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How Physics Can Regulate Stem Cells’ Fate: An Overview on Cellular Interactions with Their Substrate

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Engineering Materials for Stem Cell Regeneration

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Abstract

Despite astounding developments in regenerative medicine, efficient cell differentiation has still met some struggles in conventional methods. Since mechanical ques are responsible for the communications between stem cells and their niche, advanced tissue engineering has introduced the novel branch of mechanobiology to manipulate organogenesis. Taking advantage of unique topographical microenvironment and physiochemical features, nanomaterials provide the opportunity to control cellular functions through multidimensional approaches. An overview of mechanobiology science reveals an interface of the disparate scientific disciplines from biology to mechanics. Accordingly, mathematical modeling is instrumental in the explosive progress of this area, assisting experimental studies on myriad levels. This chapter is inspired to generate discussions in mechanobiology from the fundamental conceptions to the cutting-edge developments. Moreover, the role of various biomaterials, magnetic nanoparticles, and conductive segments are examined, besides their relative physio-mechanical computations.

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Authors and Affiliations

  1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Parinaz Abdollahiyan & Ahad Mokhtarzadeh

  2. Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Fatemeh Oroojalian

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  1. Parinaz Abdollahiyan
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  2. Fatemeh Oroojalian
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  3. Ahad Mokhtarzadeh
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Correspondence to Ahad Mokhtarzadeh .

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  1. Department of Nanotechnology, School of Biological Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Faheem A. Sheikh

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Abdollahiyan, P., Oroojalian, F., Mokhtarzadeh, A. (2021). How Physics Can Regulate Stem Cells’ Fate: An Overview on Cellular Interactions with Their Substrate. In: Sheikh, F.A. (eds) Engineering Materials for Stem Cell Regeneration. Springer, Singapore. https://doi.org/10.1007/978-981-16-4420-7_5

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