Abstract
Pediatric brain tumors are the second most common form of childhood cancer behind hematological malignancies, with close to 3,400 new cases diagnosed each year. Pediatric solid tumors, including brain tumors, have high angiogenic potential, thus increasing their ability for growth and metastases. Blood vessels are a key element to the growth of a tumor, making the endothelial and hematopoietic cells that support angiogenesis ideal for use as a biomarker, potentially able to diagnosis and monitor the progression of disease. In this chapter, data from pediatric solid tumor studies will be analyzed and reviewed to determine which current biomarkers have the most potential for influencing treatment and/or outcome. Flow cytometry has advanced significantly over the past decade, thus allowing for enhanced characterization of these circulating cell subsets, with the most recent clinical studies incorporating these newer sophisticated techniques. Moreover, utilizing multiparameter flow cytometry, a new frontier of pediatric solid tumor diagnosis and monitoring is now being explored to better understand the role of circulating cells in malignancies and the incorporation of successful biomarkers into the clinic.
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Mund, J., Case, J. (2014). Children with Solid Tumors: Identification of Hematopoietic and Endothelial Progenitor Cells as Biomarkers. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 11. Stem Cells and Cancer Stem Cells, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7329-5_17
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DOI: https://doi.org/10.1007/978-94-007-7329-5_17
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