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Pluripotent Stem Cells and Skeletal Muscle Differentiation: Challenges and Immediate Applications

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The Plasticity of Skeletal Muscle

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Abstract

Recent advances in the generation of skeletal muscle derivatives from pluripotent stem cells (PSCs) provide innovative tools for muscle development, disease modeling, and cell replacement therapies. Here, we revise major relevant findings that have contributed to these advances in the field, by the revision of how early findings using mouse embryonic stem cells (ESCs) set the bases for the derivation of skeletal muscle cells from human pluripotent stem cells (hPSCs) and patient-derived human-induced pluripotent stem cells (hiPSCs) to the use of genome editing platforms allowing for disease modeling in the petri dish.

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Acknowledgments

E.G. was partially supported by La Fundació Privada La Marató de TV3, 121430/31/32, and Spanish Ministry of Economy and Competitiveness-MINECO (SAF2014-59778). M.B. and J.S. has been financially supported by the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya (2014 SGR 1442) and developed in the context of ADVANCE(CAT) with the support of ACCIÓ (Catalonia Trade & Investment; Generalitat de Catalunya) and the European Community under the Catalonian ERDF operational program (European Regional Development Fund) 2014–2020. This work also was partially supported by the project MINDS (TEC2015-70104-P), awarded by the Spanish Ministry of Economy and Competitiveness. N.M. was partially supported by StG-2014-640525_REGMAMKID, La Fundació Privada La Marató de TV3 (121430/31/32), MINECO SAF2014-59778, and the Spanish Ministry of Science and Innovation (PLE 2009-147), RYC-2014-16242, and 2014 SGR 1442.

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Authors and Affiliations

  1. Pluripotent stem cells and activation of endogenous tissue programs for organ regeneration, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

    Elena Garreta, Andrés Marco, Carolina Tarantino, Mireia Samitier & Nuria Montserrat

  2. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain

    Elena Garreta, Andrés Marco, Carolina Tarantino, Mireia Samitier, Josep Samitier & Nuria Montserrat

  3. Basque Center for Transfusion and Human Tissues, Galdakao, Spain

    Cristina Eguizábal

  4. Nanobioengineering group, Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15-21, 08028, Barcelona, Spain

    Maider Badiola & Josep Samitier

  5. Department of Engineering: Electronics, University of Barcelona, 08028, Barcelona, Spain

    Joaquín Gutiérrez

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  1. Elena Garreta
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  1. Institute for Liberal Arts, Environment and Society, Tokyo Institute of Technology, Tokyo, Japan

    Kunihiro Sakuma

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Garreta, E. et al. (2017). Pluripotent Stem Cells and Skeletal Muscle Differentiation: Challenges and Immediate Applications. In: Sakuma, K. (eds) The Plasticity of Skeletal Muscle. Springer, Singapore. https://doi.org/10.1007/978-981-10-3292-9_1

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