TRP Channels, Oxidative Stress, and Cancer

Mandal, Amritlal; Varghese, Mathews Valuparampil; James, Joel; Chakraborti, Sajal

doi:10.1007/978-981-15-4501-6_80-1

Amritlal Mandal⁴,
Mathews Valuparampil Varghese⁵,
Joel James⁵ &
…
Sajal Chakraborti⁶

39 Accesses

Abstract

Transient receptor potential (TRP) channels have evolved as trigger for many physiological and pathophysiological conditions including cancer. These are non-selective cation-specific ion channels and are activated by many endogenous and exogenous stimuli including certain chemicals, changes in osmotic condition, and temperature. Until now, studies on TRP channels regarding its role in cancer progression are only handful. Most of the studies in this specific area have been done using either in vitro or in vivo models. Recent development in bioinformatics and big data analysis provided an advanced platform to study tumor biology, target identification, genetic analysis, and anti-cancer drug development. Exploiting this combination of strategies new research is being carried out to link TRP channels, oxidative stress, and cancer pathology. Certain TRP channel family members have been identified to be up- or downregulated and play either tumor enhancer or suppressor functions. TRPM2 and TRPA1 are the two main redox-sensor ion channels that have been relatively well-investigated in relation to cancer and the present chapter highlights the major roles played by these channels in cancer pathophysiology. The chapter briefly discusses certain tumor-specific expression pattern of TRP channels, their biological role under oxidative stress, and possible use of some proof of concepts for developing therapeutic strategies for cancer management.

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Abbreviations

AKT::

Protein kinase B (PKB)

also known as AKT

ATP::

Adenosine triphosphate

bFGF::

Basic fibroblast growth factor

Ca²⁺::

Calcium

[Ca²⁺]_i::

Intracellular calcium

CADPR::

Cyclic ADP ribose

CaM::

Calmodulin

DAG::

Diacylglycerol

ECM::

Extracellular matrix

ERK::

Extracellular signal-regulated kinase

FOXO3a::

Fork head box transcription factor 3a

GSH::

Glutathione

GSH-Px::

Glutathione peroxidase

H₂O₂::

Hydrogen peroxide

HIF::

Hypoxia-inducible factor

IC₅₀::

Half maximal inhibitory concentration

ICGC::

International cancer genome consortium

InsP3::

Inositol 1,4,5-triphosphate

IR-injury::

Ischemia-reperfusion injury

JNK::

c-Jun N-terminal kinase

KO::

Knock out

MCL-1::

Myeloid leukemia cell-1

mTOR::

The mammalian target of rapamycin

NAC::

N-acetyl-L-cysteine

NRF2::

Nuclear factor erythroid 2-related factor 2

OCR::

Oxygen consumption rate

PARG::

Poly (ADP-ribose) glycohydrolase

PARP::

Poly (ADP-ribose) polymerase

PDGF::

Platelet-derived growth factor

PI3K::

Phosphoinositide 3-kinase

PLC::

Phospholipase C

PYK2::

Proline-rich tyrosine kinase-2

RAS::

Rat sarcoma; a family of oncogene

SCLC::

Small cell lung carcinoma

SOD::

Superoxide dismutase

TGF::

Transforming growth factor

TRP channels::

Transient receptor potential channels

VEGF::

Vascular endothelial growth factor

VEGFR::

Vascular endothelial growth factor receptor

WT::

