RJ (2018) Talaropeptides A-D: structure and biosynthesis of extensively N-methylated linear peptides from an australian marine tunicate-derived Talaromyces sp. Front Chem 6:394. https://doi.org/10.3389/fchem.2018.00394
Ebada SS, Edrada RA, Lin W, Proksch P (2008) Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. Nat Protoc 3(12):1820–1831. https://doi.org/10.1038/nprot.2008.182
Ebada SS, Fischer T, Hamacher A, Du F-Y, Roth YO, Kassack MU, Wang B-G, Roth EH (2014) Psychrophilin E, a new cyclotripeptide, from co-fermentation of two marine alga-derived fungi of the genus Aspergillus. Nat Prod Res 28(11):776–781. https://doi.org/10.1080/14786419.2014.880911
Edler MC, Fernandez AM, Lassota P, Ireland CM, Barrows LR (2002) Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10. Biochem Pharmacol 63(4):707–715. https://doi.org/10.1016/s0006-2952(01)00898-x
El Maddah F, Kehraus S, Nazir M, Almeida C, König GM (2016) Insights into the biosynthetic origin of 3-(3-Furyl)alanine in Stachylidium sp. 293 K04 tetrapeptides. J Nat Prod 79(11):2838–2845. https://doi.org/10.1021/acs.jnatprod.6b00601
Elyakova LA, Vaskovsky BV, Khoroshilova NI, Vantseva SI, Agapkina YY (2011) Isolation and structure of a novel peptide inhibitor of HIV-1 integrase from marine polychaetes. Russ J Bioorg Chem 37(2):207–216. https://doi.org/10.1134/S1068162010061019
Engelhardt K, Degnes KF, Kemmler M, Bredholt H, Fjaervik E, Klinkenberg G, Sletta H, Ellingsen TE, Zotchev SB (2010) Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species. Appl Environ Microbiol 76(15):4969–4976. https://doi.org/10.1128/AEM.00741-10
Ennaas N, Hammami R, Beaulieu L, Fliss I (2015) Purification and characterization of four antibacterial peptides from protamex hydrolysate of Atlantic mackerel (Scomber scombrus) by-products. Biochem Biophys Res Commun 462(3):195–200. https://doi.org/10.1016/j.bbrc.2015.04.091
Falkenberg SS (2014) Discovery and characterization of novel bioactive peptides from marine secondary products. Electronic, Technical University of Denmark, Kongens Lyngby, Denmark
Fan X, Bai L, Zhu L, Yang L, Zhang X (2014) Marine algae-derived bioactive peptides for human nutrition and health. J Agric Food Chem 62(38):9211–9222. https://doi.org/10.1021/jf502420h
Felician FF, Yu R-H, Li M-Z, Li C-J, Chen H-Q, Jiang Y, Tang T, Qi W-Y, Xu H-M (2019) The wound healing potential of collagen peptides derived from the jellyfish Rhopilema esculentum. Chin J Traumatol 22(1):12–20. https://doi.org/10.1016/j.cjtee.2018.10.004
Fitzgerald C, Mora-Soler L, Gallagher E, O’Connor P, Prieto J, Soler-Vila A, Hayes M (2012) Isolation and characterization of bioactive pro-peptides with in vitro renin inhibitory activities from the macroalga Palmaria palmata. J Agric Food Chem 60(30):7421–7427. https://doi.org/10.1021/jf301361c
Fremlin LJ, Piggott AM, Lacey E, Capon RJ (2009) Cottoquinazoline A and Cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor. J Nat Prod 72(4):666–670. https://doi.org/10.1021/np800777f
Furuta T, Miyabe Y, Yasui H, Kinoshita Y, Kishimura H (2016) Angiotensin I converting enzyme inhibitory peptides derived from phycobiliproteins of Dulse Palmaria palmata. Mar Drugs 14(2). https://doi.org/10.3390/md14020032
Ghanbari R (2019) Review on the bioactive peptides from marine sources: indication for health effects. Int J Pept Res Ther 25(3):1187–1199. https://doi.org/10.1007/s10989-018-9766-x
Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018) Chapter five-biotechnological applications of bioactive peptides from marine sources. R. K. B. T.-A. in M. P. Poole (ed.); Vol. 73, pp. 171–220. Academic Press. https://doi.org/10.1016/bs.ampbs.2018.05.002
Gong F, Chen M-F, Zhang Y-Y, Li C-Y, Zhou C-X, Hong P-Z, Sun S-L, Qian Z-J (2019) A novel peptide from abalone (Haliotis discus hannai) to suppress metastasis and vasculogenic mimicry of tumor cells and enhance anti-tumor effect in vitro. Mar Drugs 17(4). https://doi.org/10.3390/md17040244
Gopal R, Lee JH, Kim YG, Kim M-S, Seo CH, Park Y (2013) Anti-microbial, anti-biofilm activities and cell selectivity of the NRC-16 peptide derived from witch flounder, glyptocephalus cynoglossus. Mar Drugs 11(6). https://doi.org/10.3390/md11061836
Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB (2007) Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A. Tetrahedron 63(28):6535–6541. https://doi.org/10.1016/j.tet.2007.04.025
Gu H-J, Sun Q-L, Jiang S, Zhang J, Sun L (2018) First characterization of an anti-lipopolysaccharide factor (ALF) from hydrothermal vent shrimp: Insights into the immune function of deep-sea crustacean ALF. Dev Comp Immunol 84:382–395. https://doi.org/10.1016/j.dci.2018.03.016
Gui L, Zhang P, Zhang Q, Zhang J (2016) Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro. Fish Shellfish Immunol 50:191–199. https://doi.org/10.1016/j.fsi.2016.01.038
Gulder TAM, Hong H, Correa J, Egereva E, Wiese J, Imhoff JF, Gross H (2012) Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus. Mar Drugs 10(12):2912–2935. https://doi.org/10.3390/md10122912
