Abstract
Colloidal carrier systems like solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were developed with a perspective to meet industrial needs related to a simple technology involving low costs and easiness for scaling-up ensuring the process qualification and validation required for the pharmaceutical and cosmetic industries. Production methods which are suitable for large scale production, innovative applications, recent advances and technological challenges are some of the aspects which are outlined in this chapter. Appropriate analytical techniques suitable for characterizing SLN and NLC are also discussed because of their relevance for product development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Muchow, M.: Nanocarriers for oral bioavailability enhancement (2009), http://www.scd.uhp-nancy.fr/docnum/SCD_T_2009_0073_MUCHOW.pdf (accessed August 10, 2010)
El-Harati, A.A., Charcosset, C., Fessi, H.: Influence of the formulation for solid lipid nanoparticles prepared with a membrane contactor. Pharm. Dev. Technol. 11, 153–157 (2006)
Heurtault, B., Saulnier, P., Pech, B., Proust, J.E., Benoit, J.P.: A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm. Res. 19, 875–880 (2002)
Schubert, M.A., Müller-Goymann, C.C.: Solvent injection as a new approach for manufacturing lipid nanoparticles-evaluation of the method and process parameters. Eur. J. Pharm. Biopharm. 55, 125–131 (2003)
Teeranachaideekul, V., Boonme, P., Souto, E.B., Müller, R.H., Junyaprasert, V.B.: Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC. J. Control. Rel. 128, 134–141 (2008)
Trotta, M., Debernardi, F., Caputo, O.: Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int. J. Pharm. 257, 153–160 (2003)
Gohla, S.H., Dingler, A.: Scaling up feasibility of the production of solid lipid nanoparticles (SLN). Pharmazie 56, 61–63 (2001)
Pardeike, J., Hommoss, A., Müller, R.H.: Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int. J. Pharm. 366, 170–184 (2009)
Wissing, S.A., Kayser, O., Müller, R.H.: Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug. Deliv. Rev. 56, 1257–1272 (2004)
Brioschi, A., Zenga, F., Zara, G.P., Gasco, M.R., Ducati, A., Mauro, A.: Solid lipid nanoparticles: could they help to improve the efficacy of pharmacologic treatments for brain tumors? Neurol. Res. 29, 324–330 (2007)
Yuan, H., Chen, J., Du, Y.Z., Hu, F.Q., Zeng, S., Zhao, H.L.: Studies on oral absorption of steric acid SLN by a noval fluometric method. Colloid Surf. B 58, 157–164 (2007)
Müller, R.H., Runge, S., Ravelli, V., Mehnert, W., Thunemann, A.F., Souto, E.B.: Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. Int. J. Pharm. 317, 82–89 (2006)
Priano, L., Esposti, D., Esposti, R., Castagna, G., De Medici, C., Fraschini, F., Gasco, M.R., Mauro, A.: Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems. J. Nanosci. Nanotechnol. 7, 3596–3601 (2007)
Ugazio, E., Cavalli, R., Gasco, M.R.: Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int. J. Pharm. 241, 341–344 (2002)
Attama, A.A., Müller-Goymann, C.C.: Effect of beewax modification on the lipid matrix and solid lipid nanoparticle crystallinity. Colloid Surf. A 315, 189–195 (2008)
Xiang, Q.Y., Wang, M.T., Chen, F., Gong, T., Jian, Y.L., Zhang, Z.R., Huang, Y.: Lung targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch. Pharm. Res. 30, 519–525 (2007)
Liu, J., Gong, T., Fu, H., Wang, C., Wang, X., Chen, Q., Zhang, Q., He, Q., Zhang, Z.: Solid lipid nanoparticles for pulmonary delivery of insulin. Int. J. Pharm. 356, 333–344 (2008)
Cevc, G., Vierl, U.: Nanotechnology and the transdermal route. A state of the art review and critical appraisal. J Control. Release 141, 277–299 (2010)
Jenning, V., Gysler, A., Schäfer-Korting, M., Gohla, S.H.: Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J. Control. Rel. 66(2-3), 115–126 (2000)
Jenning, V., Gysler, A., Schäfer-Korting, M., Gohla, S.H.: Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur. J. of Pharm. and Biopharm. 49(3), 211–218 (2000)
Wissing, S.A., Lippacher, A., Müller, R.H.: Investigations on the occlusive properties of solid lipid nanoparticles (SLN). J. of Cosm. Sci. 52(5), 313–324 (2001)
Andre, P.: De la Cosmétique au Développement Durable (2008), www.nanoparticles.org/pdf/P2009-Keck.pdf (accessed August 10, 2010)
Lucks, J.S., Müller, R.H.: Medication vehicles made of solid lipid particles (solid lipid Nanospheres SLN). EP0000605497 (1991)
Westesen, K., Bunjes, H., Koch, M.H.J.: Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. J. Control. Release 48, 223–236 (1997)
Müller, R.H., Radtke, M., Wissing, S.A.: Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug. Deliv. Rev. 54(suppl. 1), 131–155 (2002)
Radtke, M., Müller, R.H.: Nanostructured lipid drug carriers. New Drugs 2, 48–52 (2001)
Muchow, M., Müller, R.H.: Lipid Nanoparticles with a Solid Matrix (SLN, NLC, LDC) for Oral Drug Delivery. Drug. Develop. Ind. Pharm. 34(12), 1394–1405 (2008)
