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Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Abstract

Cancer is characterized by the uncontrolled abnormal proliferation of cells; it can be caused due to various reasons and one of the reasons is the continued oxidative stress which in turn is responsible for the early start and development of various types of cancers. It is the second most disease that causes death. So, it has been a great concern in accurate and early-stage detection to start effective treatment as soon as possible. Oxidative stress biomarkers in cancer are important in the detection of the disease state. Hence, in recent times research on the identification of oxidative stress biomarkers is increasing very rapidly. There are different omics-based approaches available that include genomics, proteomics, and metabolomics for the identification of noninvasive and reliable biomarkers. Due to the large diversity in the oxidative stress of different diseases and conditions, it is very important to take into account when selecting the correct biomarker. The recent advances in various mass spectrometry-based analytical platforms are helping in the detection of all biomarkers even if they are in very low concentration in the clinical sample. However, liquid chromatography coupled with mass spectrometry (LC-MS) and capillary electrophoresis coupled with mass spectrometry (CE-MS) are showing the leading applicability in the identification of protein- and metabolite-related biomarkers. This chapter provides detailed information on different biomarkers involved in various types of cancers, different omics approaches, and the advanced analytical platforms used for the identification of those biomarkers. It also provides detailed information on challenges being faced during the identification of biomarkers.

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Acknowledgments

Authors are also thankful to the Science and Engineering Research Board (SERB), DST, New Delhi, India, for the financial support for this research work under Extra Mural Research Funding (EMR/2016/002098).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Balanagar, Telangana, India

    Siva Nageswara Rao Gajula & Devi Naga Jyothi Bale

  2. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER Kolkata), Chunilal Bhawan, Manicktala, Kolkata, West Bengal, India

    Satheesh Kumar Nanjappan

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  1. Siva Nageswara Rao Gajula
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  2. Devi Naga Jyothi Bale
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  3. Satheesh Kumar Nanjappan
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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Bimal K. Ray

  3. CSIR-Indian Institute of Chemical Biology, Kolkata, India

    Susanta Roychoudhury

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Gajula, S.N.R., Bale, D.N.J., Nanjappan, S.K. (2022). Analytical and Omics Approaches in the Identification of Oxidative Stress-Induced Cancer Biomarkers. In: Chakraborti, S., Ray, B.K., Roychoudhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-9411-3_172

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