Guo Z, Qiao X, Cheng R, Shi N, Wang A, Feng T, Chen Y, Zhang F, Yu H, Wang Y (2017) As-CATH4 and 5, two vertebrate-derived natural host defense peptides, enhance the immuno-resistance efficiency against bacterial infections in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol 71:202–209. https://doi.org/10.1016/j.fsi.2017.10.015
Halim NRA, Yusof HM, Sarbon NM (2016) Functional and bioactive properties of fish protein hydrolysates and peptides: a comprehensive review. Trends Food Sci Technol 51:24–33. https://doi.org/10.1016/j.tifs.2016.02.007
Hamann MT, Scheuer PJ (1993) Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp. J Am Chem Soc 115(13):5825–5826. https://doi.org/10.1021/ja00066a061
Hansen AM, Peng P, Baldry M, Perez-Gassol I, Christensen SB, Vinther JMO, Ingmer H, Franzyk H (2018) Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists. Eur J Med Chem 152:370–376. https://doi.org/10.1016/j.ejmech.2018.04.053
Hansen IKØ, Isaksson J, Poth AG, Hansen KØ, Andersen AJC, Richard CSM, Blencke H-M, Stensvåg K, Craik DJ, Haug T (2020) Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian synoicum turgens. Mar Drugs 18(1). https://doi.org/10.3390/md18010051
Harnedy PA, FitzGerald RJ (2012) Bioactive peptides from marine processing waste and shellfish: a review. J Funct Foods 4(1):6–24. https://doi.org/10.1016/j.jff.2011.09.001
Herbel V, Schäfer H, Wink M (2015) Recombinant production of snakin-2 (an antimicrobial peptide from tomato) in E. coli and analysis of its bioactivity. Molecules 20(8). https://doi.org/10.3390/molecules200814889
Hong R, Yang Y (2011) Antitumor metabolites from marine sediment derived Penicillium sp.WF-06. World Notes on Antibiotics, 2
Hou X-M, Zhang Y-H, Hai Y, Zheng J-Y, Gu Y-C, Wang C-Y, Shao C-L (2017) Aspersymmetide A, a new centrosymmetric cyclohexapeptide from the marine-derived fungus Aspergillus versicolor. Mar Drugs 15(11). https://doi.org/10.3390/md15110363
Hou X-M, Wang C-Y, Gerwick WH, Shao C-L (2019) Marine natural products as potential anti-tubercular agents. Eur J Med Chem 165:273–292. https://doi.org/10.1016/j.ejmech.2019.01.026
Huang H-N, Pan C-Y, Chen J-Y (2018) Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-and-mouth disease virus in vitro. Peptides 106:91–95. https://doi.org/10.1016/j.peptides.2018.07.003
Hwang J-Y, Lee J-H, Park SC, Lee J, Oh D-C, Oh K-B, Shin J (2019) New peptides from the marine-derived Fungi Aspergillus allahabadii and Aspergillus ochraceopetaliformis. Mar Drugs 17(9). https://doi.org/10.3390/md17090488
Ibrahim SRM, Min CC, Teuscher F, Ebel R, Kakoschke C, Lin W, Wray V, Edrada-Ebel R, Proksch P (2010) Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa. Bioorg Med Chem 18(14):4947–4956. https://doi.org/10.1016/j.bmc.2010.06.012
Ibrahim AH, Attia EZ, Hajjar D, Anany MA, Desoukey SY, Fouad MA, Kamel MS, Wajant H, Gulder TAM, Abdelmohsen UR (2018) New cytotoxic cyclic peptide from the marine sponge-associated Nocardiopsis sp. UR67. Mar Drugs 16(9). https://doi.org/10.3390/md16090290
Jaspars M, De Pascale D, Andersen JH, Reyes F, Crawford AD, Ianora A (2016) The marine biodiscovery pipeline and ocean medicines of tomorrow. J Mar Biol Assoc U K 96(1):151–158. https://doi.org/10.1017/S0025315415002106
Jayaprakash R, Perera CO (2020) Partial purification and characterization of bioactive peptides from cooked New Zealand green-lipped mussel (Perna canaliculus) protein hydrolyzates. Foods (Basel, Switzerland) 9(7):879. https://doi.org/10.3390/foods9070879
Je J-G, Kim H-S, Lee H-G, Oh J-Y, Lu YA, Wang L, Rho S, Jeon Y-J (2020) Low-molecular weight peptides isolated from seahorse (Hippocampus abdominalis) improve vasodilation via inhibition of angiotensin-converting enzyme in vivo and in vitro. Process Biochem 95:30–35. https://doi.org/10.1016/j.procbio.2020.04.016
Jiang S, Jia Y, Tang Y, Zheng D, Han X, Yu F, Chen Y, Huang F, Yang Z, Ding G (2019) Anti-proliferation activity of a decapeptide from Perinereis aibuhitensis toward human lung cancer H1299 cells. Mar Drugs 17(2). https://doi.org/10.3390/md17020122
Jiménez C (2018) Marine natural products in medicinal chemistry. ACS Med Chem Lett 9(10):959–961. https://doi.org/10.1021/acsmedchemlett.8b00368
Jimenez PC, Wilke DV, Branco PC, Bauermeister A, Rezende-Teixeira P, Gaudêncio SP, Costa-Lotufo LV (2020) Enriching cancer pharmacology with drugs of marine origin. Br J Pharmacol 177(1):3–27. https://doi.org/10.1111/bph.14876
Jo H-Y, Jung W-K, Kim S-K (2008) Purification and characterization of a novel anticoagulant peptide from marine echiuroid worm, Urechis unicinctus. Process Biochem 43(2):179–184. https://doi.org/10.1016/j.procbio.2007.11.011
Jo C, Khan FF, Khan MI, Iqbal J (2017) Marine bioactive peptides: types, structures, and physiological functions. Food Rev Int 33:44–61
Jordan MA, Walker D, de Arruda M, Barlozzari T, Panda D (1998) Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry 37(50):17571–17578. https://doi.org/10.1021/bi9817414
Joseph A (2017) Chapter 9 - Oceans: abode of nutraceuticals, pharmaceuticals, and biotoxins (A. B. T.-I. S. and O. Joseph (ed.); pp. 493–554). Elsevier. https://doi.org/10.1016/B978-0-12-809357-3.00009-6
Kalina R, Gladkikh I, Dmitrenok P, Chernikov O, Koshelev S, Kvetkina A, Kozlov S, Kozlovskaya E, Monastyrnaya M (2018) New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels. Peptides 104:41–49. https://doi.org/10.1016/j.peptides.2018.04.013
