Abstract
The goal of this chapter is to provide the anesthesiologists with detailed information about the anesthetic management in patients undergoing surgery for the treatment of the pituitary diseases. The peculiar features of the underlying endocrine disturbances are illustrated. Knowledge of anatomy and pathophysiology of the pituitary gland is paramount to understand the potential complications: pituitary gland function and signs and symptoms of pituitary tumors related both to hormonal hypersecretion and hyposecretion syndromes are illustrated. Pituitary surgery has evolved over the last two decades from an open transcranial surgery to the minimally invasive endoscopic endonasal approach: surgical techniques of pituitary tumors and their advantages and disadvantages are briefly summarized. In those patients complaining of a pituitary adenoma, preoperative endocrinological assessment and tailored management strategies are required to reduce the morbidity related to the surgical pituitary procedure itself, above all, upon anesthetic issues. Therefore, multidisciplinary team case discussion is of utmost importance to rule out the optimal therapeutic option before surgery. Different anesthetic modalities and drugs can be used adequately in the intraoperative period avoiding complications and thus providing an uneventful recovery. The main goals of the anesthetic treatment include the hemodynamic stability, airway management, quick and smooth awakening at the end of surgical procedure, and prevention of intra- and postoperative complications. Anesthetic management with particular attention to that of patients suffering from acromegaly and Cushing disease is outlined. Finally, the main postoperative issues are illustrated: usually, after undergoing an endoscopic endonasal procedure, patients don’t require intensive care unit admission, unless in extraordinary conditions and/or depending on preexisting comorbidities. In these patients, the postoperative issues are mainly related to airways management, pain management, neurological and endocrine status, and fluid balance control. Endocrine disorders include hypopituitarism, diabetes insipidus, and inappropriate secretion of antidiuretic hormone.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Louis DN, Ohgaki H, Wiestler OD, Cavenne C, editors. WHO classification of tumours of the central nervous system. 4th ed. Lyon: IARC; 2016.
Del Basso De Caro M, Solari D, Pagliuca F, et al. Atypical pituitary adenomas: clinical characteristics and role of ki-67 and p53 in prognostic and therapeutic evaluation. A series of 50 patients. Neurosurg Rev. 2017;40(1):105–14.
Carroll PV, Jenkins PJ. Acromegaly. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, et al., eds. Endotext. 2016. https://www.ncbi.nlm.nih.gov/books/NBK279097/. Accessed 11 June 2018.
Asa SL, Kucharczyk W, Ezzat S. Pituitary acromegaly: not one disease. Endocr Relat Cancer. 2017;24(3):C1–4.
Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing’s syndrome. Lancet. 2006;367(9522):1605–17.
Wang EL, Qian ZR, Yamada S, et al. Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas. Endocr Pathol. 2009;20(4):209–20.
Klibanski A. Clinical practice. Prolactinomas. N Engl J Med. 2010;362(13):1219–26.
Prete A, Corsello SM, Salvatori R. Current best practice in the management of patients after pituitary surgery. Ther Adv Endocrinol Metab. 2017;8(3):33–48.
Laws ER Jr, Onofrio BM, Pearson BW, McDonald TJ, Dirrenberger RAR. Successful management of bilateral carotid-cavernous fistulae with a transsphenoidal approach. Neurosurgery. 1979;4(2):162–7.
Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayoff M. Endoscopic pituitary tumor surgery. Laryngoscope. 1992;102(2):198–202.
Jho HD, Carrau R. Endoscopy assisted transsphenoidal surgery for pituitary adenoma. Technical note. Acta Neurochir. 1996;138(12):1416–25.
Cappabianca P, Alfieri A, de Divitiis E. Endoscopic endonasal transsphenoidal approach to the sella: towards functional endoscopic pituitary surgery (FEPS). Minim Invasive Neurosurg. 1998;41(2):66–73.