Wild type

References

Aarts M, Iihara K, Wei W-L, Xiong Z-G, Arundine M, Cerwinski W, MacDonald JF, Tymianski M (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863–877
Article CAS Google Scholar
Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y (2018) TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem 293:3637–3650. https://doi.org/10.1074/jbc.M117.817635
Article CAS PubMed PubMed Central Google Scholar
Almasi S, Sterea AM, Fernando W, Clements DR, Marcato P, Hoskin DW, Gujar S, El Hiani Y (2019) TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway. Sci Rep 9:4182. https://doi.org/10.1038/s41598-019-40330-1
Article CAS PubMed PubMed Central Google Scholar
Andrikopoulos P, Eccles SA, Yaqoob MM (2017) Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells. Cell Signal 37:12–30
Article CAS Google Scholar
Antoniotti S, Lovisolo D, Fiorio Pla A, Munaron L (2002) Expression and functional role of bTRPC1 channels in native endothelial cells. FEBS Lett 510:189–195. https://doi.org/10.1016/S0014-5793(01)03256-2
Article CAS PubMed Google Scholar
Asghar MY, Magnusson M, Kemppainen K, Sukumaran P, Löf C, Pulli I, Kalhori V, Törnquist K (2015) Transient receptor potential canonical 1 (TRPC1) channels as regulators of sphingolipid and VEGF receptor expression: implications for thyroid cancer cell migration and proliferation. J Biol Chem 290:16116–16131. https://doi.org/10.1074/jbc.M115.643668
Article CAS PubMed PubMed Central Google Scholar
Azimi I, Milevskiy MJG, Kaemmerer E, Turner D, Yapa KTDS, Brown MA, Thompson EW, Roberts-Thomson SJ, Monteith GR (2017) TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells. J Cell Sci 130:2292. https://doi.org/10.1242/jcs.196659
Article CAS PubMed Google Scholar
Balzer M, Lintschinger B, Groschner K (1999) Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells1. Cardiovasc Res 42:543–549. https://doi.org/10.1016/s0008-6363(99)00025-5
Article CAS PubMed Google Scholar
Bao L, Chen S-J, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang X-Q, Hirschler-Laszkiewicz I, Wang H-G, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA (2016) Depletion of the human Ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics. J Biol Chem 291:24449–24464. https://doi.org/10.1074/jbc.M116.747147
Article CAS PubMed PubMed Central Google Scholar
Bharate SS, Bharate SB (2012) Modulation of thermoreceptor TRPM8 by cooling compounds. ACS Chem Neurosci 3:248–267. https://doi.org/10.1021/cn300006u
Article CAS PubMed PubMed Central Google Scholar
Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N (2016) Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget 7:29063–29080. https://doi.org/10.18632/oncotarget.8666
Article PubMed PubMed Central Google Scholar
Büch TRH, Büch EAM, Boekhoff I, Steinritz D, Aigner A (2018) Role of chemosensory TRP channels in lung cancer. Pharmaceuticals (Basel, Switzerland) 11(90). https://doi.org/10.3390/ph11040090
Chen S-j, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang X-Q, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang H-G, Madesh M, Cheung JY, Miller BA (2014) A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α. J Biol Chem 289:36284–36302. https://doi.org/10.1074/jbc.M114.620922
Article CAS PubMed PubMed Central Google Scholar
Chen S-J, Bao L, Keefer K, Shanmughapriya S, Chen L, Lee J, Wang J, Zhang X-Q, Hirschler-Laszkiewicz I, Merali S, Merali C, Imamura Y, Dovat S, Madesh M, Cheung JY, Wang H-G, Miller BA (2020) Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy. Cell Death Dis 11:247. https://doi.org/10.1038/s41419-020-2454-8
Article CAS PubMed PubMed Central Google Scholar
Cheng HW, James AF, Foster RR, Hancox JC, Bates DO (2006) VEGF activates receptor-operated cation channels in human microvascular endothelial cells. Arterioscler Thromb Vasc Biol 26:1768–1776. https://doi.org/10.1161/01.ATV.0000231518.86795.0f
Article CAS PubMed Google Scholar
Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, Pattisapu JV, Kyriazis GA, Sugaya K, Bushnev S, Lathia JD, Rich JN, Chan SL (2010) Receptor channel TRPC6 is a key mediator of notch-driven glioblastoma growth and invasiveness. Cancer Res 70:418. https://doi.org/10.1158/0008-5472.CAN-09-2654
Article CAS PubMed Google Scholar
Ching L-C, Kou YR, Shyue S-K, Su K-H, Wei J, Cheng L-C, Yu Y-B, Pan C-C, Lee T-S (2011) Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1. Cardiovasc Res 91:492–501. https://doi.org/10.1093/cvr/cvr104
