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Hydrogel-Based Strategies for Stem Cell Therapy

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Hydrogels

Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

Abstract

Stem cells from different sources provide considerable expectation for applications in tissue engineering and regenerative medicine because of their ability to proliferate and differentiate into functional cells. However, poor cell engraftment and survival after transplantation are key factors limiting the current stem cell-based therapy. The utilization of engineered microenvironments with synthetic biomaterials has been progressively successful in controlling the transplanted cells fate by imitating the native stem cell niche. Recently, synthetic 3D extracellular matrices (ECMs) have been extensively explored as scaffolds for tissue regeneration by emulating the components of natural stem cell niche to minimize implanted cell death. For their tunable tissue-like properties, biodegradability, and biocompatibility in all different forms of biomaterials, hydrogels are most normally used as substrates and scaffolds, which serve as a promising cell delivery vehicle to illustrate stem cell biology. Here, we will focus on recent advances in generating hydrogel, as well as the application of hydrogel for stem cell-based therapy. Finally, hydrogel-based controlled-release strategies for improving therapeutic efficiency of stem cells will be discussed.

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References

  • Allcock HR (2012) Polyphosphazene elastomers, gels, and other soft materials. Soft Matter 8:7521–7532

    Article  CAS  Google Scholar 

  • Anderson SB, Lin CC, Kuntzler DV, Anseth KS (2011) The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 32:3564–3574

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bakota EL, Wang Y, Danesh FR, Hartgerink JD (2011) Injectable multidomain peptide nanofiber hydrogel as a delivery agent for stem cell secretome. Biomacromolecules 12:1651–1657

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Banerjee SS, Aher N, Patil R, Khandare J (2012) Poly(ethylene glycol)-prodrug conjugates: concept, design, and applications. J Drug Delivery 2012:103973

    Article  CAS  Google Scholar 

  • Bardajee GR, Hooshyar Z (2013) A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release. J Polym Res 20:1–13

    Google Scholar 

  • Bueno VB, Bentini R, Catalani LH, Petri DF (2013) Synthesis and swelling behavior of xanthan-based hydrogels. Carbohydr Polym 92:1091–1099

    Article  PubMed  CAS  Google Scholar 

  • Burdick JA, Prestwich GD (2011) Hyaluronic acid hydrogels for biomedical applications. Adv Mater 23:H41–H56

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Busilacchi A, Gigante A, Mattioli-Belmonte M, Manzotti S, Muzzarelli RA (2013) Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration. Carbohydr Polym 98:665–676

    Article  CAS  PubMed  Google Scholar 

  • Calderón MÁR, Zhao W (2014) Applications of polymer nanofibers in bio-materials, biotechnology and biomedicine: a review. Wiley

    Google Scholar 

  • Cameron GJ, Alberts IL, Laing JH, Wess TJ (2002) Structure of type I and type III heterotypic collagen fibrils: an X-ray diffraction study. J Struct Biol 137:15–22

    Article  PubMed  CAS  Google Scholar 

  • Chen JP, Cheng TH (2009) Preparation and evaluation of thermo-reversible copolymer hydrogels containing chitosan and hyaluronic acid as injectable cell carriers. Polymer 50:107–116

    Article  CAS  Google Scholar 

  • Chen C, Wang Z, Li Z (2011) Thermoresponsive polypeptides from pegylated poly-l-glutamates. Biomacromolecules 12:2859–2863

    Article  PubMed  CAS  Google Scholar 

  • Cheng J, Deming TJ (2012) Synthesis of polypeptides by ring-opening polymerization of alpha-amino acid N-carboxyanhydrides. Top Curr Chem 310:1–26

    PubMed  CAS  Google Scholar 

  • Cho D-W, Lee J-S, Jang J, Jung JW, Park JH, Pati F (2015) Natural, synthetic and semi-synthetic polymers, Morgan & Claypool Publishers

    Google Scholar 

  • Choi KY, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Choi K, Jeong SY (2011) PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo. Biomaterials 32:1880–1889

    Article  PubMed  CAS  Google Scholar 

  • Chu L-Y, Xie R, Ju X-J, Wang W (2013) Functional membranes with thermo-responsive hydrogel gates. Springer, pp. 111–133

    Google Scholar 

  • Coviello T, Matricardi P, Marianecci C, Alhaique F (2007) Polysaccharide hydrogels for modified release formulations. J Control Release 119:5–24

