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Melatonin and Its Antiaging Activity: New Approaches and Strategies for Age-Related Disorders

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Molecular Basis and Emerging Strategies for Anti-aging Interventions

Abstract

Melatonin (N-acetyl-5-methoxy tryptamine, MLT) is a hormone that is produced by the pineal gland. It is synthesized regularly with high levels at night. Age-related decline in MLT contributes to an increased susceptibility to a number of pathophysiological disorders like neurodegenerative diseases, cancer, and aging. There are strong evidences that both Alzheimer’s disease and Parkinson’s disease are associated with low levels of MLT. Because of its wide-ranging antioxidant and radical scavenger effects, MLT may act as a protective agent against many age-related illnesses. MLT’s protection may be possible for both protein and fat tissues in the body by crossing all cell membrane. Currently available data make us to determine that MLT is beneficial for the aging process. Administration of MLT is able to increase the life span of several animals including some rodents. Although, to preserve health in old age becomes a primary goal for biomedicine, there is a necessity for extensive studies on the administration of MLT in order to increase the quality of life in advanced age. In this chapter experimental approaches to antiaging activity of MLT as well as its possible therapeutic significance are reviewed and discussed.

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Abbreviations

AD:

Alzheimer’s disease

CR:

Caloric restriction

GSH:

Glutathione

HD:

Huntington disease

HNE:

4-hydroxy-2-nonenal

MDA:

Malondialdehyde

miRNA:

MicroRNA

MLT:

Melatonin

mtDNA:

Mitochondrial DNA

NAS:

N-acetylserotonin

OS:

Oxidative stress

PUFA:

Fatty acid

ROS:

Reactive oxygen species

SIRT:

Sirtuin

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

    Sibel Suzen

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  1. Sibel Suzen
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Correspondence to Sibel Suzen .

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  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

  2. Medical Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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Suzen, S. (2018). Melatonin and Its Antiaging Activity: New Approaches and Strategies for Age-Related Disorders. In: Rizvi, S., Çakatay, U. (eds) Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-13-1699-9_14

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