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Bleeding Disorders and ART

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Textbook of Assisted Reproduction

Abstract

Hemostasis is a normal physiologic function that is integral to tissue perfusion as well as the appropriate functioning of organs. As such, in the event of inevitable occurrences of vessel injury, they must be resolved quickly. The process is accomplished by a sophisticated balance of clot formation and clot lysis, consisting of an interplay between platelets and the coagulation cascade when functioning correctly [1]. When vessel injury first occurs, it cues von Willebrand factor to bind to subendothelial collagen on one end with platelet receptors at the other end. Following this, platelet adhesion results in the release of numerous mediating factors, all of which contribute to vasoconstriction and platelet activation. Platelet activation is just one component of hemostasis. In the event of a substantial vascular insult, the coagulation cascade must also be involved to form a sufficient fibrin plug, achieving satisfactory hemostasis [1, 2].

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Reading Medical Center, West Reading, PA, USA

    Veronika Levin

  2. Department of Obstetrics & Gynecology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA

    Rachel Booth

  3. Department of Obstetrics and Gynecology, Reading Hospital, West Reading, PA, USA

    Shahab Minassian

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  1. Veronika Levin
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  2. Rachel Booth
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  3. Shahab Minassian
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Corresponding author

Correspondence to Shahab Minassian .

Editor information

Editors and Affiliations

  1. Consultant Reproductive Endocrinology & IVF Millennium Medical Center MMC IVF, Dubai Health Care City, Dubai, United Arab Emirates

    Gautam Nand Allahbadia

  2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Koç University School of Medicine, Istanbul, Turkey

    Baris Ata

  3. Department of Obstetrics and Gynecology, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA

    Steven R. Lindheim

  4. X&Y Fertility, Leicester, UK

    Bryan J. Woodward

  5. School of Medicine and Dentistry, University of Rochester Medical Center, Newyork, USA

    Bala Bhagavath

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Levin, V., Booth, R., Minassian, S. (2020). Bleeding Disorders and ART. In: Allahbadia, G.N., Ata, B., Lindheim, S.R., Woodward, B.J., Bhagavath, B. (eds) Textbook of Assisted Reproduction. Springer, Singapore. https://doi.org/10.1007/978-981-15-2377-9_35

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