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Metabolomics of Respiratory Diseases

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Metabolomics and Its Impact on Health and Diseases

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 277))

Abstract

Metabolomics is an expanding field of systems biology that is gaining significant attention in respiratory research. As a unique approach to understanding and diagnosing diseases, metabolomics provides a snapshot of all metabolites present in biological samples such as exhaled breath condensate, bronchoalveolar lavage, plasma, serum, urine, and other specimens that may be obtained from patients with respiratory diseases. In this article, we review the rapidly expanding field of metabolomics in its application to respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and acute lung injury, along with its more severe form, adult respiratory disease syndrome. We also discuss the potential applications of metabolomics for monitoring exposure to aerosolized occupational and environmental materials. With the latest advances in our understanding of the microbiome, we discuss microbiome-derived metabolites that arise from the gut and lung in asthma and COPD that have mechanistic implications for these diseases. Recent literature has suggested that metabolomics analysis using nuclear magnetic resonance (NMR) and mass spectrometry (MS) approaches may provide clinicians with the opportunity to identify new biomarkers that may predict progression to more severe diseases which may be fatal for many patients each year.

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Authors and Affiliations

  1. Department of Medicine, Alberta Respiratory Centre (ARC), University of Alberta, Edmonton, AB, Canada

    Subhabrata Moitra, Arghya Bandyopadhyay & Paige Lacy

Authors
  1. Subhabrata Moitra
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  2. Arghya Bandyopadhyay
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  3. Paige Lacy
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Correspondence to Paige Lacy .

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Editors and Affiliations

  1. Department of Chemistry, University of Florence, Sesto Fiorentino, Florence, Italy

    Veronica Ghini

  2. Department of Clinical Pharmacy, University of Michigan–Ann Arbor, Ann Arbor, MI, USA

    Kathleen A. Stringer

  3. Department of Chemistry, University of Florence, Sesto Fiorentino, Florence, Italy

    Claudio Luchinat

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Moitra, S., Bandyopadhyay, A., Lacy, P. (2022). Metabolomics of Respiratory Diseases. In: Ghini, V., Stringer, K.A., Luchinat, C. (eds) Metabolomics and Its Impact on Health and Diseases. Handbook of Experimental Pharmacology, vol 277. Springer, Cham. https://doi.org/10.1007/164_2022_614

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