Kuan EC, Yoo F, Kim W, Badran KW, Heineman TE, Sepahdari AR, Bergsneider M, Wang MB. Anatomic variations in pituitary endocrinopathies: implications for the surgical corridor. J Neurol Surg B Skull Base. 2017;78(2):105–11.
Cappabianca P, Alfieri A, Coloa A. Endoscopic endonasal transsphenoidal surgery in recurrent and residual pituitary adenomas: technical note. Minim Invasive Neurosurg. 2000;43(1):38–43.
de Divitiis E. Endoscopic transsphenoidal surgery: stone-in-the-pond effect. Neurosurgery. 2006;59(3):512–20.
Cappabianca P, Cavallo LM, de Divitiis E. Endoscopic endonasal transsphenoidal surgery. Neurosurgery. 2004;55(4):933–40.. discussion 940–1.
Cavallo LM, Dal Fabbro M, Jalalod’din H, Messina A, Esposito I, Esposito F, et al. Endoscopic endonasal transsphenoidal surgery. Before scrubbing in: tips and tricks. Surg Neurol. 2007;67:342–7.
Louis RG, Pouratian AG, Jane JA Jr. Endoscopic approaches for pituitary tumors. In: Kassam AB, Gardner PA, editors. Endoscopic approaches for skull base. Basel, Switzerland: S. Karger AG; 2012. p. 60–75.
Leach P, Abou-Zeid AH, Kearney T, Davis J, Trainer PJ, Gnanalingham KK. Endoscopic transsphenoidal pituitary surgery: evidence of an operative learning curve. Neurosurgery. 2010;67(5):1205–12.
Ali Z, Prabhakar H, Bithal PK, Dash HH. Bispectral index-guided administration of anesthesia for transsphenoidal resection of pituitary tumors: a comparison of 3 anesthetic techniques. J Neurosurg Anesthesiol. 2009;21(1):10–5.
Cafiero T, Mastronardi P, Gargiulo G, Cappabianca P, Cavallo LM. Intraoperative analgesia with remifentanil for the endonasal endoscopic approach to pituitary lesions. Anesthesiology. 2002;96:A70.
Chelliah YR, Manninen PH. Hazards of epinephrine in transsphenoidal pituitary surgery. J Neurosurg Anesthesiol. 2002;14(1):43–6.
Pasternak JJ, Atkinson JL, Kasperbauer JL, Lanier WL. Hemodynamic responses to epinephrine-containing local anesthetic injection and to emergence from general anesthesia in transsphenoidal hypophysectomy patients. J Neurosurg Anesthesiol. 2004;16(3):189–95.
Cafiero T, Cavallo LM, Frangiosa A, Burrelli R, Gargiulo G, Cappabianca P, de Divitiis E. Clinical comparison of remifentanil-sevoflurane vs. remifentanil-propofol for endoscopic endonasal transsphenoidal surgery. Eur J Anaesthesiol. 2007;24(5):441–6.
Hristovska AM, Duch P, Allingstrup M, Afshari A. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults. Cochrane Database Syst Rev. 2017;8:CD012763.
Ünal DY, Baran İ, Mutlu M, Ural G, Akkaya T, Özlü O. Comparison of sugammadex versus neostigmine costs and respiratory complications in patients with obstructive sleep apnoea. Turk J Anaesthesiol Reanim. 2015;43(6):387–95.
Laws ER. Surgery for acromegaly: evolution of the techniques and outcomes. Rev Endocr Metab Disord. 2008;9(1):67–70.
Marquez Y, Tuchman A, Zada G. Surgery and radiosurgery for acromegaly: a review of indications, operative techniques, outcomes, and complications. Int J Endocrinol. 2012;2012:386401.
Friedel ME, Johnston DR, Singhal S, Al Khalili K, Farrell CJ, Evans JJ, Nyquist GG, Rosen MR. Airway management and perioperative concerns in acromegaly patients undergoing endoscopic transsphenoidal surgery for pituitary tumors. Otolaryngol Head Neck Surg. 2013;149(6):840–4.
