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Acinetobacter baumannii: Infections and Drug Resistance

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Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery

Abstract

Acinetobacter baumannii is currently considered a major clinical pathogen accountable for causing several nosocomial infections and hospital outbreaks all over the globe. A. baumannii is accountable for causing bloodstream infections, pneumonia, meningitis, wound infection, urinary tract infection, endocarditis, peritonitis, and keratitis especially in individuals with low immunity. The pathogen has been reported to exhibit resistance against broad classes of antibiotics including carbapenems, aminoglycoside, quinolones, tetracyclines, cephalosporins, and polymyxin. Various virulence mechanisms have been identified and proposed for the resistance of A. baumannii towards the different class of antibiotics including inactivation or alteration of antimicrobials, alteration in membrane proteins, efflux pumps system, changes in the drug target, and biofilm formation. Furthermore, the ability to acquire and express exogenous antibiotic resistance genes is another contributing factor in imparting drug resistance to the pathogen.

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Authors and Affiliations

  1. Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India

    Jobina Rajkumari & Busi Siddhardha

Authors
  1. Jobina Rajkumari
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  2. Busi Siddhardha
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Editors and Affiliations

  1. Department of Microbiology School of Life Sciences, Pondicherry University, Puducherry, India

    Busi Siddhardha

  2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, India

    Madhu Dyavaiah

  3. Botany and Microbiology Department, King Saud University, Riyadh, Saudi Arabia

    Asad Syed

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Rajkumari, J., Siddhardha, B. (2020). Acinetobacter baumannii: Infections and Drug Resistance. In: Siddhardha, B., Dyavaiah, M., Syed, A. (eds) Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-1695-5_14

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