Abstract
The World Health Organization (WHO) identifies food safety as one of the top ten priorities. Food-borne illnesses caused by food-borne pathogens are a major cause of morbidity and mortality globally. As a serious challenge of our generation, this issue is further exacerbated by the phenomenon of antimicrobial resistance among pathogens, which is another WHO listed top ten threats to global public health. The microbes have developed capabilities to resist the action of antibiotics—once called a wonder medicine, and are threatening to send us back to pre-antibiotic era. Pathogenesis and drug resistance profile of food-borne pathogens is complex subject with a vast expanse and spans diverse segments of food, food animals, the ecological niches, human populations, the pharmaceutical industry, and the clinic. New antibiotics or novel treatment options for tackling food-borne infections could only be put to clinical practice if the association of pathogenesis, development, and spread of antimicrobial resistance among causative pathogens is well understood. Thus, this chapter reviews the trends and factors contributing to pathogenesis along with mechanisms of observed antimicrobial resistances among the food-borne pathogens. The severity of the issue has also been discussed in the context of global spread of antibiotic use. Pathogenic mechanisms adopted by few food-borne pathogens have been illustrated at the end.
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References
Aarestrup FM, Wegener HC, Collignon P (2008) Resistance in bacteria of the food chain: epidemiology and control strategies. Expert Rev Anti-Infect Ther 6:733–750
Acar J, Röstel B (2001) Antimicrobial resistance: an overview antimicrobial resistance—a responsibility of the office international des epizooties why has the office international des epizooties. Rev Sci Tech 20:797–810
Akinyemi KO, Ajoseh SO (2017) Factors contributing to the emergence and spread of antibiotics resistance in Salmonella species. In: Current topics in Salmonella and Salmonellosis. InTech
Al-Humam NA (2019) Detection of Escherichia coli, Salmonella spp. and Staphylococcus aureus in ready-to-eat food in Al-Ahsa Province, Saudi Arabia. J Nutr Food Sci 9:754. https://doi.org/10.4172/2155-9600.1000754
Andrews-Polymenis HL, Bäumler AJ, McCormick BA, Fang FC (2010) Taming the elephant: Salmonella biology, pathogenesis, and prevention. Infect Immun 78:2356–2369. https://doi.org/10.1128/IAI.00096-10
Aung KT, Hsu LY, Koh TH et al (2017) Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in retail food in Singapore. Antimicrob Resist Infect Control 6:94. https://doi.org/10.1186/s13756-017-0255-3
Backert S, Hofreuter D (2013) Molecular methods to investigate adhesion, transmigration, invasion and intracellular survival of the foodborne pathogen campylobacter jejuni. J Microbiol Methods 95:8–23. https://doi.org/10.1016/j.mimet.2013.06.031
Bhavsar AP, Guttman JA, Finlay BB (2007) Manipulation of host-cell pathways by bacterial pathogens. Nature 449:827–834. https://doi.org/10.1038/nature06247
Blázquez J, Rodríguez-Beltrán J, Matic I (2018) Antibiotic-induced genetic variation: how it arises and how it can be prevented. Annu Rev Microbiol 72:209–230. https://doi.org/10.1146/annurev-micro-090817-062139
Bridier A, Sanchez-Vizuete P, Guilbaud M et al (2015) Biofilm-associated persistence of food-borne pathogens. Food Microbiol 45:167–178. https://doi.org/10.1016/j.fm.2014.04.015
Brooks JP, Adeli A, McLaughlin MR (2014) Microbial ecology, bacterial pathogens, and antibiotic resistant genes in swine manure wastewater as influenced by three swine management systems. Water Res 57:96–103. https://doi.org/10.1016/j.watres.2014.03.017
Bryan F (1978) Factors that contribute to outbreaks of food borne disease. J Food Prot 41:816–827
Cappitelli F, Polo A, Villa F (2014) Biofilm formation in food processing environments is still poorly understood and controlled. Food Eng Rev 6:29–42. https://doi.org/10.1007/s12393-014-9077-8
Casadevall A, Pirofski L (2000) Host-pathogen interactions: basic concepts of microbial commensalism, colonization, infection, and disease. Infect Immun 68:6511–6518. https://doi.org/10.1128/IAI.68.12.6511-6518.2000
Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ (2008) The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6:17–27. https://doi.org/10.1038/nrmicro1818
Centers for Disease Control and Prevention (CDC) (2018) The core elements of human antibiotic stewardship programs in resource -limited settings: National and Hospital Levels. US Department of Health and Human Services, Atlanta, GA. https://www.cdc.gov/antibiotic-use/healthcare/implementation.html
Chen M, Wu Q, Zhang J et al (2014) Prevalence and characterization of Listeria monocytogenes isolated from retail-level ready-to-eat foods in South China. Food Control 38:1–7. https://doi.org/10.1016/j.foodcont.2013.09.061
Colavecchio A, Cadieux B, Lo A, Goodridge LD (2017) Bacteriophages contribute to the spread of antibiotic resistance genes among foodborne pathogens of the Enterobacteriaceae family—a review. Front Microbiol 8:1–13. https://doi.org/10.3389/fmicb.2017.01108
Conter M, Paludi D, Zanardi E et al (2009) Characterization of antimicrobial resistance of foodborne Listeria monocytogenes. Int J Food Microbiol 128:497–500. https://doi.org/10.1016/j.ijfoodmicro.2008.10.018
Cossart P, Toledo-Arana A (2008) Listeria monocytogenes, a unique model in infection biology: an overview. Microbes Infect 10:1041–1050. https://doi.org/10.1016/j.micinf.2008.07.043
Daniel DS, Lee SM, Dykes GA, Rahman S (2015) Public health risks of multiple-drug-resistant Enterococcus spp. in Southeast Asia. Appl Environ Microbiol 81:6090–6097. https://doi.org/10.1128/AEM.01741-15
Dasti JI, Tareen AM, Lugert R et al (2010) Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-mediating mechanisms. Int J Med Microbiol 300:205–211. https://doi.org/10.1016/j.ijmm.2009.07.002
Di Bonaventura G, Piccolomini R, Paludi D et al (2008) Influence of temperature on biofilm formation by Listeria monocytogenes on various food-contact surfaces: relationship with motility and cell surface hydrophobicity. J Appl Microbiol 104:1552–1561. https://doi.org/10.1111/j.1365-2672.2007.03688.x
Dougherty TJ, Pucci MJ (2012) Antibiotic discovery and development. Springer, Berlin. https://doi.org/10.1007/978-1-4614-1400-1_10
Doyle MP, Busta F, Cords BR et al (2006) Antimicrobial resistance: implications for the food system: an expert report, funded by the IFT foundation. Compr Rev Food Sci Food Saf 5:71–137. https://doi.org/10.1111/j.1541-4337.2006.00004.x
Du Y, Wang C, Ye Y et al (2018) Molecular identification of multidrug-resistant Campylobacter species from diarrheal patients and poultry meat in Shanghai, China. Front Microbiol 9:1–8. https://doi.org/10.3389/fmicb.2018.01642
EMA (2019) European medicines agency (EMA). Committee for medicinal products for veterinary use (CVMP). Eur Med Agency 44:1–67
Eng S-K, Pusparajah P, Ab Mutalib N-S et al (2015) Salmonella: a review on pathogenesis, epidemiology and antibiotic resistance. Front Life Sci 8:284–293. https://doi.org/10.1080/21553769.2015.1051243
Ezepchuk YV (2013) Biology of pathogenicity (theoretical review). Annu Res Rev Biol 3:805–813
Ezepchuk YV (2017) Biological concept of bacterial pathogenicity (theoretical review). Adv Microbiol 07:535–544. https://doi.org/10.4236/aim.2017.77042
Founou LL, Founou RC, Essack SY (2016) Antibiotic resistance in the food chain: a developing country-perspective. Front Microbiol 7:1–19. https://doi.org/10.3389/fmicb.2016.01881
Gasson J, Blockman M, Willems B (2018) Antibiotic prescribing practice and adherence to guidelines in primary care in the Cape Town Metro District, South Africa. S Afr Med J 108:304. https://doi.org/10.7196/samj.2018.v108i4.12564
Ge B, White DG, McDermott PF et al (2003) Antimicrobial-resistant Campylobacter species from retail raw meats. Appl Environ Microbiol 69:3005–3007. https://doi.org/10.1128/AEM.69.5.3005-3007.2003
Gilbert JM, White DG, McDermott PF (2007) The US national antimicrobial resistance monitoring system. Future Microbiol 2:493–500. https://doi.org/10.2217/17460913.2.5.493
Golob M, Pate M, Kušar D et al (2019) Antimicrobial resistance and virulence genes in Enterococcus faecium and Enterococcus faecalis from humans and retail red meat. Biomed Res Int 2019:1–12. https://doi.org/10.1155/2019/2815279