    Article  PubMed  CAS  Google Scholar 

  • Dang LTH, Feric NT, Laschinger C, Chang WY, Zhang BY, Wood GA, Stanford WL, Radisic M (2014) Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials 35:7786–7799

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Das N (2013) Preparation methods and properties of hydrogel: a review. Int J Pharm Pharm Sci 5:112–117

    CAS  Google Scholar 

  • de Moraes MA, Beppu MM (2013) Biocomposite membranes of sodium alginate and silk fibroin fibers for biomedical applications. J Appl Polym Sci 130:3451–3457

    Article  CAS  Google Scholar 

  • Dellatore SM, Garcia AS, Miller WM (2008) Mimicking stem cell niches to increase stem cell expansion. Curr Opin Biotechnol 19:534–540

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Deming TJ (2002) Methodologies for preparation of synthetic block copolypeptides: materials with future promise in drug delivery. Adv Drug Delivery Rev 54:1145–1155

    Article  CAS  Google Scholar 

  • Deng M, Kumbar SG, Wan Y, Toti US, Allcock HR, Laurencin CT (2010) Polyphosphazene polymers for tissue engineering: an analysis of material synthesis, characterization and applications. Soft Matter 6:3119

    Article  CAS  Google Scholar 

  • Discher DE, Mooney DJ, Zandstra PW (2009) Growth factors, matrices, and forces combine and control stem cells. Science 324:1673–1677

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dragan ES (2014) Design and applications of interpenetrating polymer network hydrogels. a review. Chem Eng J 243:572–590

    Article  CAS  Google Scholar 

  • Elluru M, Ma HY, Hadjiargyrou M, Hsiao BS, Chu B (2013) Synthesis and characterization of biocompatible hydrogel using pluronics-based block copolymers. Polymer 54:2088–2095

    Article  CAS  Google Scholar 

  • Eshghi S, Schaffer DV (2008) Engineering microenvironments to control stem cell fate and function. The Stem Cell Research Community

    Google Scholar 

  • Feng X, Tonnesen MG, Mousa SA, Clark RA (2013) Fibrin and collagen differentially but synergistically regulate sprout angiogenesis of human dermal microvascular endothelial cells in 3-dimensional matrix. Int J Cell Biol 2013:231279

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Che Y, Xu Y, Kong D, Zhao Q, Li Z (2016) IGF-1 C Domain-modified hydrogel enhances cell therapy for AKI. J Am Soc Nephrol

    Google Scholar 

  • Fullana MJ, Wnek GE (2012) Electrospun collagen and its applications in regenerative medicine. Drug Delivery Transl Res 2:313–322

    Article  CAS  Google Scholar 

  • Gao H, Wang N, Hu X, Nan W, Han Y, Liu W (2013a) Double hydrogen-bonding pH-sensitive hydrogels retaining high-strengths over a wide pH range. Macromol Rapid Commun 34:63–68

    Article  PubMed  CAS  Google Scholar 

  • Gao J, Zheng W, Zhang J, Guan D, Yang Z, Kong D, Zhao Q (2013b) Enzyme-controllable delivery of nitric oxide from a molecular hydrogel. Chem Commun (Camb) 49:9173–9175

    Article  CAS  Google Scholar 

  • Glotzbach JP, Wong VW, Levi B, Longaker MT, Gurtner GC (2012) Delivery strategies for stem cell-based therapy. J Healthc Eng 3:1–20

    Article  Google Scholar 

  • Gombotz WR, Wee SF (2012) Protein release from alginate matrices. Adv Drug Deliver Rev 64:194–205

    Article  Google Scholar 

  • Guvendiren M, Burdick JA (2013) Engineering synthetic hydrogel microenvironments to instruct stem cells. Curr Opin Biotechnol 24:841–846

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hager AS, Arendt EK (2013) Influence of hydroxypropylmethylcellulose (HPMC), xanthan gum and their combination on loaf specific volume, crumb hardness and crumb grain characteristics of gluten-free breads based on rice, maize, teff and buckwheat. Food Hydrocolloids 32:195–203

    Article  CAS  Google Scholar 

  • Harding SE, Smith IH, Lawson CJ, Gahler RJ, Wood S (2011) Studies on macromolecular interactions in ternary mixtures of konjac glucomannan, xanthan gum and sodium alginate. Carbohyd Polym 83:329–338

    Article  CAS  Google Scholar 

  • He L, Zuo Q, Xie S, Huang Y, Xue W (2011) Intelligent hydrogels for drug delivery system. Recent Pat Drug Delivery Formulation 5:265–274