Kang HK, Choi M-C, Seo CH, Park Y (2018) Therapeutic properties and biological benefits of marine-derived anticancer peptides. Int J Mol Sci 19(3). https://doi.org/10.3390/ijms19030919
Kang HK, Lee HH, Seo CH, Park Y (2019) Antimicrobial and immunomodulatory properties and applications of marine-derived proteins and peptides. Mar Drugs 17(6). https://doi.org/10.3390/md17060350
Karpiński TM, Adamczak A (2018) Anticancer activity of bacterial proteins and peptides. Pharmaceutics 10(2). https://doi.org/10.3390/pharmaceutics10020054
Kayal E, Bentlage B, Sabrina Pankey M, Ohdera AH, Medina M, Plachetzki DC, Collins AG, Ryan JF (2018) Phylogenomics provides a robust topology of the major cnidarian lineages and insights on the origins of key organismal traits. BMC Evol Biol 18(1):68. https://doi.org/10.1186/s12862-018-1142-0
Kim S-K, Wijesekara I (2010) Development and biological activities of marine-derived bioactive peptides: a review. J Funct Foods 2(1):1–9. https://doi.org/10.1016/j.jff.2010.01.003
Kim E-K, Joung H-J, Kim Y-S, Hwang J-W, Ahn C-B, Jeon Y-J, Moon S-H, Park P-J (2012) Purification of a novel anticancer peptide from enzymatic hydrolysate of Mytilus coruscus. J Microbiol Biotechnol 22(10):1381–1387. https://doi.org/10.4014/jmb.1207.07015
Kim C-H, Go H-J, Oh HY, Park JB, Lee TK, Seo J-K, Elphick MR, Park NG (2018) Identification of a novel antimicrobial peptide from the sea star Patiria pectinifera. Dev Comp Immunol 86:203–213. https://doi.org/10.1016/j.dci.2018.05.002
Ko S-C, Kim E-A, Jung W-K, Kim W-S, Lee S-C, Son K-T, Kim J-I, Jeon Y-J (2016) A hexameric peptide purified from Styela plicata protects against free radical-induced oxidative stress in cells and zebrafish model. RSC Adv 6(59):54169–54178. https://doi.org/10.1039/C6RA06308J
Ko S-C, Jang J, Ye B-R, Kim M-S, Choi I-W, Park W-S, Heo S-J, Jung W-K (2017) Purification and molecular docking study of angiotensin I-converting enzyme (ACE) inhibitory peptides from hydrolysates of marine sponge Stylotella aurantium. Process Biochem 54:180–187. https://doi.org/10.1016/j.procbio.2016.12.023
Kobayashi J (2016) Search for new bioactive marine natural products and application to drug development. Chem Pharm Bull 64(8):1079–1083. https://doi.org/10.1248/cpb.c16-00281
Komatsu K, Shigemori H, Kobayashi J (2001) Dictyonamides A and B, new peptides from marine-derived fungus. J Org Chem 66(18):6189–6192. https://doi.org/10.1021/jo0156767
Kormilets DY, Polyanovsky AD, Dadali VA, Maryanovich AT (2019) Antibiotic peptides. J Evol Biochem Physiol 55(4):269–276. https://doi.org/10.1134/S0022093019040021
Lassoued I, Mora L, Barkia A, Aristoy M-C, Nasri M, Toldrá F (2015) Bioactive peptides identified in thornback ray skin’s gelatin hydrolysates by proteases from Bacillus subtilis and Bacillus amyloliquefaciens. J Proteome 128:8–17. https://doi.org/10.1016/j.jprot.2015.06.016
Lee JK, Jeon J-K, Kim S-K, Byun H-G (2012) Characterization of bioactive peptides obtained from marine invertebrates. Adv Food Nutr Res 65:47–72. https://doi.org/10.1016/B978-0-12-416003-3.00004-4
Lee H-A, Kim I-H, Nam T-J (2015) Bioactive peptide from Pyropia yezoensis and its anti-inflammatory activities. Int J Mol Med 36(6):1701–1706. https://doi.org/10.3892/ijmm.2015.2386
Lee Y, Phat C, Hong S-C (2017) Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications. Peptides 95:94–105. https://doi.org/10.1016/j.peptides.2017.06.002
Lee M-K, Choi J-W, Choi YH, Nam T-J (2019) Protective effect of pyropia yezoensis peptide on dexamethasone-induced myotube atrophy in C2C12 myotubes. Mar Drugs 17(5). https://doi.org/10.3390/md17050284
Leisch M, Egle A, Greil R (2019) Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma. Future Oncol (London, England) 15(2):109–120. https://doi.org/10.2217/fon-2018-0492
Lemes AC, Sala L, Ores JD, Braga ARC, Egea MB, Fernandes KF (2016) A review of the latest advances in encrypted bioactive peptides from protein-rich waste. Int J Mol Sci 17(6). https://doi.org/10.3390/ijms17060950
Li C, Haug T, Styrvold OB, Jørgensen TØ, Stensvåg K (2008) Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis. Dev Comp Immunol 32(12):1430–1440. https://doi.org/10.1016/j.dci.2008.06.013
Li Y, Xu Y, Liu L, Han Z, Lai PY, Guo X, Zhang X, Lin W, Qian P-Y (2012) Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis. Mar Drugs 10(2):319–328. https://doi.org/10.3390/md10020319
Li C, Blencke H-M, Haug T, Jørgensen Ø, Stensvåg K (2014a) Expression of antimicrobial peptides in coelomocytes and embryos of the green sea urchin (Strongylocentrotus droebachiensis). Dev Comp Immunol 43(1):106–113. https://doi.org/10.1016/j.dci.2013.10.013
Li J, Li Q, Li J, Zhou B (2014b) Peptides derived from Rhopilema esculentum hydrolysate exhibit angiotensin converting enzyme (ACE) inhibitory and antioxidant abilities. Molecules (Basel, Switzerland) 19(9):13587–13602. https://doi.org/10.3390/molecules190913587
Li H-X, Lu X-J, Li C-H, Chen J (2015) Molecular characterization of the liver-expressed antimicrobial peptide 2 (LEAP-2) in a teleost fish, Plecoglossus altivelis: antimicrobial activity and molecular mechanism. Mol Immunol 65(2):406–415. https://doi.org/10.1016/j.molimm.2015.02.022