Article CAS PubMed Google Scholar
Derouiche S, Mariot P, Warnier M, Vancauwenberghe E, Bidaux G, Gosset P, Mauroy B, Bonnal JL, Slomianny C, Delcourt P, Dewailly E, Prevarskaya N, Roudbaraki M (2017) Activation of TRPA1 channel by antibacterial agent triclosan induces VEGF secretion in human prostate cancer stromal cells. Cancer Prev Res 10:177–187. https://doi.org/10.1158/1940-6207.CAPR-16-0257
Article CAS Google Scholar
Du G-J, Li J-H, Liu W-J, Liu Y-H, Zhao B, Li H-R, Hou X-D, Li H, Qi X-X, Duan Y-J (2014) The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer. Tumor Biol 35:1251–1261. https://doi.org/10.1007/s13277-013-1167-3
Article CAS Google Scholar
Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515–1520
CAS PubMed Google Scholar
Fantozzi I, Shen Z, Platoshyn O, Remillard CV, Cowling RT, Yuan JXJ (2003) Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Phys Lung Cell Mol Phys 285:L1233–L1245. https://doi.org/10.1152/ajplung.00445.2002
Article CAS Google Scholar
Farquhar MJ, Bowen DT (2003) Oxidative stress and the myelodysplastic syndromes. Int J Hematol 77:342–350. https://doi.org/10.1007/bf02982641
Article CAS PubMed Google Scholar
Fels B, Bulk E, Pethő Z, Schwab A (2018) The role of TRP channels in the metastatic cascade. Pharmaceuticals (Basel) 11. https://doi.org/10.3390/ph11020048
Fonseca BM, Correia-da-Silva G, Teixeira NA (2018) Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. J Physiol Biochem 74:261–272. https://doi.org/10.1007/s13105-018-0611-7
Article CAS PubMed Google Scholar
Garreis F, Schröder A, Reinach PS, Zoll S, Khajavi N, Dhandapani P, Lucius A, Pleyer U, Paulsen F, Mergler S (2016) Upregulation of transient receptor potential vanilloid type-1 channel activity and Ca2+ influx dysfunction in human pterygial cells. Invest Ophthalmol Vis Sci 57:2564–2577. https://doi.org/10.1167/iovs.16-19170
Article CAS PubMed Google Scholar
Gkika D, Prevarskaya N (2009) Molecular mechanisms of TRP regulation in tumor growth and metastasis. Biochim Biophys Acta 1793:953–958. https://doi.org/10.1016/j.bbamcr.2008.11.010
Article CAS PubMed Google Scholar
Gorrini C, Harris IS, Mak TW (2013) Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov 12:931–947. https://doi.org/10.1038/nrd4002
Article CAS PubMed Google Scholar
Hamdollah Zadeh MA, Glass CA, Magnussen A, Hancox JC, Bates DO (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation (New York, NY: 1994) 15:605–614
Article CAS Google Scholar
Hantute-Ghesquier A, Haustrate A, Prevarskaya N, Lehen’kyi V (2018) TRPM family channels in cancer. Pharmaceuticals (Basel) 11. https://doi.org/10.3390/ph11020058
Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163–173. https://doi.org/10.1016/s1097-2765(01)00438-5
Article CAS PubMed Google Scholar
Hole PS, Darley RL, Tonks A (2011) Do reactive oxygen species play a role in myeloid leukemias? Blood 117:5816–5826. https://doi.org/10.1182/blood-2011-01-326025
Article CAS PubMed Google Scholar
Ishii M, Oyama A, Hagiwara T, Miyazaki A, Mori Y, Kiuchi Y, Shimizu S (2007) Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. Anticancer Res 27:3987–3992
CAS PubMed Google Scholar
Iyer SC, Kannan A, Gopal A, Devaraj N, Halagowder D (2015) Receptor channel TRPC6 orchestrate the activation of human hepatic stellate cell under hypoxia condition. Exp Cell Res 336:66–75. https://doi.org/10.1016/j.yexcr.2015.03.023
Article CAS PubMed Google Scholar
Jaquemar D, Schenker T, Trueb B (1999) An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem 274:7325–7333. https://doi.org/10.1074/jbc.274.11.7325
Article CAS PubMed Google Scholar
Kashio M, Tominaga M (2017) Redox-sensitive TRP channels: TRPA1 and TRPM2. In Redox – principles and advanced applications, pp 203–223. https://doi.org/10.5772/intechopen.69202
Kwan H-Y, Huang Y, Yao X (2007) TRP channels in endothelial function and dysfunction. Biochim Biophys Acta (BBA) – Mol Basis Dis 1772:907–914
Article CAS Google Scholar
Li S, Wang J, Wei Y, Liu Y, Ding X, Dong B, Xu Y, Wang Y (2015) Crucial role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia. J Cell Sci 128:3317–3329. https://doi.org/10.1242/jcs.173161
Article CAS PubMed Google Scholar
Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, Laezza C, Portella G, Bifulco M, Di Marzo V (2006) Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 318:1375–1387. https://doi.org/10.1124/jpet.106.105247
Article CAS PubMed Google Scholar