    Article  CAS  Google Scholar 

  • He N, Xu Y, Du W, Qi X, Liang L, Wang Y, Feng G, Fan Y, Han Z, Kong D, Cheng Z, Wu JC, He Z, Li Z (2015) Extracellular matrix can recover the downregulation of adhesion molecules after cell detachment and enhance endothelial cell engraftment. Sci Rep 5:10902

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Heng BC, Cao T, Haider HK, Wang DZ, Sim EK, Ng SC (2004) An overview and synopsis of techniques for directing stem cell differentiation in vitro. Cell Tissue Res 315:291–303

    Article  PubMed  Google Scholar 

  • Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliver Rev 64:18–23

    Article  Google Scholar 

  • Hu Y, You J-O, Auguste DT, Suo Z, Vlassak JJ (2011) Indentation: a simple, nondestructive method for characterizing the mechanical and transport properties of pH-sensitive hydrogels. J Mater Res 27:152–160

    Article  CAS  Google Scholar 

  • Huang J, Heise A (2013) Stimuli responsive synthetic polypeptides derived from N-carboxyanhydride (NCA) polymerisation. Chem Soc Rev 42:7373–7390

    Article  PubMed  CAS  Google Scholar 

  • Huang X, Huang X-J, Yu A-G, Wang C, Dai Z-W, Xu Z-K (2011) “Click chemistry” as a facile approach to the synthesis of polyphosphazene glycopolymers. Macromol Chem Phys 212:272–277

    Article  CAS  Google Scholar 

  • Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ (2010) Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater 9:518–526

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hwang Y, Phadke A, Varghese S (2011) Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells. Regenerative Med 6:505–524

    Article  Google Scholar 

  • Ibrahim S, Johan MR (2012) Thermolysis and conductivity studies of poly(ethylene oxide) (PEO) based polymer electrolytes doped with carbon nanotube. Int J Electrochem Sci 7:2596–2615

    CAS  Google Scholar 

  • Ichikawa H, Fukumori Y (2000) A novel positively thermosensitive controlled-release microcapsule with membrane of nano-sized poly(N-isopropylacrylamide) gel dispersed in ethylcellulose matrix. J Control Release 63:107–119

    Article  PubMed  CAS  Google Scholar 

  • Ingavle GC, Gehrke SH, Detamore MS (2014) The bioactivity of agarose PEGDA interpenetrating network hydrogels with covalently immobilized RGD peptides and physically entrapped aggrecan. Biomaterials 35:3558–3570

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jaiswal A, Ghosh SS, Chattopadhyay A (2012) One step synthesis of C-dots by microwave mediated caramelization of poly(ethylene glycol). Chem Commun (Camb) 48:407–409

    Article  CAS  Google Scholar 

  • Jannesari M, Varshosaz J, Morshed M, Zamani M (2011) Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs. Int J Nanomed 6:993–1003

    CAS  Google Scholar 

  • Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983) Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609–611

    Article  PubMed  CAS  Google Scholar 

  • Jin SP, Gu JX, Shi YJ, Shao KR, Yu XH, Yue GR (2013) Preparation and electrical sensitive behavior of poly (N-vinylpyrrolidone-co-acrylic acid) hydrogel with flexible chain nature. Eur Polym J 49:1871–1880

    Article  CAS  Google Scholar 

  • Jo S, Shin H, Mikos AG (2001) Modification of oligo(poly(ethylene glycol) fumarate) macromer with a GRGD peptide for the preparation of functionalized polymer networks. Biomacromolecules 2:255–261

    Article  PubMed  CAS  Google Scholar 

  • Kazanis I, ffrench-Constant C (2011) Extracellular matrix and the neural stem cell niche. Dev Neurobiol 71:1006–1017

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kempf M, Miyamura Y, Liu PY, Chen AC, Nakamura H, Shimizu H, Tabata Y, Kimble RM, McMillan JR (2011) A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting. Biomaterials 32:4782–4792

    Article  PubMed  CAS  Google Scholar 

  • Khetan S, Guvendiren M, Legant WR, Cohen DM, Chen CS, Burdick JA (2013) Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater 12:458–465

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kim J, Kim IS, Cho TH, Lee KB, Hwang SJ, Tae G, Noh I, Lee SH, Park Y, Sun K (2007) Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 28:1830–1837