Li Z, Wang P, Jiang C, Cui P, Zhang S (2016) Antibacterial activity and modes of action of phosvitin-derived peptide Pt5e against clinical multi-drug resistance bacteria. Fish Shellfish Immunol 58:370–379. https://doi.org/10.1016/j.fsi.2016.09.044
Li J, Liu Z, Zhao Y, Zhu X, Yu R, Dong S, Wu H (2018a) Novel natural angiotensin converting enzyme (ACE)-inhibitory peptides derived from sea cucumber-modified hydrolysates by adding exogenous proline and a study of their structure–activity relationship. Mar Drugs 16(8). https://doi.org/10.3390/md16080271
Li X, Tang Y, Yu F, Sun Y, Huang F, Chen Y, Yang Z, Ding G (2018b) Inhibition of prostate cancer DU-145 cells proliferation by Anthopleura anjunae oligopeptide (YVPGP) via PI3K/AKT/mTOR signaling pathway. Mar Drugs 16(9). https://doi.org/10.3390/md16090325
Liang X, Zhang X-Y, Nong X-H, Wang J, Huang Z-H, Qi S-H (2016) Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020. Tetrahedron 72(22):3092–3097. https://doi.org/10.1016/j.tet.2016.04.032
Liang X, Nong X-H, Huang Z-H, Qi S-H (2017) Antifungal and antiviral cyclic peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020. J Agric Food Chem 65(25):5114–5121. https://doi.org/10.1021/acs.jafc.7b01238
Lin W-C, Chang H-Y, Chen J-Y (2016) Electrotransfer of the tilapia piscidin 3 and tilapia piscidin 4 genes into skeletal muscle enhances the antibacterial and immunomodulatory functions of Oreochromis niloticus. Fish Shellfish Immunol 50:200–209. https://doi.org/10.1016/j.fsi.2016.01.034
Liu J, Gu B, Yang L, Yang F, Lin H (2018) New anti-inflammatory cyclopeptides from a sponge-derived fungus Aspergillus violaceofuscus. Front Chem 6:226. https://doi.org/10.3389/fchem.2018.00226
Loganzo F, Discafani CM, Annable T, Beyer C, Musto S, Hari M, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM (2003) HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res 63(8):1838–1845
López-Abarrategui C, McBeth C, Mandal SM, Sun ZJ, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, García-Villarino M, Nolasco DO, Falcão R, Cherobim MD, Dias SC, Brandt W, Wessjohann L, Starnbach M, Franco OL, Otero-González AJ (2015) Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J 29(8):3315–3325. https://doi.org/10.1096/fj.14-269860
Lu Z, Van Wagoner RM, Harper MK, Baker HL, Hooper JNA, Bewley CA, Ireland CM (2011) Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J Nat Prod 74(2):185–193. https://doi.org/10.1021/np100613p
Luo X-W, Lin Y, Lu Y-J, Zhou X-F, Liu Y-H (2019) Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chin J Nat Med 17(2):149–154. https://doi.org/10.1016/S1875-5364(19)30017-2
Ma J, Huang H, Xie Y, Liu Z, Zhao J, Zhang C, Jia Y, Zhang Y, Zhang H, Zhang T, Ju J (2017a) Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat Commun 8(1):391. https://doi.org/10.1038/s41467-017-00419-5
Ma X, Nong X-H, Ren Z, Wang J, Liang X, Wang L, Qi S-H (2017b) Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp. SCSIO 41501. Tetrahedron Lett 58(12):1151–1155. https://doi.org/10.1016/j.tetlet.2017.02.005
Machado H, Månsson M, Gram L (2014) Draft genome sequence of photobacterium halotolerans S2753, producer of bioactive secondary metabolites. Genome Announc 2(3). https://doi.org/10.1128/genomeA.00535-14
Mansson M, Nielsen A, Kjærulff L, Gotfredsen CH, Wietz M, Ingmer H, Gram L, Larsen TO (2011) Inhibition of virulence gene expression in Staphylococcus aureus by novel depsipeptides from a marine photobacterium. Mar Drugs 9(12):2537–2552. https://doi.org/10.3390/md9122537
Marggraf MB, Panteleev PV, Emelianova AA, Sorokin MI, Bolosov IA, Buzdin AA, Kuzmin DV, Ovchinnikova TV (2018) Cytotoxic potential of the novel horseshoe crab peptide polyphemusin III. Mar Drugs 16(12). https://doi.org/10.3390/md16120466
Martín J, Sousa DS, Crespo G, Palomo S, González I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F (2013) Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris. Mar Drugs 11(2):387–398. https://doi.org/10.3390/md11020387
Martins A, Vieira H, Gaspar H, Santos S (2014) Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success. Mar Drugs 12(2):1066–1101. https://doi.org/10.3390/md12021066
Mevers E, Liu W-T, Engene N, Mohimani H, Byrum T, Pevzner PA, Dorrestein PC, Spadafora C, Gerwick WH (2011) Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod 74(5):928–936. https://doi.org/10.1021/np200077f
Minic SL, Stanic-Vucinic D, Mihailovic J, Krstic M, Nikolic MR, Cirkovic Velickovic T (2016) Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina. J Proteome 147:132–139. https://doi.org/10.1016/j.jprot.2016.03.043
Mosunova O, Navarro-Muñoz JC, Collemare JB (2020) The biosynthesis of fungal secondary metabolites: from fundamentals to biotechnological applications. Elsevier. https://doi.org/10.1016/B978-0-12-809633-8.21072-8
Munawar A, Ali SA, Akrem A, Betzel C (2018) Snake venom peptides: tools of biodiscovery. Toxins 10(11). https://doi.org/10.3390/toxins10110474
Nakamukai S, Takada K, Furihata K, Ise Y, Okada S, Morii Y, Yamawaki N, Takatani T, Arakawa O, Gustafson KR, Matsunaga S (2018) Stellatolide H, a cytotoxic peptide lactone from a deep-sea sponge Discodermia sp. Tetrahedron Lett 59(26):2532–2536. https://doi.org/10.1016/j.tetlet.2018.05.033
