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Proteomics of Male Infertility

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Male Infertility: Understanding, Causes and Treatment

Abstract

Screening of male infertility cases via clinical semen analysis is not apt to diagnose the causes in 30–50% of infertility cases. Such idiopathic cases with no known cause are difficult to monitor and thus provide momentum toward enhanced and sensitive diagnostic tools for infertility examinations. “Omics,” the system biology approach to study the biological system on a large scale, includes proteomics as a newcomer. The era of clinical proteomics in combination with bioinformatics has emerged as a new tool to identify novel molecular markers for pathology. The supremacy of proteomics technology to characterize the proteome content of a cell or tissue on a large scale has enabled it to explicate both global and targeted proteins. Both seminal plasma and sperm serve to have the potential to be a preliminary material for identifying protein signatures related to infertility. The current chapter illustrates the lacunae allied with the clinical semen analysis for infertility investigations and exemplifies the role of clinical semen proteomics in male infertility identification.

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  1. Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India

    Ashima Sinha & Savita Yadav

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  1. Ashima Sinha
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  2. Savita Yadav
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Correspondence to Savita Yadav .

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  1. Endocrinology Division, Central Drug Research Institute, Lucknow, Uttar Pradesh, India

    RAJENDER SINGH

  2. Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Kiran Singh

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Sinha, A., Yadav, S. (2017). Proteomics of Male Infertility. In: SINGH, R., Singh, K. (eds) Male Infertility: Understanding, Causes and Treatment. Springer, Singapore. https://doi.org/10.1007/978-981-10-4017-7_18

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