    Article  PubMed  CAS  Google Scholar 

  • Kim J, Kim IS, Cho TH, Kim HC, Yoon SJ, Choi J, Park Y, Sun K, Hwang SJ (2010) In vivo evaluation of MMP sensitive high-molecular weight HA-based hydrogels for bone tissue engineering. J Biomed Mater Res A 95:673–681

    Article  PubMed  CAS  Google Scholar 

  • Kim IL, Mauck RL, Burdick JA (2011) Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials 32:8771–8782

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kinard LA, Kasper FK, Mikos AG (2012) Synthesis of oligo(poly(ethylene glycol) fumarate). Nat Protoc 7:1219–1227

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Komeri R, Thankam FG, Muthu J (2015) Influence of matrix and bulk behaviour of an injectable hydrogel on the survival of encapsulated cardiac cells. Rsc Adv 5:31439–31449

    Article  CAS  Google Scholar 

  • Korotych O, Samchenko Y, Boldeskul I, Ulberg Z, Zholobak N, Sukhodub L (2013) N-isopropylacrylamide-based fine-dispersed thermosensitive ferrogels obtained via in-situ technique. Mater Sci Eng C Mater Biol Appl 33:892–900

    Article  PubMed  CAS  Google Scholar 

  • Kost J, Langer R (2012) Responsive polymeric delivery systems. Adv Drug Delivery Rev 64:327–341

    Article  Google Scholar 

  • Kulkarni M, O’Loughlin A, Vazquez R, Mashayekhi K, Rooney P, Greiser U, O’Toole E, O’Brien T, Malagon MM, Pandit A (2014) Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds. Biomaterials 35:2001–2010

    Article  PubMed  CAS  Google Scholar 

  • Laftah WA, Hashim S, Ibrahim AN (2011) Polymer hydrogels: a Review. Polym-Plast Technol 50:1475–1486

    Article  CAS  Google Scholar 

  • Lee KY, Mooney DJ (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37:106–126

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leipzig ND, Wylie RG, Kim H, Shoichet MS (2011) Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds. Biomaterials 32:57–64

    Article  PubMed  CAS  Google Scholar 

  • Leslie-Barbick JE, Saik JE, Gould DJ, Dickinson ME, West JL (2011) The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide. Biomaterials 32:5782–5789

    Article  PubMed  CAS  Google Scholar 

  • Li H, Chen J, Lam KY (2007) Transient simulation of kinetics of electric-sensitive hydrogels. Biosens Bioelectron 22:1633–1641

    Article  PubMed  CAS  Google Scholar 

  • Li Z, Han Z, Wu JC (2009a) Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases. J Cell Biochem 106:194–199

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC (2009b) Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol 53:1229–1240

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li W, Yue J, Liu S (2012) Preparation of nanocrystalline cellulose via ultrasound and its reinforcement capability for poly(vinyl alcohol) composites. Ultrason Sonochem 19:479–485

    Article  PubMed  CAS  Google Scholar 

  • Liu Z, Wang H, Wang Y, Lin Q, Yao A, Cao F, Li D, Zhou J, Duan C, Du Z, Wang Y, Wang C (2012) The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials 33:3093–3106

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Xu HH, Zhou H, Weir MD, Chen Q, Trotman CA (2013) Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering. Acta Biomater 9:4688–4697

    Article  PubMed  CAS  Google Scholar 

  • Liu FY, Seuring J, Agarwal S (2014a) A non-ionic thermophilic hydrogel with positive thermosensitivity in water and electrolyte solution. Macromol Chem Phys 215:1466–1472

    Article  CAS  Google Scholar 

  • Liu H, Cheng J, Chen F, Hou F, Bai D, Xi P, Zeng Z (2014b) Biomimetic and cell-mediated mineralization of hydroxyapatite by carrageenan functionalized graphene oxide. ACS Appl Mater Interfaces 6:3132–3140

    Article  PubMed  CAS  Google Scholar 

  • Liu Y, Qi N, Song T, Jia M, Xia Z, Yuan Z, Yuan W, Zhang KQ, Sun B (2014c) Highly flexible and lightweight organic solar cells on biocompatible silk fibroin. ACS Appl Mater Interfaces 6:20670–20675

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Willför S, Xu C (2015) A review of bioactive plant polysaccharides: biological activities, functionalization, and biomedical applications. Bioact Carbohydr Dietary Fibre 5:31–61