Narayanasamy A, Balde A, Raghavender P, Shashanth D, Abraham J, Joshi I, Nazeer RA (2020) Isolation of marine crab (Charybdis natator) leg muscle peptide and its anti-inflammatory effects on macrophage cells. Biocatal Agric Biotechnol 25:101577. https://doi.org/10.1016/j.bcab.2020.101577
Newman DJ, Cragg GM (2014) Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Mar Drugs 12(1):255–278. https://doi.org/10.3390/md12010255
Oh D-C, Kauffman CA, Jensen PR, Fenical W (2007) Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture. J Nat Prod 70(4):515–520. https://doi.org/10.1021/np060381f
Oh R, Lee MJ, Kim Y-O, Nam B-H, Kong HJ, Kim J-W, Park J, Seo J-K, Kim D-G (2020) Myticusin-beta, antimicrobial peptide from the marine bivalve, Mytilus coruscus. Fish Shellfish Immunol 99:342–352. https://doi.org/10.1016/j.fsi.2020.02.020
Ohtsuka Y, Inagaki H (2020) In silico identification and functional validation of linear cationic α-helical antimicrobial peptides in the ascidian Ciona intestinalis. Sci Rep 10(1):12619. https://doi.org/10.1038/s41598-020-69485-y
Okamoto S, Iwasaki A, Ohno O, Suenaga K (2015) Isolation and structure of Kurahyne B and total synthesis of the Kurahynes. J Nat Prod 78(11):2719–2725. https://doi.org/10.1021/acs.jnatprod.5b00662
Oku N, Adachi K, Matsuda S, Kasai H, Takatsuki A, Shizuri Y (2008) Ariakemicins A and B, novel polyketide-peptide antibiotics from a marine gliding bacterium of the genus Rapidithrix. Org Lett 10(12):2481–2484. https://doi.org/10.1021/ol8007292
Orlov DS, Shamova OV, Eliseev IE, Zharkova MS, Chakchir OB, Antcheva N, Zachariev S, Panteleev PV, Kokryakov VN, Ovchinnikova TV, Tossi A (2019) Redesigning arenicin-1, an antimicrobial peptide from the marine polychaeta arenicola marina, by strand rearrangement or branching, substitution of specific residues, and backbone linearization or cyclization. Mar Drugs 17(6). https://doi.org/10.3390/md17060376
Ott PA, Pavlick AC, Johnson DB, Hart LL, Infante JR, Luke JJ, Lutzky J, Rothschild NE, Spitler LE, Cowey CL, Alizadeh AR, Salama AK, He Y, Hawthorne TR, Bagley RG, Zhang J, Turner CD, Hamid O (2019) A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma. Cancer 125(7):1113–1123. https://doi.org/10.1002/cncr.31892
Ovchinnikova TV (2019) Structure, function, and therapeutic potential of marine bioactive peptides. Mar Drugs 17(9):505. https://doi.org/10.3390/md17090505
Paiva L, Lima E, Neto AI, Baptista J (2016) Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from Ulva rigida C. Agardh protein hydrolysate. J Funct Foods 26:65–76. https://doi.org/10.1016/j.jff.2016.07.006
Pan C-Y, Tsai T-Y, Su B-C, Hui C-F, Chen J-Y (2017) Study of the antimicrobial activity of tilapia Piscidin 3 (TP3) and TP4 and their effects on immune functions in hybrid tilapia (Oreochromis spp.). PLoS One 12(1):e0169678–e0169678. https://doi.org/10.1371/journal.pone.0169678
Panteleev PV, Tsarev AV, Bolosov IA, Paramonov AS, Marggraf MB, Sychev SV, Shenkarev ZO, Ovchinnikova TV (2018) Novel antimicrobial peptides from the arctic polychaeta nicomache minor provide new molecular insight into biological role of the BRICHOS domain. Mar Drugs 16(11). https://doi.org/10.3390/md16110401
Park SY, Kim Y-S, Ahn C-B, Je J-Y (2016) Partial purification and identification of three antioxidant peptides with hepatoprotective effects from blue mussel (Mytilus edulis) hydrolysate by peptic hydrolysis. J Funct Foods 20:88–95. https://doi.org/10.1016/j.jff.2015.10.023
Peng J, Gao H, Zhang X, Wang S, Wu C, Gu Q, Guo P, Zhu T, Li D (2014) Psychrophilins E-H and versicotide C, cyclic peptides from the marine-derived fungus Aspergillus versicolor ZLN-60. J Nat Prod 77(10):2218–2223. https://doi.org/10.1021/np500469b
Petersen L-E, Kellermann MY, Schupp PJ (2020) In: Jungblut S, Liebich V, Bode-Dalby M (eds) Secondary metabolites of marine microbes: from natural products chemistry to chemical ecology BT - YOUMARES 9 - The Oceans: Our Research, Our Future: Proceedings of the 2018 conference for YOUng MArine RESearcher in Oldenburg, Germany. Springer International Publishing, pp 159–180. https://doi.org/10.1007/978-3-030-20389-4_8
Piel J (2006) Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals. Curr Med Chem 13(1):39–50
Pimentel FB, Alves RC, Harnedy PA, FitzGerald RJ, Oliveira MBPP (2019) Macroalgal-derived protein hydrolysates and bioactive peptides: enzymatic release and potential health enhancing properties. Trends Food Sci Technol 93:106–124. https://doi.org/10.1016/j.tifs.2019.09.006
Pozzolini M, Millo E, Oliveri C, Mirata S, Salis A, Damonte G, Arkel M, Scarfì S (2018) Elicited ROS scavenging activity, photoprotective, and wound-healing properties of collagen-derived peptides from the marine sponge Chondrosia reniformis. Mar Drugs 16(12). https://doi.org/10.3390/md16120465
Prasad P, Aalbersberg W, Feussner K-D, Van Wagoner RM (2011) Papuamides E and F, cytotoxic depsipeptides from the marine sponge Melophlus sp. Tetrahedron 67(44):8529–8531. https://doi.org/10.1016/j.tet.2011.08.100