Liu D, Scholze A, Zhu Z, Krueger K, Thilo F, Burkert A, Streffer K, Holz S, Harteneck C, Zidek W, Tepel M (2006) Transient receptor potential channels in essential hypertension. J Hypertens 24:1105–1114
Article CAS Google Scholar
Mandal A (2020) TRP channels: potential therapeutic targets in blood disorders. In: Atta-ur-Rahman (ed) Frontiers in clinical drug research hematology, vol 4. (in press). Bentham Science Publishers, Sharjah, United Arab Emirates, p 1–41. https://doi.org/10.2174/97898114695581200401
Meng X, Cai C, Wu J, Cai S, Ye C, Chen H, Yang Z, Zeng H, Shen Q, Zou F (2013) TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. Cancer Lett 333:96–102. https://doi.org/10.1016/j.canlet.2013.01.031
Article CAS PubMed Google Scholar
Miller BA, Zhang W (2011) TRP channels as mediators of oxidative stress. Adv Exp Med Biol 704:531–544. https://doi.org/10.1007/978-94-007-0265-3_29
Article CAS PubMed Google Scholar
Mittal M, Urao N, Hecquet CM, Zhang M, Sudhahar V, Gao X-P, Komarova Y, Ushio-Fukai M, Malik AB (2015) Novel role of reactive oxygen species-activated Trp melastatin channel-2 in mediating angiogenesis and postischemic neovascularization. Arterioscler Thromb Vasc Biol 35:877–887
Article CAS Google Scholar
Moran MM, McAlexander MA, Bíró T, Szallasi A (2011) Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov 10:601–620. https://doi.org/10.1038/nrd3456
Article CAS PubMed Google Scholar
Muz B, de la Puente P, Azab F, Azab AK (2015) The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy. Hypoxia (Auckland, N.Z.) 3:83–92. https://doi.org/10.2147/HP.S93413
Article Google Scholar
Nazıroğlu M, Blum W, Jósvay K, Çiğ B, Henzi T, Oláh Z, Vizler C, Schwaller B, Pecze L (2018) Menthol evokes Ca(2+) signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells. Redox Biol 14:439–449. https://doi.org/10.1016/j.redox.2017.10.009
Article CAS PubMed Google Scholar
Nilius B, Owsianik G (2011) The transient receptor potential family of ion channels. Genome Biol 12:218. https://doi.org/10.1186/gb-2011-12-3-218
Article CAS PubMed PubMed Central Google Scholar
Nilius B, Szallasi A (2014) Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine. Pharmacol Rev 66:676–814. https://doi.org/10.1124/pr.113.008268
Article CAS PubMed Google Scholar
Öz A, Çelik Ö, Bejarano I and Uğuz AC (2017) Antioxidants: Novel approach to ROS sensitive TRP channels gating manner. Electronic Journal of Biology 13: 243–246.
Google Scholar
Paria BC, Vogel SM, Ahmmed GU, Alamgir S, Shroff J, Malik AB, Tiruppathi C (2004) Tumor necrosis factor-α-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am J Phys Lung Cell Mol Phys 287:L1303–L1313. https://doi.org/10.1152/ajplung.00240.2004
Article CAS Google Scholar
Paria BC, Bair AM, Xue J, Yu Y, Malik AB, Tiruppathi C (2006) Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-Î°B activation in endothelial cells. J Biol Chem 281:20715–20727. https://doi.org/10.1074/jbc.M600722200
Article CAS PubMed Google Scholar
Park YR, Chun JN, So I, Kim HJ, Baek S, Jeon JH, Shin SY (2016) Data-driven analysis of TRP channels in cancer: linking variation in gene expression to clinical significance. Cancer Genomics Proteomics 13:83–90
CAS PubMed Google Scholar
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (2015) Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature 520:511–517. https://doi.org/10.1038/nature14367
Article CAS PubMed PubMed Central Google Scholar
Pocock TM, Foster RR, Bates DO (2004) Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Phys Heart Circ Phys 286:H1015–H1026. https://doi.org/10.1152/ajpheart.00826.2003
Article CAS Google Scholar
Poteser M, Graziani A, Rosker C, Eder P, Derler I, Kahr H, Zhu MX, Romanin C, Groschner K (2006) TRPC3 and TRPC4 associate to form a redox-sensitive cation channel: evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells. J Biol Chem 281:13588–13595. https://doi.org/10.1074/jbc.M512205200
Article CAS PubMed Google Scholar
Ramer R, Hinz B (2008) Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst 100:59–69. https://doi.org/10.1093/jnci/djm268
Article CAS PubMed Google Scholar
Reczek CR, Chandel NS (2017) The two faces of reactive oxygen species in cancer. Annu Rev Cancer Bio 1:79–98
Article Google Scholar
Reczek CR, Chandel NS (2018) ROS promotes cancer cell survival through calcium signaling. Cancer Cell 33:949–951. https://doi.org/10.1016/j.ccell.2018.05.010
Article CAS PubMed Google Scholar