    Article  CAS  Google Scholar 

  • Lu Q, Zhang B, Li M, Zuo B, Kaplan DL, Huang Y, Zhu H (2011) Degradation mechanism and control of silk fibroin. Biomacromolecules 12:1080–1086

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu H, Wang J, Song Z, Yin L, Zhang Y, Tang H, Tu C, Lin Y, Cheng J (2014) Recent advances in amino acid N-carboxyanhydrides and synthetic polypeptides: chemistry, self-assembly and biological applications. Chem Commun (Camb) 50:139–155

    Article  CAS  Google Scholar 

  • Lutolf MP, Gilbert PM, Blau HM (2009) Designing materials to direct stem-cell fate. Nature 462:433–441

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ma GP, Fang DW, Liu Y, Zhu XD, Nie J (2012) Electrospun sodium alginate/poly(ethylene oxide) core-shell nanofibers scaffolds potential for tissue engineering applications. Carbohyd Polym 87:737–743

    Article  CAS  Google Scholar 

  • Macaya D, Spector M (2012) Injectable hydrogel materials for spinal cord regeneration: a review. Biomed Mater 7:012001

    Article  PubMed  CAS  Google Scholar 

  • Madl CM, Mehta M, Duda GN, Heilshorn SC, Mooney DJ (2014) Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells. Biomacromolecules 15:445–455

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mallakpour S, Barati A (2011) Efficient preparation of hybrid nanocomposite coatings based on poly(vinyl alcohol) and silane coupling agent modified TiO2 nanoparticles. Prog Org Coat 71:391–398

    Article  CAS  Google Scholar 

  • Mano JF, Silva GA, Azevedo HS, Malafaya PB, Sousa RA, Silva SS, Boesel LF, Oliveira JM, Santos TC, Marques AP, Neves NM, Reis RL (2007) Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. J R Soc Interface 4:999–1030

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Masters KS (2011) Covalent growth factor immobilization strategies for tissue repair and regeneration. Macromol Biosci 11:1149–1163

    Article  PubMed  CAS  Google Scholar 

  • Mikac U, Baumgartner S, Sepe A, Kristl J (2013) MRI study of hydrophilic xanthan tablets with incorporated model drug. JB Principles Diffus Theor Exp Appl 18:1–5

    Google Scholar 

  • Milosavljevic NB, Ristic MD, Peric-Grujic AA, Filipovic JM, Strbac SB, Rakocevic Z, Kalagasidis Krusic MT (2011) Sorption of zinc by novel pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. J Hazard Mater 192:846–854

    Article  PubMed  CAS  Google Scholar 

  • Mitra T, Sailakshmi G, Gnanamani A, Raja ST, Thiruselvi T, Gowri VM, Selvaraj NV, Ramesh G, Mandal AB (2011) Preparation and characterization of a thermostable and biodegradable biopolymers using natural cross-linker. Int J Biol Macromol 48:276–285

    Article  PubMed  CAS  Google Scholar 

  • Mogosanu GD, Grumezescu AM (2014) Natural and synthetic polymers for wounds and burns dressing. Int J Pharm 463:127–136

    Article  PubMed  CAS  Google Scholar 

  • Moloney TC, Fhlathartaigh MN, Kulkarni M, Pandit A, Dowd E (2015) Fibrin as a scaffold for delivery of GDNF overexpressing stem cells to the adult rat brain. ACS Biomater Sci Eng 1:559–566

    Article  CAS  PubMed  Google Scholar 

  • Morimune S, Kotera M, Nishino T, Goto K, Hata K (2011) Poly(vinyl alcohol) nanocomposites with nanodiamond. Macromolecules 44:4415–4421

    Article  CAS  Google Scholar 

  • Murali R, Anumary A, Ashokkumar M, Thanikaivelan P, Chandrasekaran B (2011) Hybrid biodegradable films from collagenous wastes and natural polymers for biomedical applications. Waste Biomass Valor 2:323–335

    Article  CAS  Google Scholar 

  • Neffe AT, Wischke C, Racheva M, Lendlein A (2013) Progress in biopolymer-based biomaterials and their application in controlled drug delivery. Expert Rev Med Devices 10:813–833

    Article  PubMed  CAS  Google Scholar 

  • Obermeier B, Wurm F, Mangold C, Frey H (2011) Multifunctional Poly(ethylene glycol)s. Angew Chem Int Ed Engl 50:7988–7997

    Article  PubMed  CAS  Google Scholar 

  • Oh EJ, Choi JS, Kim H, Joo CK, Hahn SK (2011) Anti-Flt1 peptide—hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy. Biomaterials 32:3115–3123