Prompanya C, Fernandes C, Cravo S, Pinto MMM, Dethoup T, Silva AMS, Kijjoa A (2015) A new cyclic hexapeptide and a new isocoumarin derivative from the marine sponge-associated fungus Aspergillus similanensis KUFA 0013. Mar Drugs 13(3):1432–1450. https://doi.org/10.3390/md13031432
Ray A, Okouneva T, Manna T, Miller HP, Schmid S, Arthaud L, Luduena R, Jordan MA, Wilson L (2007) Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate. Cancer Res 67(8):3767–3776. https://doi.org/10.1158/0008-5472.CAN-06-3065
Rekha R, Vaseeharan B, Ishwarya R, Anjugam M, Alharbi NS, Kadaikunnan S, Khaled JM, Al-Anbr MN, Govindarajan M (2018) Searching for crab-borne antimicrobial peptides: Crustin from Portunus pelagicus triggers biofilm inhibition and immune responses of Artemia salina against GFP tagged Vibrio parahaemolyticus Dahv2. Mol Immunol 101:396–408. https://doi.org/10.1016/j.molimm.2018.07.024
Rocha-Lima CM, Bayraktar S, Macintyre J, Raez L, Flores AM, Ferrell A, Rubin EH, Poplin EA, Tan AR, Lucarelli A, Zojwalla N (2012) A phase 1 trial of E7974 administered on day 1 of a 21-day cycle in patients with advanced solid tumors. Cancer 118(17):4262–4270. https://doi.org/10.1002/cncr.27428
Rosa R, Barracco M (2010) Antimicrobial peptides in crustaceans. Inv Surv J 7:262–284
Rosa GP, Tavares WR, Sousa PMC, Pagès AK, Seca AML, Pinto DCGA (2020) Seaweed secondary metabolites with beneficial health effects: an overview of successes in in vivo studies and clinical trials. Mar Drugs 18(1). https://doi.org/10.3390/md18010008
Rouse GW (2001) Annelida (Segmented Worms). eLS. https://doi.org/10.1038/npg.els.0001599
Rowley DC, Kelly S, Kauffman CA, Jensen PR, Fenical W (2003) Halovirs A–E, new antiviral agents from a marine-Derived fungus of the genus Scytalidium. Bioorg Med Chem 11(19):4263–4274. https://doi.org/10.1016/S0968-0896(03)00395-X
Saadaoui I, Rasheed R, Abdulrahman N, Bounnit T, Cherif M, Al Jabri H, Mraiche F (2020) Algae-derived bioactive compounds with anti-lung cancer potential. Mar Drugs 18(4). https://doi.org/10.3390/md18040197
Sable R, Parajuli P, Jois S (2017) Peptides, peptidomimetics, and polypeptides from marine sources: a wealth of natural sources for pharmaceutical applications. Mar Drugs 15(4). https://doi.org/10.3390/md15040124
Safavi-Hemami H, Brogan SE, Olivera BM (2019) Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways. J Proteome 190:12–20. https://doi.org/10.1016/j.jprot.2018.05.009
Salger SA, Cassady KR, Reading BJ, Noga EJ (2016) A diverse family of host-defense peptides (Piscidins) exhibit specialized anti-bacterial and anti-protozoal activities in fishes. PLoS One 11(8):e0159423. https://doi.org/10.1371/journal.pone.0159423
Salvador LA, Biggs JS, Paul VJ, Luesch H (2011) Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J Nat Prod 74(5):917–927. https://doi.org/10.1021/np200076t
Sánchez A, Vázquez A (2017) Bioactive peptides: a review. Food Qual Saf 1(1):29–46. https://doi.org/10.1093/fqsafe/fyx006
Schillaci D, Cusimano MG, Spinello A, Barone G, Russo D, Vitale M, Parrinello D, Arizza V (2014) Paracentrin 1, a synthetic antimicrobial peptide from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation. AMB Express 4:78. https://doi.org/10.1186/s13568-014-0078-z
Schmidt CA, Daly NL, Wilson DT (2019) Coral venom toxins. Front Ecol Evol 7:320. https://doi.org/10.3389/fevo.2019.00320
Scopel M, Abraham W-R, Henriques AT, Macedo AJ (2013) Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis. Bioorg Med Chem Lett 23(3):624–626. https://doi.org/10.1016/j.bmcl.2012.12.020
Seo J-K, Lee MJ, Go H-J, Do Kim G, Do Jeong H, Nam B-H, Park NG (2013) Purification and antimicrobial function of ubiquitin isolated from the gill of Pacific oyster, Crassostrea gigas. Mol Immunol 53(1–2):88–98. https://doi.org/10.1016/j.molimm.2012.07.003
Serova M, de Gramont A, Bieche I, Riveiro ME, Galmarini CM, Aracil M, Jimeno J, Faivre S, Raymond E (2013) Predictive factors of sensitivity to elisidepsin, a novel Kahalalide F-derived marine compound. Mar Drugs 11(3):944–959. https://doi.org/10.3390/md11030944
Shan Z, Zhu K, Peng H, Chen B, Liu J, Chen F, Ma X, Wang S, Qiao K, Wang K (2016) The new antimicrobial peptide SpHyastatin from the Mud Crab Scylla paramamosain with multiple antimicrobial mechanisms and high effect on bacterial infection. Front Microbiol 7:1140. https://doi.org/10.3389/fmicb.2016.01140
Sheih I-C, Fang TJ, Wu T-K, Lin P-H (2010) Anticancer and antioxidant activities of the peptide fraction from algae protein waste. J Agric Food Chem 58(2):1202–1207. https://doi.org/10.1021/jf903089m
Shenkar N, Swalla BJ (2011) Global diversity of ascidiacea. PLoS One 6(6):e20657. https://doi.org/10.1371/journal.pone.0020657
Shin HJ, Rashid MA, Cartner LK, Bokesch HR, Wilson JA, McMahon JB, Gustafson KR (2015) Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. Tetrahedron Lett 56(28):4215–4219. https://doi.org/10.1016/j.tetlet.2015.05.058
Shin SC, Ahn IH, Ahn DH, Lee YM, Lee J, Lee JH, Kim H-W, Park H (2017) Characterization of two antimicrobial peptides from antarctic fishes (Notothenia coriiceps and Parachaenichthys charcoti). PLoS One 12(1):e0170821. https://doi.org/10.1371/journal.pone.0170821
Sila A, Bougatef A (2016) Antioxidant peptides from marine by-products: isolation, identification and application in food systems. A review. J Funct Foods 21:10–26. https://doi.org/10.1016/j.jff.2015.11.007
