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CFD-DEM Study the Effect of Carrier-Drug Mass Ratio on the Aerosolisation Process in Original and Modified Dry Powder Inhalers

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Proceedings of the 7th International Conference on Discrete Element Methods (DEM 2016)

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 188))

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Abstract

Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation . Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased.

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Authors and Affiliations

  1. School of Energy and Environment, Southeast University, Nanjing, 210096, China

    Zhenbo Tong

  2. Centre for Simulation and Modelling of Particulate Systems, Southeast University-Monash University Joint Research Institute, Suzhou, 215123, China

    Zhenbo Tong, Wenqi Zhong & Aibing Yu

  3. Department of Chemical Engineering, Monash University, Clayton, VIC, 3800, Australia

    Wenqi Zhong & Aibing Yu

Authors
  1. Zhenbo Tong
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  2. Wenqi Zhong
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  3. Aibing Yu
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Correspondence to Zhenbo Tong .

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Editors and Affiliations

  1. Dalian University of Technology, Department of Engineering Mechanics Dalian University of Technology, Dalian, Liaoning, China

    Xikui Li

  2. Swansea University, College of Engineering Swansea University, Swansea, United Kingdom

    Yuntian Feng

  3. Colorado School of Mines, Department of Mechanical Engineering Colorado School of Mines, Golden, Colorado, USA

    Graham Mustoe

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Tong, Z., Zhong, W., Yu, A. (2017). CFD-DEM Study the Effect of Carrier-Drug Mass Ratio on the Aerosolisation Process in Original and Modified Dry Powder Inhalers. In: Li, X., Feng, Y., Mustoe, G. (eds) Proceedings of the 7th International Conference on Discrete Element Methods. DEM 2016. Springer Proceedings in Physics, vol 188. Springer, Singapore. https://doi.org/10.1007/978-981-10-1926-5_100

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  • DOI: https://doi.org/10.1007/978-981-10-1926-5_100

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1925-8

  • Online ISBN: 978-981-10-1926-5

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