    Article  PubMed  CAS  Google Scholar 

  • Park H, Temenoff JS, Holland TA, Tabata Y, Mikos AG (2005) Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials 26:7095–7103

    Article  PubMed  CAS  Google Scholar 

  • Park H, Temenoff JS, Tabata Y, Caplan AI, Mikos AG (2007) Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 28:3217–3227

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Peach MS, Kumbar SG, James R, Toti US, Balasubramaniam D, Deng M, Ulery B, Mazzocca AD, McCarthy MB, Morozowich NL, Allcock HR, Laurencin CT (2012) Design and optimization of polyphosphazene functionalized fiber matrices for soft tissue regeneration. J Biomed Nanotechnol 8:107–124

    Article  PubMed  CAS  Google Scholar 

  • Phadke A, Zhang C, Arman B, Hsu CC, Mashelkar RA, Lele AK, Tauber MJ, Arya G, Varghese S (2012) Rapid self-healing hydrogels. Proc Natl Acad Sci U S A 109:4383–4388

    Article  PubMed  PubMed Central  Google Scholar 

  • Popa EG, Gomes ME, Reis RL (2011) Cell delivery systems using alginate–carrageenan hydrogel beads and fibers for regenerative medicine applications. Biomacromolecules 12:3952–3961

    Article  PubMed  CAS  Google Scholar 

  • Prestwich GD (2011) Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. J Control Release 155:193–199

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Priya James H, John R, Alex A, Anoop KR (2014) Smart polymers for the controlled delivery of drugs—a concise overview. Acta Pharm Sin B 4:120–127

    Article  PubMed  PubMed Central  Google Scholar 

  • Qiu Y, Park K (2012) Environment-sensitive hydrogels for drug delivery. Adv Drug Deliver Rev 64:49–60

    Article  Google Scholar 

  • Rayahin JE, Buhrman JS, Zhang Y, Koh TJ, Gemeinhart RA (2015) High and low molecular weight hyaluronic acid differentially influence macrophage activation. ACS Biomater Sci Eng 1:481–493

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Reis LA, Chiu LL, Liang Y, Hyunh K, Momen A, Radisic M (2012) A peptide-modified chitosan-collagen hydrogel for cardiac cell culture and delivery. Acta Biomater 8:1022–1036

    Article  PubMed  CAS  Google Scholar 

  • Roberts MJ, Bentley MD, Harris JM (2012) Chemistry for peptide and protein PEGylation. Adv Drug Deliver Rev 64:116–127

    Article  Google Scholar 

  • Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2012) Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation 125: e2–e220

    Google Scholar 

  • Ruvinov E, Leor J, Cohen S (2010) The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model. Biomaterials 31:4573–4582

    Article  PubMed  CAS  Google Scholar 

  • Samchenko Y, Ulberg Z, Korotych O (2011) Multipurpose smart hydrogel systems. Adv Colloid Interface Sci 168:247–262

    Article  PubMed  CAS  Google Scholar 

  • Sharma S, Lohan S, Murthy RS (2014) Formulation and characterization of intranasal mucoadhesive nanoparticulates and thermo-reversible gel of levodopa for brain delivery. Drug Dev Ind Pharm 40:869–878

    Article  PubMed  CAS  Google Scholar 

  • Silva Nykänen VP, Nykänen A, Puska MA, Silva GG, Ruokolainen J (2011) Dual-responsive and super absorbing thermally cross-linked hydrogel based on methacrylate substituted polyphosphazene. Soft Matter 7:4414

    Article  CAS  Google Scholar 

  • Sipahigil O, Dortunc B (2001) Preparation and in vitro evaluation of verapamil HCl and ibuprofen containing carrageenan beads. Int J Pharm 228:119–128

    Article  PubMed  CAS  Google Scholar 

  • Snippert HJ, Clevers H (2011) Tracking adult stem cells. EMBO Rep 12:113–122

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Srivastava A, Shukla S, Kumar R (2016) Applications and characteristics properties of polymeric hydrogel. J Chem Chem Sci 6(2):166–181

    Google Scholar 

  • Tabar V, Studer L (2014) Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nat Rev Genet 15:82–92

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H (2008) Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction. J Am Coll Cardiol 52:1858–1865

    Article  PubMed  CAS  Google Scholar 

  • Temenoff JS, Athanasiou KA, LeBaron RG, Mikos AG (2002) Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res 59:429–437