Solstad RG, Li C, Isaksson J, Johansen J, Svenson J, Stensvåg K, Haug T (2016) Novel antimicrobial peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp post-translational modifications. PLoS One 11(3):e0151820. https://doi.org/10.1371/journal.pone.0151820
Song R, Wei R, Luo H, Yang Z (2014a) Isolation and identification of an antiproliferative peptide derived from heated products of peptic hydrolysates of half-fin anchovy (Setipinna taty). J Funct Foods 10:104–111. https://doi.org/10.1016/j.jff.2014.06.010
Song Y, Li Q, Liu X, Chen Y, Zhang Y, Sun A, Zhang W, Zhang J, Ju J (2014b) Cyclic hexapeptides from the deep south china sea-derived streptomyces scopuliridis SCSIO ZJ46 active against pathogenic gram-positive bacteria. J Nat Prod 77(8):1937–1941. https://doi.org/10.1021/np500399v
Sudhakar S, Nazeer RA (2015) Preparation of potent antioxidant peptide from edible part of shortclub cuttlefish against radical mediated lipid and DNA damage. LWT Food Sci Technol 64(2):593–601. https://doi.org/10.1016/j.lwt.2015.06.031
Sugumaran M, Robinson WE (2012) Structure, biosynthesis and possible function of tunichromes and related compounds. Comp Biochem Physiol B: Biochem Mol Biol 163(1):1–25. https://doi.org/10.1016/j.cbpb.2012.05.005
Sun P, Maloney KN, Nam S-J, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W (2011) Fijimycins A–C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem 19(22):6557–6562. https://doi.org/10.1016/j.bmc.2011.06.053
Sun L, Wu B, Yan M, Hou H, Zhuang Y (2019a) Antihypertensive effect in vivo of QAGLSPVR and its transepithelial transport through the Caco-2 cell monolayer. Mar Drugs 17(5). https://doi.org/10.3390/md17050288
Sun S, Xu X, Sun X, Zhang X, Chen X, Xu N (2019b) Preparation and identification of ACE inhibitory peptides from the marine macroalga Ulva intestinalis. Mar Drugs 17(3). https://doi.org/10.3390/md17030179
Tak YJ, Kim YJ, Lee JG, Yi Y-H, Cho YH, Kang GH, Lee SY (2019) Effect of oral ingestion of low-molecular collagen peptides derived from skate (Raja Kenojei) skin on body fat in overweight adults: a randomized, double-blind, placebo-controlled trial. Mar Drugs 17(3). https://doi.org/10.3390/md17030157
Tan RX, Jensen PR, Williams PG, Fenical W (2004) Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. J Nat Prod 67(8):1374–1382. https://doi.org/10.1021/np049920b
Tareq FS, Lee MA, Lee H-S, Lee J-S, Lee Y-J, Shin HJ (2014) Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis. Mar Drugs 12(2):871–885. https://doi.org/10.3390/md12020871
Thirumurugan D, Cholarajan A, Raja S, Vijayakumar R (2018) An introductory chapter: secondary metabolites. https://doi.org/10.5772/intechopen.79766
Thornburg CC, Thimmaiah M, Shaala LA, Hau AM, Malmo JM, Ishmael JE, Youssef DTA, McPhail KL (2011) Cyclic depsipeptides, grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya cyanobacterium. J Nat Prod 74(8):1677–1685. https://doi.org/10.1021/np200270d
Tian T, Takada K, Ise Y, Ohtsuka S, Okada S, Matsunaga S (2020) Microsclerodermins N and O, cytotoxic cyclic peptides containing a p-ethoxyphenyl moiety from a deep-sea marine sponge Pachastrella sp. Tetrahedron 76(10):130997. https://doi.org/10.1016/j.tet.2020.130997
Torres-García C, Pulido D, Albericio F, Royo M, Nicolás E (2014) Triazene as a powerful tool for solid-phase derivatization of phenylalanine containing peptides: zygosporamide analogues as a proof of concept. J Org Chem 79(23):11409–11415. https://doi.org/10.1021/jo501830w
Tripathi A, Puddick J, Prinsep MR, Rottmann M, Tan LT (2010) Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 73(11):1810–1814. https://doi.org/10.1021/np100442x
Umnyakova ES, Gorbunov NP, Zhakhov AV, Krenev IA, Ovchinnikova TV, Kokryakov VN, Berlov MN (2018) Modulation of Human Complement System by Antimicrobial Peptide Arenicin-1 from Arenicola marina. Mar Drugs 16(12). https://doi.org/10.3390/md16120480
Vaklavas C, Forero A (2014) Management of metastatic breast cancer with second-generation antibody-drug conjugates: focus on glembatumumab vedotin (CDX-011, CR011-vcMMAE). BioDrugs 28(3):253–263. https://doi.org/10.1007/s40259-014-0085-2
Van Bohemen A-I, Zalouk-Vergnoux A, Poirier L, Phuong NN, Inguimbert N, Ben Haj Salah K, Ruiz N, Pouchus YF (2016) Development and validation of LC-MS methods for peptaibol quantification in fungal extracts according to their lengths. J Chromatogr B 1009–1010:25–33. https://doi.org/10.1016/j.jchromb.2015.11.039
Van Soest RWM, Boury-Esnault N, Vacelet J, Dohrmann M, Erpenbeck D, De Voogd NJ, Santodomingo N, Vanhoorne B, Kelly M, Hooper JNA (2012) Global diversity of sponges (Porifera). PLoS One 7(4):e35105–e35105. https://doi.org/10.1371/journal.pone.0035105
Wang Q, Li W, He Y, Ren D, Kow F, Song L, Yu X (2014) Novel antioxidative peptides from the protein hydrolysate of oysters (Crassostrea talienwhanensis). Food Chem 145:991–996. https://doi.org/10.1016/j.foodchem.2013.08.099
Wang N, Cui C-B, Li C-W (2016a) A new cyclic dipeptide penicimutide: the activated production of cyclic dipeptides by introduction of neomycin-resistance in the marine-derived fungus Penicillium purpurogenum G59. Arch Pharm Res 39(6):762–770. https://doi.org/10.1007/s12272-016-0751-7
