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Advances in Microfluidic Techniques for Detection and Isolation of Circulating Tumor Cells

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Advanced Micro- and Nano-manufacturing Technologies

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

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Abstract

Circulating tumor cells (CTC) are released from the primary tumors into the bloodstream. These CTCs hold a crucial role in cancer metastasis; hence, they could be used for early diagnosis of cancer, evaluation of cancer development, and even helpful in drug development. In recent years, many novel microfluidic-based techniques for CTCs detection and isolation are explored. However, still, they cannot fulfill the current clinical requirement because of numerous current technological limitations. The heterogeneous nature of CTCs makes it further complicated. This chapter provides current advancements in CTC detection and isolation in a microfluidics platform. Different techniques are evaluated based on various parameters, such as purity, throughput, and cell viability. We discussed the concepts, limitations, advantages, drawbacks, and challenges, and at the end, we also discussed future application prospect.

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Authors and Affiliations

  1. Indian Institute of Technology Madras, Chennai, Tamil Nadu, 600036, India

    K. Mirkale, R. Gaikwad, B. Majhy, G. Narendran & A. K. Sen

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  1. K. Mirkale
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  2. R. Gaikwad
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  3. B. Majhy
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  4. G. Narendran
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  5. A. K. Sen
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Correspondence to A. K. Sen .

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Editors and Affiliations

  1. Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Shrikrishna Nandkishor Joshi

  2. School of Biochemical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh, India

    Pranjal Chandra

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Mirkale, K., Gaikwad, R., Majhy, B., Narendran, G., Sen, A.K. (2022). Advances in Microfluidic Techniques for Detection and Isolation of Circulating Tumor Cells. In: Joshi, S.N., Chandra, P. (eds) Advanced Micro- and Nano-manufacturing Technologies. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-3645-5_8

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  • DOI: https://doi.org/10.1007/978-981-16-3645-5_8

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