Gousia P, Economou V, Sakkas H et al (2011) Antimicrobial resistance of major foodborne pathogens from major meat products. Foodborne Pathog Dis 8:27–38. https://doi.org/10.1089/fpd.2010.0577
Gwida M (2015) Prevalence and characterization of antibiotic resistance food borne pathogens isolated from locally produced chicken raw meat and their handlers. J Dairy Vet Anim Res 2:238–244. https://doi.org/10.15406/jdvar.2015.02.00062
Hald T, Aspinall W, Devleesschauwer B et al (2016) World Health Organization estimates of the relative contributions of food to the burden of disease due to selected foodborne hazards: a structured expert elicitation. PLoS One 11:1–35. https://doi.org/10.1371/journal.pone.0145839
Hamilton WL, Wenlock R (2016) Antimicrobial resistance: a major threat to public health. Cambridge Med J. https://doi.org/10.7244/cmj.2016.01.001
Jo SH, Park JM (2019) The dark side of organic vegetables: interactions of human enteropathogenic bacteria with plants. Plant Biotechnol Rep 13:105–110. https://doi.org/10.1007/s11816-019-00536-1
Karp BE, Tate H, Plumblee JR et al (2017) National Antimicrobial Resistance Monitoring System: two decades of advancing public health through integrated surveillance of antimicrobial resistance. Foodborne Pathog Dis 14:545–557. https://doi.org/10.1089/fpd.2017.2283
Katsikogianni M, Missirlis YF, Harris L, Douglas J (2004) Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. Eur Cells Mater 8:37–57. https://doi.org/10.22203/eCM.v008a05
Kim M, Ashida H, Ogawa M et al (2010) Bacterial interactions with the host epithelium. Cell Host Microbe 8:20–35. https://doi.org/10.1016/j.chom.2010.06.006
Klein EY, Van Boeckel TP, Martinez EM et al (2018) Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci 115:E3463–E3470. https://doi.org/10.1073/pnas.1717295115
Kline KA, Fälker S, Dahlberg S et al (2009) Bacterial Adhesins in host-microbe interactions. Cell Host Microbe 5:580–592. https://doi.org/10.1016/j.chom.2009.05.011
Laaksonen S, Oksanen A, Julmi J et al (2017) Presence of foodborne pathogens, extended-spectrum β-lactamase -producing Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus in slaughtered reindeer in northern Finland and Norway. Acta Vet Scand 59(2):2. https://doi.org/10.1186/s13028-016-0272-x
Lakhundi S, Zhang K (2018) Methicillin- resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Rev 31:e00020–e00018. https://doi.org/10.1128/CMR.00020-18
LeClerc JE, Li B, Payne WL, Cebula TA (1996) High mutation frequencies among Escherichia coli and Salmonella pathogens. Science (80-) 274:1208–1211. https://doi.org/10.1126/science.274.5290.1208
Leung E, Weil DE, Raviglione M, Nakatani H (2011) The WHO policy package to combat antimicrobial resistance. Bull World Health Organ 89:390–392. https://doi.org/10.2471/BLT.11.088435
Li D, Wang Y, Schwarz S et al (2016) Co-location of the oxazolidinone resistance genes optrA and cfr on a multiresistance plasmid from Staphylococcus sciuri. J Antimicrob Chemother 71:1474–1478. https://doi.org/10.1093/jac/dkw040
Long KS, Vester B (2012) Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother 56:603–612. https://doi.org/10.1128/AAC.05702-11
Magee JT, Pritchard EL, Fitzgerald KA et al (1999) Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996-8. BMJ 319:1239–1240. https://doi.org/10.1136/bmj.319.7219.1239
Mąka Ł, Maćkiw E, Ścieżyńska H, Popowska M (2015) Occurrence and antimicrobial resistance of Salmonella spp. isolated from food other than meat in Poland. Ann Agric Environ Med 22:403–408. https://doi.org/10.5604/12321966.1167701
Marshall BM, Levy SB (2011) Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev 24:718–733. https://doi.org/10.1128/CMR.00002-11
Marteyn BS, Gazi AD, Sansonetti PJ (2012) Shigella: a model of virulence regulation in vivo. Gut Microbes 3:104–120. https://doi.org/10.4161/gmic.19325
Martínez L, Baquero F (2002) Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin Microbiol Rev 15:647–679. https://doi.org/10.1128/CMR.15.4.647
Martinez A, Lin J (2006) Effect of an efflux pump inhibitor on the function of the multidrug efflux pump CmeABC and antimicrobial resistance in Campylobacter. Foodborne Pathog Dis 3:393–402. https://doi.org/10.1089/fpd.2006.3.393