Sadofsky LR, Ramachandran R, Crow C, Cowen M, Compton SJ, Morice AH (2012) Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Exp Lung Res 38:75–81. https://doi.org/10.3109/01902148.2011.644027
Article CAS PubMed Google Scholar
Schaefer EAM, Stohr S, Meister M, Aigner A, Gudermann T, Buech TRH (2013) Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells. Biochem Pharmacol 85:426–438. https://doi.org/10.1016/j.bcp.2012.11.019
Article CAS PubMed Google Scholar
Schenker T, Trueb B (1998) Down-regulated proteins of mesenchymal tumor cells. Exp Cell Res 239:161–168. https://doi.org/10.1006/excr.1997.3896
Article CAS PubMed Google Scholar
Simons M, Gordon E, Claesson-Welsh L (2016) Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol 17:611–625
Article CAS Google Scholar
Smani T, Gómez LJ, Regodon S, Woodard GE, Siegfried G, Khatib A-M, Rosado JA (2018) TRP channels in angiogenesis and other endothelial functions. Front Physiol 9:1731–1731
Article Google Scholar
Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS (2018) Cancer cells co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance. Cancer Cell 33:985–1003.e7. https://doi.org/10.1016/j.ccell.2018.05.001
Article CAS PubMed PubMed Central Google Scholar
Tiruppathi C, Minshall RD, Paria BC, Vogel SM, Malik AB (2002) Role of Ca2+ signaling in the regulation of endothelial permeability. Vasc Pharmacol 39:173–185
Article CAS Google Scholar
Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769
CAS PubMed Google Scholar
Turlova E, Feng Z-P, Sun H-S (2018) The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia. Acta Pharmacol Sin 39:713–721. https://doi.org/10.1038/aps.2017.194
Article CAS PubMed PubMed Central Google Scholar
Uslusoy F, Nazıroğlu M, Çiğ B (2017) Inhibition of the TRPM2 and TRPV1 channels through Hypericum perforatum in sciatic nerve injury-induced rats demonstrates their key role in apoptosis and mitochondrial oxidative stress of sciatic nerve and dorsal root ganglion. Front Physiol 8:335–335. https://doi.org/10.3389/fphys.2017.00335
Article PubMed PubMed Central Google Scholar
Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V (2001) Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem 276:19461–19468. https://doi.org/10.1074/jbc.M009895200
Article CAS PubMed Google Scholar
Yamamoto S, Shimizu S (2016) Significance of TRP channels in oxidative stress. Eur J Pharmacol 793:109–111. https://doi.org/10.1016/j.ejphar.2016.11.007
Article CAS PubMed Google Scholar
Yang Y, Karakhanova S, Werner J, Bazhin AV (2013) Reactive oxygen species in cancer biology and anticancer therapy. Curr Med Chem 20:3677–3692. https://doi.org/10.2174/0929867311320999165
Article CAS PubMed Google Scholar
Yao X, Garland CJ (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res 97:853–863. https://doi.org/10.1161/01.RES.0000187473.85419.3e
Article CAS PubMed Google Scholar
Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JXJ (2004) Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101:13861–13866
Article CAS Google Scholar

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Department of Physiology, University of Arizona, Tucson, AZ, USA
Amritlal Mandal
Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ, USA
Mathews Valuparampil Varghese & Joel James
Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India
Sajal Chakraborti

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Amritlal Mandal
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Mathews Valuparampil Varghese
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Joel James
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Sajal Chakraborti
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Department of Biochemistry and Biophysic, University of Kalyani Department of Biochemistry and Biophysic, Kalyani, West Bengal, India
Sajal Chakraborti
Dept of Veterinary Pathobiology, University of Missouri, College Vet, Columbia, MO, USA
Bimal K Ray
Saroj Gupta Cancer Centre & Research Ins, Kolkata, India
Sushanta Roychowdhury

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Mandal, A., Varghese, M.V., James, J., Chakraborti, S. (2021). TRP Channels, Oxidative Stress, and Cancer. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_80-1

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DOI: https://doi.org/10.1007/978-981-15-4501-6_80-1
Received: 16 October 2020
Accepted: 18 December 2020
Published: 28 April 2021
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-4501-6
Online ISBN: 978-981-15-4501-6
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