Liedtke, S., Wissing, S., Müller, R.H., Mader, K.: Influence of high pressure homogenization equipment on nanodispersions characteristics. Int. J. Pharm. 196, 183–185 (2000)
Mehnert, W., Mäder, K.: Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. 47, 165–196 (2001)
Gasco, M.R.: Method for producing solid lipid microspheres having a narrow size distribution. USA Patent 188, 837 (1993)
Gasco, M.R.: Solid lipid nanospheres from warm microemuslion. Pharm. Technol. Eur. 9, 32–42 (1997)
Pietkiewicz, J., Sznitowska, M.: The choice of lipids and surfactants for injectable extravenous microspheres. Pharmazie 59, 325–326 (2004)
Puglia, C., Blasi, P., Rizza, L., Schoubben, A., Bonina, F., Rossi, C., Ricci, M.: Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation. Int. J. Pharm. 357, 295–304 (2008)
Charcosset, C., El-Harati, A., Fessi, H.: Preparation of solid lipid nanoparticles using a membrane contactor. J. Control. Release 108, 112–120 (2005)
Zhanga, S., Shen, S., Chen, Z., Yun, J., Ya, K., Chen, B., Chen, J.: Preparation of solid lipid nanoparticles in co-flowing microchannels. Chem. Eng. J. 144, 324–328 (2008)
Müller, R.H., Mäder, K., Gohla, S.: Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur. J. Pharm. Biopharm. 50, 161–177 (2000)
Jebors, S., Leydier, A., Wu, Q., Ghera, B.B., Malbouyre, M., Coleman, A.W.: Solid lipid nanoparticles (SLNs) derived from para-acyl-calix[9]-arene: preparation and stability. J. Microencapsul. 27(7), 561–571 (2010)
Sandri, G., Bonferoni, M.C., Gökçe, E.W., Ferrari, F., Rossi, S., Patrini, M., Caramella, C.: Chitosan-associated SLN: in vitro and ex vivo characterization of cyclosporine A loaded ophthalmic systems. J. Microencapsul. 27(8), 735–746 (2010)
Gonzalez-Mira, E., Egea, M.A., Garcia, M.L., Souto, E.B.: Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. Colloids and Surfaces B: Biointerfaces 81, 412–421 (2010)
Rahman, Z., Zidan, A.S., Khan, M.A.: Non-destructive methods of characterization of risperidone solid lipid nanoparticles. Eur. J. Pharm. Biopharm. 76, 127–137 (2010)
Saupe, A., Gordon, K.C., Rades, T.: Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy. Int. J. Pharm. 314, 56–62 (2006)
Schwarz, C., Mehnert, W.: Solid lipid nanoparticles (SLN) for controlled active agent delivery. II. Active agent incorporation and physicochemical characterization. J. Microencapsul. 16, 205–213 (1999)
Müller, R.H., Mehnert, W., Lucks, J.S., Schwarz, C., zur Mühlen, A., Weyhers, H., Freitas, C., Rühl, D.: Solid lipid nanoparticles (SLN) as an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. 41, 62–69 (1995)
Dingler, A.: Feste Lipid-Nanopartikel als kolloidale Wirstoffträgersysteme zur dermalen Applikation. Dissertation, Free University of Berlin (1998)
Puglia, C., Filosa, R., Peduto, A., de Caprariis, P., Rizza, L., Bonina, F., Blasi, P.: Evaluation of alternative strategies to optimize ketorolac transdermal delivery. AAPS Pharm. Sci. Technol. 7, 1–9 (2006)
Teeranachaideekul, V., Müller, R.H., Junyaprasert, V.B.: Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC) - effects of formulation parameters on physicochemical stability. Int. J. Pharm. 340, 198–206 (2007)
Jenning, V.: Solid Lipid Nanoparticles (SLN) as a Carrier System for the Dermal Application of Retinol. Dissertation, Free University of Berlin (1999)
Jenning, V., Gohla, S.H.: Encapsulation of retinoids in solid lipid nanoparticles (SLN). J. Microencapsul. 18, 149–158 (2001)
Jee, J.P., Lim, S.J., Park, J.S., Kim, C.K.: Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles. Eur. J. Pharm. Biopharm. 63, 134–139 (2006)
Wissing, S.A., Mäder, K., Müller, R.H.: Solid lipid nanoparticles (SLN) as a novel carrier system offereing prolonged release of perfume Allure (Chanel). In: Int. Symp. Control. Release Bioact. Mater., vol. 27, pp. 311–312 (2000)
de Vringer, T.: Topical preparation containing a suspension of solid lipid particles. USA patent 91-200,664 (1999)
Souto, E.B., Wissing, S.A., Barbosa, C.M., Müller, R.H.: Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int. J. Pharm. 278, 71–77 (2004)
Wissing, S.A., Müller, R.H.: The influence of solid lipid nanoparticles on skin hydration and viscoelasticity—in vivo study. Eur. J. Pharm. Biopharm. 56, 67–72 (2003)
Villalobos-Hernandez, J.R., Müller-Goymann, C.C.: Novel nanoparticulate carrier system based on carnauba wax and decyl oleate for the dispersion of inorganic sunscreens in aqueous media. Eur. J. Pharm. Biopharm. 60, 113–122 (2005)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Guimarães, K.L., Ré, M.I. (2011). Lipid Nanoparticles as Carriers for Cosmetic Ingredients: The First (SLN) and the Second Generation (NLC). In: Beck, R., Guterres, S., Pohlmann, A. (eds) Nanocosmetics and Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19792-5_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-19792-5_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19791-8
Online ISBN: 978-3-642-19792-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)