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Magnetic Nanoparticles for Image-Guided Drug Delivery

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Magnetic Nanoparticles

Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

Abstract

Owing to the advances in nanotechnology, magnetic iron oxide nanoparticle has been emerged as a promising theranostic agent due to their intrinsic diagnostic capabilities for various biomedical applications like imaging (specifically, magnetic resonance imaging/MRI) techniques, Magnetic Targeted Carrier (MTC) drug technology, hyperthermia properties, and novel therapeutics. Extensive and significant pre-clinical and clinical investigations have explored various characteristics of magnetic iron oxide nanoparticle which includes surface modification via conjugation with targeting components to provide multimodal functionalities. These important and valuable characteristics can be applied to image-guided drug delivery especially magnetic resonance-based drug delivery. MRI-based guided drug delivery provide guidance and monitor drug delivery at target site as well as ability to evaluate therapeutic response in real time. This review summarizes physiochemical properties and pharmacokinetics of magnetic iron oxide nanoparticle as well as an attempt to provide an overview of hierarchical advances describing theranostic system which includes approaches and strategies utilized by magnetic iron oxide nanoparticle-based nanoplatform as well as enhancement in the application of image-guided drug delivery technique.

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  1. Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, 689101, India

    Ruby Varghese, Namitha Vijay & Yogesh Bharat Dalvi

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  1. Ruby Varghese
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  2. Namitha Vijay
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  1. IIUCNN, Mahatma Gandhi University, Kottayam, Kerala, India

    K. S. Joshy

  2. IIUCNN, Mahatma Gandhi University, Kottayam, Kerala, India

    Thomas Sabu

  3. School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford, UK

    Vijay Kumar Thakur

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Varghese, R., Vijay, N., Dalvi, Y.B. (2021). Magnetic Nanoparticles for Image-Guided Drug Delivery. In: Joshy, K.S., Sabu, T., Thakur, V.K. (eds) Magnetic Nanoparticles. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-16-1260-2_3

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