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Natural Polyphenols a New Paradigm in Treatment of Various Diseases

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Polyphenols-based Nanotherapeutics for Cancer Management

Abstract

Natural products are infinite resources of phytochemicals which continue to serve humans as natural drugs since ancient times. Polyphenols are natural plant-derived pharmacologically active compounds which have potential therapeutic properties including antioxidant, anti-inflammatory, and antitumor. Edible plants particularly phytochemicals and their biological activity in the human body is a trending subject of scientific investigations. Polyphenols are divided into three categories: flavonoids, non-flavonoids, and phenolic acids. Flavonoids have been further categorized as flavones, flavanones, flavonols, flavanols, and isoflavones, even as phenolic acids are classified into hydroxybenzoic and hydroxycinnamic acids. Polyphenols are bioactive compounds to manage the several autoimmune disorder such as vitiligo, ulcerative colitis, and multiple sclerosis through eliciting various intracellular pathways specifically (NF-κB), signaling pathway, mitogen-activated protein kinases (MAPKs) pathway, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. This chapter tends to provide a new insight into biomedical application of polyphenol for cancer, UTIs, diabetes, cardiovascular disorders, and neurodegenerative disorders.

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  1. All Authors contributed equally.

Authors and Affiliations

  1. State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei Province, College of Life Science, Hubei University, Wuhan, China

    Ali Raza Ishaq & Chen Shouwen

  2. Departments of Zoology, Government College University Faisalabad, Faisalabad, Pakistan

    Tahira Younis & Ayesha Noor

  3. Department of Zoology, University of Education, Lahore, Pakistan

    Faiza Jabeen

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  1. Ali Raza Ishaq
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  2. Tahira Younis
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  3. Ayesha Noor
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  4. Faiza Jabeen
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  5. Chen Shouwen
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  1. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Shams Tabrez

  2. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Mohammad Imran Khan

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Ishaq, A.R., Younis, T., Noor, A., Jabeen, F., Shouwen, C. (2021). Natural Polyphenols a New Paradigm in Treatment of Various Diseases. In: Tabrez, S., Imran Khan, M. (eds) Polyphenols-based Nanotherapeutics for Cancer Management. Springer, Singapore. https://doi.org/10.1007/978-981-16-4935-6_2

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