Nemergut EC, Zuo Z. Airway management in patients with pituitary disease: a review of 746 patients. J Neurosurg Anesthesiol. 2006;18(1):73–7.
Zhang Y, Guo X, Pei L, Zhang Z, Tan G, Xing B. High levels of IGF-1 predict difficult intubation of patients with acromegaly. Endocrine. 2017;57(2):326–34.
Bindra A, Prabhakar H, Bithal PK, Singh GP, Chowdhury T. Predicting difficult laryngoscopy in acromegalic patients undergoing surgery for excision of pituitary tumors: a comparison of extended Mallampati score with modified Mallampati classification. J Anaesthesiol Clin Pharmacol. 2013;29(2):187–90.
Law-Koune JD, Liu N, Szekely B, Fischler M. Using the intubating laryngeal mask airway for ventilation and endotracheal intubation in anesthetized and unparalyzed acromegalic patients. J Neurosurg Anesthesiol. 2004;16(1):11–3.
Paolini JB, Donati F, Drolet P. Review article: video-laryngoscopy: another tool for difficult intubation or a new paradigm in airway management? Can J Anaesth. 2013;60(2):184–91.
Agro FE, Vennari M. The videolaryngoscopes are now the first choice to see around the corner. Minerva Anestesiol. 2016;82(12):1247–9.
Cafiero T, Esposito F, Fraioli G, Gargiulo G, Frangiosa A, Cavallo LM, Mennella N, Cappabianca P. Remifentanil-TCI and propofol-TCI for conscious sedation during fibreoptic intubation in the acromegalic patient. Eur J Anaesthesiol. 2008;25(8):670–4.
Clayton RN. Cardiovascular function in acromegaly. Endocr Rev. 2003;24(3):272–7.
Srinivasan A, Bahl A, Bhagat H, Dutta P, Rai A, Devgun JS, Kaur R, Mukherjee KK. Impact of transsphenoidal surgery on asymptomatic cardiomyopathy in patients with acromegaly. A single-blinded study. Neurol India. 2017;65(6):1312–6.
Chung SY, Sylvester MJ, Patel VR, Zaki M, Baredes S, Liu JK, Eloy JA. Impact of obstructive sleep apnea in transsphenoidal pituitary surgery: an analysis of inpatient data. Laryngoscope. 2018;128(5):1027–32.
Molitch ME. Diagnosis and treatment of pituitary adenomas: a review. JAMA. 2017;317(5):516–24.
Debono M, Newell-Price JD. Cushing’s syndrome: where and how to find it. Front Horm Res. 2016;46:15–27.
Wagner-Bartak NA, Baiomy A, Habra MA, Mukhi SV, Morani AC, Korivi BR, Waguespack SG, Elsayes KM. Cushing syndrome: diagnostic workup and imaging features, with clinical and pathologic correlation. AJR Am J Roentgenol. 2017;209(1):19–32.
Pekic S, Popovic V. Diagnosis of endocrine disease: expanding the cause of hypopituitarism. Eur J Endocrinol. 2017;176(6):R269–82.
Johnston PC, Kennedy L, Hamrahian AH, Sandouk Z, Bena J, Hatipoglu B, Weil RJ. Surgical outcomes in patients with Cushing’s disease: the Cleveland clinic experience. Pituitary. 2017;20(4):430–40.
Czirják S, Bezzegh A, Gál A, Rácz K. Intra- and postoperative plasma ACTH concentrations in patients with Cushing’s disease cured by transsphenoidal pituitary surgery. Acta Neurochir. 2002;144(10):971–7.. discussion 977.
Marchand L, Segrestin B, Lapoirie M, Favrel V, Dementhon J, Jouanneau E, Raverot G. Dilated cardiomyopathy revealing Cushing disease: a case report and literature review. Medicine (Baltimore). 2015;94(46):e2011.
