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Understanding and Diagnosing Asthma and COPD by Metabolomics

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Genomic Approach to Asthma

Part of the book series: Translational Bioinformatics ((TRBIO,volume 12))

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Abstract

Metabolomics is an emerging analytical technology which offers unique molecular insights into respiratory diseases such as asthma, COPD, lung cancer, tuberculosis and influenza. Increasing number of studies have demonstrated that metabolomics is valuable in identifying disease phenotypes by revealing disease-relevant metabolic biomarkers in various lung diseases, especially asthma. These unique and distinctive disease metabolic signatures can be useful for clinical discrimination of various airway diseases. Latest reports have demonstrated that metabolomics may also be useful in diagnosing and separating different disease outcomes and stages, implicating the diagnostic value of this analytical approach. In this chapter, we provide a comprehensive overview of metabolomics investigations in asthma and COPD. This review will also discuss the prospective applications, advances and challenges in applying metabolomics to biomarker discovery, and the understanding of molecular disease mechanisms of these major respiratory diseases. With emerging technological advances in metabolomics-related analytical platforms, it is anticipated that metabolomics will become a major analytical technology for clinical phenotyping, diagnosis and understanding of asthma and COPD.

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Authors and Affiliations

  1. IPOS-International Pte. Ltd., a subsidiary of the Intellectual Property Office of Singapore, Singapore, Singapore

    Wanxing Eugene Ho

  2. Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore

    W. S. Fred Wong

  3. Immunology Program, Life Science Institute, National University of Singapore, Singapore, Singapore

    W. S. Fred Wong

  4. Singapore-HUJ Alliance for Research and Enterprise, Molecular Mechanisms of Inflammatory Diseases Interdisciplinary Research Group, Campus for Research Excellence and Technological Enterprise, Singapore, Singapore

    W. S. Fred Wong

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  1. Wanxing Eugene Ho
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Correspondence to W. S. Fred Wong .

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Editors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Shanghai Medical School Fudan University, Shanghai, China

    Xiangdong Wang

  2. Shanghai Respiratory Research Institute, Respiratory Division of Zhongshan Hospital, Fudan University, Shanghai, China

    Zhihong Chen

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Ho, W.E., Fred Wong, W.S. (2018). Understanding and Diagnosing Asthma and COPD by Metabolomics. In: Wang, X., Chen, Z. (eds) Genomic Approach to Asthma. Translational Bioinformatics, vol 12. Springer, Singapore. https://doi.org/10.1007/978-981-10-8764-6_8

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