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Impact of Sarcopenia in Healthy Aging and Suggested Interventions

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Molecular Basis and Emerging Strategies for Anti-aging Interventions

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Abstract

Sarcopenia is a condition characterized by loss of skeletal muscle mass and function with aging and is associated with frailty, physical disability, falls, and higher mortality.

Many factors play role in the pathophysiology of sarcopenia. These include genetic factors, mitochondrial defects, decreased anabolic hormones, inflammatory cytokines, insulin resistance, decreased protein intake and activity, poor blood flow to muscle, and growth-derived factor-11 deficiency. The molecular mechanisms underlying and/or associated with sarcopenia have significant role in aging. Hence, interventions targeting sarcopenia shall have an impact on healthy aging. At present, the best-demonstrated and practically recommended approaches to prevent/treat sarcopenia are resistance exercises and intake of adequate protein and vitamin D. Adequate intake of protein and resistance exercises are mandatory to preserve muscle mass. Many other promising treatment modalities are currently being investigated listed on the way.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Geriatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

    Tuğba Erdoğan, Gülistan Bahat & Mehmet Akif Karan

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  1. Tuğba Erdoğan
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  2. Gülistan Bahat
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Editors and Affiliations

  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

  2. Medical Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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Erdoğan, T., Bahat, G., Karan, M.A. (2018). Impact of Sarcopenia in Healthy Aging and Suggested Interventions. In: Rizvi, S., Çakatay, U. (eds) Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-13-1699-9_20

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