Lambert JK, Goldberg L, Fayngold S, Kostadinov J, Post KD, Geer EB. Predictors of mortality and long-term outcomes in treated Cushing’s disease: a study of 346 patients. J Clin Endocrinol Metab. 2013;98(3):1022–30.
Isidori AM, Graziadio C, Paragliola RM, Cozzolino A, Ambrogio AG, Colao A, et al. The hypertension of Cushing’s syndrome: controversies in the pathophysiology and focus on cardiovascular complications. J Hypertens. 2015;33(1):44–60.
Heaney AP, Hunter SJ, Sheridan B, Brew Atkinson A. Increased pressor response to noradrenaline in pituitary dependent Cushing’s syndrome. Clin Endocrinol. 1999;51(3):293–9.
Tack LJ, Tatsi C, Stratakis CA, Lodish MB. Effects of glucocorticoids on bone: what we can learn from pediatric endogenous Cushing’s syndrome. Horm Metab Res. 2016;48(11):764–70.
Giugni AS, Mani S, Kannan S, Hatipoglu B. Exophthalmos: a forgotten clinical sign of Cushing’s syndrome. Case Rep Endocrinol. 2013;2013:205208.
Wang LU, Wang TY, Bai YM, Hsu JW, Huang KL, Su TP, et al. Risk of obstructive sleep apnea among patients with Cushing’s syndrome: a nationwide longitudinal study. Sleep Med. 2017;36:44–7.
Ghirardello S, Hopper N, Albanese A, Maghnie M. Diabetes insipidus in craniopharyngioma: postoperative management of water and electrolyte disorders. J Pediatr Endocrinol Metab. 2006;19(Suppl. 1):413–21.
Finken MJ, Zwaveling-Soonawala N, Walenkamp MJ, Vulsma T, van Trotsenburg AS, Rotteveel J. Frequent occurrence of the triphasic response (diabetes insipidus/hyponatremia/diabetes insipidus) after surgery for craniopharyngioma in childhood. Horm Res Paediatr. 2011;76(1):22–6.
Hussain NS, Piper M, Ludlam WG, Ludlam WH, Fuller CJ, Mayberg MR. Delayed postoperative hyponatremia after transsphenoidal surgery: prevalence and associated factors. J Neurosurg. 2013;119(6):1453–60.
Adrogué HJ, Madias NE. The challenge of hyponatremia. J Am Soc Nephrol. 2012;23(7):1140–8.
Ishiguro T, Ishihara T, Hatano Y, Abe T, Shimohata T, Nishizawa M. A case of central pontine and extrapontine myelinolysis after surgery for a pituitary tumor. Rinsho Shinkeigaku. 2017;57(1):21–5.
Berl T, Rastegar A. A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion. Am J Kidney Dis. 2010;55(4):742–8.
Gralla RJ, Ahmad F, Blais JD, Chiodo J 3rd, Zhou W, Glaser LA, Czerwiec FS. Tolvaptan use in cancer patients with hyponatremia due to the syndrome of inappropriate antidiuretic hormone: a post hoc analysis of the SALT-1 and SALT-2 trials. Cancer Med. 2017;6(4):723–9.
Acknowledgment
The author would like to thank Prof Paolo Cappabianca, Prof Luigi Maria Cavallo, and Dr Domenico Solari at the Division of Neurosurgery of UniversitĂ degli Studi di Napoli Federico II, for having shared their experience and work all along the case series. Further, they have been a precious asset in the English language assistance and iconographic section.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Cafiero, T. (2019). Anesthesia for Pituitary Lesions. In: Prabhakar, H., Ali, Z. (eds) Textbook of Neuroanesthesia and Neurocritical Care. Springer, Singapore. https://doi.org/10.1007/978-981-13-3387-3_10
Download citation
DOI: https://doi.org/10.1007/978-981-13-3387-3_10
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-3386-6
Online ISBN: 978-981-13-3387-3
eBook Packages: MedicineMedicine (R0)