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An Overview of Hemostasis

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Congenital Bleeding Disorders

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Abstract

Hemostasis is a physiological well-controlled complex process in the body in which the integrity of the circulatory system is maintained after vascular injury. This process consists of three main components: the vascular system, cellular components, and non-cellular components. These work together closely to keep the circulatory system in the best condition.

Hemostasis is divided into primary and secondary parts. In primary hemostasis, vascular endothelial cells and platelets initially form an unstable hemostatic platelet plug. Secondary hemostasis activates the coagulation cascade, resulting in formation of a stable fibrin clot. Overall, the goal of hemostasis is to stop bleeding from a site of injury. However, natural anticoagulants are necessary for limiting clot formation at the site, and the formed clot must be removed after healing to restore unimpeded blood flow. To achieve this, fibrinolysis is one of the most important processes, anticoagulants interacting in a complicated dance with pro-coagulants to limit vascular injury to the injured site.

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Authors and Affiliations

  1. Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Arak Branch, Islamic Azad University, Arak, Iran

    Maryam Daneshi

  2. Independent Researcher, Tehran, Iran

    Jamal Rashidpanah & Fatemeh Narouei

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  1. Maryam Daneshi
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  2. Jamal Rashidpanah
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  3. Fatemeh Narouei
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  1. Hamin Pazhuhan Tis Institute, Tehran, Iran

    Akbar Dorgalaleh

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Daneshi, M., Rashidpanah, J., Narouei, F. (2023). An Overview of Hemostasis. In: Dorgalaleh, A. (eds) Congenital Bleeding Disorders . Springer, Cham. https://doi.org/10.1007/978-3-031-43156-2_1

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