Mathur S, Singh R (2005) Antibiotic resistance in food lactic acid bacteria—a review. Int J Food Microbiol 105:281–295. https://doi.org/10.1016/j.ijfoodmicro.2005.03.008
Mazel D, Davies J (1999) Antibiotics, present and future. microbial biosystems: new frontiers. In: Bell CR, Brylinsky M, Johnson-Green P (eds) Proceedings of the 8th international symposium on microbial ecology. Atlantic Canada Society for Microbial Ecology, Halifax
McDermott PF, Zhao S, Wagner DD et al (2002) The food safety perspective of antibiotic resistance. Anim Biotechnol 13:71–84. https://doi.org/10.1081/ABIO-120005771
McGettigan P, Roderick P, Kadam A, Pollock AM (2017) Access, watch, and reserve antibiotics in India: challenges for WHO stewardship. Lancet Glob Health 5:e1075–e1076. https://doi.org/10.1016/S2214-109X(17)30365-0
Munita JM, Arias CA (2016) Mechanisms of antibiotic resistance. Microbiol Spectr 4(2). https://doi.org/10.1128/microbiolspec.VMBF-0016-2015
Murray AK, Zhang L, Yin X, Zhang T, Buckling A, Snape J, Gaze WH (2018) Novel insights into selection for antibiotic resistance in complex microbial communities. mBio 9:e00969–e00918. https://doi.org/10.1128/mBio.00969-18
Narasanna R, Chavadi M, Oli A, Chandrakanth K (2017) Effect of subinhibitory concentration of cefotaxime on biofilm formation. J Microbiol Infect Dis 7:67–74. https://doi.org/10.5799/ahinjs.02.2017.02.0257
Nikaido H (1996) Multidrug efflux pumps of gram-negative bacteria. J Bacteriol 178:5853–5859. https://doi.org/10.1128/jb.178.20.5853-5859.1996
Odeyemi OA, Sani NA (2016) Antibiotic resistance and burden of foodborne diseases in developing countries. Futur Sci OA 2:FSO139. https://doi.org/10.4155/fsoa-2016-0023
Palframan SL, Kwok T, Gabriel K (2012) Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis. Front Cell Infect Microbiol 2:1–9. https://doi.org/10.3389/fcimb.2012.00092
Pesavento G, Ducci B, Comodo N, Nostro AL (2007) Antimicrobial resistance profile of Staphylococcus aureus isolated from raw meat: a research for methicillin resistant Staphylococcus aureus (MRSA). Food Control 18:196–200. https://doi.org/10.1016/j.foodcont.2005.09.013
Pinchuk IV, Beswick EJ, Reyes VE (2010) Staphylococcal enterotoxins. Toxins (Basel) 2:2177–2197. https://doi.org/10.3390/toxins2082177
Poppe C, Smart N, Khakhria R et al (1998) Salmonella typhimurium DT104: a virulent and drug-resistant pathogen. Can Vet J 39:559–565
Ribet D, Cossart P (2015) How bacterial pathogens colonize their hosts and invade deeper tissues to cite this version: HAL Id: pasteur-01115526. Microbes Infect 17:173–183
Roberts AJ, Wiedmann M (2003) Pathogen, host and environmental factors contributing to the pathogenesis of listeriosis. Cell Mol Life Sci 60:904–918. https://doi.org/10.1007/s00018-003-2225-6
Rodloff A, Bauer T, Ewig S et al (2008) Susceptible, intermediate, and resistant—the intensity of antibiotic action. Dtsch Aerzteblatt Online 105:657–662. https://doi.org/10.3238/arztebl.2008.0657
Sanlibaba P, Senturk E (2018) Prevalence, characterization and antibiotic resistance of Enterococci from traditional cheeses in Turkey. Int J Food Prop 21:1955–1963. https://doi.org/10.1080/10942912.2018.1489413
Sasidharan S, Prema B, Yoga Latha L (2011) Antimicrobial drug resistance of Staphylococcus aureus in dairy products. Asian Pac J Trop Biomed 1:130–132. https://doi.org/10.1016/S2221-1691(11)60010-5
Sergelidis D, Angelidis AS (2017) Methicillin-resistant Staphylococcus aureus: a controversial food-borne pathogen. Lett Appl Microbiol 64:409–418. https://doi.org/10.1111/lam.12735
Singh R, Schroeder CM, Meng J et al (2005) Identification of antimicrobial resistance and class 1 integrons in Shiga toxin-producing Escherichia coli recovered from humans and food animals. J Antimicrob Chemother 56:216–219. https://doi.org/10.1093/jac/dki161
Strawn LK, Fortes ED, Bihn EA et al (2013) Landscape and meteorological factors affecting prevalence of three food-borne pathogens in fruit and vegetable farms. Appl Environ Microbiol 79:588–600. https://doi.org/10.1128/AEM.02491-12
Swartz MN (2002) Human diseases caused by foodborne pathogens of animal origin. Clin Infect Dis 34:S111–S122. https://doi.org/10.1086/340248