Wang N, Huang Y, Li A, Jiang H, Wang J, Li J, Qiu L, Li K, Lu Y (2016b) Hydrostatin-TL1, an anti-inflammatory active peptide from the venom gland of hydrophis cyanocinctus in the South China Sea. Int J Mol Sci 17(11). https://doi.org/10.3390/ijms17111940
Wang A, Zhang F, Guo Z, Chen Y, Zhang M, Yu H, Wang Y (2019a) Characterization of a cathelicidin from the colubrinae snake, Sinonatrix annularis. Zool Sci 36(1):68–76. https://doi.org/10.2108/zs180064
Wang X, Yu H, Xing R, Liu S, Chen X, Li P (2019b) Preparation and Identification of antioxidative peptides from Pacific Herring (Clupea pallasii) protein. Molecules 24(10). https://doi.org/10.3390/molecules24101946
Watters DJ (2018) Ascidian toxins with potential for drug development. Mar Drugs 16(5). https://doi.org/10.3390/md16050162
Wei L, Gao J, Zhang S, Wu S, Xie Z, Ling G, Kuang Y-Q, Yang Y, Yu H, Wang Y (2015) Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and anti-inflammatory activity and special mechanism. J Biol Chem 290(27):16633–16652. https://doi.org/10.1074/jbc.M115.642645
Won TH, Kim C-K, Lee S-H, Rho BJ, Lee SK, Oh D-C, Oh K-B, Shin J (2015) Amino acid-derived metabolites from the ascidian Aplidium sp. Mar Drugs 13(6). https://doi.org/10.3390/md13063836
Wu HT, Jin WG, Sun SG, Li XS, Duan XH, Li Y, Yang YT, Han JR, Zhu BW (2016) Identification of antioxidant peptides from protein hydrolysates of scallop (Patinopecten yessoensis) female gonads. Eur Food Res Technol 242(5):10–722. https://doi.org/10.1007/s00217-015-2579-7
Wu M, Li Y, Chang Q, Zhao X, Chen Q (2018) Total synthesis and modification of proline-rich cyclopeptides Phakellistatins 17 and 18 isolated from marine sponge. Tetrahedron Lett 59(45):4011–4014. https://doi.org/10.1016/j.tetlet.2018.09.059
Wyche TP, Hou Y, Vazquez-Rivera E, Braun D, Bugni TS (2012) Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp. J Nat Prod 75(4):735–740. https://doi.org/10.1021/np300016r
Yang X-R, Zhang L, Ding D-G, Chi C-F, Wang B, Huo J-C (2019) Preparation, identification, and activity evaluation of eight antioxidant peptides from protein hydrolysate of Hairtail (Trichiurus japonicas) muscle. Mar Drugs 17(1). https://doi.org/10.3390/md17010023
You M, Liao L, Hong SH, Park W, Kwon DI, Lee J, Noh M, Oh D-C, Oh K-B, Shin J (2015) Lumazine peptides from the marine-derived fungus Aspergillus terreus. Mar Drugs 13(3). https://doi.org/10.3390/md13031290
Youssef DTA, Shaala LA, Mohamed GA, Badr JM, Bamanie FH, Ibrahim SRM (2014) Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei. Mar Drugs 12(4):1911–1923. https://doi.org/10.3390/md12041911
Youssef FS, Ashour ML, Singab ANB, Wink M (2019) A comprehensive review of bioactive peptides from marine fungi and their biological significance. Mar Drugs 17(10). https://doi.org/10.3390/md17100559
Zan J, Li Z, Tianero MD, Davis J, Hill RT, Donia MS (2019) A microbial factory for defensive kahalalides in a tripartite marine symbiosis. Science 364(6445):eaaw6732. https://doi.org/10.1126/science.aaw6732
Zhang Y, Li X-M, Feng Y, Wang B-G (2010) Phenethyl-alpha-pyrone derivatives and cyclodipeptides from a marine algous endophytic fungus Aspergillus niger EN-13. Nat Prod Res 24(11):1036–1043. https://doi.org/10.1080/14786410902940875
Zhang Q, Song C, Zhao J, Shi X, Sun M, Liu J, Fu Y, Jin W, Zhu B (2018) Separation and characterization of antioxidative and angiotensin converting enzyme inhibitory peptide from Jellyfish Gonad hydrolysate. Molecules (Basel, Switzerland) 23(1). https://doi.org/10.3390/molecules23010094
Zheng J, Zhu H, Hong K, Wang Y, Liu P, Wang X, Peng X, Zhu W (2009) Novel cyclic hexapeptides from marine-derived fungus, Aspergillus sclerotiorum PT06-1. Org Lett 11(22):5262–5265. https://doi.org/10.1021/ol902197z
Zheng Z, Jiang H, Huang Y, Wang J, Qiu L, Hu Z, Ma X, Lu Y (2016) Screening of an anti-inflammatory peptide from hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Sci Rep 6(1):25672. https://doi.org/10.1038/srep25672
Zhou X, Fang P, Tang J, Wu Z, Li X, Li S, Wang Y, Liu G, He Z, Gou D, Yao X, Wang L (2016) A novel cyclic dipeptide from deep marine-derived fungus Aspergillus sp. SCSIOW2. Nat Prod Res 30(1):52–57. https://doi.org/10.1080/14786419.2015.1033623
Zhu B, Dong X, Zhou D, Gao Y, Yang J, Li D, Zhao X, Ren T, Ye W, Tan H, Wu H, Yu C (2012) Physicochemical properties and radical scavenging capacities of pepsin-solubilized collagen from sea cucumber Stichopus japonicus. Food Hydrocoll 28(1):182–188. https://doi.org/10.1016/j.foodhyd.2011.12.010
Zhuang Z, Yang X, Huang X, Gu H, Wei H, He Y, Deng L (2017) Three new piscidins from orange-spotted grouper (Epinephelus coioides): phylogeny, expression and functional characterization. Fish Shellfish Immunol 66:240–253. https://doi.org/10.1016/j.fsi.2017.04.011
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Dehghani, M., Taherizadeh, M.R., Homaei, A. (2022). Marine Origin Bioactive Peptides: Novel Advances in the Therapeutic Potential. In: Jana, S., Jana, S. (eds) Marine Biomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-5374-2_11
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