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Current Evidence and Future Perspectives About Herbal Therapeutics for Cancer Therapy

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  • First Online:
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer leads to dynamic alterations in the genome and causes millions of deaths worldwide. It has become a major health concern in the past decades and is now with uncontrolled cell growth and proliferation. Although there are different types of therapeutics against cancer with their pros and cons. Herbal products are used as an alternative therapy due to their anticarcinogenic and chemoprotective potentials. Natural antioxidants and phytopharmaceuticals might exert cancer chemopreventive effects through several mechanisms. Two evidently contradictory and virtually supportive therapeutic approaches for the ROS (reactive oxygen species) induced cancer involve chemoprevention by employing antioxidants and ROS-mediated anticancer therapy. Translation of such products into clinical practice remains difficult due to their limited bioavailability and/or toxicity. Bioavailability and concentration around tumor tissues can be improved with alternate therapeutic modalities and novel delivery approaches. Great progress had been made in the identification and explorative analysis of natural chemopreventive agents using modern analytical tools. This chapter aims to outline the current perspectives of herbal therapeutics for the treatment of ROS-induced cancer. In addition to the above, the chapter will also extend to the prospects with an elaborative guide for natural product researchers to carry out systematic studies and research in preventing and treating cancer.

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Abbreviations

ADR:

Adverse drug reaction

COX-2:

Cyclooxygenase 2

CNT:

Carbon nanotubes

ESI:

Electrospray ionization

FTIR:

Fourier Transform Infrared Spectroscopy

GC-MS:

Gas chromatography-mass spectrometry analysis

HBV:

Hepatitis B virus

HCG:

10-Hydroxy camptothecin

HCV:

Hepatitis C virus

HepG2:

Human hepatocellular carcinoma cells

HRMS:

High-resolution mass spectrometry

HPV:

Human Papilloma Virus

LC-MS:

Liquid chromatography-mass spectrometry

LC-NMR:

Liquid chromatography-nuclear magnetic resonance spectrometry

LDHA:

Lactate dehydrogenase A

MAPK:

Mitogen-activated protein kinase pathway

MDR:

Multidrug resistance

MWNTs:

Multiwalled carbon nanotubes

NOX:

NADPH oxidase

Nfr2:

Nuclear factor-erythroid factor 2-related factor 2

OXCT1:

3-Oxoacid CoA-transferase 1

PCD:

Programmed cell death pathways

PI3K/Akt:

Phosphoinositide 3-kinases/protein kinase B

PP1:

Protein phosphatase 1

PP2A:

Protein phosphatase 2A

PR MT5:

Protein arginine methyltransferase 5

RCS:

Reactive chloride species

RIE:

Rat intestinal epithelial

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

RSS:

Reactive sulfur species

SNS:

Sympathetic nervous system

STAT3:

Signal transducer and activator of transcription 3

SWNTs:

Single-walled carbon nanotubes

TOF:

Time of flight

TPA:

12-O-Tetradecanoyl phorbol-13-acetate

UGDH/UDP:

Glucose 6-dehydrogenase

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Authors and Affiliations

  1. Department of Pharmaceutical Analysis, St. James’ College of Pharmaceutical Sciences (SJCOPS), Chalakudy, Kerala, India

    David Paul & K. S. Aswathi

  2. Department of Natural Products, National Institute of Pharmaceutical Education & Research [NIPER-Kolkata], Chunilal Bhawan, Kolkata, West Bengal, India

    A. Parag & Satheesh Kumar Nanjappan

  3. Department of Life Sciences, International Medical University, KualaLumpur, Malaysia

    Dinesh Kumar Chellappan

  4. Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, West Bengal, India

    Somasundaram Arumugam

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  1. David Paul
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  2. A. Parag
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  3. K. S. Aswathi
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  4. Dinesh Kumar Chellappan
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  5. Somasundaram Arumugam
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  6. Satheesh Kumar Nanjappan
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Correspondence to Satheesh Kumar Nanjappan .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Paul, D., Parag, A., Aswathi, K.S., Chellappan, D.K., Arumugam, S., Nanjappan, S.K. (2022). Current Evidence and Future Perspectives About Herbal Therapeutics for Cancer Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_269-1

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