United States Centers for Disease Control (2013) Antibiotic resistance threats in the United States, 2013. Current 114:CS239559-B
Uyttendaele M, Franz E, Schlüter O (2015) Food safety, a global challenge. Int J Environ Res Public Health 13:2–7. https://doi.org/10.3390/ijerph13010067
van Baarlen P, van Belkum A, Summerbell RC et al (2007) Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev 31:239–277. https://doi.org/10.1111/j.1574-6976.2007.00065.x
van Boeckel TP, Brower C, Gilbert M et al (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci 112:5649–5654. https://doi.org/10.1073/pnas.1503141112
Vanderhaeghen W, Hermans K, Haesebrouck F, Butaye P (2010) Methicillin-resistant Staphylococcus aureus (MRSA) in food production animals. Epidemiol Infect 138:606–625. https://doi.org/10.1017/S0950268809991567
Vedantam G, Clark A, Chu M et al (2012) Clostridium difficile infection: toxins and non-toxin virulence factors, and their contributions to disease establishment and host response. Gut Microbes 3:121–134. https://doi.org/10.4161/gmic.19399
Verraes C, van Boxstael S, van Meervenne E et al (2013) Antimicrobial resistance in the food chain: a review. Int J Environ Res Public Health 10:2643–2669. https://doi.org/10.3390/ijerph10072643
Vivant A-L, Garmyn D, Piveteau P (2013) Listeria monocytogenes, a down-to-earth pathogen. Front Cell Infect Microbiol 3:1–10. https://doi.org/10.3389/fcimb.2013.00087
VT Nair D, Venkitanarayanan K, Kollanoor Johny A (2018) Antibiotic-resistant Salmonella in the food supply and the potential role of antibiotic alternatives for control. Foods 7:167. https://doi.org/10.3390/foods7100167
Walsh C (2010) The problem of antimicrobial resistance in the food chain. Teagasc, Dublin
Walsh C, Duffy G (2013) Antibiotic resistance in foodborne pathogens. Teagasc final report project RMIS no 5036
Wang Y, Zhang M, Deng F et al (2014) Emergence of multidrug-resistant Campylobacter species isolates with a horizontally acquired rRNA methylase. Antimicrob Agents Chemother 58:5405–5412. https://doi.org/10.1128/AAC.03039-14
Wang X, Biswas S, Paudyal N et al (2019) Antibiotic resistance in Salmonella Typhimurium isolates recovered from the food chain through National Antimicrobial Resistance Monitoring System between 1996 and 2016. Front Microbiol 10:1–12. https://doi.org/10.3389/fmicb.2019.00985
White DG, Zhao S, Simjee S et al (2002) Antimicrobial resistance of foodborne pathogens. Microbes Infect 4:405–412
WHO (2017) Report of the 21st WHO expert committee on the selection and use of essential medicines WHO headquarters, Geneva 27–31 March 2017 Table of contents annexes. 4:13
WHO (2018) Whole genome sequencing for foodborne disease surveillance: landscape paper. World Health Organization, Geneva
WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR) (2019) Critically important antimicrobials for human medicine 6th Revision 2018. Ranking of medically important antimicrobials for risk management of antimicrobial resistance due to non-human use
WHO Press (2013) Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. WHO, Geneva, pp 1–7. https://doi.org/10.1590/S0100-15742013000100018
Wilson JW (2002) Mechanisms of bacterial pathogenicity. Postgrad Med J 78:216–224. https://doi.org/10.1136/pmj.78.918.216
Ye Q, Wu Q, Zhang S et al (2018) Characterization of extended-spectrum β-lactamase-producing enterobacteriaceae from retail food in China. Front Microbiol 9:1–12. https://doi.org/10.3389/fmicb.2018.01709
Yucel N, Citak S, Bayhün S (2011) Antimicrobial resistance profile of Staphylococcus aureus isolated from clinical samples and foods of animal origin. Foodborne Pathog Dis 8:427–431. https://doi.org/10.1089/fpd.2010.0707
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The author would like to express her deepest thanks to Dr. Nivedita M. Matkar for carefully reviewing the manuscript and valuable feedback.
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Sangave, P.C. (2020). Pathogenesis and Drug Resistance Profile of Food-Borne Pathogens. In: Siddhardha, B., Dyavaiah, M., Syed, A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1695-5_18
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