    Article  PubMed  CAS  Google Scholar 

  • Teramoto H, Kojima K (2014) Production of Bombyx mori silk fibroin incorporated with unnatural amino acids. Biomacromolecules 15:2682–2690

    Article  PubMed  CAS  Google Scholar 

  • Terella A, Mariner P, Brown N, Anseth K, Streubel SO (2010) Repair of a calvarial defect with biofactor and stem cell-embedded polyethylene glycol scaffold. Arch Facial Plast Surg 12:166–171

    Article  PubMed  PubMed Central  Google Scholar 

  • Thakur VK, Kessler MR (2015) Self-healing polymer nanocomposite materials: a review. Polymer 69:369–383

    Article  CAS  Google Scholar 

  • Thakur VK, Thakur MK (2014a) Recent trends in hydrogels based on psyllium polysaccharide: a review. J Clean Prod 82:1–15

    Article  CAS  Google Scholar 

  • Thakur VK, Thakur MK (2014b) Recent Advances in Graft Copolymerization and Applications of Chitosan: a Review. ACS Sustain Chem Eng 2(12):2637–2652

    Article  CAS  Google Scholar 

  • Thakur VK, Thakur MK (2015) Recent advances in green hydrogels from lignin: a review. Int J Biol Macromol 72:834–847

    Article  PubMed  CAS  Google Scholar 

  • Thakur MK, Thakur VK, Gupta RK, Pappu A (2016) Synthesis and applications of biodegradable soy based graft copolymers: a review. ACS Sustain Chem Eng 4:1–17

    Article  CAS  Google Scholar 

  • Tian HY, Tang ZH, Zhuang XL, Chen XS, Jing XB (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 37:237–280

    Article  CAS  Google Scholar 

  • Trombino S, Cassano R, Ferrarelli T, Isacchi B, Bilia AR, Picci N (2012) Collagen α-tocopherulate for topical applications: preparation, characterization, and antioxidant activity evaluation. Macromol Res 20:939–943

    Article  CAS  Google Scholar 

  • Vaghani SS, Patel MM (2011) pH-sensitive hydrogels based on semi-interpenetrating network (semi-IPN) of chitosan and polyvinyl pyrrolidone for clarithromycin release. Drug Dev Ind Pharm 37:1160–1169

    Article  PubMed  CAS  Google Scholar 

  • Van Vlierberghe S, Dubruel P, Schacht E (2011) Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromolecules 12:1387–1408

    Article  PubMed  CAS  Google Scholar 

  • Vermonden T, Censi R, Hennink WE (2012) Hydrogels for protein delivery. Chem Rev 112:2853–2888

    Article  PubMed  CAS  Google Scholar 

  • Walker MR, Patel KK, Stappenbeck TS (2009) The stem cell niche. J Pathol 217:169–180

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Zhou J, Liu Z, Wang C (2010) Injectable cardiac tissue engineering for the treatment of myocardial infarction. J Cell Mol Med 14:1044–1055

    PubMed  PubMed Central  CAS  Google Scholar 

  • Wang JC, Wang XB, Xu CH, Zhang M, Shang XP (2011) Preparation of graphene/poly(vinyl alcohol) nanocomposites with enhanced mechanical properties and water resistance. Polym Int 60:816–822

    Article  CAS  Google Scholar 

  • Wang H, Liu Z, Li D, Guo X, Kasper FK, Duan C, Zhou J, Mikos AG, Wang C (2012) Injectable biodegradable hydrogels for embryonic stem cell transplantation: improved cardiac remodelling and function of myocardial infarction. J Cell Mol Med 16:1310–1320

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang M, Fu J, Huang D, Zhang C, Xu Q (2013) Silver nanoparticles-decorated polyphosphazene nanotubes: synthesis and applications. Nanoscale 5:7913–7919

    Article  PubMed  CAS  Google Scholar 

  • Weber C, Hoogenboom R, Schubert US (2012) Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s. Prog Polym Sci 37:686–714

    Article  CAS  Google Scholar 

  • Weisel JW, Litvinov RI (2013) Mechanisms of fibrin polymerization and clinical implications. Blood 121:1712–1719

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wichterle O, Lim D (1960) Hydrophilic gels for biological use. Nature 185:117–118

    Article  Google Scholar 

  • Wu J, Ren Y, Sun J, Feng L (2013) Carbon nanotube-coated macroporous poly(N-isopropylacrylamide) hydrogel and its electrosensitivity. ACS Appl Mater Interfaces 5:3519–3523

