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Cysteine Cathepsins: In Health and Rheumatoid Arthritis

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Proteases in Human Diseases

Abstract

Proteases are enzymes which catalyze the irreversible hydrolysis of peptide bonds in proteins. Cysteine cathepsins belonging to proteases have also been termed as papain-like proteases because they resemble the overall fold of papain. The present chapter aims to focus on the historical aspects, structure, cellular distribution, biosynthesis, mechanism of catalysis, its regulation, physiological functions, and its association with rheumatoid arthritis. As these enzymes are also new therapeutic drug targets, information on available assays of cysteine cathepsins and their inhibitors are also highlighted which will help in the development of therapies in various diseases.

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Acknowledgements

The author acknowledges K.M. Vasanth, Ph.D. research scholar, Department of Biochemistry, SRMC & RI, Sri Ramachandra University, Chennai, India for the technical support rendered for preparing this chapter.

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  1. Department of Biochemistry, SRMC & RI, Sri Ramachandra University, Chennai, India

    Nalini Ganesan

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Faculty of Medicine, St. Boniface General Hospital, Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Ganesan, N. (2017). Cysteine Cathepsins: In Health and Rheumatoid Arthritis. In: Chakraborti, S., Chakraborti, T., Dhalla, N. (eds) Proteases in Human Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-10-3162-5_6

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