    Article  PubMed  CAS  Google Scholar 

  • Xia Y, Zhu K, Lai H, Lang M, Xiao Y, Lian S, Guo C, Wang C (2015) Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation. Exp Biol Med (Maywood) 240:593–600

    Article  CAS  Google Scholar 

  • Xu J, Zhao Q, Jin Y, Qiu L (2014) High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy. Nanomedicine 10:349–358

    Article  PubMed  CAS  Google Scholar 

  • Yamada N, Yanai R, Nakamura M, Inui M, Nishida T (2004) Role of the C domain of IGFs in synergistic promotion, with a substance P-derived peptide, of rabbit corneal epithelial wound healing. Invest Ophthalmol Vis Sci 45:1125–1131

    Article  PubMed  Google Scholar 

  • Yang JA, Park K, Jung H, Kim H, Hong SW, Yoon SK, Hahn SK (2011) Target specific hyaluronic acid-interferon alpha conjugate for the treatment of hepatitis C virus infection. Biomaterials 32:8722–8729

    Article  PubMed  CAS  Google Scholar 

  • Yao X, Liu Y, Gao J, Yang L, Mao D, Stefanitsch C, Li Y, Zhang J, Ou L, Kong D, Zhao Q, Li Z (2015) Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials 60:130–140

    Article  PubMed  CAS  Google Scholar 

  • Ye Z, Zhou Y, Cai H, Tan W (2011) Myocardial regeneration: roles of stem cells and hydrogels. Adv Drug Delivery Rev 63:688–697

    Article  CAS  Google Scholar 

  • Yi SY, Hao YB, Nan KJ, Fan TL (2013) Cancer stem cells niche: a target for novel cancer therapeutics. Cancer Treat Rev 39:290–296

    Article  PubMed  CAS  Google Scholar 

  • Zhang C, Huang S, Tjiu WW, Fan W, Liu T (2012) Facile preparation of water-dispersible graphene sheets stabilized by acid-treated multi-walled carbon nanotubes and their poly(vinyl alcohol) composites. J Mater Chem 22:2427–2434

    Article  CAS  Google Scholar 

  • Zhao Q, Zhang J, Song L, Ji Q, Yao Y, Cui Y, Shen J, Wang PG, Kong D (2013) Polysaccharide-based biomaterials with on-demand nitric oxide releasing property regulated by enzyme catalysis. Biomaterials 34:8450–8458

    Article  PubMed  CAS  Google Scholar 

  • Zheng C, Xu J, Yao X, Xu J, Qiu L (2011) Polyphosphazene nanoparticles for cytoplasmic release of doxorubicin with improved cytotoxicity against Dox-resistant tumor cells. J Colloid Interface Sci 355:374–382

    Article  PubMed  CAS  Google Scholar 

  • Zhou H, Xu HH (2011) The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering. Biomaterials 32:7503–7513

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhu J, Marchant RE (2011) Design properties of hydrogel tissue-engineering scaffolds. Expert Rev Med Devices 8:607–626

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgements

This work was partially supported by grants from the National Natural Science Foundation of China (81671734, 81371620, 81320108014), National Key R & D Program of China (2017YFA0103200), and Key Projects of Tianjin Science and Technology Support Program.

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Authors and Affiliations

  1. Department of Pathophysiology, Nankai University School of Medicine, 94 Weijin Road, Tianjin, 300071, China

    Shuaiqiang Zhang, Yan Nie, Hongyan Tao & Zongjin Li

  2. The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, College of Life Sciences, Tianjin, 300071, China

    Zongjin Li

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  1. Shuaiqiang Zhang
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  2. Yan Nie
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  3. Hongyan Tao
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  4. Zongjin Li
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Correspondence to Zongjin Li .

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  1. Faculty in Manufacturing, Enhanced Composites and Structures Centre, School of Aerospace, Transport and Manufacturing, Cranfield University, Cranfield, UK

    Vijay Kumar Thakur

  2. Division of Chemistry, Government Degree College Bhoranj, Himachal Pradesh University, Shimla, Himachal Pradesh, India

    Manju Kumari Thakur

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Zhang, S., Nie, Y., Tao, H., Li, Z. (2018). Hydrogel-Based Strategies for Stem Cell Therapy. In: Thakur, V., Thakur, M. (eds) Hydrogels. Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-10-6077-9_4

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